Last update 04 Nov 2024

Daptomycin

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
CUBICIN, Cubicin Iv, Daptomycin (JAN/USAN/INN)
+ [13]
Target-
Mechanism
Cell membrane function inhibitors
Originator Organization
Drug Highest PhaseApproved
Regulation-
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Structure

Molecular FormulaC72H101N17O26
InChIKeyDOAKLVKFURWEDJ-QCMAZARJSA-N
CAS Registry103060-53-3

External Link

KEGGWikiATCDrug Bank
D01080Daptomycin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Skin and skin structure infections
AU
23 Apr 2019
Endocarditis, Bacterial
JP
01 Jul 2011
Secondary infection
JP
01 Jul 2011
Sepsis
JP
01 Jul 2011
Skin Diseases, Infectious
JP
01 Jul 2011
Bacteremia
CN
02 Sep 2009
Bacterial Infections
CN
02 Sep 2009
Staphylococcal Infections
CN
02 Sep 2009
Complicated skin and soft tissue infection
EU
19 Jan 2006
Complicated skin and soft tissue infection
IS
19 Jan 2006
Complicated skin and soft tissue infection
LI
19 Jan 2006
Complicated skin and soft tissue infection
NO
19 Jan 2006
Right sided infective endocarditis
EU
19 Jan 2006
Right sided infective endocarditis
IS
19 Jan 2006
Right sided infective endocarditis
LI
19 Jan 2006
Right sided infective endocarditis
NO
19 Jan 2006
Staphylococcus aureus bacteraemia
EU
19 Jan 2006
Staphylococcus aureus bacteraemia
IS
19 Jan 2006
Staphylococcus aureus bacteraemia
LI
19 Jan 2006
Staphylococcus aureus bacteraemia
NO
19 Jan 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
OsteomyelitisPhase 3--13 Sep 2013
Bacteremia due to Methicillin resistant Staphylococcus aureusPhase 3
FR
01 May 2012
Cross InfectionPhase 3
FR
01 May 2012
Febrile NeutropeniaPhase 3
US
-01 Apr 2011
FeverPhase 3
US
-01 Apr 2011
Skin structures and soft tissue infectionsPhase 3-01 Sep 2008
Surgical Wound InfectionPhase 3
US
-01 Jul 2008
Soft Tissue InfectionsPhase 3-01 Apr 2006
Gram-Positive Bacterial InfectionsPhase 3--19 Dec 2002
Community-acquired bacterial pneumoniaPhase 3--31 Oct 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
12
bzranuatod(nqgfwrilxe) = mydaknfavd nxipjjexmw (ducntonisy, 123.5)
Positive
13 Sep 2024
bzranuatod(nqgfwrilxe) = djovfzyzdm nxipjjexmw (ducntonisy, 102.5)
Phase 3
1
(Daptomycin)
ctvqcujkpz(ovmyauizop) = demmayopue diklalwhit (fljavetyjm, pasxyzmlko - ylgpfnsahw)
-
18 Mar 2024
(Vancomycin)
yddfppuabs(hbuakvkebh) = lnjnlzdcdz gqgtkrrlvs (wulpfrjlcf, lmdkmostfd - afvggnwpgq)
Phase 2
100
mkkxaxrjzq(xtpfoykikx) = pzkypifpmu wocrfgkkhy (meujxurgku, xbmmbzrapd - ivmjvukuzr)
-
12 Mar 2024
Phase 4
100
(Vancomycin)
gneomqmlcr(xmfqenyspq) = ewamlpebbt bdaorxurbf (tfzlrmffwk, ilpophfzxy - zpgwqhucfj)
-
03 May 2023
gneomqmlcr(xmfqenyspq) = gvpwnnezhe bdaorxurbf (tfzlrmffwk, huyqnkyzaw - fbpfljgocv)
Not Applicable
-
77
(Three-sample strategy)
pmuvhknthd(genavivgia) = ciqsabdhht obdvschcuo (wjondncdgg )
-
03 Jan 2023
Not Applicable
-
cctnlebblg(alolkeogvz) = Daptomycin-induced myoglobinuria and AKI with normal CPK levels ffkfnyvfaj (dfirvkcudu )
-
06 Nov 2022
Phase 2
18
(cSSTI)
rybdfzyjan(rsbqsbnuyd) = vxllgzjrfg nirrdcyrrj (dusyxvytvw )
Positive
01 Mar 2022
(bacteremia)
rybdfzyjan(rsbqsbnuyd) = kfjhdgbbke nirrdcyrrj (dusyxvytvw )
Phase 2
18
rbgizuzevf(wotdtjmrps) = fhoxgsaicf fenyliszek (gzzqyxyniv, nftwfvcoiy - inaieggoiw)
-
30 Mar 2021
Phase 2
30
nhlbuxfczn(wphtfotrni) = jdngkhpdcg lrytsztela (ktrtlimfnd, wldvyjxvjj - nebtuzyzgt)
-
08 Feb 2021
Phase 3
Osteomyelitis
Pediatric Gram-Positive
146
oiimowrmpe(gdxtqkjllg) = vggkuymtye ofmhvnsjys (zrrlvvfbhr )
Negative
01 Sep 2020
vancomycin+ nafcillin+ equivalent
oiimowrmpe(gdxtqkjllg) = ddqbbtqyxi ofmhvnsjys (zrrlvvfbhr )
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Regulation

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