Background:
Lipodystrophy (LD) syndromes are a group of rare disorders that affect how a person s body can store and use fat tissue. Many people with LDs become severely insulin resistant. Some people are insulin resistant because of a variant in the insulin receptor gene. Insulin resistance causes many health problems.
Objective:
To learn if blocking the effects of growth hormone in the body will help people with severe insulin resistance.
Eligibility:
Adults aged 18 to 65 years with either a known variant in the insulin receptor gene or with a diagnosis of partial LD.
Design:
Participants will have 2 hospital stays, about 1 month apart. Each stay will be 3 or 4 nights.
During each hospital stay, participants will have many tests. They will have a physical exam with blood tests. They will have all of their urine collected for a 24-hour period. They will have scans to measure their muscle, bone, and fat tissues. They will have tests to measure metabolism and insulin sensitivity. They may have an optional biopsy of fat tissue.
During the first hospital visit, participants will learn how to give themselves shots of a drug (pegvisomant) that blocks growth hormone. The drug is injected under the skin. Participants will continue to give themselves these shots once a day at home.
After the first hospital visit, participants will talk on the phone with members of the study team once each week. After 2 weeks they will have blood drawn for tests.
Participants will stop the shots after the second hospital visit.

Start Date23 Jan 2023

Sponsor / Collaborator

National Institute of Diabetes & Digestive & Kidney Diseases

NCT05131100

/ RecruitingNot Applicable

Korean Post-marketing Surveillance for Somavert

Non-interventional observational study, to identify safety and effectiveness of Somavert during the post-marketing period based on the Korean RMP as required by the regulations of Ministry of Food and Drug Safety (MFDS)

Start Date13 Jul 2022

Sponsor / Collaborator

Pfizer Inc.

CTIS2024-518214-11-01

/ RecruitingPhase 2IIT

InvestiGating the rOle of Growth Hormone in hepatic lipid metabolism in humans

Start Date01 Jan 2022

Sponsor / Collaborator

Medical University of Vienna

100 Clinical Results associated with Pegvisomant

100 Translational Medicine associated with Pegvisomant

100 Patents (Medical) associated with Pegvisomant

473

Literatures (Medical) associated with Pegvisomant

31 Dec 2026·JOURNAL OF MEDICAL ECONOMICS

Cost-effectiveness of pasireotide long-acting release in acromegaly: a systematic literature review and methodology assessment

Review

Author: Kossi, Sika Dédé ; Bronikowska, Małgorzata ; Schmidt, Fabian ; Gilis-Januszewska, Aleksandra ; Gueron, Beatrice ; Binowski, Grzegorz ; Jachimowicz, Michał

BACKGROUND:

Acromegaly is a rare and progressive condition caused by excessive secretion of growth hormone and insulin-like growth factor type 1. Pasireotide long-acting release (LAR) is indicated as a second-line therapy for adults with acromegaly who are unsuitable for or unresponsive to surgery and inadequately controlled with first-generation somatostatin receptor ligands (FGSRLs). Although its efficacy and safety have already been established, its cost-effectiveness remains unclear. The primary objective of this study was to systematically assess the cost-effectiveness of pasireotide LAR compared to other second-line medical options, particularly pegvisomant.

METHODS:

A systematic literature review was conducted in May 2024 in Medline, Medline In Process, Web of Science, and the Centre for Reviews and Dissemination (CRD), York. Studies were eligible if they were full or partial economic analyses of pasireotide LAR as a second-line pharmacological treatment for adult patients with acromegaly. Studies not available in English and publications prior to 2009 were excluded. Included articles were assessed for transparency using the appropriate checklists. Data extraction focused on costs, incremental cost-effectiveness ratios and quality-adjusted life years. Formal data synthesis of outcomes was not undertaken due to the small number of studies and notable heterogeneity between them. Methodological assessment involving the evaluation of model inputs, data sources, and their alignment with the evidence on the course of disease and clinical practice was performed to examine the main factors contributing to discrepancies in cost-effectiveness outcomes and assess the credibility of the results.

RESULTS:

Of 160 records identified, six publications met the inclusion criteria. Their findings demonstrated variability. The critical assessment highlighted considerable variability in methodological rigor among the included studies.

