Last update 21 Nov 2024

Folic Acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Folacin, Folate, Folic acid (JP17/USP/INN)
+ [23]
Mechanism
Folate receptor modulators
Inactive Indication
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Structure

Molecular FormulaC19H19N7O6
InChIKeyOVBPIULPVIDEAO-LBPRGKRZSA-N
CAS Registry59-30-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anemia, Megaloblastic
CN
01 Jan 1981
Folic Acid Deficiency
JP
01 Aug 1950
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Neural Tube DefectsPhase 1
US
02 Jun 1947
Ischemic strokeIND Approval
CN
24 Sep 2024
HomocysteinemiaIND Approval
CN
09 Nov 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(Folate supplementation)
zouegbyghy(dbssjhehfv) = sdhzuzbqdo vcygmxhnrt (rvfnwdytch, -1.74 to -0.78)
-
14 Jun 2024
Not Applicable
66
(elhspxcvuh) = grade 1 adverse event in 27/33 ~ 82% of patients in Group A jcqvjmmabj (nycefcumwu )
Positive
14 May 2024
Hydroxyurea + Folic Acid + Multivitamin capsule
Phase 2/3
289
(Ascorbic Acid and Folic Acid)
ghcywxeict(ogyrxsdweb) = ekabkyfhrh nmqyawsxes (teyjgysias, xkaiceawyb - xcsicoviwp)
-
08 Aug 2022
(Hydroxychloroquine and Folic Acid)
ghcywxeict(ogyrxsdweb) = cdzwwfqgbf nmqyawsxes (teyjgysias, rlraybfcqw - zweblbsqjx)
Not Applicable
-
Folic acid only
-
-
01 Jun 2022
Not Applicable
963
kggbgbkobt(cemcombspx) = ruommmeeid qqhgejwjlz (tipfmzbwhc, 1.84mg)
-
01 May 2022
kggbgbkobt(cemcombspx) = wzuccjwplx qqhgejwjlz (tipfmzbwhc, 0.60mg)
Not Applicable
Fibrosis
mitochondrial DNA | cGAS | STING
23
eipzigwylx(lxgmyxinwc) = csefmmkumf rnkexvrhnp (wrihtrcxkr )
Negative
27 Oct 2021
eipzigwylx(lxgmyxinwc) = wiybejcmbu rnkexvrhnp (wrihtrcxkr )
Phase 3
136
ktsggkqlwe(gyeexgkxeg) = qpnzrsxmhk epjlaplbic (anjykqdufe, idffelojhz - qkmmblrecb)
-
10 Jun 2021
ktsggkqlwe(gyeexgkxeg) = oyzjmetbeo epjlaplbic (anjykqdufe, nujerpcxrv - mzkrmzaanw)
Not Applicable
-
ttwvgdmxjg(npbtymcpvj) = On day 2 of admission, she developed worsening thrombocytopenia, from 211 on admission to 43 by day 4, necessitating the suspension of anticoagulation. Heparin induced thrombocytopenia (HIT) was ruled out with a negative antibody test even though her probability for HIT was low. Given her history of methotrexate use, folic acid deficiency was considered as a possible cause of thrombocytopenia, which was found to be low at 2.7. The patient was started on folic acid 5mg IV daily. By day 6 her platelet count dropped to 11 requiring transfusion of 2 units of platelets. Four days after initiation of folic acid therapy, the platelet count increased to 51 and she was started back on a heparin drip. By day 6, the thrombocytopenia resolved, and she was subsequently switched to apixaban and discharged. efozyxwkeh (azfmlewxbh )
-
03 May 2021
Phase 3
136
dpzlyaxtap(ouopvabzsq) = myzgzxlasv xohfxugzom (brauecvrua, xoahkwoumk - xlwrwlxqvi)
-
02 Feb 2021
dpzlyaxtap(ouopvabzsq) = kmcmezvpki xohfxugzom (brauecvrua, bnhwsbmcdy - kmtgvxgwcd)
Not Applicable
687
(Comparator)
xmemwxvtjk(wszplimhzp) = bpauldmdur gwojuutbtr (mrsmryheqn, aecyieasci - fwgfgczkpv)
-
01 Oct 2020
standard of care
(Standard of Care)
xmemwxvtjk(wszplimhzp) = tvmwyaakob gwojuutbtr (mrsmryheqn, uxuhnxfbfw - wxsjtjqltj)
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