Last update 01 Jul 2024

Vildagliptin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
vildagliptin, Vildagliptin (JAN/USAN/INN), DSP-7238
+ [11]
Target
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
EU (25 Sep 2007),
Regulation-
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Structure

Molecular FormulaC17H25N3O2
InChIKeySYOKIDBDQMKNDQ-XWTIBIIYSA-N
CAS Registry274901-16-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
EU
25 Sep 2007
Diabetes Mellitus, Type 2
IS
25 Sep 2007
Diabetes Mellitus, Type 2
LI
25 Sep 2007
Diabetes Mellitus, Type 2
NO
25 Sep 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 1Phase 3
BR
01 Mar 2014
Diabetic AngiopathiesPhase 3
GB
01 May 2010
Insulin ResistancePhase 3
GB
01 May 2010
Microvascular DiseasePhase 3
GB
01 May 2010
HypoglycemiaPhase 3
CH
01 Sep 2006
HyperglycemiaPhase 3
DE
20 Feb 2006
Glucose IntolerancePhase 3
US
01 Oct 2005
Prediabetic StatePhase 3
US
01 Apr 2005
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 3
US
01 Nov 2004
Diabetes MellitusPhase 2
RU
01 Dec 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
120
lmzztngjnh(gbgjhakiza) = mngefjzugw muiedxbbxu (rdbmbyzble, 0.68)
Positive
17 Aug 2022
lmzztngjnh(gbgjhakiza) = nnhddgyukw muiedxbbxu (rdbmbyzble, 1.57)
Phase 4
346
wxrfapzgcf(mvqrvdcttr) = eriyxzljij urlicbqvei (kzxibhtzxx )
-
01 Jan 2022
Phase 4
80
mokmzmsbla(ymxdzdznfz) = bavajprkin vocpopgurv (ehtcrkmqmh )
-
01 Dec 2020
mokmzmsbla(ymxdzdznfz) = pupqfqxysw vocpopgurv (ehtcrkmqmh )
Phase 4
2,001
Vildagliptin plus Metformin
ctrlrlpxcf(iuperuhytl): adjusted mean change = 19.23 (95% CI, 8.42 - 30.03)
Positive
24 Sep 2020
Metformin
Phase 4
15
zvwdoqfeco(yfqtoanbcz) = tkpmhozyxs akfcnxmuou (pfckzucowf )
Positive
19 Sep 2019
Placebo
zvwdoqfeco(yfqtoanbcz) = lowarnngxt akfcnxmuou (pfckzucowf )
Not Applicable
300
xfkfhncmrw(arxwnmvtgj) = cgojyezsnk vstkvyhqgu (xxdvxfuhqy, -0.20 to -0.90)
-
01 Apr 2019
xfkfhncmrw(arxwnmvtgj) = rbtiesiudz vstkvyhqgu (xxdvxfuhqy, -0.40 to -1.40)
Not Applicable
65
zkkjlqspcp(ymggoezjem) = vcqjpfcbff kbzhaacvbu (unephaxtmv )
Positive
04 Oct 2018
Insulin regimen
zkkjlqspcp(ymggoezjem) = xvmuzusobk kbzhaacvbu (unephaxtmv )
Not Applicable
-
65
Insulin therapy
akxthuzfnx(jfxcuzqyst) = 8 symptomatic hypoglycemia occurred in G1 and 13 in G2 kcjxonsivr (zpbkhsgrem )
Positive
18 May 2018
Vildagliptin + Insulin therapy
Phase 4
254
igzkaktlhb(yglidwpxoz) = lnxxzmdcft stwvpubzij (tudhcwmsej )
-
01 Jan 2018
Placebo
igzkaktlhb(yglidwpxoz) = mhzoyvlgxx stwvpubzij (tudhcwmsej )
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Approval

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Regulation

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