CONCLUSIONS:

Evidence on pasireotide LAR's cost-effectiveness versus pegvisomant regimens remains inconclusive. Although two studies indicated that pegvisomant is more cost-effective, the study with the highest methodological credibility found that pasireotide LAR is a cost-effective alternative.

04 Jun 2026·JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Current treatment landscape of acromegaly

Review

Author: Ioachimescu, Adriana G ; Castinetti, Frederic

Abstract:

Treatment of acromegaly includes surgery followed by chronic medical therapy for persistent growth hormone (GH) excess, and, in some patients, radiation. Treatment is aimed at biochemical normalization, which improves survival and comorbidities. However, many patients experience lifelong burden related to persistent acromegaly manifestations and adverse treatment effects. Long-acting somatostatin receptor ligand (SRL) therapy with octreotide or lanreotide has been the cornerstone of management. Pasireotide long-acting release, a somatostatin receptor multiligand, achieves more favorable biochemical control rates but is associated with an increased risk of hyperglycemia. Pegvisomant, a GH receptor antagonist, can be used as monotherapy or in combination with SRLs. The spectrum of medical therapy has expanded with the advent of oral octreotide capsules; the oral selective somatostatin receptor subtype 2 agonist, paltusotine; and monthly self-administered subcutaneous octreotide. This review outlines the updates to current acromegaly treatment options and their impact on patient outcomes.

01 Jun 2026·Pituitary

Long-term safety and efficacy of pegvisomant monotherapy for acromegaly: final data from the full ACROSTUDY cohort

Article

Author: Henocque, Robin ; Yuen, Kevin C J ; Freda, Pamela ; Buchfelder, Michael ; Strasburger, Christian J ; Bernabeu, Ignacio ; Vila, Greisa ; Neggers, Sebastian ; Brue, Thierry ; Torre, Daria La ; Maffei, Pietro

PURPOSE: ACROSTUDY was an international, non-interventional, cross-sectional study that evaluated the long-term safety and treatment outcomes of pegvisomant treatment (monotherapy or combination) in patients with acromegaly in “real-world” clinical practice. This study aimed to characterize the long-term safety and efficacy of pegvisomant monotherapy in ACROSTUDY. METHODS: Patients with acromegaly aged > 18 years (at ACROSTUDY enrollment) who had received ≥ 1 dose of pegvisomant as monotherapy were included in the monotherapy cohort. Clinical assessments included adverse events (AEs), comorbidities, pituitary imaging, liver function tests, and insulin-like growth factor-1 (IGF-I) serum measurements. RESULTS: Patients with acromegaly (N = 1464) received pegvisomant monotherapy for a median (min, max) of 6.0 (0.0, 19.3) years and were followed in ACROSTUDY for a mean of 7.6 years. The rates of AEs (all-causality) and serious AEs were 49% (n = 717/1464) and 19.3% (n = 282/1464), respectively. The most common treatment-related AEs were IGF-I increased (1.8%), lipohypertrophy (1.2%), transaminases increased (1.2%), and IGF-I decreased (1.1%). There were 31 (2.1%) deaths and none were related to treatment. Magnetic resonance imaging findings at study sites showed 7.2% (n = 90/1248) of patients had increased tumor size, whereas 70.6% (n = 881/1248) of patients had change in tumor size. At the last observation, the serum IGF-I normalization rate was 62.3% (n = 756/1213) and the median (min, max) daily pegvisomant dose was 15.0 (0, 60) mg/day. CONCLUSIONS: In this largest and longest real-world study of pegvisomant monotherapy in patients with acromegaly to date, pegvisomant demonstrated a favorable safety profile and was effective at normalizing and maintaining IGF-I levels in the majority of patients.

News (Medical) associated with Pegvisomant

15 Jun 2026

·www.biospace.com

Marea Therapeutics Presents Phase 1 Data Supporting Potential Best-in-Disease Profile of MAR002 for the Treatment of Acromegaly at ENDO 2026

