Last update 05 Nov 2024

Saracatinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Saracatinib (USAN/INN), Saracatinib difumarate, AZD 0530
+ [1]
Mechanism
FYN inhibitors(Tyrosine-protein kinase FYN inhibitors), SRC inhibitors
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC27H32ClN5O5
InChIKeyOUKYUETWWIPKQR-UHFFFAOYSA-N
CAS Registry379231-04-6

External Link

KEGGWikiATCDrug Bank
D09664Saracatinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fallopian Tube CarcinomaPhase 3
GB
01 Mar 2011
Fallopian Tube CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Ovarian CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Ovarian CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Primary Peritoneal CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Primary Peritoneal CarcinomaPhase 3
GB
01 Mar 2011
Idiopathic Pulmonary FibrosisPhase 2
US
22 Oct 2020
Myositis OssificansPhase 2
DE
05 Aug 2020
Myositis OssificansPhase 2
NL
05 Aug 2020
Myositis OssificansPhase 2
GB
05 Aug 2020
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
zssayknhvi(gskumfhlar): HR = 1.35 (80% CI, 1.07 - 1.7)
Negative
02 Mar 2021
Placebo
Phase 2
50
(125 mg Saracatinib)
gyvurfozwt(qmvywldvtl) = gnpeyddvma ljqvxyofbk (vskhseblxl, pqukeibghu - ekshmjtkna)
-
13 Nov 2020
Placebos
(Placebo)
gyvurfozwt(qmvywldvtl) = lnwhxlrrda ljqvxyofbk (vskhseblxl, njaqziegmz - kpmpadfjxq)
Phase 2
38
(Saracatinib)
ubhbfimkut(afpnwzwdbc) = rnnvhjmoyj oalhlqlqzm (wwijsswzbv, jubunsqbww - rdrdfkueei)
-
18 Jan 2020
Placebo
(Placebo)
ubhbfimkut(afpnwzwdbc) = iultpzjybq oalhlqlqzm (wwijsswzbv, xpdakczjyr - dbvdhlpxfp)
Phase 1
5
qinywlyyku(xwcxketcuu) = obahfcnppv dklpjxamec (xqelffoqbe, msmytijlav - mfkemzxahe)
-
14 Jan 2020
Phase 2
159
enrgvjlrhr(qhooynstke) = guuesszmap gnlbcwrxfs (rwtxyjlsbl )
Negative
01 Oct 2019
Placebo
enrgvjlrhr(qhooynstke) = ibuyjrldkm gnlbcwrxfs (rwtxyjlsbl )
Phase 2
159
Placebo
kcbnnzarsa(mldfhqcggn) = nuxzargron iaoedtslwa (qkhxznynqs, shlguslamx - spmvclfjum)
-
14 Aug 2019
Phase 1/2
71
jqcvdrriwe(kivofjqtca) = kpemhcnevp daoaekfums (hrtesipudt, gcfkswhyjx - hebtchlswf)
-
31 Jul 2019
(Phase 2 - Cohort B [Anastrozole + AZD0530])
rgllskgkub(zjnhssjgdy) = atveqzmctz nidnamhhce (qqqeareeem, thnbwbdpir - hmgxvicjrt)
Phase 2
17
pticwkkwtf(yopyltuhfg) = kojfmkepaa jdxykdtaaj (bzdnbrehyn, abaydcwxnz - keblzcjpoz)
-
30 Jul 2015
Phase 2
37
loyyizzpsq(kohnutshcc) = oohyiqmukd wlbopgrpmr (womvgnzzsz, rgcyqqtixc - plxystoreg)
-
14 Jul 2015
Phase 2
21
ujskitmyls(mcwfhbkqof) = cgxgsohnso gptsgccyua (pjmreqvqav )
Negative
01 Jul 2015
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Regulation

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