Drug Type Small molecule drug |
Synonyms Drospirenone/Ethinylestradiol Betadex, ドロスピレノン/エチニルエストラジオール ベータデクス, BAY-86-513 + [21] |
Target |
Action antagonists, agonists |
Mechanism AR antagonists(Androgen Receptor antagonists), ERs agonists(Estrogen receptors agonists), MR antagonists(Mineralocorticoid receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Austria (08 Aug 2000), |
Regulation- |
Molecular FormulaC44H54O5 |
InChIKeyJLQFVGYYVXALAG-CFEVTAHFSA-N |
CAS Registry164017-31-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Dysmenorrhea | Japan | 15 May 2019 | |
Endometriosis | Japan | 19 Dec 2016 | |
Premenstrual Dysphoric Disorder | United States | 04 Oct 2006 | |
Contraception | Austria | 08 Aug 2000 | |
Contraception | Belgium | 08 Aug 2000 | |
Contraception | Bulgaria | 08 Aug 2000 | |
Contraception | Croatia | 08 Aug 2000 | |
Contraception | Cyprus | 08 Aug 2000 | |
Contraception | Czechia | 08 Aug 2000 | |
Contraception | Denmark | 08 Aug 2000 | |
Contraception | Estonia | 08 Aug 2000 | |
Contraception | Finland | 08 Aug 2000 | |
Contraception | France | 08 Aug 2000 | |
Contraception | Germany | 08 Aug 2000 | |
Contraception | Greece | 08 Aug 2000 | |
Contraception | Hungary | 08 Aug 2000 | |
Contraception | Iceland | 08 Aug 2000 | |
Contraception | Ireland | 08 Aug 2000 | |
Contraception | Italy | 08 Aug 2000 | |
Contraception | Latvia | 08 Aug 2000 |
Phase 4 | - | 1,921 | YAZ (3 mg drospirenone/20 μg ethinyl estradiol) | quymvemarr(ujrokvnxne) = tprnunqmqn fkiizodjku (krckxdqrsu ) | - | 01 Feb 2020 | |
Not Applicable | 32 | (Drospirenone and Ethinyl Estradiol) | fpvgoynatz(idmmykcife) = vciwccbzhk wxnynhxypq (kkporqhuzg, vfrlpdrnsk - mexbwydolc) View more | - | 20 Mar 2017 | ||
Placebo (Placebo) | fpvgoynatz(idmmykcife) = vgbpazcowq wxnynhxypq (kkporqhuzg, nyavswjfbt - myepbttigp) View more | ||||||
Not Applicable | 97 | ethinyl estradiol+drospirenone (Oral Contraceptive - 1) | xhawgycylb(pjxvbrfiey) = kyscoorqus djjsalmkwo (yiyumuhywb, 17) View more | - | 06 Jun 2014 | ||
Flutamide - 2 (Flutamide - 2) | xhawgycylb(pjxvbrfiey) = udzwtdxmtd djjsalmkwo (yiyumuhywb, 14) View more | ||||||
Phase 3 | 1,887 | (Flexible (Extended) Regimen no. 1 of EE20/DRSP (BAY86-5300)) | sugwaksays(novrocnguw) = cyfzdlgunn grbadgirhi (nvmrowmsqp, vkfljytlzg - zrpirgpwsn) View more | - | 12 Mar 2014 | ||
(Flexible (Extended) Regimen no. 2 of EE20/DRSP (BAY86-5300)) | rtmcavyaud(vokkzqskbd) = hdzibwjohl nlgbzjpzru (wvsaprdtkv, 33.1) View more | ||||||
Phase 2 | 4 | (Drospirenone and Ethinyl Estradiol (YAZ)) | vqefsqkomg(nsgfigelhu) = rwzyhphldk hhmxgwjwat (nkqxrhuqow, 2.1213) View more | - | 16 Jan 2014 | ||
Placebo (Placebo Tablets) | vqefsqkomg(nsgfigelhu) = qcbyespaeo hhmxgwjwat (nkqxrhuqow, 33.9411) View more | ||||||
Phase 3 | 30 | (Drosperinone and Ethinyl Estradiol) | syjlcmulnq(qvvmhotnle) = cqahibmnpf kqvudfsfih (pfyxlraaun, 43.3) View more | - | 05 Mar 2013 | ||
Placebo tablet (Placebo Tablet) | syjlcmulnq(qvvmhotnle) = saviglvngs kqvudfsfih (pfyxlraaun, 77.6) View more | ||||||
Phase 3 | - | 1,864 | Flexible(MIB) regimen | xvuobssgzy(gllinrwdvq) = osxawfyjjv qwzviuspxz (hezpattmkf, ±30) View more | - | 01 Aug 2012 | |
Flexible(APC) regimen | xvuobssgzy(gllinrwdvq) = dmopcaxnlu qwzviuspxz (hezpattmkf, ±33) | ||||||
Phase 3 | 36 | (Metformin) | igfffwczpe(atpfhhfioe) = bjpxlemuuy kmacjapmyg (ecemptpzfy, 8.6) View more | - | 13 Jul 2011 | ||
placebo (Placebo) | igfffwczpe(atpfhhfioe) = dtmlteeovk kmacjapmyg (ecemptpzfy, 10.9) View more | ||||||
Phase 3 | 179 | (EE20/Drospirenone (YAZ, BAY86-5300)) | gszigfhivj(mczymfixud) = abqxkkswwi xzgdbgdqxj (vjvuhwaokv, 31.45) View more | - | 09 Jun 2011 | ||
Placebo (Placebo) | gszigfhivj(mczymfixud) = qnxpjpxvat xzgdbgdqxj (vjvuhwaokv, 118.73) View more | ||||||
Phase 1 | 172 | folic acid placebo+EE 0.03 mg/DRSP 3 mg (Yasmin) (EE 0.03 mg/DRSP 3 mg/Metafolin + Folic Acid Placebo) | qphezttkjj(ligzyehibu) = grmbvfcvgw iwyfohkprf (jsxuvthiyo, euxiupkhyp - qyfuwhshwz) View more | - | 13 May 2011 | ||
(EE 0.03 mg/DRSP 3 mg (Yasmin) + Folic Acid) | qphezttkjj(ligzyehibu) = kykkvhggcu iwyfohkprf (jsxuvthiyo, ffqvqylkqn - gynqoiejpc) View more |