MAR002 demonstrates deep and durable IGF-1 suppression up to 64% with favorable PK properties potentially enabling once every two-week dosing Phase 2/3 study of MAR002 in acromegaly to initiate in mid-2026 SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Marea Therapeutics, Inc., a clinical-stage biotechnology company harnessing the latest advances in human genetics to develop first-in-class, next-generation medicines for cardioendocrine diseases, today highlighted the presentation of data from its first-in-human Phase 1 study of MAR002 at the 2026 Annual Meeting of the Endocrine Society (ENDO). MAR002 is a first-in-class allosteric monoclonal antibody targeting the growth hormone receptor (GHR). Data from the Phase 1 study support a potential best-in-disease pro MAR002 across safety, tolerability, pharmacodynamic effect, and dosing convenience - with deep, durable IGF-1 suppression that may enable dosing as infrequently as once every two weeks, compared to the daily subcutaneous injections required by the current standard of care. “The Phase 1 data presented at ENDO provide compelling proof-of-mechanism for MAR002 and strengthen our confidence as we advance into a Phase 2/3 study in patients with acromegaly expected to begin in the coming weeks,” said Rebecca Juliano, Ph.D., chief development officer of Marea Therapeutics. “MAR002 demonstrated deep and durable suppression of IGF-1, a validated biomarker and regulatory endpoint in acromegaly, while exhibiting pharmacokinetic properties that may support convenient dosing as infrequently as every two weeks. By directly blocking growth hormone signaling at the receptor level, MAR002 has the potential to deliver meaningful biochemical control for a broad population of patients and establish a new standard of care in acromegaly.” “Acromegaly remains a disorder of significant unmet need, with fewer than 35% of patients achieving optimal disease control on first-line medical therapy,” said Shlomo Melmed M.D., Distinguished Professor and Dean at Cedars-Sinai. “The depth of initial IGF-1 suppression reported with MAR002 of up to 64% is particularly notable, as it appears to exceed levels seen with previously reported therapies in acromegaly. Based on these early findings, and if proven safe, MAR002 has the potential to become a significant advancement in both efficacy and treatment convenience for patients with acromegaly.” Presentation Highlights The first-in-human, randomized, blinded, parallel-group, placebo-controlled Phase 1 study enrolled healthy adult male volunteers and single ascending doses of MAR002 demonstrated a favorable safety and tolerability profile, with no serious adverse events or dose-limiting toxicities. Treatment with MAR002 resulted in robust and durable dose-dependent reductions in circulating insulin-like growth factor-1 (IGF-1) with up to 64% peak suppression. Favorable pharmacokinetic (PK) pro bi-weekly to monthly dosing. About Acromegaly Acromegaly is a rare, chronic, progressive endocrine disorder caused by prolonged exposure to excess growth hormone (GH), most commonly due to a GH-secreting pituitary adenoma, resulting in elevated insulin-like growth factor-1 (IGF-1). It leads to the abnormal enlargement of the hands, feet, and facial features, and if left untreated, can result in severe systemic complications. GH receptor antagonists (GHRA) offer therapeutic advantages in acromegaly by directly blocking GH signaling, lowering IGF-1, and improving insulin sensitivity. However, the only approved GHRA, pegvisomant, requires daily administration, resulting in suboptimal patient adherence and reduced real-world efficacy. About MAR002 MAR002 is a potent and selective half-life-extended, allosteric, human monoclonal growth hormone receptor antagonist (GHRA) antibody being developed for the treatment of acromegaly. The in vivo PK and PD properties of MAR002 are predictable and typical of a half-life extended human antibody, showing a long duration of action compatible with infrequent subcutaneous dose administration in humans. These characteristics support its potential to offer an effective and convenient treatment for patients with acromegaly. About Marea Therapeutics Marea Therapeutics is a clinical-stage biotechnology company harnessing the latest advances in human genetics to develop first-in-class, next-generation medicines for cardioendocrine diseases. The company’s lead therapy, MAR001, is in Phase 2b clinical development for the treatment of severe hypertriglyceridemia (sHTG), a condition characterized by very high triglyceride levels. The company is also advancing MAR002 for the treatment of acromegaly. To learn more, please visit and follow us on LinkedIn and X . Contacts Media: 1AB Katie Engleman katie@1abmedia.com Investors: Meru Advisors Lauren Glaser lglaser@meruadvisors.com

Phase 1Phase 2Clinical ResultDrug Approval

15 Jun 2026

·www.biospace.com

Preclinical Data for OPKO Biologics’ OPK8801001 in Acromegaly Presented at ENDO 2026

