A Phase 1, Open-Label, Safety and Immunogenicity Trial of Boost-2867, an IgG-Fc-RBD Fusion Protein Next Generation SARS-CoV-2 Booster Vaccine, Via Intranasal and Intramuscular Routes in Previously Vaccinated Adults

This phase 1 clinical trial will evaluate the safety, reactogenicity, and immunogenicity of Boost-2867, given intramuscular (IM) with or without adjuvant or intranasal (IN) without adjuvant, as a booster dose to previously vaccinated healthy adults. Each of the six study sites will be assigned to enroll either only participants who will receive IM administration (3 sites) or only participants who will receive IN administration (3 sites); no site will administer both IM and IN study product administrations. Within the IM and IN Arms the cohorts will be sequentially enrolled. The study is designed as a non-randomized, open-label, dose-escalation clinical trial evaluating one dose level of Boost-2867 without adjuvant administered IM, three dose levels of Boost-2867 with adjuvant administered IM, and three dose levels of Boost-2867 without adjuvant administered IN. A sample size of 140 participants (20 participants per dose cohort) is anticipated. To evaluate for early safety signals for this first-in-human trial, study product administration of participants enrolled for IM administration and those enrolled for IN administration will proceed in a staged fashion. For Cohorts 1 (IM administration without adjuvant) and 5 (IN administration), which may be enrolled and dosed concurrently, 3 sentinel participants under 50 years of age will be enrolled in each Cohort over at least 2 days. For each of those Cohorts independently, a safety review of halting rules and clinical safety data through at least Day 8 will be conducted by the Protocol Safety Review Team (PSRT) prior to enrollment of the remainder of the cohort. Enrollment, dosing, and safety oversight for IM Cohorts 2, 3, and 4 will proceed in the same fashion as Cohort 1, except that sentinel enrollment need not be spaced over at least 2 days. Similarly, for IN Cohorts 6 and 7, enrollment and safety oversight will proceed in the same fashion as Cohort 5, except that sentinel enrollment need not be spaced over at least 2 days.
The primary objectives are: 1) To evaluate the safety and reactogenicity of a single IM injection of three different antigen dose levels (5, 15, and 50 microgram) of Boost-2867 with Alhydrogel (R) (alum) and CpG 7909 adjuvants, and a single injection of 50 microgram Boost-2867 without adjuvant, in previously vaccinated healthy adults. 2) To evaluate the safety and reactogenicity of a single IN administration of three different antigen dose levels (20, 50, and 125 microgram) of Boost-2867 without adjuvant in previously vaccinated healthy adults.

Start Date17 Nov 2025

Sponsor / Collaborator

National Institute of Allergy & Infectious Diseases

ChiCTR2000036023

/ Not yet recruitingEarly Phase 1IIT

Combined treatment of thermal ablation and CpG 7909/Pembrolizumab for colorectal liver metastases

Start Date01 Sep 2020

Sponsor / Collaborator

Shanghai No. 10 People's Hospital

JPRN-jRCTs061180034

/ CompletedPhase 1IIT

A phase I study of combination immunotherapy with five peptides cocktail, CpG, and immune modulators for patients with advanced or metastatic colorectal cancer - A phase I study of combination immunotherapy with five peptides cocktail, CpG, and immune modulators for patients with advanced or metastatic colorectal cancer

Start Date17 May 2016

Sponsor / Collaborator-

100 Clinical Results associated with Agatolimod

100 Translational Medicine associated with Agatolimod

100 Patents (Medical) associated with Agatolimod

1,230

Literatures (Medical) associated with Agatolimod

31 Dec 2025·Human Vaccines & Immunotherapeutics

Safety and immunogenicity of SARS-CoV-2 protein subunit recombinant vaccine (Indovac®) in healthy populations aged 18 years and above in Indonesia: A phase I, observer-blind, randomized, controlled study

Article

Author: Hapsari, Rebriarina ; Farhanah, Nur ; Pramudo, Setyo Gundi ; Sekartini, Rini ; Wirahmadi, Angga ; Sari, Rini Mulia ; Maria, Suzy ; Mahati, Endang ; Yeremia, Glenn Fernandez ; Mulyono, Mulyono ; Anantyo, Dimas Tri ; Puspita, Mita ; Maharani, Nani ; Nency, Yetty Movieta ; Setyaningsih, Lilis

