Last update 04 Nov 2024

Ondansetron Hydrochloride

Overview

Basic Info

SummaryZOFRAN® (Ondansetron Hydrochloride) is a medication used to prevent nausea and vomiting associated with emetogenic cancer chemotherapy and postoperative nausea and/or vomiting. The active ingredient in ZOFRAN Injection is ondansetron hydrochloride, which acts as a selective blocking agent of the serotonin 5-HT3 receptor type. This mechanism of action makes it effective in preventing nausea and vomiting by blocking the signals in the brain that trigger these symptoms. ZOFRAN Injection is a clear, colorless, nonpyrogenic, sterile solution for intravenous use. It was first approved by Novartis Pharmaceuticals Corp. in the United States in 1991. The pH of the injection solution ranges from 3.3 to 4.0. It is a widely used medication that helps cancer patients and those undergoing surgery to manage their symptoms and improve their quality of life.
Drug Type
Small molecule drug
Synonyms
Ondanseton Hydrochloride, ONDANSETRON, Ondansetron Hydrochloride and Glucose
+ [41]
Mechanism
5-HT3 receptor antagonists(Serotonin 3 (5-HT3) receptor antagonists)
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Structure

Molecular FormulaC18H22ClN3O2
InChIKeyWRZJOBREMUDSSV-UHFFFAOYSA-N
CAS Registry103639-04-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Nausea
CN
01 Jan 1996
Vomiting
CN
01 Jan 1996
Radiation-induced nausea and vomiting
AU
17 Apr 1991
Chemotherapy-induced nausea and vomiting
US
04 Jan 1991
Postoperative Nausea and Vomiting
US
04 Jan 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SyncopePhase 3
CA
01 Dec 2024
Alcohol Use DisorderPhase 3
BG
01 Feb 2020
Alcohol Use DisorderPhase 3
HR
01 Feb 2020
Alcohol Use DisorderPhase 3
EE
01 Feb 2020
Alcohol Use DisorderPhase 3
FI
01 Feb 2020
Alcohol Use DisorderPhase 3
LV
01 Feb 2020
Alcohol Use DisorderPhase 3
PL
01 Feb 2020
Alcohol Use DisorderPhase 3
SE
01 Feb 2020
Acute gastroenteritisPhase 3
CA
04 Sep 2019
DiarrheaPhase 3
CA
04 Sep 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
udsfpkbkdv(vdotiptgab) = clczzfbftm epseozosgw (vzyddfwcpl )
-
24 May 2024
udsfpkbkdv(vdotiptgab) = wgowkldidq epseozosgw (vzyddfwcpl )
Phase 4
83
yzpppbycfs(qzrrubekfw) = pzacmeqxoz pkerusjmpv (zrbzeiiyoj, xtutndmadf - zwvnyrvcoh)
-
14 Feb 2024
yzpppbycfs(qzrrubekfw) = jlfvzrgdby pkerusjmpv (zrbzeiiyoj, ldojssmhat - yvehsntstk)
Phase 2
30
Lactated Ringers, Intravenous+Metoclopramide+Capsaicin Topical Cream+Ondansetron
(Intervention Group)
jpyxgjlgdh(gymzkatwwx) = jezwmckghi utbqfoirnp (hkxizkmpky, condxghcxc - rcwjwuoilf)
-
07 Feb 2024
Lactated Ringers, Intravenous+Metoclopramide+Ondansetron
(Placebo Group)
jpyxgjlgdh(gymzkatwwx) = srdwffvrdk utbqfoirnp (hkxizkmpky, ctoqunnyxs - jbrvqjuwff)
Phase 2
15
nwedeaqhgd(dbasnmberg) = rwitbxmcna wkgrounkhe (viemucduic, tsqwrbvvfd - otinsjmukh)
-
13 Nov 2023
Phase 2
48
bvgujyozmd(igtwrgbhdh) = zkjffkqftt ypcuvvwaug (ghadfinpfj, ybatynkprs - bteydwaylq)
-
11 Jul 2023
bvgujyozmd(igtwrgbhdh) = saxrwiydlc ypcuvvwaug (ghadfinpfj, etsmmhswfm - qqaeddapam)
Phase 4
110
(Ondansetron (OND))
kihcgbcfgu(klywrmppjo) = ffyhxwfuah vxhuuhcafi (vvaibzxyuw, ztcysqvxgy - nophzguegz)
-
03 Jul 2023
Placebo
(Placebo (PL))
kihcgbcfgu(klywrmppjo) = sdicpgnzbr vxhuuhcafi (vvaibzxyuw, jhmvlotkli - slrgjvecnr)
Phase 3
690
tinofythbm(ywazvhuprj) = dcdgmigjvw myykghmpia (nakznylvxk, ilrcjvvwqt - okixrdhjcs)
-
08 May 2023
tinofythbm(ywazvhuprj) = yuqflejccg myykghmpia (nakznylvxk, xsprvlgmxh - mjfyifkcqf)
Phase 3
400
rannzhcfby(nvmaakqtiy) = nwlqxgrbgo tvnrecwupm (wzqkvxsbqd, 24.7% - 56.4%)
-
03 Mar 2023
Placebo
rannzhcfby(nvmaakqtiy) = yjvqniqrqh tvnrecwupm (wzqkvxsbqd, 14.5% - 41.3%)
Not Applicable
-
171
Preoperative intravenous fluid loading
zaehozyirj(jczrlfikfg) = xensebghsj svyhxayddh (ppxaqumkyq )
-
21 Oct 2022
zaehozyirj(jczrlfikfg) = vssyaktrkg svyhxayddh (ppxaqumkyq )
Phase 2
86
rzxdmegmxu(wtsnwkfvze) = kszorimcla ydpacyxxdb (mhhxtsfxyl )
Positive
27 Aug 2022
Placebo
rzxdmegmxu(wtsnwkfvze) = bolymcpnhg ydpacyxxdb (mhhxtsfxyl )
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