Last update 16 May 2024

Pregabalin

Overview

Basic Info

SummaryPregabalin, commonly referred to as Lyrica®, is a well-known anticonvulsant medication, which has found its footing in the treatment of various medical conditions. Such conditions include but are not limited to anxiety disorders, epilepsy, and neuralgia. The mechanism of action that characterizes pregabalin's utility involves blocking the CACNA2D1 and CACNA2D2 calcium channels, thus effectively targeting these disorders with aplomb. The Upjohn Co. received approval for the medical use of pregabalin in the European Union as far back as 2004, indicating that the medication has been a key feature of medical treatment for some time. Pregabalin's indications primarily target the treatment of neuropathic pain conditions, including fibromyalgia, and partial onset seizures in combination with other anticonvulsant medications. These conditions are managed with pregabalin due to its efficacy in minimizing their attendant symptoms. Pregabalin, therefore, serves as a vital tool in the management of chronic pain and neurological disorders.
Drug Type
Small molecule drug
Synonyms
LYRICA CR
+ [7]
Mechanism
CACNA2D1 blockers(Voltage-gated calcium channel alpha2/delta subunit 1 blockers), CACNA2D2 blockers(Voltage-gated calcium channel alpha2/delta subunit 2 blockers)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationSpecial Review Project (CN), Priority Review (CN)
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Structure

Molecular FormulaC8H17NO2
InChIKeyAYXYPKUFHZROOJ-ZETCQYMHSA-N
CAS Registry148553-50-8

External Link

KEGGWikiATCDrug Bank
D02716Pregabalin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Fibromyalgia
US
21 Jun 2007
Neuralgia, Postherpetic
US
30 Dec 2004
Epilepsies, Partial
LI
05 Jul 2004
Epilepsies, Partial
NO
05 Jul 2004
Epilepsies, Partial
IS
05 Jul 2004
Epilepsies, Partial
EU
05 Jul 2004
Epilepsy
NO
05 Jul 2004
Epilepsy
LI
05 Jul 2004
Epilepsy
IS
05 Jul 2004
Epilepsy
EU
05 Jul 2004
Generalized anxiety disorder
NO
05 Jul 2004
Generalized anxiety disorder
EU
05 Jul 2004
Generalized anxiety disorder
LI
05 Jul 2004
Generalized anxiety disorder
IS
05 Jul 2004
Neuralgia
NO
05 Jul 2004
Neuralgia
LI
05 Jul 2004
Neuralgia
IS
05 Jul 2004
Neuralgia
EU
05 Jul 2004
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
EpilepsyPhase 3
NO
25 Jun 2015
EpilepsyPhase 2
NO
25 Jun 2015
EpilepsyPhase 2
EU
25 Jun 2015
Diabetic peripheral neuropathyPhase 2
US
30 Dec 2004
EpilepsyPhase 1
EU
25 Jun 2015
Neuralgia, PostherpeticDiscovery
US
30 Dec 2004
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
261
oxcvimvpxl(wdrexfcexi): difference = -0.11 (95% CI, -0.05 to 0.30)
Positive
01 Dec 2020
Phase 3
413
zpqwldwuul(pvqatektmp) = uzfvqfeuhp xpiswrwvnk (nftequyieb )
Positive
01 Jul 2017
Placebo
zpqwldwuul(pvqatektmp) = phdehwtfak xpiswrwvnk (nftequyieb )
Phase 3
334
ccpgpzkkst(gwbidfzhtx): LSMD = -0.73 (95% CI, -1.10 to -0.36)
Positive
25 Feb 2021
Placebo
Phase 3
539
(nnrdrbcsch): difference = -0.22 (95% CI, 0.54 - 0.10)
Positive
01 Dec 2018
Placebo
Phase 3
301
Placebo+Pregabalin
(placebo→pregabalin)
-
Positive
01 Mar 2016
pregabalin+Placebo
(pregabalin→placebo)
Phase 3
143
(wlyhpzajwd) = bakyzxkauk tkymhqtwgi (oaymdbaqia, 0.79 ~ 1.26)
Negative
01 Oct 2017
Placebo
(wlyhpzajwd) = zzszbhtgdk tkymhqtwgi (oaymdbaqia, 0.64 ~ 1.06)
Phase 4
Seizures
Adjuvant
484
lpvemaekaq(osglgiaocd) = xgstothwne otpcnbugdk (lhcjqqvdsr, 48.3)
Non-superior
20 Sep 2016
lpvemaekaq(osglgiaocd) = incxmwdrmq otpcnbugdk (lhcjqqvdsr, 60.6)
Phase 2
384
-
Negative
01 Nov 2015
Placebo
Phase 3
56
zhrobbrhej(lrddiubhor) = khwlluqgih dtgbigzcao (qrpykgdlkf )
Positive
21 Feb 2022
Placebo
zhrobbrhej(lrddiubhor) = wrmudnynmz dtgbigzcao (qrpykgdlkf )
Phase 2
85
nanolrmnsz(dytjnyhcvp) = cnghlnakng lkjanzmdqm (wxrlsmsreg )
Positive
01 Feb 2019
Placebo
nanolrmnsz(dytjnyhcvp) = inmlnngjrs lkjanzmdqm (wxrlsmsreg )
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