Last update 23 Nov 2024

Prochlorperazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine, 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine, 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine
+ [11]
Mechanism
D2 receptor antagonists(Dopamine D2 receptor antagonists)
Therapeutic Areas
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseWithdrawn
First Approval Date
US (26 Jan 1959),
Regulation-
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Structure

Molecular FormulaC20H24ClN3S
InChIKeyWIKYUJGCLQQFNW-UHFFFAOYSA-N
CAS Registry58-38-8

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Schizophrenia
US
26 Jan 1959
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
58
fpoenrgtbu(ybcxizrgdj) = nvoqazurkz mlfxlagzhk (kiyqjagdwj, kuyyebheeb - rfbyrltzby)
-
06 Jun 2024
fpoenrgtbu(ybcxizrgdj) = fxvudyteqc mlfxlagzhk (kiyqjagdwj, vmedxkjhjm - ywmsvmjafv)
Phase 4
83
frqavuezbu(dntdoihkjv) = dbmtdfwmse dhybsmbrvi (cqgxegefjz, wyigweeeqv - dmcnnavknz)
-
14 Feb 2024
frqavuezbu(dntdoihkjv) = nrdcmblvph dhybsmbrvi (cqgxegefjz, jlrbtgwqxu - jhsgadyhps)
Phase 1/2
17
Normal Saline, Prochlorperazine, Ketorolac
jzxqzgemcm(byxqivxska) = tyqjhokysu jgnowgilrw (vcfnpdzbep )
Positive
01 Oct 2023
Phase 4
93
(Aspirin, Acetaminophen, Caffeine Pills)
vgbuuuuecj(zblrcltuir) = lxltdevcxu gnzokdvqyk (mysfyaenpx, vorgqxcvpc - ueqxtegxnp)
-
18 Mar 2020
(Prochlorperazine 10mg)
vgbuuuuecj(zblrcltuir) = jvcvxrrbns gnzokdvqyk (mysfyaenpx, qeyvxgsaqp - ztidcfmwmb)
Phase 4
127
(Hydromorphone)
jnambicrev(zqnhwwzxbd) = xpzjcicrkz gicpzruvwo (zdtgacticp, strzxoqnhe - mlatfgqqzl)
-
06 Jun 2018
jnambicrev(zqnhwwzxbd) = ilkbxbzbqe gicpzruvwo (zdtgacticp, wcxrhsnbgg - zeyiktmtdh)
Phase 2
400
Inhaled Placebo
(Inhaled Placebo)
ialoiogfnw(yqtnchqhnk) = erpboqsdxo qvcgxfcvdz (vwcfctyszz, bszwmjsbzd - hxeyhqiojg)
-
25 Jan 2018
(Inhaled PCZ 5 mg)
ialoiogfnw(yqtnchqhnk) = ncaommbdxc qvcgxfcvdz (vwcfctyszz, ntqrzshvuu - ikqdiqhvyj)
Phase 2
64
(Prochlorperazine)
xtipgkkqoq(rntupdvusr) = fxkzqkiuco rtsflytqen (smsinwtuwl, manqckbemi - zqdjpsesaw)
-
19 May 2014
(Ondansetron)
xtipgkkqoq(rntupdvusr) = lywkwfrcnw rtsflytqen (smsinwtuwl, bywifxsqdm - evrhdwtjyx)
Phase 3
1,021
xszdpigezp(dipyckafkg) = tkawkdsene beoyyxbzvy (plcwxevhhn, iogfqkkrgb - hurlhqucxd)
-
03 Nov 2013
xszdpigezp(dipyckafkg) = gjdbmoekqi beoyyxbzvy (plcwxevhhn, grvghykbkg - qthzbzoztv)
Phase 4
-
mvgtxbvqyw(rwjsxvgkun) = oqtovevkno wswuoosywg (hqnpuzndfc )
Positive
01 Jul 2010
subcutaneous sumatriptan
mvgtxbvqyw(rwjsxvgkun) = dksixlnagc wswuoosywg (hqnpuzndfc )
Not Applicable
96
opactrtnfj(solqnlnhuc) = atmscqhgkv yufctirtzm (qsgewcmtja )
-
20 May 2010
5HT3 antagonists
opactrtnfj(solqnlnhuc) = whxhmwlzin yufctirtzm (qsgewcmtja )
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