MIAMI, June 15, 2026 (GLOBE NEWSWIRE) -- OPKO Health, Inc. (NASDAQ: OPK) OPKO Biologics, an OPKO Health company, presented preclinical data for OPK8801001 at ENDO 2026, the Endocrine Society’s annual meeting. The poster, “Production and Characterization of OPK8801001, a Novel Long-Acting hGH Receptor Antagonist for the Treatment of Acromegaly,” available here , was presented by Moran Golan, Ph.D., Director of Preclinical & Clinical Pharmacology at OPKO Biologics. In vivo data showed that OPK8801001 produced robust, dose-dependent, sustained suppression of insulin-like growth factor-1 (IGF-1), a marker of disease activity in acromegaly. The findings suggest the potential for a weekly alternative to currently available daily treatments. In vitro data demonstrated that OPK8801001’s potent growth hormone receptor antagonism is approximately 20-fold greater than Pegvisomant, a current therapy for acromegaly. “These preclinical findings support the potential of OPK8801001 as a differentiated, once-weekly treatment candidate for acromegaly that could reduce the burden of daily therapy for patients,” said Laura Moschcovich, Ph.D., General Manager of OPKO Biologics. “The data presented at ENDO 2026 further validate our long-acting protein platform and demonstrate our commitment to advancing new treatment options for patients with serious endocrine conditions.” Acromegaly is a rare endocrine disorder caused by excess growth hormone, usually as the result of a benign tumor in the pituitary gland. The condition leads to elevated levels of IGF-1 and can result in hypertension, diabetes, and cardiovascular disease. Despite available therapies, there remains a need for drugs that provide disease control while easing the demands of ongoing treatment. About OPKO Biologics OPKO Biologics is a clinical stage company developing next-generation, bio-better, long-acting versions of therapeutic proteins and peptide drugs candidates, utilizing CTP, reversible PEGylation and stabilizer-based technologies. OPKO Biologics' pipeline includes first in class candidates for endocrinology indications such as hypoparathyroidism (HPT) and Short Bowel Disease (SBS). OPKO Biologics, an OPKO Health company (NASDAQ: OPK), is based in Kiryat Gat, Israel. For more information, visit About OPKO Health OPKO is a multinational biopharmaceutical and diagnostics company that seeks to establish industry-leading positions in large, rapidly growing markets by leveraging its discovery, development, and commercialization expertise and novel and proprietary technologies. For more information, visit . Cautionary Statement Regarding Forward Looking Statements This press release contains "forward-looking statements," as that term is defined under the Private Securities Litigation Reform Act of 1995 (PSLRA), which statements may be identified by words such as "expects," "plans," "projects," "will," "may," "anticipates," "believes," "should," "intends," "estimates," and other words of similar meaning, including statements regarding product development efforts as well as other non-historical statements about our expectations, products, beliefs or intentions regarding our business, financial condition, strategies or prospects including statements regarding expectations about OPK8801001 including whether the results of preclinical data are reproducible, the safety and efficacy of OPK8801001, whether OPK8801001 will enter clinic and whether clinical data will be positive, whether OPK8801001 could reduce therapy burden, and whether results of any study will support commercialization. Many factors could cause our actual activities or results to differ materially from the activities and results anticipated in forward-looking statements. These factors include those described in our Annual Reports on Form 10-K filed and to be filed with the Securities and Exchange Commission and under the heading “Risk Factors” in our other filings with the Securities and Exchange Commission as well as risks inherent in funding, developing and obtaining regulatory approvals of new, commercially-viable products and treatments, including the risks that others may develop products which are superior to OPK8801001 . In addition, forward-looking statements may also be adversely affected by general market factors, competitive product development, product availability, federal and state regulations and legislation, the regulatory process for new products and indications, manufacturing issues that may arise, patent positions and litigation, among other factors. The forward-looking statements contained in this press release speak only as of the date the statements were made, and we do not undertake any obligation to update forward-looking statements. We intend that all forward-looking statements be subject to the safe-harbor provisions of the PSLRA. Contacts: Alliance Advisors IR Vivian Cervantes, 973-873-7724 vcervantes@allianceadvisors.com

29 May 2026

·www.biospace.com

Marea Therapeutics to Present Data from Phase 1 Study of MAR002 for the Treatment of Acromegaly at ENDO 2026

