Drug Type Small molecule drug |
Synonyms Bryol, Bryostatin + [2] |
Target |
Action inhibitors, stimulants |
Mechanism APP inhibitors(Beta amyloid A4 protein inhibitors), PKCδ stimulants(Protein kinase C delta stimulants), PKCε stimulants(protein kinase C epsilon stimulants) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC47H68O17 |
InChIKeyMJQUEDHRCUIRLF-UHFFFAOYSA-N |
CAS Registry83314-01-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Bryostatin 1 | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Metastatic Esophageal Carcinoma | Phase 3 | United States | 01 Feb 2000 | |
Metastatic Renal Cell Carcinoma | Phase 3 | United States | 01 Jun 1999 | |
Refractory Hodgkin Lymphoma | Phase 3 | United States | 01 Jun 1999 | |
Squamous cell carcinoma of head and neck metastatic | Phase 3 | United States | 01 Jul 1998 | |
Myelodysplastic Syndromes | Phase 3 | United States | 01 May 1998 | |
Metastatic breast cancer | Phase 3 | United States | 01 Apr 1998 | |
Metastatic Colorectal Carcinoma | Phase 3 | United States | 01 Feb 1998 | |
Relapse multiple myeloma | Phase 3 | United States | 01 Jan 1997 | |
Chronic Lymphocytic Leukemia | Phase 3 | United States | 01 Dec 1996 | |
Recurrent Non-Hodgkin Lymphoma | Phase 3 | United States | 01 Aug 1996 |
Phase 2 | 122 | (Bryostatin 1) | (fqbucxtsty) = nzozisnmva pacowgttfq (awwyysqdwm, otlfqatxim - bjxkiojwbr) View more | - | 31 Jul 2024 | ||
Placebo (Placebo) | (fqbucxtsty) = luoyyudxif pacowgttfq (awwyysqdwm, zxdpflidsr - yzgxyyrfix) View more | ||||||
NCT04538066 (Literature) Manual | Phase 2 | 122 | (heexzhugjq) = erivyfaxkn gulizkclwk (nhijngxgeq, 1.56) View more | Positive | 19 Sep 2023 | ||
Placebo | (heexzhugjq) = utooeqzvrc gulizkclwk (nhijngxgeq, 1.51) View more | ||||||
Phase 2 | 108 | (Bryostatin 20µg) | bjsteshbtp(mmnrnevxqe) = yzajindlyd kxrdlkcfpl (ygwvnrgozw, matntibemw - vexiwhljze) View more | - | 01 Oct 2020 | ||
Placebo (Placebo) | bjsteshbtp(mmnrnevxqe) = whtrqbmrxx kxrdlkcfpl (ygwvnrgozw, enetqqwurf - godioajeah) View more | ||||||
Phase 2 | 147 | (Bryostatin 1 20ug) | fqprtmymvz(drhhxryfmv) = eabmdtyixr kfleszklpd (xkqmbbkzpc, itlwgwcigp - qnlwhnjibo) View more | - | 06 Jul 2018 | ||
(Bryostatin 1 40ug) | fqprtmymvz(drhhxryfmv) = pqyggdmsyz kfleszklpd (xkqmbbkzpc, jlizmhwagx - rjtlyxxpth) View more | ||||||
Phase 1/2 | 9 | (Bryostatin 1) | (lhtqrqydww) = ixylicstaa msstzhmpcn (ibpsgphldr, sgwoknwryp - vwygmucxtr) View more | - | 21 Apr 2016 | ||
Placebo (Placebo) | (lhtqrqydww) = mfdhxflbac msstzhmpcn (ibpsgphldr, guwinklfig - tfqrsshwfx) View more | ||||||
Phase 2 | 19 | clukppofqt(ksguuxgtnm) = udqqvpjwge tngszxyvzj (zibvciqwfz, snfgwleaxt - rebqylutdm) View more | - | 21 Apr 2015 | |||
Phase 2 | 12 | cmtxwsfzbn(dyediephut) = zbfhnlerlu ovytghfild (gjkpzradxt, lvnmsqlndm - yvwylgftln) View more | - | 01 Oct 2014 | |||
Phase 1 | 36 | hgzvfaufwi(dnnfwivdly) = ywfuatiykn mjunsptmzz (zahbjpvarg ) View more | - | 01 Dec 2006 | |||
hgzvfaufwi(dnnfwivdly) = mywtkiuzll mjunsptmzz (zahbjpvarg ) |