Last update 20 Mar 2025

Bryostatin 1

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bryol, Bryostatin
+ [2]
Action
inhibitors, stimulants
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors), PKCδ stimulants(Protein kinase C delta stimulants), PKCε stimulants(protein kinase C epsilon stimulants)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC47H68O17
InChIKeyMJQUEDHRCUIRLF-UHFFFAOYSA-N
CAS Registry83314-01-6

External Link

KEGGWikiATCDrug Bank
-Bryostatin 1-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic Esophageal CarcinomaPhase 3
United States
01 Feb 2000
Metastatic Renal Cell CarcinomaPhase 3
United States
01 Jun 1999
Refractory Hodgkin LymphomaPhase 3
United States
01 Jun 1999
Squamous cell carcinoma of head and neck metastaticPhase 3
United States
01 Jul 1998
Myelodysplastic SyndromesPhase 3
United States
01 May 1998
Metastatic breast cancerPhase 3
United States
01 Apr 1998
Metastatic Colorectal CarcinomaPhase 3
United States
01 Feb 1998
Relapse multiple myelomaPhase 3
United States
01 Jan 1997
Chronic Lymphocytic LeukemiaPhase 3
United States
01 Dec 1996
Recurrent Non-Hodgkin LymphomaPhase 3
United States
01 Aug 1996
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
122
(Bryostatin 1)
(fqbucxtsty) = nzozisnmva pacowgttfq (awwyysqdwm, otlfqatxim - bjxkiojwbr)
-
31 Jul 2024
Placebo
(Placebo)
(fqbucxtsty) = luoyyudxif pacowgttfq (awwyysqdwm, zxdpflidsr - yzgxyyrfix)
Phase 2
122
(heexzhugjq) = erivyfaxkn gulizkclwk (nhijngxgeq, 1.56)
Positive
19 Sep 2023
Placebo
(heexzhugjq) = utooeqzvrc gulizkclwk (nhijngxgeq, 1.51)
Phase 2
108
(Bryostatin 20µg)
bjsteshbtp(mmnrnevxqe) = yzajindlyd kxrdlkcfpl (ygwvnrgozw, matntibemw - vexiwhljze)
-
01 Oct 2020
Placebo
(Placebo)
bjsteshbtp(mmnrnevxqe) = whtrqbmrxx kxrdlkcfpl (ygwvnrgozw, enetqqwurf - godioajeah)
Phase 2
147
(Bryostatin 1 20ug)
fqprtmymvz(drhhxryfmv) = eabmdtyixr kfleszklpd (xkqmbbkzpc, itlwgwcigp - qnlwhnjibo)
-
06 Jul 2018
(Bryostatin 1 40ug)
fqprtmymvz(drhhxryfmv) = pqyggdmsyz kfleszklpd (xkqmbbkzpc, jlizmhwagx - rjtlyxxpth)
Phase 1/2
9
(Bryostatin 1)
(lhtqrqydww) = ixylicstaa msstzhmpcn (ibpsgphldr, sgwoknwryp - vwygmucxtr)
-
21 Apr 2016
Placebo
(Placebo)
(lhtqrqydww) = mfdhxflbac msstzhmpcn (ibpsgphldr, guwinklfig - tfqrsshwfx)
Phase 2
19
clukppofqt(ksguuxgtnm) = udqqvpjwge tngszxyvzj (zibvciqwfz, snfgwleaxt - rebqylutdm)
-
21 Apr 2015
Phase 2
12
laboratory biomarker analysis+bryostatin 1+cisplatin
cmtxwsfzbn(dyediephut) = zbfhnlerlu ovytghfild (gjkpzradxt, lvnmsqlndm - yvwylgftln)
-
01 Oct 2014
Phase 1
36
hgzvfaufwi(dnnfwivdly) = ywfuatiykn mjunsptmzz (zahbjpvarg )
-
01 Dec 2006
hgzvfaufwi(dnnfwivdly) = mywtkiuzll mjunsptmzz (zahbjpvarg )
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