Indonesian vaccine producer (PT BIOFARMA), conducted a study to assess the safety and immunogenicity of a new COVID-19 vaccine candidate. This vaccine is based on a recombinant subunit protein platform, with the SARS-CoV-2 receptor-binding domain (RBD) as its target antigen. The study compared the candidate's safety and immunogenicity to the control group vaccine, the Sinovac vaccine, 28 days after administration. This was an observer-blinded and randomized Phase 1 trial which recruited 175 subjects. The subject received 0.5 ml of vaccine in two doses. The subjects were split into five treatment groups, consisting of different combinations of doses between RBD and CpG. The safety of this vaccine was evaluated within 7 days after the first dose and for 6 months after the second dose, while the immunogenicity was evaluated on days 14 and 28 after the second dose. The overall incidence of AEs was 54.86% from the beginning of the vaccination to 28 days after each injection. Most AEs were local pain and had no serious AEs. The study revealed a significant rise in the Geometric Mean Titer (GMT) of IgG antibodies in every group, indicating a strong immune response. The phase I data demonstrated that the new vaccine candidate showed promising results in safety and immunogenicity.

01 Nov 2025·INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Incorporation of monophosphoryl lipid A and CpG-oligodeoxynucleotides into lipid nanoparticles activates toll-like receptor signaling pathways while maintaining antigen expression for mRNA-based vaccinations

Article

Author: Gambaro, Rocio ; Vaquero, Ana Pena ; Gehring, Stephan ; Huck-Iriart, Cristián ; Si, Shutian ; Limeres, María-José ; Ghazi, Silvia Fraude-El ; Calderon-Ruiz, Paula ; Meyer, Claudius U ; Rivero-Berti, Ignacio ; Hankeln, Thomas ; Bros, Matthias ; Tekiel, Valeria ; Lieberwirth, Ingo ; Landfester, Katharina ; Alba Soto, Catalina ; Islan, German A ; Cacicedo, Maximiliano L

Lipid nanoparticles (LNPs) were engineered for efficient mRNA delivery and immune enhancement through co-encapsulation of adjuvants. CpG-oligodeoxynucleotides (CpG-ODN, TLR9 agonist) and monophosphoryl lipid A (MPLA, TLR4 agonist) were incorporated to activate intra- and extracellular Toll-like receptor pathways. Formulated via microfluidics, CpG was added in the aqueous phase and MPLA in the lipid phase. The final LNP-MPLA-CpG formulation included Luc mRNA and CpG-ODN (5:1 ratio) with ALC-0315/DSPC/cholesterol/ALC-0159/MPLA (1 %). Particle characterization by DLS and NTA confirmed neutral, homogeneous nanoparticles (∼80 nm). Cryo-TEM and SAXS verified structural integrity. The formulation maintained over 80 % mRNA encapsulation after storage at 4 °C and - 80 °C. Transfection of human and murine dendritic cells (MoDCs and DC2.4) led to robust protein expression. The LNPs showed minimal hemotoxicity and low cytotoxicity, while significantly increasing pro-inflammatory cytokines (IFN-γ, TNF-α, IL-6) in both cell types. DC uptake of LNP-MPLA-CpG was efficient. In the in vivo biodistribution, Luc mRNA was primarily expressed in liver and spleen following intramuscular injection. Serum cytokine levels peaked at 6 h post-injection, and flow cytometry of stimulated splenocytes and liver non-parenchymal cells confirmed a strong innate activation. These results support LNP co-delivery of dual adjuvants as a potent platform for enhancing mRNA vaccine efficacy and innate immune activation.

01 Nov 2025·CARBOHYDRATE POLYMERS

Enhanced underwater adhesion of chitooligosaccharide-based pressure-sensitive adhesives and their potential in wound healing applications

Article

Author: Zhang, Qi ; Zhang, Dahong ; Zhang, Zhen ; Zhang, Lifang ; Hu, Xin ; Liu, Xiliang ; Chen, Geng ; Hou, Peijie

