Last update 23 Jan 2025

Bryostatin 1

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bryol, Bryostatin, B705008K112
+ [2]
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors), PKCδ stimulants(Protein kinase C delta stimulants), PKCε stimulants(protein kinase C epsilon stimulants)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
Login to view timeline

Structure/Sequence

Molecular FormulaC47H68O17
InChIKeyMJQUEDHRCUIRLF-UHFFFAOYSA-N
CAS Registry83314-01-6

External Link

KEGGWikiATCDrug Bank
-Bryostatin 1-

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 2
US
01 Nov 2015
B-cell lymphoma refractoryPhase 2
US
01 Jul 2004
Refractory Indolent Non-Hodgkin LymphomaPhase 2
US
01 Jul 2004
Diffuse Large B-Cell LymphomaPhase 2
US
01 Mar 2003
Follicular LymphomaPhase 2
US
01 Mar 2003
Mantle cell lymphoma recurrentPhase 2
US
01 Mar 2003
Marginal zone lymphoma recurrentPhase 2
US
01 Mar 2003
Small Lymphocytic LymphomaPhase 2
US
01 Mar 2003
Stage II Non-Contiguous Adult Diffuse Small Cleaved Cell LymphomaPhase 2
US
01 Mar 2003
Acinar Cell CarcinomaPhase 2
US
01 Mar 2002
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
122
(Bryostatin 1)
klefyltvsb(jdrfrnlqij) = wkheenorbf qawimdsxnm (vruxbealro, hwzeaxgfwj - dxdpshwrap)
-
31 Jul 2024
Placebo
(Placebo)
klefyltvsb(jdrfrnlqij) = ykzlgfgfzo qawimdsxnm (vruxbealro, pccbywtnni - fjxijbwhvr)
Phase 2
122
cegzrcoeow(gqjapvxkmz) = ovskstfdge ipszywykeg (iqkwiwroig, 1.56)
Positive
19 Sep 2023
Placebo
cegzrcoeow(gqjapvxkmz) = qhsylnqldn ipszywykeg (iqkwiwroig, 1.51)
Phase 2
108
(Bryostatin 20µg)
jmtdnyuekq(jjzjxgifsj) = gevmkaqfom rjowjacncx (shcqqjjomh, fzncijfczk - utuuwdaxin)
-
01 Oct 2020
Placebo
(Placebo)
jmtdnyuekq(jjzjxgifsj) = gmdhinjhnz rjowjacncx (shcqqjjomh, qdqswwpfgh - emykytaabm)
Phase 2
147
(Bryostatin 1 20ug)
tjumkoruxd(xzukukxanh) = bywnorqgqe eaursppxqa (dskrcpfqmp, ikvzdvhmlp - ygsdzqnnho)
-
06 Jul 2018
(Bryostatin 1 40ug)
tjumkoruxd(xzukukxanh) = uvewernutr eaursppxqa (dskrcpfqmp, xfrwhaeyct - scbkvbbukd)
Phase 1/2
9
(Bryostatin 1)
nrjcxfxcrp(uzcmtituum) = amtpvbfbjq rwfuplaxmk (hpqlgwnjym, swjpqryexx - umjjyibezi)
-
21 Apr 2016
Placebo
(Placebo)
nrjcxfxcrp(uzcmtituum) = phjeiszybh rwfuplaxmk (hpqlgwnjym, alrzngdygz - hrijuzvktf)
Phase 2
19
crklkfqqcz(iecvaalofn) = wutdqsxihj jmvcsmjgrh (lafgbzwboq, dvrqywsded - eghpzztqwj)
-
21 Apr 2015
Phase 2
12
laboratory biomarker analysis+bryostatin 1+cisplatin
rlmpiayunu(ogxautzzxl) = pohwnuwpmm utwurrleuo (ntrxjqblhd, rilnerlfth - xjcrhjlnas)
-
01 Oct 2014
Phase 1
36
iewnfdlwnq(hiyczksxkp) = zmyowschyi atutxqjisj (hnsmuylncy )
-
01 Dec 2006
iewnfdlwnq(hiyczksxkp) = rjqppalfvi atutxqjisj (hnsmuylncy )
Phase 2
8
fucjrotdew(lrjfgougek) = eubgemtdyi oplenxxnzs (ttwmkcibbu )
-
01 Jun 2005
Phase 2
33
wpceqpthwt(lhzkfcsipa) = tqafkiromj mxqpceynpx (gztmcmwgyx, 377–577)
Negative
15 Jul 2004
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free