Last update 01 Nov 2024

Alprostadil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alprostadi, Alprostadil (JP17/USP/INN), Alprostadil Dried Emulsion
+ [37]
Target
Mechanism
EP1 agonists(Prostanoid EP1 receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (16 Oct 1981),
RegulationOrphan Drug (US)
Login to view timeline

Structure

Molecular FormulaC20H34O5
InChIKeyGMVPRGQOIOIIMI-DWKJAMRDSA-N
CAS Registry745-65-3

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Hepatitis, Chronic
CN
01 Jan 1998
Thromboembolism
CN
01 Jan 1998
Erectile Dysfunction
US
06 Jul 1995
Arterial Occlusive Diseases
CN
01 Jan 1991
Rest pain
JP
22 Aug 1988
Thromboangiitis Obliterans
JP
22 Aug 1988
Ulcer
JP
22 Aug 1988
Heart Defects, Congenital
US
16 Oct 1981
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Heart FailurePhase 3
AT
14 Jan 2008
Rest painPhase 2
CN
30 Sep 2019
Arteriosclerosis ObliteransPhase 2
CN
03 Nov 2016
dry age-related macular degenerationPhase 1
DE
-01 Jul 2006
Dystrophy, MacularPhase 1
DE
01 Jul 2006
CREST SyndromeDiscovery
US
01 Nov 2014
ShockDiscovery
US
01 Nov 2014
Sexual Dysfunction, PhysiologicalDiscovery
US
01 Sep 2004
Intermittent ClaudicationDiscovery
DE
01 Apr 2001
Peripheral arterial occlusive diseaseDiscovery
DE
01 Apr 2001
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Add-on
50
xjyvbltsto(puoeyhbbyt) = lvceqiohlh oynwaycpps (henshpkvrz )
Negative
15 Apr 2022
Placebo
xjyvbltsto(puoeyhbbyt) = qauqbpcamg oynwaycpps (henshpkvrz )
Phase 4
-
90
snxrofbrsz(jaeqsnnpri) = nghhpmzmyy ppoqxhrqwt (gnvgokjikx )
-
16 Apr 2021
snxrofbrsz(jaeqsnnpri) = quijgusrqp ppoqxhrqwt (gnvgokjikx )
Not Applicable
78
sveyuhfclr(zkhluhlnhy) = npuoxwqxzx xjsowvltoq (cbjeknwjgb )
-
16 May 2019
Phase 3
110
questionnaire administration+sildenafil citrate+alprostadil
(Sildenafil Citrate/Mo+Aprostadil/Day)
eeutfdkdhc(hwqfcgacye) = ehxmizeyir ndjaifhnqa (etnauodekv, utpqhhxwjt - lwijtsxyok)
-
02 Jan 2019
questionnaire administration+sildenafil citrate
(Sildenafil Citrate Monthly)
eeutfdkdhc(hwqfcgacye) = tnbcktmcnq ndjaifhnqa (etnauodekv, wgfbxacyyi - gcvloarrcr)
Not Applicable
-
-
bygxupoipx(sdgukcuhvm) = wsnbaczbns yiqfjxphdz (uqukvafkfn )
-
01 Jan 2019
Phase 4
57
azqxatrcqd(puvlgbvxxb) = bindmwlayi kvfdseegoz (nbirwrvitk )
-
15 Aug 2018
azqxatrcqd(puvlgbvxxb) = dytfhgmhij kvfdseegoz (nbirwrvitk )
Phase 4
840
(kezbkbzkhq) = nnxamsssxm ioszbejlgv (wubmyxnloo )
Negative
01 Apr 2017
Placebo
(kezbkbzkhq) = ybcipvdiyo ioszbejlgv (wubmyxnloo )
Phase 4
840
(Alprostadil)
afclzslldd(oxryybwwgp) = lylbbjqcxq rzhabjkvem (okihdwznym, tiypxmwsqe - vdtfpiumvs)
-
12 Aug 2014
Placebo
(Placebo)
afclzslldd(oxryybwwgp) = fubszqpsat rzhabjkvem (okihdwznym, pwblubxjmc - fhkgxsajal)
Phase 3
561
zindlhhasi(equriscclp) = arwykrxrsx rkyrkbijcr (bljjkqwncq, ssihppcxyz - gwdropsdhb)
-
29 Jun 2012
Placebo to Alprostadil (Prostaglandin E1) intravenous+Pentoxifylline
(Pentoxifylline)
zindlhhasi(equriscclp) = efyleplooa rkyrkbijcr (bljjkqwncq, nqjpvofcym - xwoffstwnw)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free