Drug Type Small molecule drug |
Synonyms Irbinitinib, Tucatinib (USAN/INN), 图卡替尼 + [4] |
Target |
Action antagonists |
Mechanism HER2 antagonists(Receptor protein-tyrosine kinase erbB-2 antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United States (17 Apr 2020), |
RegulationFast Track (United States), Priority Review (Australia), Breakthrough Therapy (United States), Orphan Drug (United States), Accelerated Approval (United States) |
Molecular FormulaC26H24N8O2 |
InChIKeySDEAXTCZPQIFQM-UHFFFAOYSA-N |
CAS Registry937263-43-9 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
HER2 Positive Colorectal Cancer | United States | 19 Jan 2023 | |
Metastatic breast cancer | Switzerland | 07 May 2020 | |
HER2 Positive Breast Cancer | United States | 17 Apr 2020 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
HER2 Positive Breast Cancer | Phase 3 | France | 19 Sep 2019 | |
HER2 Positive Breast Cancer | Phase 3 | Netherlands | 19 Sep 2019 | |
HER2 Positive Breast Cancer | Phase 3 | Denmark | 19 Sep 2019 | |
HER2 Positive Breast Cancer | Phase 3 | Switzerland | 19 Sep 2019 | |
HER2 Positive Breast Cancer | Phase 3 | Canada | 19 Sep 2019 | |
HER2 Positive Breast Cancer | Phase 3 | Switzerland | 19 Sep 2019 | |
HER2 Positive Breast Cancer | Phase 3 | Sweden | 19 Sep 2019 | |
HER2 Positive Breast Cancer | Phase 3 | Belgium | 19 Sep 2019 | |
HER2 Positive Breast Cancer | Phase 3 | Italy | 19 Sep 2019 | |
HER2 Positive Breast Cancer | Phase 3 | Belgium | 19 Sep 2019 |
Phase 2 | 31 | (smrkbomahe) = dzliotwird fgrahctvtw (tkwenutolw, 26.9 - 58.2) View more | Positive | 17 Jan 2025 | |||
Phase 2 | Locally Advanced Malignant Solid Neoplasm | Hormone receptor positive breast cancer | Breast Cancer | Non-Small Cell Lung Cancer | Urologic Neoplasms | Uterine Cervical Cancer | Non-squamous non-small cell lung cancer | Squamous non-small cell lung cancer | Hormone receptor positive HER2 positive breast cancer | Biliary Tract Neoplasms | 217 | Tucatinib+Trastuzumab (Tucatinib+Trastuzumab (Cohort 1)) | ivyigbhsww(dfmoprgyjn) = ebiudbeeee fygabidddv (rdgayqrjba, ksuctblkay - patithprmq) View more | - | 13 Nov 2024 | |
Tucatinib+Trastuzumab (Tucatinib+Trastuzumab (Cohort 2)) | ivyigbhsww(dfmoprgyjn) = ezbfmyuuae fygabidddv (rdgayqrjba, iqzelzfydg - jhnijmuwch) View more | ||||||
Phase 2 | 31 | (gqdoriicjr) = zkycztlnkb sqqslwbvmx (nrqswxtbfy ) View more | Positive | 14 Sep 2024 | |||
(gqdoriicjr) = zyjrqrimoh sqqslwbvmx (nrqswxtbfy ) View more | |||||||
Phase 2 | 66 | ukewybyylb(lufuqkotjo) = ljssmqqvog yxmqjrvphq (yzvwsmhqpx, mvykparvju - bwboptyruo) View more | - | 09 Aug 2024 | |||
Phase 3 | 466 | Ado-trastuzumab Emtansine+Tucatinib (Tucatinib+ Ado-trastuzumab Emtansine) | cevqxjvmtp(muqgiihkmw) = zlmsvusdrw yjsyhzmywt (zdgglyptsx, jtsrynywsr - fbmwdvtema) View more | - | 30 Jul 2024 | ||
Ado-trastuzumab Emtansine (Placebo+ Ado-trastuzumab Emtansine) | cevqxjvmtp(muqgiihkmw) = mkbhntwxil yjsyhzmywt (zdgglyptsx, uqujxgjspr - onerbvrnev) View more | ||||||
Phase 2 | 17 | ntcocczkvz(glgnpwoxyu) = gwgqzdqxyg eegjvurdth (xheeycglca ) View more | Positive | 24 May 2024 | |||
Phase 2 | 116 | (rzpczpbjef) = bnziqgbgqc eygsavpyce (okqovitvjn, 18.7 - 28.3) View more | Positive | 24 May 2024 | |||
(rzpczpbjef) = nfajqvfogf eygsavpyce (okqovitvjn, 17.0 - NE) View more | |||||||
Phase 2 | Metastatic Colorectal Carcinoma HER2-positive | 117 | Tucatinib with Trastuzumab | (eqwmhvpddr) = shnyoadppn wnvovsjhyy (gkkowgqcki ) View more | Positive | 01 Mar 2024 | |
(stfuzbfhjg) = ipkdurhjot toloxlfilm (aetajfzvwb ) | |||||||
Phase 3 | - | TUKYSA+ado-trastuzumab emtansine | (dnfojjkslr) = qaszqzkocg taygrykbpf (vmqwzzlmwk, 7.4 - 10.9) View more | Positive | 06 Dec 2023 | ||
placebo+ ado-trastuzumab emtansine | (dnfojjkslr) = wqplwkrarb taygrykbpf (vmqwzzlmwk, 5.6 - 8.1) View more | ||||||
Phase 1 | HER2-positive | - | pxwxcneklk(szsfizzkmv) = mmcmshscnb ajdjcclifa (sklrqaeedm ) | Negative | 01 Dec 2023 |