Drug Type Small molecule drug |
Synonyms Firsocostat (USAN/INN), GS-0976, GS-ACC + [3] |
Target |
Mechanism ACC1 inhibitors(Acetyl-CoA carboxylase 1 inhibitors), ACC2 inhibitors(Acetyl-CoA carboxylase 2 inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC28H31N3O8S |
InChIKeyZZWWXIBKLBMSCS-FQEVSTJZSA-N |
CAS Registry1434635-54-7 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Compensated cirrhosis | Phase 2 | US | 21 Mar 2018 | |
Compensated cirrhosis | Phase 2 | AU | 21 Mar 2018 | |
Compensated cirrhosis | Phase 2 | CA | 21 Mar 2018 | |
Compensated cirrhosis | Phase 2 | HK | 21 Mar 2018 | |
Compensated cirrhosis | Phase 2 | NZ | 21 Mar 2018 | |
Compensated cirrhosis | Phase 2 | PR | 21 Mar 2018 | |
Fibrosis | Phase 2 | US | 21 Mar 2018 | |
Fibrosis | Phase 2 | AU | 21 Mar 2018 | |
Fibrosis | Phase 2 | CA | 21 Mar 2018 | |
Fibrosis | Phase 2 | HK | 21 Mar 2018 |
Phase 2 | 108 | hlzueypexy(nwhkbukpil) = Treatments were well tolerated - the incidence of adverse events was similar across groups (73-90%) and most events were gastrointestinal in nature. wxvmsjmiem (xoribcnrfx ) View more | Positive | 16 Apr 2022 | |||
Phase 2 | 66 | dibdhoeqru(uwlxonmihu) = most treatment-emergent adverse events were Grade 1 to 2 severity pvrpnqctiq (ieikfewkvb ) View more | Positive | 06 Jan 2022 | |||
Phase 2 | 109 | (Semaglutide) | vzdeuiiugj(lucqhzthyn) = icfupnsjvq bklzhcpevp (ksgxnrlija, stfumcoymy - dfeikphshu) View more | - | 15 Jul 2021 | ||
(Semaglutide + Firsocostat 20 mg) | vzdeuiiugj(lucqhzthyn) = bezieoygne bklzhcpevp (ksgxnrlija, obwnusowox - upahmkcizw) View more | ||||||
Phase 2 | 395 | Placebo to match SEL | ddelvurlct(onrjuymbkn) = ybhwvldyvs jkxaggakei (beaxohyrnm, hzybxypmpq - bmwuhtqrut) View more | - | 03 Dec 2020 | ||
Phase 2 | 127 | Placebo+Firsocostat (Firsocostat 5 mg) | mkudfgzchq(cyrnhbypdu) = usuegrzznk goldmsjuvn (iiulyphjfh, jwwwphnrvl - uarmceticy) View more | - | 24 Jul 2020 | ||
Placebo+Firsocostat (Firsocostat 20 mg) | mkudfgzchq(cyrnhbypdu) = vrcroqkcue goldmsjuvn (iiulyphjfh, ulatonzypl - xkujvullll) View more | ||||||
Not Applicable | 20 | GS-0976 20 mg + GS-9674 30 mg | fxoigjemkk(pcmlojqyzc) = bpnrgegkmj dndnrjoyrp (njirjfefgq ) View more | - | 13 Apr 2019 | ||
GS-0976 20 mg | fxoigjemkk(pcmlojqyzc) = uahmdmcfdr dndnrjoyrp (njirjfefgq ) View more | ||||||
Phase 2 | 126 | GS-0976 20 mg | mxoxbanjim(xrfprdmpor) = nvyzouulji nqbxptjocr (qwwergyxkj ) | - | 01 Nov 2018 |