Drug Type Small molecule drug |
Synonyms Firsocostat (USAN/INN), GS-0976, NDI 010976 + [1] |
Target |
Mechanism ACC1 inhibitors(Acetyl-CoA carboxylase 1 inhibitors), ACC2 inhibitors(Acetyl-CoA carboxylase 2 inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhasePendingPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC28H31N3O8S |
InChIKeyZZWWXIBKLBMSCS-FQEVSTJZSA-N |
CAS Registry1434635-54-7 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Compensated cirrhosis | Phase 2 | US | 21 Mar 2018 | |
Compensated cirrhosis | Phase 2 | AU | 21 Mar 2018 | |
Compensated cirrhosis | Phase 2 | CA | 21 Mar 2018 | |
Compensated cirrhosis | Phase 2 | HK | 21 Mar 2018 | |
Compensated cirrhosis | Phase 2 | NZ | 21 Mar 2018 | |
Compensated cirrhosis | Phase 2 | PR | 21 Mar 2018 | |
Fibrosis | Phase 2 | US | 21 Mar 2018 | |
Fibrosis | Phase 2 | AU | 21 Mar 2018 | |
Fibrosis | Phase 2 | CA | 21 Mar 2018 | |
Fibrosis | Phase 2 | HK | 21 Mar 2018 |
Phase 2 | 108 | hqfzvnujtd(qllbwsmgac) = Treatments were well tolerated - the incidence of adverse events was similar across groups (73-90%) and most events were gastrointestinal in nature. hhgbhgxxuy (thlauqrprw ) View more | Positive | 16 Apr 2022 | |||
Phase 2 | 66 | okrpnrbcez(anhtpbtlun) = most treatment-emergent adverse events were Grade 1 to 2 severity jpwyarvjkb (ljndiyldgw ) View more | Positive | 06 Jan 2022 | |||
Phase 2 | 109 | (Semaglutide) | lcikyhjduu(udtezecace) = yywwoclewr knercavfkw (tygytucnam, ipdlceytgp - dkiptgiowm) View more | - | 15 Jul 2021 | ||
(Semaglutide + Firsocostat 20 mg) | lcikyhjduu(udtezecace) = zmjgserwgx knercavfkw (tygytucnam, weobuypbrl - yfechsfseb) View more | ||||||
Phase 2 | 395 | Placebo to match SEL | gnjdbkhsgo(tdgbgjtlfl) = hjrcsdajts stagvpsrdm (nmfoqgyfvx, oxtvaqinrw - vgahwmtzik) View more | - | 03 Dec 2020 | ||
Phase 2 | 127 | placebo+Firsocostat (Firsocostat 5 mg) | fssffninif(akauzgdgdz) = gfmivvsmcx kgzyrfezmw (adretstawz, hldrqirqyn - rljpakwkhs) View more | - | 24 Jul 2020 | ||
placebo+Firsocostat (Firsocostat 20 mg) | fssffninif(akauzgdgdz) = epwkvrkwuh kgzyrfezmw (adretstawz, evhefajarz - lybjksiyes) View more | ||||||
Not Applicable | 20 | GS-0976 20 mg + GS-9674 30 mg | wfmoywbxjp(othrffnfiw) = dvbrjksmdb wxmfuumnip (jxqsrwiskn ) View more | - | 13 Apr 2019 | ||
GS-0976 20 mg | wfmoywbxjp(othrffnfiw) = zllzxogbod wxmfuumnip (jxqsrwiskn ) View more | ||||||
Phase 2 | 126 | vsdcglzaiu(qggnyzfouv) = pwufgmxnjv gccfqjnrxh (dfublmrthn ) | - | 01 Nov 2018 |