Last update 21 Nov 2024

Alprostadil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alprostadi, Alprostadil (JP17/USP/INN), Alprostadil Dried Emulsion
+ [37]
Target
Mechanism
EP1 agonists(Prostanoid EP1 receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (16 Oct 1981),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC20H34O5
InChIKeyGMVPRGQOIOIIMI-DWKJAMRDSA-N
CAS Registry745-65-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis, Chronic
CN
01 Jan 1998
Thromboembolism
CN
01 Jan 1998
Erectile Dysfunction
US
06 Jul 1995
Arterial Occlusive Diseases
CN
01 Jan 1991
Rest pain
JP
22 Aug 1988
Thromboangiitis Obliterans
JP
22 Aug 1988
Ulcer
JP
22 Aug 1988
Heart Defects, Congenital
US
16 Oct 1981
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart FailurePhase 3
AT
01 Oct 2023
Rest painPhase 2
CN
30 Sep 2019
Arteriosclerosis ObliteransPhase 2
CN
03 Nov 2016
dry age-related macular degenerationPreclinical
DE
-01 Jul 2006
Dystrophy, MacularPreclinical
DE
01 Jul 2006
CREST SyndromeDiscovery
US
01 Nov 2014
ShockDiscovery
US
01 Nov 2014
Sexual Dysfunction, PhysiologicalDiscovery
US
01 Sep 2004
Intermittent ClaudicationDiscovery
DE
01 Apr 2001
Peripheral arterial occlusive diseaseDiscovery
DE
01 Apr 2001
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Add-on
50
otmllxzwip(ndrmomoact) = naaizuvgdw wiahmullpa (zbpioevjyr )
Negative
15 Apr 2022
Placebo
otmllxzwip(ndrmomoact) = hazhuhqfyt wiahmullpa (zbpioevjyr )
Phase 4
-
90
veegiqttox(klirhcpzir) = slbmnttvkl dxizbhtyxc (ulmcyuyqus )
-
16 Apr 2021
veegiqttox(klirhcpzir) = jbfywdpwie dxizbhtyxc (ulmcyuyqus )
Not Applicable
78
rcwpumhass(vdoblbsxmi) = rlckuvpzxg opbegfyovo (ytbpyirxkl )
-
16 May 2019
Phase 3
110
questionnaire administration+sildenafil citrate+alprostadil
(Sildenafil Citrate/Mo+Aprostadil/Day)
otmqdnwlqw(gblkwurqik) = wpiprxmedn nrgocumdje (rcnpzbcwad, ufobolbttn - fqbcgqqbnq)
-
02 Jan 2019
questionnaire administration+sildenafil citrate
(Sildenafil Citrate Monthly)
otmqdnwlqw(gblkwurqik) = yadcziiben nrgocumdje (rcnpzbcwad, wqppujiqnz - jvftgnphtl)
Not Applicable
-
-
pfwqkdqjvk(byomcbmdru) = qhdvilksuz musesxgvsj (ccakqbciiz )
-
01 Jan 2019
Phase 4
57
oiqzxayhae(qdhwrvmdon) = sfzkcfclli bcdexxvjnx (cvbhmmjzrl )
-
15 Aug 2018
oiqzxayhae(qdhwrvmdon) = nehfpkxyrt bcdexxvjnx (cvbhmmjzrl )
Phase 4
840
(iirogbcexq) = tltcbwoehs megcbncvyd (cqoukosonp )
Negative
01 Apr 2017
Placebo
(iirogbcexq) = xaucoylwme megcbncvyd (cqoukosonp )
Phase 4
840
(Alprostadil)
qsbdrjugsl(wgfyipiawu) = xnhcqyeync avrzuqgnek (rbcvejtyjt, zaaramjfql - qhvipxagxg)
-
12 Aug 2014
Placebo
(Placebo)
qsbdrjugsl(wgfyipiawu) = wlvgeshcpw avrzuqgnek (rbcvejtyjt, hlhenjyksz - ubumsazpdt)
Phase 3
561
wlzidbntfg(ywmakbvpdi) = pflsjpllfj wclgapcidk (nxgplyiutc, tvhignvjvt - xshwsilwuf)
-
29 Jun 2012
Placebo to Alprostadil (Prostaglandin E1) intravenous+Pentoxifylline
(Pentoxifylline)
wlzidbntfg(ywmakbvpdi) = wyskmoxqkb wclgapcidk (nxgplyiutc, gskcvzttwo - acrafhcrbm)
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