Achieving strong and biocompatible underwater adhesion remains a major challenge for medical pressure-sensitive adhesives (PSAs), due to the inherent trade-offs between interfacial adhesion, cohesive strength, and bioactivity. Here, we report the design of a multifunctional chitosan-based PSA that integrates biocompatible chitooligosaccharide (COS) backbones with hydrophobic poly(trimethylene carbonate) (PTMC) side chains to enhance cohesive energy, and catechol-functionalized gallic acid (GA) moieties to improve underwater interfacial adhesion. Molecular dynamics simulations revealed that catechol groups effectively disrupt interfacial hydration layers, enabling closer contact with tissue surfaces. The optimized adhesive (CPG) exhibited strong wet adhesion, with a shear strength of 17.7 kPa and a burst pressure of 31.3 kPa, outperforming commercial fibrin glue. In vitro assays showed good cytocompatibility, low hemolysis (<2%), and antibacterial activity. Moreover, in vivo studies in a rat skin wound model indicated that CPG supported tissue regeneration by modulating inflammation, reducing oxidative stress, and promoting neovascularization. These findings suggest that CPG holds potential for biomedical applications requiring reliable underwater adhesion and tissue compatibility.

News (Medical) associated with Agatolimod

22 Oct 2025

·www.prnewswire.com

ACM Biolabs Reports Favorable Safety Signals and Early Pharmacodynamics from Intramuscular Administration of ACM-CpG in Patients with Advanced Solid Tumors

SINGAPORE, Oct. 22, 2025 /PRNewswire/ -- ACM Biolabs, a clinical-stage biotechnology company developing next-generation nanoparticle-based immunotherapies, today announced encouraging early clinical findings from its ongoing Phase 1 study of ACM-CpG, a TLR9 agonist formulated with ACM's proprietary polymersome platform through a strategic collaboration with the National Cancer Centre Singapore (NCCS). Preclinical experiments show that the ACM nanoparticle formulation fundamentally alters CpG's mechanism of action, enabling myeloid modulation through comprehensive TLR9 engagement in immunologically "cold" tumors. The ongoing Phase 1 trial (NCT06587295) [i] is enrolling patients with advanced solid tumors at NCCS to assess the safety, tolerability, and pharmacodynamic effects of ACM-CpG. Early clinical data indicate that these preclinical findings are translating into humans. In patients with advanced solid tumors, intramuscular administration of ACM-CpG - at weekly or biweekly doses as low as 0.25mg CpG – has demonstrated robust systemic immune activation as evidenced through immune biomarker data. The therapy shows a highly favorable safety and tolerability profile and to date, no dose-limiting toxicities have been observed. "TLR9 has long been recognized as a validated immunologic target, but its therapeutic potential has been limited by delivery and safety limitations," said Dr. Madhavan Nallani, CEO of ACM Biolabs. "Our intramuscular nanoparticle delivery enables systemic immune activation with an excellent safety profile, creating opportunities not only for combination approaches but also for targeted monotherapy in patient populations with few treatment options. Over time, this platform can also support additional routes of administration allowing us to tailor treatment strategies to diverse tumor settings and address significant unmet medical needs." "The safety profile and clear pharmacodynamic activity we have observed so far are very encouraging, with two out of the three patients enrolled at the 0.25mg dose level having ongoing disease control for eight months with monotherapy alone." said Dr. Amit Jain, Senior Consultant, Division of Medical Oncology, National Cancer Centre Singapore. "We look forward to exploring ways to optimize its delivery and maximize its therapeutic potential for patients with advanced cancers." The collaboration is supported in part by funding from Singapore's Industry Alignment Fund – Pre-Positioning (IAF-PP), which fosters strategic collaborations between industry and research institutes. This study is evaluating ACM-CpG in patients with advanced head and neck, lung, bladder, and kidney cancers and is designed to establish proof of mechanism to support global clinical development. About ACM Biolabs Pte Ltd ACM Biolabs is headquartered in Singapore, with subsidiaries in Basel, Switzerland, and Sydney, Australia. It is a clinical-stage biotechnology company developing targeted vaccines and immunotherapies using its proprietary polymer-lipid hybrid nanoparticle delivery platform. The company's pipeline includes candidates across oncology, infectious diseases, and inflammation, with a focus on precision immune modulation and next-generation drug delivery. SOURCE ACM Biolabs WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

ImmunotherapyPhase 1

22 Oct 2025

·acmbiolabs.com

ACM Biolabs Reports Favorable Safety Signals and Early Pharmacodynamics from Intramuscular Administration of ACM-CpG in Patients with Advanced Solid Tumors

