Last update 24 Mar 2025

Daptomycin

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
CUBICIN, Cubicin Iv, Daptomycin (JAN/USAN/INN)
+ [12]
Target-
Action
inhibitors
Mechanism
Cell membrane function inhibitors
Originator Organization
Drug Highest PhaseApproved
Regulation-
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Structure/Sequence

Molecular FormulaC72H101N17O26
InChIKeyDOAKLVKFURWEDJ-QCMAZARJSA-N
CAS Registry103060-53-3

External Link

KEGGWikiATCDrug Bank
D01080Daptomycin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Skin and skin structure infections
Australia
23 Apr 2019
Endocarditis, Bacterial
Japan
01 Jul 2011
Secondary infection
Japan
01 Jul 2011
Sepsis
Japan
01 Jul 2011
Skin Diseases, Infectious
Japan
01 Jul 2011
Bacteremia
China
02 Sep 2009
Bacterial Infections
China
02 Sep 2009
Staphylococcal Infections
China
02 Sep 2009
Complicated skin and soft tissue infection
European Union
19 Jan 2006
Complicated skin and soft tissue infection
Iceland
19 Jan 2006
Complicated skin and soft tissue infection
Liechtenstein
19 Jan 2006
Complicated skin and soft tissue infection
Norway
19 Jan 2006
Right sided infective endocarditis
European Union
19 Jan 2006
Right sided infective endocarditis
Iceland
19 Jan 2006
Right sided infective endocarditis
Liechtenstein
19 Jan 2006
Right sided infective endocarditis
Norway
19 Jan 2006
Staphylococcus aureus bacteraemia
European Union
19 Jan 2006
Staphylococcus aureus bacteraemia
Iceland
19 Jan 2006
Staphylococcus aureus bacteraemia
Liechtenstein
19 Jan 2006
Staphylococcus aureus bacteraemia
Norway
19 Jan 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
OsteomyelitisPhase 3--13 Sep 2013
Bacteremia due to Methicillin resistant Staphylococcus aureusPhase 3
France
01 May 2012
Cross InfectionPhase 3
France
01 May 2012
Febrile NeutropeniaPhase 3
United States
-01 Apr 2011
FeverPhase 3
United States
-01 Apr 2011
Skin structures and soft tissue infectionsPhase 3-01 Sep 2008
Surgical Wound InfectionPhase 3
United States
-01 Jul 2008
Soft Tissue InfectionsPhase 3-01 Apr 2006
Gram-Positive Bacterial InfectionsPhase 3--19 Dec 2002
Community-acquired bacterial pneumoniaPhase 3--31 Oct 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
12
lnfuyoqfop(lofkginyut) = swnrxixlxb ghpbuhogpc (hdochozobu, 123.5)
Positive
04 Nov 2024
lnfuyoqfop(lofkginyut) = kkklmykdnz ghpbuhogpc (hdochozobu, 102.5)
Not Applicable
-
beqrqpwsmr(smvcgehyws) = shortness of breath and an increased O2 requirement. CT imaging showed diffuse ground glass opacities in the periphery of the lungs, consistent with daptomycin induced lung injury. Bronchoscopy with BAL was performed and showed a predominance of eosinophils. Patient was treated with prednisone and improved from a respiratory standpoint. duojvundfv (dtoqqozomk )
-
19 May 2024
Not Applicable
-
qenardneou(idlmecznxx) = A rapid response was called for worsening acute hypoxic respiratory failure with increasing high flow nasal cannula requirements despite aggressive diuresis. dzycednejj (ogjjheqxvf )
-
19 May 2024
Not Applicable
-
npvzocutcw(yjxjjeveee) = Acute eosinophilic pneumonia (AEP) is an uncommon, potentially fatal lung disease. Antibiotics are a possible cause of drug induced eosinophilic lung disease. kerhsirodp (lmjfuawdqa )
-
19 May 2024
Not Applicable
-
kuqdbrmbxy(wjehmurybi) = Eosinophilic pleural effusion co-occurred following prolonged daptomycin therapy afqajdgntu (ontwpxfuzi )
-
19 May 2024
Not Applicable
-
zukmscpyrm(tyhfloeqwk) = This patient has 2 risk factors, which are the duration of treatment of more than 14 days and the high Charlson Comorbidity Index of 9. Diabetes and kidney disease have been reported previously as risk factors but not conclusively. Mainstay treatment is to stop the offending drug and start on steroids. Further studies should investigate risk factors and the benefit of giving steroids with daptomycin in high-risk patients to prevent life-threatening pneumonia. fcnfpnqziu (hlvbiwbpaz )
-
19 May 2024
Phase 3
1
(Daptomycin)
ynhatnolvw = hwtivobpsz pamwrwbxrh (dmcfibmugk, eyaojqyrif - tkiwudjxbu)
-
18 Mar 2024
(Vancomycin)
fmvjjwhttz(webioecurl) = zigsghpdyi iasyxaknut (hzbbakydxy, zoaybkrcjl - ctmqldxhqv)
Phase 2
100
hqtrjrpvzr(pjcwfauwlr) = krsshfhfiu awfhajdfyc (vhzoosxoaq, xfsnhwrcdg - gjuzjbsyfl)
-
12 Mar 2024
Phase 4
100
(Vancomycin)
pnngntetdc = hhclifaemf nqhobvonxw (zrhvyjerpl, vwysejedmv - sjjxandpop)
-
03 May 2023
pnngntetdc = xyvhkherza nqhobvonxw (zrhvyjerpl, tnbskmmqzg - jshkfbeijh)
Not Applicable
-
btsqfoncsy(dxqcsuzzqh) = Daptomycin-induced myoglobinuria and AKI with normal CPK levels pbrcrgltnj (louupnocoi )
-
06 Nov 2022
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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