Drug Type Small molecule drug |
Synonyms 2-Nicotinamidoethyl nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate, N-(2-Hydroxyethyl)nicotinamide nitrate (ester) + [12] |
Target |
Mechanism KATP channels activators |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date JP (21 Sep 1983), |
Regulation- |
Molecular FormulaC8H9N3O4 |
InChIKeyLBHIOVVIQHSOQN-UHFFFAOYSA-N |
CAS Registry65141-46-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D01810 | Nicorandil |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Angina, Stable | AU | 14 Nov 2014 | |
Heart Failure | JP | 19 Oct 2007 | |
Angina Pectoris | JP | 21 Sep 1983 |
Not Applicable | 150 | eggucruuyt(xxgeifoarm) = owazsekelp lwwyqnyalu (kfirjyjkhq ) View more | Negative | 30 Aug 2024 | |||
Isosorbide mononitrate 50 mg daily | eggucruuyt(xxgeifoarm) = nxnnjigkwk lwwyqnyalu (kfirjyjkhq ) View more | ||||||
Not Applicable | - | - | Control (no nicorandil) | dfoockpuoh(umtgvlxzor) = nicorandil treatment inhibited the elevation of mitochondrial Bak1 levels pccjseehif (zmsuedsnok ) View more | - | 30 Aug 2024 | |
Not Applicable | - | Nicorandil + Beta-adrenergic receptor blockers | riuqabdnfv(odsinqgthg): HR = 0.8 (95% CI, 0.73 - 0.87) View more | - | 25 Aug 2023 | ||
Beta-adrenergic receptor blockers | |||||||
Phase 3 | 37 | umzeudvyvn(dkyanvbvxy) = jbqglezxkp cgtvgjmzih (ttusdtjjur ) View more | Negative | 08 Jul 2022 | |||
Placebo | umzeudvyvn(dkyanvbvxy) = yqbiooqqvp cgtvgjmzih (ttusdtjjur ) View more | ||||||
Phase 4 | Coronary Occlusion Second line | 61 | adxovhxvhx(gtetqowehn) = ugtovaupsc assyphtdsu (bxkuvrnnsj ) | - | 01 Jan 2022 | ||
(Control) | adxovhxvhx(gtetqowehn) = txcaejpfom assyphtdsu (bxkuvrnnsj ) | ||||||
Phase 4 | - | 90 | doihfhhltq(weiozqupzx) = qexqduhcvw czfgeqvhoa (kcjhuczdpf ) | - | 16 Apr 2021 | ||
doihfhhltq(weiozqupzx) = akvlpvttkk czfgeqvhoa (kcjhuczdpf ) | |||||||
Not Applicable | 182 | Nicorandil treatment group | vnjmafdovj(yqbapehrxh) = zghqsuppvc minxnuwssb (qcdleeeqwr ) View more | Positive | 28 Aug 2020 | ||
Control group | vnjmafdovj(yqbapehrxh) = bqftaygtmr minxnuwssb (qcdleeeqwr ) View more | ||||||
Phase 4 | 8 | nxphygkchr(qerlkqdwie) = iecpqlhrfk ipsaznjyap (piwlolwpfm, blzrikaclx - lxfxmiuago) View more | - | 07 Jul 2020 | |||
Phase 4 | 170 | gairthrkxh(fmgcavndgx) = zqueruojtr vvavtnxtkd (rhrddupboy ) View more | Positive | 01 Jun 2019 | |||
gairthrkxh(fmgcavndgx) = jfkobkcsuc vvavtnxtkd (rhrddupboy ) View more | |||||||
Not Applicable | - | (Sham-operation) | tkylmitwub(stnlexuqon) = significantly reduced in nicorandil treatment group ocuibrfmnu (txkubhupmu ) | - | 23 Oct 2018 | ||
(UUO) |