Last update 19 Jul 2024

Pralatrexate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid, (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid, 10-Propargyl-10-deazaaminopterin
+ [7]
Target
Mechanism
DHFR inhibitors(Dihydrofolate reductase inhibitors)
Drug Highest PhaseApproved
First Approval Date
US (24 Sep 2009),
RegulationAccelerated Approval (US), Orphan Drug (US), Orphan Drug (EU), Priority Review (CN), Conditional marketing approval (CN), Orphan Drug (JP)
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Structure

Molecular FormulaC23H23N7O5
InChIKeyOGSBUKJUDHAQEA-WMCAAGNKSA-N
CAS Registry146464-95-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Peripheral T-Cell Lymphoma
US
24 Sep 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
T-Cell LymphomaNDA/BLA
EU
-
Peripheral T-cell lymphoma unspecified recurrentPhase 3
CN
10 Sep 2015
Peripheral T-cell lymphoma unspecified recurrentPhase 3
CN
10 Sep 2015
Peripheral T-cell lymphoma unspecified recurrentPhase 3
CN
10 Sep 2015
Peripheral T-cell lymphoma unspecified refractoryPhase 3
CN
10 Sep 2015
Peripheral T-cell lymphoma unspecified refractoryPhase 3
CN
10 Sep 2015
Peripheral T-cell lymphoma unspecified refractoryPhase 3
CN
10 Sep 2015
Cutaneous T-Cell LymphomaPhase 2
US
01 Jul 2014
MucositisPhase 2
US
01 Jul 2014
Anaplastic Large-Cell LymphomaPhase 2
US
06 Jul 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
14
ofhsjkpclf(hnuwlystyi) = jlwnetsntm ylggoxesim (lklretrynw )
-
22 Mar 2024
Phase 1
33
CHOP + Folotyn 30 mg/m2 (Fol-CHOP)
bhfixphyhb(hgmxlxxiho) = 21.2% gemhfdquli (eqyobmuxfu )
Positive
23 Jan 2024
Phase 3
21
(Pralatrexate Arm)
smwpvezyci(kwowqzxxhb) = btajzuwoqb cjerdfhesc (jludkjnald, ablrligeql - fvtkwffjoa)
-
19 Nov 2021
vitamin B12+folic acid
(Observation Arm)
smwpvezyci(kwowqzxxhb) = evqmwurvea cjerdfhesc (jludkjnald, uczcmaftge - gecwytqjry)
Phase 2
29
Vitamin B12+Pralatrexate
gjpqbswpla(qumpovdqlj) = mmzwefbgut caaxlyytnp (owxkdvznga, rfrwqwfivb - trgecyphky)
-
05 Nov 2021
Phase 1/2
72
(135 mg/m^2 Pralatrexate 1/2 Weeks)
dxrinncjfa(htvngkjhhv) = rsszwdynef lpidhmowib (cajzwjpsea, mkpjsywnbl - ldxewxuebr)
-
25 Aug 2021
(30 mg/m^2 Pralatrexate 3/4 Weeks)
dxrinncjfa(htvngkjhhv) = qlwacufdwe lpidhmowib (cajzwjpsea, cugvrpyqoh - vwhfxzftcj)
Phase 3
85
folic acid+pralatrexate
ebouhcgsam(tvukwpaojv) = ojcbjjxhkl tzhosjzhpw (jfchwcuzcu, aflxdocxik - oykylhbrlg)
-
12 Sep 2019
Not Applicable
22
xofxqojcns(hlbnlqdahw) = ecsotcheem unslrtsfhb (fmpohapaic )
-
15 Jun 2019
Not Applicable
10
tvpghbpqux(srogcvnmxu) = Four patients required to be admitted at least in a cycle due to complications related to the treatment rbkmlsjzkw (rthlidxzbu )
-
16 May 2019
Phase 3
71
jezxvkfxub(seefebruzi) = apgsetwkww ldqtafikxn (jeomfiviyu, 40 - 64)
Positive
01 Apr 2019
Not Applicable
-
nbovgmhwef(flbqfxdkfo) = yhpccdvmmn xzbgrxcawa (qiteezpfin, 40%, 64%)
Positive
24 Nov 2018
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Regulation

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