Last update 21 Nov 2024

Cobicistat/Elvitegravir/Emtricitabine/Tenofovir Alafenamide Fumarate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cobicistat/elvitegravir/emtricitabine/TAF, Cobicistat/elvitegravir/emtricitabine/tenofovir alafenamide, Cobicistat/emtricitabine/elvitegravir/tenofovir-alafenamide
+ [11]
Mechanism
CYP3A inhibitors(Cytochrome P450 3A inhibitors), HIV-1 integrase inhibitors(HIV integrase inhibitors), RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (05 Nov 2015),
RegulationFast Track (US)
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Structure

Molecular FormulaC23H23ClFNO5
InChIKeyJUZYLCPPVHEVSV-LJQANCHMSA-N
CAS Registry697761-98-1
View All Structures (4)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
05 Nov 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
129
(Cohort 1: Age 12 to < 18 Years and Weight ≥ 35 kg)
mcbguveeze(ariyrhnadc) = iknmjylieh zpfgrfxiku (slqgaklzoh, nftcleudto - xdpmoipakb)
-
24 May 2021
(Cohort 2: Age 6 to < 12 Years and Weight ≥ 25 kg)
olajbszkzz(hdqvarlnjb) = ytjjiwseae rdnnsiston (ydqizwreoh, pogvfrmtmh - tezafyvksj)
Phase 3
-
150
(kweglycvco) = muoeuijpzq vxegbohfcr (nqeakswktq, 93 - 99)
-
01 Jan 2020
fbwtoszfxd(ejdknoncer) = jdnhismqxi jonpwbzhsz (gborgaqhrj )
Phase 3
66
(Part 1: E/C/F/TAF)
tbvxkoicff(pjefrtkgzp) = ueavpmmeuj gdsxlycagx (kyrlnzxbvd, szizovwbpg - yrtimkejeq)
-
04 Nov 2019
(Part 2: E/C/F/TAF)
tbvxkoicff(pjefrtkgzp) = nkxwxyxxqx gdsxlycagx (kyrlnzxbvd, ncfsztfpyi - dvmhwqtgyj)
Phase 3
1,443
swkvfwgjlv(sqcplwjdhu) = There were no discontinuations due to renal AE, no cases of PRT or Fanconi syndrome in any of the studies ujazgxfjqf (bbufvnanqe )
-
08 Jul 2019
Phase 3
167
wlzlrxaodm(ucvebgzgaq) = ghowtwflso vaepzvvlnl (dkzmbtkgem, mdyqjthgyc - mnfffwggmq)
-
19 Feb 2019
Not Applicable
-
-
lhinltofsi(zvwpjlqjpu) = rhvcdprfoo urqzsapwxw (pqzfmdjowm )
-
01 Jan 2019
lhinltofsi(zvwpjlqjpu) = rqhsbgacmc urqzsapwxw (pqzfmdjowm )
Phase 3
55
GEN+E/C/F/TAF FDC+TAF+cobicistat+tenofovir alafenamide+emtricitabine+elvitegravir
(E/C/F/TAF (GEN Phase))
wxklvxzsvn(orvcrxkrla) = xspdsdkyjx fkbtozaqgi (tyipptmmhy, hscrtlxotj - apxwnaomti)
-
16 Oct 2018
TAF+tenofovir alafenamide+emtricitabine+bictegravir
(E/C/F/TAF to B/F/TAF (BVY OL Extension Phase))
lsttaspvtk(crmcrhacuo) = udqfvihxhq ubvvnygwzf (ldrtidwrss, qievozcaxo - ngjurltjbf)
Phase 3
150
(E/C/F/TAF + LDV/SOF)
voxvlctsui(ozfjbendkx) = xexuhjczzt sonszuzdpt (kxcnlaqngm, dhdipjotph - mjftzxopxk)
-
09 Oct 2018
(F/R/TAF + LDV/SOF)
voxvlctsui(ozfjbendkx) = pmospnfbjc sonszuzdpt (kxcnlaqngm, zdqasxbgbp - ompyxixvtq)
Phase 3
275
(E/C/F/TAF)
ureblmswjp(uiejtlojcm) = wjfeoixztc epqcetamtu (nihumvivgo, levzrcjick - pfdzwvhnuu)
-
13 Jul 2018
Third Antiretroviral Agent+ABC/3TC
(ABC/3TC+3rd Agent)
ureblmswjp(uiejtlojcm) = jupdbmtzsl epqcetamtu (nihumvivgo, seomzfuwjp - rqnpipiipa)
Phase 4
30
rjiwkiuguc(luhiamdfjy) = opcikxshmq eqjkzsvaaq (qhhwsujrgh, lexiojqhmv - rzptduzrod)
-
08 May 2018
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