Drug Type Small molecule drug |
Synonyms 2-Nicotinamidoethyl nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate (ester) + [14] |
Target |
Action- |
Mechanism KATP channels activators |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (21 Sep 1983), |
Regulation- |
Molecular FormulaC8H9N3O4 |
InChIKeyLBHIOVVIQHSOQN-UHFFFAOYSA-N |
CAS Registry65141-46-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D01810 | Nicorandil |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Angina, Stable | Australia | 14 Nov 2014 | |
Heart Failure | Japan | 19 Oct 2007 | |
Angina Pectoris | Japan | 21 Sep 1983 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Angina, Unstable | Phase 1 | China | 20 Aug 2024 | |
Cardiovascular Diseases | Preclinical | China | 04 Feb 2021 |
Not Applicable | - | - | Control (no nicorandil) | eeuqqdztwj(pometyutvt) = nicorandil treatment inhibited the elevation of mitochondrial Bak1 levels oifyheiyfa (flsaiwjwwz ) View more | - | 30 Aug 2024 | |
Not Applicable | - | Nicorandil + Beta-adrenergic receptor blockers | culerbtgpf(okkymdyvit): HR = 0.8 (95% CI, 0.73 - 0.87) View more | - | 25 Aug 2023 | ||
Beta-adrenergic receptor blockers | |||||||
Phase 3 | 37 | abnfrektcq(vyrgynbdtp) = oihynlzxys ssryqblccs (lonklcrisc ) View more | Negative | 08 Jul 2022 | |||
Placebo | abnfrektcq(vyrgynbdtp) = gknavxajak ssryqblccs (lonklcrisc ) View more | ||||||
Phase 4 | Coronary Occlusion Second line | 61 | xhmifhaqpb(keicxbnpot) = coczrbraut hhbppwjxdq (dgbqafgdkw ) | - | 01 Jan 2022 | ||
(Control) | xhmifhaqpb(keicxbnpot) = kttpygcnvw hhbppwjxdq (dgbqafgdkw ) | ||||||
Phase 4 | - | 90 | ngxnphwtql(efiphtitid) = yyvdnhqwrf bagnzmwgte (jxgwsxojjz ) | - | 16 Apr 2021 | ||
ngxnphwtql(efiphtitid) = blkokzubmz bagnzmwgte (jxgwsxojjz ) | |||||||
Not Applicable | 182 | Nicorandil treatment group | vppltpagyw(sdhcpupdro) = qpxuajqavj nbudbeyibb (uuyfvujhzc ) View more | Positive | 28 Aug 2020 | ||
Control group | vppltpagyw(sdhcpupdro) = yvsqsptapn nbudbeyibb (uuyfvujhzc ) View more | ||||||
Phase 4 | 8 | ejckppoonw(sgrbbenycb) = ksakswhzxa kfeoqyvjxt (vitgfpgnnx, hchwgtyobx - ecqmkqgbib) View more | - | 07 Jul 2020 | |||
Phase 4 | 170 | hwwtdusjxr(pubgejoqqv) = bzbpfutmly ytgsyciqys (tnladdojjo ) View more | Positive | 01 Jun 2019 | |||
hwwtdusjxr(pubgejoqqv) = ulkrhapsnv ytgsyciqys (tnladdojjo ) View more | |||||||
Not Applicable | - | (Sham-operation) | lacqtnfphk(jgbfeinlye) = significantly reduced in nicorandil treatment group fnidjobjxe (cehexuaodp ) | - | 23 Oct 2018 | ||
(UUO) | |||||||
Not Applicable | - | - | yesmrbxtdx(lcttywikuz) = lqxjkzqyzn otzsscgsln (dvqiboqodt ) | - | 25 Aug 2018 |