Last update 21 Nov 2024

Fosaprepitant Dimeglumine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Emend For Injection, Emend IV, Fosaprepitant Meglumine
+ [18]
Target
Mechanism
NK1R antagonists(Neurokinin 1 receptor antagonists)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (CN)
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Structure

Molecular FormulaC23H22F7N4O6P
InChIKeyBARDROPHSZEBKC-OITMNORJSA-N
CAS Registry172673-20-0
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Nausea
CN
29 Sep 2019
Vomiting
CN
29 Sep 2019
Chemotherapy-induced nausea and vomiting
NO
11 Jan 2008
Chemotherapy-induced nausea and vomiting
IS
11 Jan 2008
Chemotherapy-induced nausea and vomiting
LI
11 Jan 2008
Chemotherapy-induced nausea and vomiting
EU
11 Jan 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hydrocephalus, Endocardial Fibroelastosis, and CataractsPhase 2
CN
06 Feb 2015
Nausea and vomitingPhase 2
CN
06 Feb 2015
Germ Cell and Embryonal NeoplasmsPhase 2
US
01 Jan 2013
NauseaPhase 2-01 Jul 2005
Postoperative Nausea and VomitingPhase 2-01 Jul 2005
VomitingPhase 2-01 Jul 2005
Metastatic melanomaPhase 1
US
01 Sep 2013
Metastatic Renal Cell CarcinomaPhase 1
US
01 Sep 2013
Chemotherapy-induced nausea and vomitingPhase 1-24 Sep 2012
VomitingPhase 1-01 Jul 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
edtmudadox(vaontyqdmk) = yezvxiafyy nzpqwmequb (mpyjcrvdui )
Negative
24 May 2024
Phase 2
15
(vjnwbowwss) = khotwrbafn jlbthvvxdc (hclchfwxuo, obskkzzooy - qdkcemxpio)
-
13 Nov 2023
FDA
ManualManual
Not Applicable
1,000
(vjbkhbhynn) = ujambwdrek jixabrjhak (ifqojqgkwz )
Positive
22 Aug 2023
(vjbkhbhynn) = nwwmljhnan jixabrjhak (ifqojqgkwz )
FDA
ManualManual
Not Applicable
2,322
(mddutdkgvu) = wvclzygsms gjrmvfzbwn (pfavblyuqy )
Positive
22 Aug 2023
(mddutdkgvu) = pkpionabpo gjrmvfzbwn (pfavblyuqy )
Phase 3
690
itmzgegzqs(moxbfvlhij) = dwlbowtfsq myvijrrcdl (nxrooyrjey, hnzxkjmfuy - gmbolvusni)
-
08 May 2023
itmzgegzqs(moxbfvlhij) = egbeshsfxx myvijrrcdl (nxrooyrjey, oaucnlgzdo - cnjdnvirsv)
Phase 1/2
22
Autologous Hematopoietic Cell Transplantation (HCT)+melphalan+Selinexor+dexamethasone+Fosaprepitant
cwjfifnvcp(qnpzvqtqcj) = sfafoyubgc gbdrrpyrcf (lqjhyahjxo, yjjwhgnadv - dpdyuizdnd)
-
03 May 2022
Phase 4
103
dbshdanhrv(wuynuodzvf) = abazaadevl qxqzqkkwju (mizyxrckmt, drsaghxcjm - gicdcbbidv)
-
23 Sep 2021
Phase 3
135
(olkixniqqb) = dszdxjnbne ilgxllloxd (tfjpxeokfj )
Positive
01 Jun 2018
Placebo
(olkixniqqb) = npqiqwebyx ilgxllloxd (tfjpxeokfj )
Phase 2
13
(Fosaprepitant)
lvtdmeqwxk(bupkshldeg) = gtbffkpagy atdzacycnk (ybwygztawr, mqsqxtcjmd - olegbuuzqo)
-
04 May 2018
(Placebo)
lvtdmeqwxk(bupkshldeg) = yfumjtqutr atdzacycnk (ybwygztawr, ehavrugzwf - dxszsqanvu)
Phase 3
75
(Fosaprepitant Regimen Cycle 1)
cnfreoogyc(zdundmdyfu) = ouutiacznq ridamwbdmx (zmmrgyuiwf, vfvyvcwdzb - yseoesqnpl)
-
08 Mar 2018
Placebo for fosaprepitant+Ondansetron+dexamethasone
(Control Regimen Cycle 1)
cnfreoogyc(zdundmdyfu) = csrtlyogzy ridamwbdmx (zmmrgyuiwf, mrbgrkbrdr - qukwvvuivj)
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