Singapore, 22nd October 2025 – ACM Biolabs, a clinical-stage biotechnology company developing next-generation nanoparticle-based immunotherapies, today announced encouraging early clinical findings from its ongoing Phase 1 study of ACM-CpG, a TLR9 agonist formulated with ACM’s proprietary polymersome platform through a strategic collaboration with the National Cancer Centre Singapore (NCCS). Preclinical experiments show that the ACM nanoparticle formulation fundamentally alters CpG’s mechanism of action, enabling myeloid modulation through comprehensive TLR9 engagement in immunologically “cold” tumors. The ongoing Phase 1 trial (NCT06587295)i is enrolling patients with advanced solid tumors at NCCS to assess the safety, tolerability, and pharmacodynamic effects of ACM-CpG. Early clinical data indicate that these preclinical findings are translating into humans. In patients with advanced solid tumors, intramuscular administration of ACM-CpG – at weekly or biweekly doses as low as 0.25mg CpG – has demonstrated robust systemic immune activation as evidenced through immune biomarker data. The therapy shows a highly favorable safety and tolerability profile and to date, no dose-limiting toxicities have been observed. “TLR9 has long been recognized as a validated immunologic target, but its therapeutic potential has been limited by delivery and safety limitations,” said Dr. Madhavan Nallani, CEO of ACM Biolabs. “Our intramuscular nanoparticle delivery enables systemic immune activation with an excellent safety profile, creating opportunities not only for combination approaches but also for targeted monotherapy in patient populations with few treatment options. Over time, this platform can also support additional routes of administration allowing us to tailor treatment strategies to diverse tumor settings and address significant unmet medical needs.” “TLR9 has long been recognized as a validated immunologic target, but its therapeutic potential has been limited by delivery and safety limitations,” said Dr. Madhavan Nallani, CEO of ACM Biolabs. “Our intramuscular nanoparticle delivery enables systemic immune activation with an excellent safety profile, creating opportunities not only for combination approaches but also for targeted monotherapy in patient populations with few treatment options. Over time, this platform can also support additional routes of administration allowing us to tailor treatment strategies to diverse tumor settings and address significant unmet medical needs.” “The safety profile and clear pharmacodynamic activity we have observed so far are very encouraging, with two out of the three patients enrolled at the 0.25mg dose level having ongoing disease control for eight months with monotherapy alone.” said Dr. Amit Jain, Senior Consultant, Division of Medical Oncology, National Cancer Centre Singapore. “We look forward to exploring ways to optimize its delivery and maximize its therapeutic potential for patients with advanced cancers.” “The safety profile and clear pharmacodynamic activity we have observed so far are very encouraging, with two out of the three patients enrolled at the 0.25mg dose level having ongoing disease control for eight months with monotherapy alone.” said Dr. Amit Jain, Senior Consultant, Division of Medical Oncology, National Cancer Centre Singapore. “We look forward to exploring ways to optimize its delivery and maximize its therapeutic potential for patients with advanced cancers.” The collaboration is supported in part by funding from Singapore’s Industry Alignment Fund – Pre-Positioning (IAF-PP), which fosters strategic collaborations between industry and research institutes. This study is evaluating ACM-CpG in patients with advanced head and neck, lung, bladder, and kidney cancers and is designed to establish proof of mechanism to support global clinical development. About ACM Biolabs Pte Ltd ACM Biolabs is headquartered in Singapore, with subsidiaries in Basel, Switzerland, and Sydney, Australia. It is a clinical-stage biotechnology company developing targeted vaccines and immunotherapies using its proprietary polymer-lipid hybrid nanoparticle delivery platform. The company’s pipeline includes candidates across oncology, infectious diseases, and inflammation, with a focus on precision immune modulation and next-generation drug delivery. Media contacts Dr Peter Moran Email: peter.moran@acmbiolabs.com General Inquiries: BD@acmbiolabs.com About ACM Biolabs Pte Ltd ACM Biolabs is headquartered in Singapore, with subsidiaries in Basel, Switzerland, and Sydney, Australia. It is a clinical-stage biotechnology company developing targeted vaccines and immunotherapies using its proprietary polymer-lipid hybrid nanoparticle delivery platform. The company’s pipeline includes candidates across oncology, infectious diseases, and inflammation, with a focus on precision immune modulation and next-generation drug delivery. Media contacts Dr Peter Moran Email: peter.moran@acmbiolabs.com General Inquiries: BD@acmbiolabs.com ACM Biolabs is headquartered in Singapore, with subsidiaries in Basel, Switzerland, and Sydney, Australia. It is a clinical-stage biotechnology company developing targeted vaccines and immunotherapies using its proprietary polymer-lipid hybrid nanoparticle delivery platform. The company’s pipeline includes candidates across oncology, infectious diseases, and inflammation, with a focus on precision immune modulation and next-generation drug delivery. Media contacts Dr Peter Moran Email: peter.moran@acmbiolabs.com General Inquiries: BD@acmbiolabs.com 1 https://www.clinicaltrials.gov/study/NCT06587295