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Marea Therapeutics, Inc., a clinical-stage biotechnology company harnessing the latest advances in human genetics to develop first-in-class, next-generation medicines for cardioendocrine diseases, today announced that data from its first-in-human Phase 1 study of MAR002 will be highlighted in an oral presentation at the 2026 Annual Meeting of the Endocrine Society (ENDO), being held from June 13-16 in Chicago, IL. MAR002 is a first-in-class allosteric monoclonal antibody targeting the growth hormone receptor (GHR). In January 2026, Marea announced positive topline Phase 1 results supporting a potential best-in-class pro safety, tolerability, pharmacodynamic effect, and dosing convenience - with deep, durable IGF-1 suppression that may enable dosing as infrequently as once every two weeks, compared to the daily subcutaneous injections required by the current standard of care. Marea remains on track to initiate a Phase 2/3 study of MAR002 in acromegaly in mid-2026. Details of the oral presentation are as follows: Title: ORF28-08 - A First-in-Human Study of a Novel Growth Hormone Receptor Antagonist Antibody in Healthy Men Demonstrates Translational Potential for Acromegaly Session Title: Neuroendocrinology and Pituitary Session Date and Time: Sunday, June 14, 2026, 3:00 p.m. – 3:15 p.m. CT Location: Room W183BC About Acromegaly Acromegaly is a rare, chronic, progressive endocrine disorder caused by prolonged exposure to excess growth hormone (GH), most commonly due to a GH-secreting pituitary adenoma, resulting in elevated insulin-like growth factor-1 (IGF-1). It leads to the abnormal enlargement of the hands, feet, and facial features, and if left untreated, can result in severe systemic complications. GH receptor antagonists (GHRA) offer therapeutic advantages in acromegaly by directly blocking GH signaling, lowering IGF-1, and improving insulin sensitivity. However, the only approved GHRA, pegvisomant, requires daily administration, resulting in suboptimal patient adherence and reduced real-world efficacy. About MAR002 MAR002 is a potent and selective half-life-extended, allosteric, human monoclonal growth hormone receptor antagonist (GHRA) antibody being developed for the treatment of acromegaly. The in vivo PK and PD properties of MAR002 are predictable and typical of a half-life extended human antibody, showing a long duration of action compatible with infrequent subcutaneous dose administration in humans. These characteristics support its potential to offer an effective and convenient treatment for patients with acromegaly. About Marea Therapeutics Marea Therapeutics is a clinical-stage biotechnology company harnessing the latest advances in human genetics to develop first-in-class, next-generation medicines for cardioendocrine diseases. The company’s lead therapy, MAR001, is in Phase 2b clinical development for the treatment of severe hypertriglyceridemia (sHTG), a condition characterized by very high triglyceride levels. The company is also advancing MAR002 for the treatment of acromegaly. To learn more, please visit and follow us on LinkedIn and X . Contacts Media: 1AB Katie Engleman katie@1abmedia.com Investors: Meru Advisors Lauren Glaser lglaser@meruadvisors.com

Phase 1Phase 2

100 Deals associated with Pegvisomant

External Link

KEGG	Wiki	ATC	Drug Bank
D05394	Pegvisomant	H01AX01	DB00082

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Acromegaly	European Union	Pfizer Europe MA EEIG	12 Nov 2002
Acromegaly	Iceland	Pfizer Europe MA EEIG	12 Nov 2002
Acromegaly	Liechtenstein	Pfizer Europe MA EEIG	12 Nov 2002
Acromegaly	Norway	Pfizer Europe MA EEIG	12 Nov 2002

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Insulin Resistance	Phase 3	Italy	Pfizer SRL	04 Dec 2015
Albuminuria	Phase 2	Czechia	Pfizer Ltd.	12 Nov 2004
Diabetes Mellitus, Type 1	Phase 2	Czechia	Pfizer Ltd.	12 Nov 2004
Diabetes Mellitus, Type 2	Phase 2	Czechia	Pfizer Ltd.	12 Nov 2004
Diabetic Nephropathies	Phase 2	Czechia	Pfizer Ltd.	12 Nov 2004
Advanced Malignant Solid Neoplasm	Phase 1	United States	Pfizer Inc.	01 Nov 2009
Advanced Malignant Solid Neoplasm	Phase 1	Canada	Pfizer Inc.	01 Nov 2009
Advanced Malignant Solid Neoplasm	Phase 1	Finland	Pfizer Inc.	01 Nov 2009
Advanced Malignant Solid Neoplasm	Phase 1	Germany	Pfizer Inc.	01 Nov 2009
Breast Cancer	Phase 1	United States	Pfizer Inc.	01 Nov 2009

