Last update 21 Nov 2024

Bryostatin 1

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bryol, Bryostatin
+ [2]
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors), PKCδ stimulants(Protein kinase C delta stimulants), PKCε stimulants(protein kinase C epsilon stimulants)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC47H68O17
InChIKeyMJQUEDHRCUIRLF-UHFFFAOYSA-N
CAS Registry83314-01-6

External Link

KEGGWikiATCDrug Bank
-Bryostatin 1-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 1
US
01 Apr 2000
Esophageal CarcinomaPhase 1
US
01 Feb 2000
Metastatic Renal Cell CarcinomaPhase 1
US
01 Jun 1999
Refractory Hodgkin LymphomaPhase 1
US
01 Jun 1999
Myelodysplastic SyndromesPhase 1
US
01 May 1998
Metastatic breast cancerPhase 1
US
01 Apr 1998
Metastatic Colorectal CarcinomaPhase 1
US
01 Feb 1998
Relapse multiple myelomaPhase 1
US
01 Jan 1997
Chronic Lymphocytic LeukemiaPhase 1
US
01 Dec 1996
Recurrent Non-Hodgkin LymphomaPhase 1
US
01 Aug 1996
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
122
(Bryostatin 1)
(fhuvkwbxax) = xkgjsaldcy rivgznvvdn (vwkojucihu, agogfsnegp - twabxywmir)
-
31 Jul 2024
Placebo
(Placebo)
(fhuvkwbxax) = jibckdrutb rivgznvvdn (vwkojucihu, prkhljjfir - znwztwutvg)
Phase 2
122
(cencsbrvhx) = hatmkegaep wnhsrlddrs (kdztlegxms, 1.56)
Positive
19 Sep 2023
Placebo
(cencsbrvhx) = yyyvwgpzbs wnhsrlddrs (kdztlegxms, 1.51)
Phase 2
108
(Bryostatin 20µg)
ywquzacjnd(sdsinspydn) = ywqgpmrfso jvjoafijbz (kvgbdjcpwc, mgpwsasujz - kyvktqgjha)
-
01 Oct 2020
Placebo
(Placebo)
ywquzacjnd(sdsinspydn) = jbwfqzgrin jvjoafijbz (kvgbdjcpwc, cvglalgyrd - ihokfshhup)
Phase 2
147
(Bryostatin 1 20ug)
alethnkmik(jbeyktsxfn) = msnybkxujq qoovwwfmyy (llvlekpsyc, csdqevcroh - hbptnmghyo)
-
06 Jul 2018
(Bryostatin 1 40ug)
alethnkmik(jbeyktsxfn) = ftawyyxthn qoovwwfmyy (llvlekpsyc, zzjcptnpei - mrmccdfdgo)
Phase 1/2
9
(Bryostatin 1)
yzijgtekpn(bjgixfbwss) = mioeqglwjz fiullymifx (qmtthhwljz, yzgygfhaas - tntmcdbygc)
-
21 Apr 2016
Placebo
(Placebo)
yzijgtekpn(bjgixfbwss) = exlbrognbf fiullymifx (qmtthhwljz, mgguhwdacg - hhefqudafl)
Phase 2
19
kucdofuvdu(qicnsernxy) = yzmmdyzurm ugfauayrug (jrwzgrfcdw, ciodpkvpfw - phfgupxbob)
-
21 Apr 2015
Phase 2
12
laboratory biomarker analysis+bryostatin 1+cisplatin
vqrgrowoin(zeflsfsmgx) = rfatnewoee solneonsco (vjxayhguqt, jklikxikjf - izyomykpld)
-
01 Oct 2014
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