ImmunotherapyPhase 1

28 Aug 2025

·liddspharma.com

LIDDS AB (publ) Interim Report January – June 2025

April – June 2025 Net sales amounted to 0 (0) KSEK The operating result for the period was -836 (-2 391) KSEK The net result was -733 (-2 398) KSEK corresponding to earnings per share of -0,01 (-0.02) SEK Cash flow from operating activities amounted to -1 594 (-2 938) KSEK Cash and cash equivalents amounted to 2 350 (8 009) KSEK January – June 2025 Net sales amounted to 0 (0) KSEK The operating result for the period was -2 091 (-2 392) KSEK The net result was -2 044 (-2 404) KSEK corresponding to earnings per share of -0,01 (-0.02) SEK Cash flow from operating activities amounted to -2 333 (-3 002) KSEK Significant events January – June 2025 On April 2, the board of directors decided to cease further development of the project areas Nanodotax, Nanoimod and NOV 202. Taking into account the principle of prudence, the board of directors, decided on April 10 to write down the book values of all intangible assets in LIDDS and Noviga as of 2024-12-31. This decision resulted in a deviation for the annual report compared to the published year-end report for 2024. Due to the reasons to believe that the company’s equity was less than on-half of the registered share capital, the board of directors decided to prepare a balance sheet for liquidation purpose on April 22. The balance sheet for liquidation purpose prepared and reviewed by the company’s auditor showed that the equity was less than half of the registered share capital and therefore the board of directors decided on April 24 to call a first control meeting. At the annual general meeting, at the same time first control meeting, on May 28, it was decided that the company will continue its operations and not be liquidated. CEO Statement During the second quarter, the company has continued to focus on the commercialisation of the three projects Nanoimod, Nanodotax and NOV 202, as well as exploring interest in the company’s listing on First North. So far, these efforts have not yet resulted in any concrete successes. The quarter has also been characterised by extensive work on finalising the annual report, holding the annual general meeting, and managing the situation where the company’s equity was found to be less than half of the share capital. Following the decision at the first control meeting to continue operations and not initiate liquidation, the company now has eight months before the question of potential liquidation needs to be reconsidered. Mats WikingCEO and CFO The interim report is available on the company’s website https://liddspharma.com/en/investors/financial-reports/ For additional information, please contact Mats Wiking, CEO and CFOPhone: +46 (0)70 620 04 00E-mail: mats.wiking@liddspharma.com Daniel Lifveredson, Chairman of the BoardTelefon: +46 (0) 70-916 21 01Email: d.li@excore.com LIDDS’ Certified Adviser is Redeye AB LIDDS in brief: LIDDS is a Swedish pharmaceutical company focused on the development of oncology drugs. LIDDS has a proprietary drug delivery technology, NanoZolid®, on which several projects are based. With NanoZolid, LIDDS can formulate drugs for local/intratumoral administration, with a maintained and controlled release and with minimal negative side-effects. In addition to these projects, LIDDS develops proprietary drug candidate NOV202 that have shown very good results in pre-clinical studies. The company is listed on Nasdaq First North Growth market. Attachments LIDDS Interim Report Q2 2025

Financial Statement

100 Deals associated with Agatolimod

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D08841	Agatolimod	-	DB15018

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Indication	Highest Phase	Country/Location	Organization	Date
Advanced Lung Non-Small Cell Carcinoma	Phase 3	United States	Pfizer Inc.	01 Nov 2005
Advanced Lung Non-Small Cell Carcinoma	Phase 3	China	Pfizer Inc.	01 Nov 2005
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Australia	Pfizer Inc.	01 Nov 2005
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Austria	Pfizer Inc.	01 Nov 2005
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Belgium	Pfizer Inc.	01 Nov 2005
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Brazil	Pfizer Inc.	01 Nov 2005
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Canada	Pfizer Inc.	01 Nov 2005
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Cyprus	Pfizer Inc.	01 Nov 2005
Advanced Lung Non-Small Cell Carcinoma	Phase 3	Czechia	Pfizer Inc.	01 Nov 2005
Advanced Lung Non-Small Cell Carcinoma	Phase 3	France	Pfizer Inc.	01 Nov 2005

