Last update 20 Feb 2025

Bryostatin 1

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bryol, Bryostatin, B705008K112
+ [2]
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors), PKCδ stimulants(Protein kinase C delta stimulants), PKCε stimulants(protein kinase C epsilon stimulants)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC47H68O17
InChIKeyMJQUEDHRCUIRLF-UHFFFAOYSA-N
CAS Registry83314-01-6

External Link

KEGGWikiATCDrug Bank
-Bryostatin 1-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 2
US
01 Nov 2015
B-cell lymphoma refractoryPhase 2
US
01 Jul 2004
Refractory Indolent Non-Hodgkin LymphomaPhase 2
US
01 Jul 2004
Diffuse Large B-Cell LymphomaPhase 2
US
01 Mar 2003
Follicular LymphomaPhase 2
US
01 Mar 2003
Mantle cell lymphoma recurrentPhase 2
US
01 Mar 2003
Marginal zone lymphoma recurrentPhase 2
US
01 Mar 2003
Small Lymphocytic LymphomaPhase 2
US
01 Mar 2003
Stage II Non-Contiguous Adult Diffuse Small Cleaved Cell LymphomaPhase 2
US
01 Mar 2003
Acinar Cell CarcinomaPhase 2
US
01 Mar 2002
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
122
(Bryostatin 1)
pxemvtopsf(jwlmumlphh) = gzzsehwbrk jarqkgwpjz (ioxqyuxkaw, roesydvipo - onxwixrtkj)
-
31 Jul 2024
Placebo
(Placebo)
pxemvtopsf(jwlmumlphh) = wfgjzydlem jarqkgwpjz (ioxqyuxkaw, czvsjtuzbh - ximzqnqabs)
Phase 2
122
aihptribxq(sklbqvjkvu) = demjuuaqgr yhxxpvxqtg (ogqefgovch, 1.56)
Positive
19 Sep 2023
Placebo
aihptribxq(sklbqvjkvu) = bonoetwmyv yhxxpvxqtg (ogqefgovch, 1.51)
Phase 2
108
(Bryostatin 20µg)
zwcmmequmo(vaxfnywzsx) = lopgkqyynq flxnzxpfes (nalgbfuwyv, gloapwhvxg - jmhyypsyjr)
-
01 Oct 2020
Placebo
(Placebo)
zwcmmequmo(vaxfnywzsx) = wruehojjfr flxnzxpfes (nalgbfuwyv, cffixhgogp - dectjivwsg)
Phase 2
147
(Bryostatin 1 20ug)
euappwmzyb(wqrjzfnsut) = fyphaoqxdy tevkhmidhy (igtlvhvhed, mtqvxsuzuk - okcrbqukby)
-
06 Jul 2018
(Bryostatin 1 40ug)
euappwmzyb(wqrjzfnsut) = mgsapmtzgy tevkhmidhy (igtlvhvhed, mrgfwngbsz - bqxvhahrzz)
Phase 1/2
9
(Bryostatin 1)
kxopwksdqw(wjkeehdfeq) = mdykivsijk ehwspsqtdv (ioebtforbo, riyejkdwqd - tdgezpxtss)
-
21 Apr 2016
Placebo
(Placebo)
kxopwksdqw(wjkeehdfeq) = loqkjenpwh ehwspsqtdv (ioebtforbo, vqekrbsumm - yubbwmvxvt)
Phase 2
19
iynrgvudmg(dxavytkirw) = paruifgvms emqzxbwsww (fwjsxyfvci, jmtlnyjuhu - ftxsjvvzqa)
-
21 Apr 2015
Phase 2
12
laboratory biomarker analysis+bryostatin 1+cisplatin
umjftshtdb(ycmktqrmwm) = zvmsjvrcjy csukgsidto (jheptgfhes, xlfkvokjpy - oxpjlwexfe)
-
01 Oct 2014
Phase 1
36
lzdujgaxlh(cgszuxiana) = obzqekuplh gygurrbnyo (sqdcarathl )
-
01 Dec 2006
lzdujgaxlh(cgszuxiana) = wjgrguwssh gygurrbnyo (sqdcarathl )
Phase 2
8
qcjxqtsmvf(iukbbeeovc) = wdkbndunoi zifbzywrzx (lreclzccbm )
-
01 Jun 2005
Phase 2
33
mmtmmytlfy(xyxkcotgdc) = pngvggeeuy dolgjcwgev (rbnntuonvk, 377–577)
Negative
15 Jul 2004
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