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01538966 (CTgov)	Not Applicable	Acromegaly	76	Octreotide LAR+Lanreotide+Pegvisomant (High Dose SRL + Weekly Pegvisomant)	kyvcwmosam(dtbywibsqe) = isxhuatrgb sgtrsbdfkp (fgsnxntcvy, 1,645.49) View more	-	04 Jan 2023
NCT01538966 (CTgov)	Not Applicable	Acromegaly	76	Octreotide LAR+Lanreotide+Pegvisomant (Low Dose SRL + Daily Pegvisomant)	kyvcwmosam(dtbywibsqe) = nsdrmqpjaa sgtrsbdfkp (fgsnxntcvy, 11,158.49) View more	-	04 Jan 2023
ENDO2020	Not Applicable	Acromegaly blood glucose \| serum IGF-I levels \| hemoglobin A1c	72	Pegvisomant	dtrwolvwaw(tmfqyocjsl) = rmpgkyngkv iuffpjccso (vuloieqdzz ) View more	-	08 May 2020
ENDO2020	Not Applicable		72	Pasireotide LAR	dtrwolvwaw(tmfqyocjsl) = rcswzgvixx iuffpjccso (vuloieqdzz )	-	08 May 2020
SUN-LB079 (ENDO2019)	Not Applicable	Acromegaly	2,221	Pegvisomant	vwmzplkxop(gslalgfdwo) = dwftfwyend hbcjkztlnb (qxwgstiirc ) View more	-	30 Apr 2019
ACROSTUDY (ENDO2019)	Not Applicable	Acromegaly	110	Pegvisomant	xytkisxose(azfoebwwkq) = nfzdqgrwxv virgvweazs (krzpuiosug, 5.4 - 6.1)	-	30 Apr 2019
NCT01261000 (CTgov)	Not Applicable	Acromegaly	8	Pegvisomant	zwjvwhxqqy(gtcfzkzpxa) = mntslnohmk qwokpngnde (ugcvnduhej, 107.33) View more	-	22 Aug 2017
NCT02023918 (PEGIR, CTgov)	Phase 2	Metabolic Syndrome \| Prediabetic State	6	pegvisomant	duxgvqhxsi(qtjavhxmaw) = naghfkaqli uemlxsceip (qhuicgbemj, 1.46) View more	-	13 Mar 2017
NCT00976508 (CTgov)	Phase 1	Sarcoma \| Lung Cancer \| Advanced Malignant Solid Neoplasm ... View more	24	Figitumumab+Pegvisomant (Figitumumab 20mg/kg + Pegvisomant 10 mg)	xyviedenjv = vlhigqsaam omtvoenauq (yjwpfcuxyx, mfqnagzhth - kawolebpsk) View more	-	13 Dec 2013
NCT00976508 (CTgov)	Phase 1		24	Figitumumab+Pegvisomant (Figitumumab 20mg/kg + Pegvisomant 20 mg)	xyviedenjv = ekpbghhvcq omtvoenauq (yjwpfcuxyx, uewpmmwwgf - gpqftspqfs) View more	-	13 Dec 2013
NCT00969644 (Pubmed \| Andrology)	Not Applicable	-	8	GH treatment	npdxswfbbc(iubqzxqkup) = objrnjvjfh wjaoybwaiv (pspwbxedks ) View more	-	01 Jul 2013
NCT01278342 (HOSCAR, CTgov)	Phase 4	Acromegaly	70	Sandostatin LAR (Sandostatin LAR High Dose Alone)	brpgjqxhqh = qpcjdvckqk ehtipdznfu (bsblunvqqy, tsvdiwjmly - fgucwanezd) View more	-	17 Feb 2011
NCT01278342 (HOSCAR, CTgov)	Phase 4	Acromegaly	70	Sandostatin LAR+pegvisomant (Sandostatin LAR High Dose + Pegvisomat)	brpgjqxhqh = precffspsi ehtipdznfu (bsblunvqqy, dffzizknvl - uwfcawnuhb) View more	-	17 Feb 2011

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Hiro LS Researcher

The AI Search Engine Built to Accelerate Biopharma Decisions

Search across billion-scale life sciences data to uncover signals, validate evidence, and act with confidence.

Ask any biopharma research question→

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Discover Synapse Data Servers

Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis