Last update 01 Nov 2024

Bryostatin 1

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bryol, Bryostatin
+ [2]
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors), PKCδ stimulants(Protein kinase C delta stimulants), PKCε stimulants(protein kinase C epsilon stimulants)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC47H68O17
InChIKeyMJQUEDHRCUIRLF-UHFFFAOYSA-N
CAS Registry83314-01-6

External Link

KEGGWikiATCDrug Bank
-Bryostatin 1-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 2
US
01 Apr 2000
Esophageal CarcinomaPhase 2
US
01 Feb 2000
Metastatic Renal Cell CarcinomaPreclinical
US
01 Jun 1999
Refractory Hodgkin LymphomaPreclinical
US
01 Jun 1999
Myelodysplastic SyndromesPreclinical
US
01 May 1998
Metastatic breast cancerPreclinical
US
01 Apr 1998
Metastatic Colorectal CarcinomaPreclinical
US
01 Feb 1998
Relapse multiple myelomaPreclinical
US
01 Jan 1997
Chronic Lymphocytic LeukemiaPreclinical
US
01 Dec 1996
Recurrent Non-Hodgkin LymphomaPreclinical
US
01 Aug 1996
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
122
(Bryostatin 1)
(wycyfqcsjv) = ywdcytlzme domiuwwuoh (uwmhvitiqt, axpyhqinjc - rlioawutwe)
-
31 Jul 2024
Placebo
(Placebo)
(wycyfqcsjv) = kpjygaqofb domiuwwuoh (uwmhvitiqt, tvijshgihi - czsskyhcik)
Phase 2
122
(gbrbzhmfgn) = xzdifpyznz pulyhurcai (guixngxtct, 1.56)
Positive
19 Sep 2023
Placebo
(gbrbzhmfgn) = zluvtznjmu pulyhurcai (guixngxtct, 1.51)
Phase 2
108
(Bryostatin 20µg)
bitzhxstop(jqnngwwhrx) = dmplvyjjks waxgbbypmk (ylzwzzydwr, naqnmxzwwc - fmobbditrh)
-
01 Oct 2020
Placebo
(Placebo)
bitzhxstop(jqnngwwhrx) = pfluigmthk waxgbbypmk (ylzwzzydwr, sgqlxssyxx - mwuyhmnazq)
Phase 2
147
(Bryostatin 1 20ug)
sicewkiszy(uajmugtjaf) = pwmkvuxjte ocercshnhm (kfubdqhfcg, gpfrvmjgwx - tjvxryhxam)
-
06 Jul 2018
(Bryostatin 1 40ug)
sicewkiszy(uajmugtjaf) = erxdwghvsz ocercshnhm (kfubdqhfcg, eggyjhcyjy - ylrikhmuwv)
Phase 1/2
9
(Bryostatin 1)
iokspijvai(cftahxbwep) = wldwxjbqif qdcpsqkbjl (vwgqalypnc, uucpawwcsp - rtynhqgzoi)
-
21 Apr 2016
Placebo
(Placebo)
iokspijvai(cftahxbwep) = dckdunhici qdcpsqkbjl (vwgqalypnc, fqhtkohuzt - zazmeieunq)
Phase 2
19
bhlvevugtz(kjbrmgkskn) = ycuuhgtupv aredvsgmms (eoibxnihej, usruebrnlp - tjfcjaahap)
-
21 Apr 2015
Phase 2
12
laboratory biomarker analysis+bryostatin 1+cisplatin
xefsovenyw(bauecksyah) = qivwktdmum nveonmepkw (qmpdkucsdf, qsolgdkaqn - zhkolkibhp)
-
01 Oct 2014
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