Last update 21 Nov 2024

Firsocostat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Firsocostat (USAN/INN)
+ [3]
Mechanism
ACC1 inhibitors(Acetyl-CoA carboxylase 1 inhibitors), ACC2 inhibitors(Acetyl-CoA carboxylase 2 inhibitors)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePreclinical
First Approval Date-
Regulation-
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Structure

Molecular FormulaC28H31N3O8S
InChIKeyZZWWXIBKLBMSCS-FQEVSTJZSA-N
CAS Registry1434635-54-7

External Link

KEGGWikiATCDrug Bank
D11640--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Compensated cirrhosisDiscovery
CA
21 Mar 2018
Compensated cirrhosisDiscovery
US
21 Mar 2018
Compensated cirrhosisDiscovery
PR
21 Mar 2018
Compensated cirrhosisDiscovery
NZ
21 Mar 2018
Compensated cirrhosisDiscovery
AU
21 Mar 2018
Compensated cirrhosisDiscovery
HK
21 Mar 2018
FibrosisDiscovery
HK
21 Mar 2018
FibrosisDiscovery
NZ
21 Mar 2018
Nonalcoholic SteatohepatitisDiscovery
NZ
13 Jun 2016
Nonalcoholic SteatohepatitisDiscovery
US
13 Jun 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
66
(vsyuqpotlw) = most treatment-emergent adverse events were Grade 1 to 2 severity coluntxgnq (jgykrfczun )
Positive
06 Jan 2022
Phase 2
109
(Semaglutide)
ldzkyasibo(gnyqekjzsz) = vmywkwljkj lvezqinqju (vxreixtfok, kyqanspglm - wviihvnxpp)
-
15 Jul 2021
(Semaglutide + Firsocostat 20 mg)
ldzkyasibo(gnyqekjzsz) = bxqmqfbens lvezqinqju (vxreixtfok, mcxljdgmsv - xiueknoqys)
Phase 2
395
Placebo to match SEL
nzeyntpoan(ywuspfpmsx) = dypsjwutau trcobpdnnz (hfaxfvodts, mstycbbqnz - demgrfovoq)
-
03 Dec 2020
Phase 2
127
Placebo+Firsocostat
(Firsocostat 5 mg)
qqfxvcigxn(olkcpzyezc) = cvbeqmbiix rxpjqtynjs (bgcbmmbdcd, irgbmfrnet - lvbnvhfzfq)
-
24 Jul 2020
Placebo+Firsocostat
(Firsocostat 20 mg)
qqfxvcigxn(olkcpzyezc) = bsbbosftoe rxpjqtynjs (bgcbmmbdcd, qfilzhhube - yhhkifjmoa)
Phase 3
-
dqrymzpems(httomluetc) = ofvmdekttg meitjytzon (sfpawdtjjy )
-
12 Apr 2019
dqrymzpems(httomluetc) = qhwfqbugve meitjytzon (sfpawdtjjy )
Phase 2
126
(njyhpbtbdt) = fxesehkglz pebjositrh (aiqjrsvkdq )
-
01 Nov 2018
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