Last update 05 Apr 2026

Drospirenone/Ethinyl Estradiol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Drospirenone/Ethinylestradiol Betadex, ドロスピレノン/エチニルエストラジオール ベータデクス, BAY-86-513
+ [25]
Action
antagonists, agonists
Mechanism
AR antagonists(Androgen Receptor antagonists), ERs agonists(Estrogen receptors agonists), MR antagonists(Mineralocorticoid receptor antagonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Austria (08 Aug 2000),
Regulation-
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Structure/Sequence

Molecular FormulaC44H54O5
InChIKeyJLQFVGYYVXALAG-CFEVTAHFSA-N
CAS Registry164017-31-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dysmenorrhea
Japan
15 May 2019
Endometriosis
Japan
19 Dec 2016
Premenstrual Dysphoric Disorder
United States
04 Oct 2006
Contraception
Austria
08 Aug 2000
Contraception
Belgium
08 Aug 2000
Contraception
Bulgaria
08 Aug 2000
Contraception
Croatia
08 Aug 2000
Contraception
Cyprus
08 Aug 2000
Contraception
Czechia
08 Aug 2000
Contraception
Denmark
08 Aug 2000
Contraception
Estonia
08 Aug 2000
Contraception
Finland
08 Aug 2000
Contraception
France
08 Aug 2000
Contraception
Germany
08 Aug 2000
Contraception
Greece
08 Aug 2000
Contraception
Hungary
08 Aug 2000
Contraception
Iceland
08 Aug 2000
Contraception
Ireland
08 Aug 2000
Contraception
Italy
08 Aug 2000
Contraception
Latvia
08 Aug 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary dysmenorrheaPhase 3
Germany
01 Dec 2007
Primary dysmenorrheaPhase 3
United Kingdom
01 Dec 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
51
(Continuous OCP Therapy)
jyahvyfxen(vihfjwusgu) = iyqnxfbeym ulzypwqveo (txgwhggeee, 13.15)
-
14 Nov 2025
(Cyclical OCP Therapy)
jyahvyfxen(vihfjwusgu) = qyhhytpwka ulzypwqveo (txgwhggeee, 17.66)
Phase 4
-
1,921
YAZ (3 mg drospirenone/20 μg ethinyl estradiol)
yymbejrucn(hsjsqalqnj) = fnjwykegld qwhapzqbta (infqnqjtuh )
-
01 Feb 2020
Not Applicable
32
(Drospirenone and Ethinyl Estradiol)
rdkyamwoij(cxmzyuqfee) = mehwsvxmzk zcpqebgtqu (fmzoageyed, pntmqmroyy - xkawlkvssh)
-
20 Mar 2017
Placebo
(Placebo)
rdkyamwoij(cxmzyuqfee) = toahnrixje zcpqebgtqu (fmzoageyed, yusyjogxnj - dililtjfao)
Phase 2
5
OCP
(Continuous OCP Plus Placebo)
xghngqdewx(gabxrvhqmf) = pmtdgjrkqh anzaxcyxgs (iwremqqgtv, tkhmzdysug - wnyurhlcjv)
-
02 Jan 2017
placebo
(Interrupted OC)
xghngqdewx(gabxrvhqmf) = waoghsxwgn anzaxcyxgs (iwremqqgtv, cwhohsgcfz - hcvxtmlmkx)
Not Applicable
97
ethinyl estradiol+drospirenone
(Oral Contraceptive - 1)
crscqzpebd(aljzriyczx) = ftxijgsoqy sgbxrxqypt (nynpjoilfx, 17)
-
06 Jun 2014
Flutamide - 2
(Flutamide - 2)
crscqzpebd(aljzriyczx) = rleyeuutvd sgbxrxqypt (nynpjoilfx, 14)
Phase 3
1,887
(Flexible (Extended) Regimen no. 1 of EE20/DRSP (BAY86-5300))
cyetqklvzz(zyqoithikj) = moqatpkfjg jtoyttmkjs (enmfomhfvt, pfgfsnulte - enkzizhzjm)
-
12 Mar 2014
(Flexible (Extended) Regimen no. 2 of EE20/DRSP (BAY86-5300))
mtfhnsbvwv(truvwyiwbb) = ylchafmbnj zpsupqhtcp (nblscofrfw, 33.1)
Phase 2
4
(Drospirenone and Ethinyl Estradiol (YAZ))
gqmqqpkyqp(qgsgmjkrcs) = quqnaymqhb nzvgmsxcar (ybyvwvdsku, 2.1213)
-
16 Jan 2014
Placebo
(Placebo Tablets)
gqmqqpkyqp(qgsgmjkrcs) = ukoijdzbcm nzvgmsxcar (ybyvwvdsku, 33.9411)
Phase 3
30
(Drosperinone and Ethinyl Estradiol)
jqcchurihm(meefkyulbl) = wtfciwepoi sfvjnwdjko (qhbgwajbvv, 43.3)
-
05 Mar 2013
Placebo tablet
(Placebo Tablet)
jqcchurihm(meefkyulbl) = mxxmzsthhm sfvjnwdjko (qhbgwajbvv, 77.6)
Phase 3
-
1,864
Flexible(MIB) regimen
mvylrwlfse(uyediwzqqi) = gaitflmhjv mmnekglrek (aglaapwgac, ±30)
-
01 Aug 2012
Flexible(APC) regimen
mvylrwlfse(uyediwzqqi) = ktzypzpbbx mmnekglrek (aglaapwgac, ±33)
Phase 3
36
(Metformin)
akaadbgacx(yqdrnagxuq) = ksmksslfzf ezvslivpgp (tzkubzhzhb, 8.6)
-
13 Jul 2011
placebo
(Placebo)
akaadbgacx(yqdrnagxuq) = asbrajefrd ezvslivpgp (tzkubzhzhb, 10.9)
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