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00199836 (CTgov)	Phase 1	Neoplasms	14	NY-ESO-1b peptide plus CpG 7909 and Montanide® ISA-51	tvjnmtmclk = dnptmvgtet xufnexpugm (qgtaqcrgjb, lytatrnpnp - iitahjgqrq) View more	-	15 Jul 2021
AACR2017	Phase 2	Melanoma Adjuvant	-	Saline	mjppzzqzgt(jcthoczfzv) = tkfwjrhukh riogkmrvnk (jdltfgfhkt, 21 - 71)	Positive	01 Jul 2017
NCT00880581 (CTgov)	Phase 2	Indolent B-Cell Non-Hodgkin Lymphoma	30	Local radiotherapy+PF-3512676	rarudywuxc = cskllbsfbe uqyxbitfkk (gokmjuogqm, fzbexvgqna - ypyhonkwxz) View more	-	14 Mar 2017
NCT00824733 (CTgov)	Phase 2	Locally advanced breast cancer \| Metastatic breast cancer	6	Correlative Studies+PF03512676+Trastuzumab	lgbnvokpnc(tppxpcabuw) = ylgevkdgwo dqgpmmizut (elbammovov, sdehcjwguy - laurntfqer) View more	-	14 Jan 2016
SITC2015	Phase 2	Melanoma Adjuvant	62	GM-CSF (3 μg/kg)	muolcxwxet(zfiqlanlzr) = at a median follow-up of 79 months, this translated into a significantly longer recurrence-free survival (RFS) in the CpG-treated group (p=0.010) sdrzbxranx (eqrufgefng )	Positive	04 Nov 2015
SITC2015	Phase 2	Melanoma Adjuvant	62	CpG-B (PF-3512676/CpG7909, 8 mg)		Positive	04 Nov 2015
NCT00185965 (CTgov)	Phase 1/2	Mycosis Fungoides	30	CPG 7909 (Lymphoma, B-cell Low-grade (BCL))	xbqrrriutv = gxioksfsoa sfqjufzvmo (wwbnfwpznj, bjyknvotsu - kdkplagwre) View more	-	01 Aug 2014
NCT00185965 (CTgov)	Phase 1/2	Mycosis Fungoides	30	CPG 7909 (Mycosis Fungoides (MF))	xbqrrriutv = lnydaixrkz sfqjufzvmo (wwbnfwpznj, vgdfbisyel - wqijxrerfr) View more	-	01 Aug 2014
NCT00471471 (Pubmed \| J Immunother)	Phase 1	Metastatic melanoma Adjuvant	22	Vaccination with MART-1, gp100, and Tyrosinase peptides + PF-3512676 + GM-CSF	fikqusxyom(ylevqcvxar) = shjhzwypvt ypwhtmuyfd (qljuhztoly, 11.3 - ∞)	-	01 May 2012
NCT00984763 (Pubmed \| PLoS One)	Phase 1	Malaria	5	AMA1-C1/Alhydrogel+CPG 7909 (AMA1/C1-Alhydrogel+CPG 7909)	mztuckncev(llmlmjknes): Pearson r = -0.93 (95% CI, -0.99 to -0.25), P-Value = 0.02	-	22 Jul 2011
NCT00984763 (Pubmed \| PLoS One)	Phase 1	Malaria	5	AMA1-C1/Alhydrogel+CPG 7909 (Unvaccinated controls)		-	22 Jul 2011
AACR2011	Not Applicable	Melanoma	12	Vaccination with MART-1 (27-35), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) peptides given in-oil-adjuvant with TLR-9 agonist PF-3512676 and GMCSF	bxkgogeibd(zvsysasmph) = vcfofhptag ejswjzotzn (qvgmstusoa ) View more	-	15 Apr 2011
Pubmed \| J Am Acad Dermatol	Phase 1	Cutaneous T-Cell Lymphoma	28	PF-3512676 (CPG 7909)	atbvjqiqie(rleyrquxtq) = pnpffyfncb inkvwchzvf (odfcbpnlli )	Positive	01 Dec 2010

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