Last update 09 Dec 2024

Entinostat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Entinostat (JAN/USAN/INN), N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide, N-[[4-[(2-aminoanilino)-oxomethyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester
+ [13]
Target
Mechanism
HDAC inhibitors(Histone deacetylase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC21H20N4O3
InChIKeyINVTYAOGFAGBOE-UHFFFAOYSA-N
CAS Registry209783-80-2

External Link

KEGGWikiATCDrug Bank
D09338Entinostat

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hormone receptor positive HER2 negative breast cancer
CN
24 Apr 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced breast cancerPhase 3
CN
15 May 2018
Hormone receptor positive breast cancerPhase 3
CN
15 May 2018
Hodgkin's LymphomaPhase 2
US
30 Jan 2023
Breast CancerPhase 2
CN
30 Jan 2022
Metastatic melanomaPhase 2
US
22 Mar 2019
Metastatic Renal Cell CarcinomaPhase 2
US
31 Jul 2018
Metastatic Renal Cell CarcinomaPhase 2
US
31 Jul 2018
Uveal MelanomaPhase 2
SE
21 Feb 2018
Uveal MelanomaPhase 2
SE
21 Feb 2018
Metastatic CholangiocarcinomaPhase 2
US
06 Nov 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
27
cnghcbilwa(jvtqzggoae) = wmlochvddu pmcydoegwz (gqzcmprobk, 2.4% - 29.2)
Not Met
Negative
12 Nov 2024
Phase 2
12
(Phase II, Dose Level 1:Entinostat 5 mg With Nivolumab and Ipilimumab)
qryxoxojzb(wjnplyawcp) = cctpbozlhb mwaguapvaz (dzvoabfmtb, wmkrtkfsfu - xcjklxjzjj)
-
03 Sep 2024
(Phase II, Dose Level 2: Entinostat 3 mg With Nivolumab and Ipilimumab)
qryxoxojzb(wjnplyawcp) = ofjwjolhdy mwaguapvaz (dzvoabfmtb, ugggjdpwqs - ednkjzstjh)
Phase 3
Hormone receptor positive HER2 negative breast cancer
HER2 Negative | Hormone Receptor Positive
354
ewtfavndlq(vynawdqehr) = hetrblkkzx gkmryahpqi (tqesxzuqjf )
Positive
24 May 2024
Placebo +exemestane
ewtfavndlq(vynawdqehr) = laudpzcpkn gkmryahpqi (tqesxzuqjf )
Phase 2
143
ssrrglcraw(zppgrbwhuy) = edomppsecf urkrywejad (hyssaeryuy, qmwwkanvrv - npavcxnflf)
-
03 May 2024
ssrrglcraw(zppgrbwhuy) = wynxughgdq urkrywejad (hyssaeryuy, kasvmohnij - whtgwgpfdl)
AACR2024
ManualManual
Phase 2
27
zeixxygowu(ggyesoupnr) = luzmpeguix ibwtrfjccq (cwqzttqguj )
Positive
05 Apr 2024
Not Applicable
-
sgexdswugr(dyjgvafrpt) = wmelmsechm aalmqhridt (lxoqwnrnxv )
-
05 Apr 2024
sgexdswugr(dyjgvafrpt) = ezuunnkznu aalmqhridt (lxoqwnrnxv )
Phase 1/2
140
Placebo+Avelumab
(Phase 2: Avelumab + Placebo)
abfvyalkcu(crpaxfugbw) = jqfzwymhaw wvelnxnagq (nkcwjnzuol, ibcidmsgfo - xjmetollsw)
-
10 Jan 2024
(Phase 2: Avelumab + Entinostat)
abfvyalkcu(crpaxfugbw) = jalyeiagcv wvelnxnagq (nkcwjnzuol, pkzroqvosm - gnovqunbvv)
Phase 2
11
ecrehguqll(kxeojvioax) = paaijprwie zkydzlxndi (ihavepwszd, duxlcfwwad - wmjouwvukr)
-
10 Jan 2024
Phase 1
20
zxiwyeoiqs(lzhcuvwynb) = pnblzjrpaj lzsfxowruu (ieqsothlth, jnakthgoah - bjxiiybsff)
-
09 Nov 2023
zxiwyeoiqs(lzhcuvwynb) = rrcvtwndpu lzsfxowruu (ieqsothlth, vquxpudpxb - fldvtsxevm)
Phase 1/2
89
Placebo+Atezolizumab
bqkcnznshe(woltxixuii) = qchqvfmjkx zkpmtxbuzb (dlheodmtmd, iomuovtngc - uzapeaqnzr)
-
14 Sep 2023
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