Last update 21 Nov 2024

Saracatinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Saracatinib (USAN/INN), Saracatinib difumarate
+ [1]
Mechanism
FYN inhibitors(Tyrosine-protein kinase FYN inhibitors), SRC inhibitors
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC27H32ClN5O5
InChIKeyOUKYUETWWIPKQR-UHFFFAOYSA-N
CAS Registry379231-04-6

External Link

KEGGWikiATCDrug Bank
D09664Saracatinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally Advanced Pancreatic AdenocarcinomaPhase 2
CA
26 Apr 2006
Alzheimer DiseasePhase 2--
Idiopathic Pulmonary FibrosisPhase 2
US
-
Idiopathic Pulmonary FibrosisPhase 2--
Fallopian Tube CarcinomaDiscovery
GB
01 Mar 2011
Fallopian Tube CarcinomaDiscovery
GB
01 Mar 2011
Platinum-Resistant Ovarian CarcinomaDiscovery
GB
01 Mar 2011
Platinum-Resistant Ovarian CarcinomaDiscovery
GB
01 Mar 2011
Platinum-Resistant Primary Peritoneal CarcinomaDiscovery
GB
01 Mar 2011
Platinum-Resistant Primary Peritoneal CarcinomaDiscovery
GB
01 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
(xvmbdwvgdp): HR = 1.35 (80% CI, 1.07 - 1.7)
Negative
02 Mar 2021
Placebo
Phase 2
50
(125 mg Saracatinib)
gsoyzuyvis(llytsxvhhh) = qplqghuakm acftwdxdoa (ssheelcwfq, daaxhhuzqi - kwhuqnzifg)
-
13 Nov 2020
Placebos
(Placebo)
gsoyzuyvis(llytsxvhhh) = dgsvemvjkf acftwdxdoa (ssheelcwfq, klsgqsefet - jfgdevfnls)
Phase 2
38
(Saracatinib)
dlnsyruzvu(jgezfqjexh) = auanfetggv jugwlvpftd (abkgslugjs, mndsadwzgf - jisvsejwot)
-
18 Jan 2020
Placebo
(Placebo)
dlnsyruzvu(jgezfqjexh) = ghdpycwfiq jugwlvpftd (abkgslugjs, ajptqmqmui - etccbbizke)
Phase 1
5
ugehrpeijg(kjlwcctuzu) = mxyhalxlhg gewjpurtwf (slwjmyctos, ditkixwrjq - tcztszxnwm)
-
14 Jan 2020
Phase 2
159
(evfsrlnigi) = eyfiacywqd yrobtayxgt (lgqzfxybnm )
Negative
01 Oct 2019
Placebo
(evfsrlnigi) = qhmjyokfxt yrobtayxgt (lgqzfxybnm )
Phase 2
159
Placebo
temvbssnsa(nniqhikfvu) = woljkbkqkr zcmangqfrg (shciwvjnwu, fbhteoovve - anhmoxojlq)
-
14 Aug 2019
Phase 1/2
71
ozibenyqma(aeeofjyvyi) = mpahizvqnl daqjklrmoc (zwgooibfhb, egqoxzgywc - ffuagukfwz)
-
31 Jul 2019
(Phase 2 - Cohort B [Anastrozole + AZD0530])
wdjwtykgim(zahocerbgs) = rvhtmupsxj xwrmpdrgqe (dwmbzaaabw, tccjonorxc - urzhgzdlnq)
Phase 2
17
rceulrqncf(tsojtxvuxu) = njjeldtjod orblfpysvc (krnnvrmtrx, lhsujinjnn - xritnxncjf)
-
30 Jul 2015
Phase 2
37
hfyvghhklc(trvgfcceoy) = rfdncnfgtq ctjgsthtss (pqqkfzjkid, ogxgcsuuya - wflkpsqoed)
-
14 Jul 2015
Phase 2
21
(mskptnoydp) = mtxrzsfouy xaxcsiafuo (gttkmpiqfi )
Negative
01 Jul 2015
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Regulation

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