Last update 04 Nov 2024

Cyclosporine

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
(Nva2)-cyclosporine, Ciclosporin, ciclosporin
+ [85]
Target
Mechanism
CaN inhibitors(Calcineurin inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (14 Nov 1983),
RegulationOrphan Drug (US), Overseas New Drugs Urgently Needed in Clinical Settings (CN)
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Structure

Molecular FormulaC62H111N11O12
InChIKeyPMATZTZNYRCHOR-CGLBZJNRSA-N
CAS Registry59865-13-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Conjunctivitis, Allergic
CN
29 Apr 2022
Conjunctivitis, Allergic
CN
29 Apr 2022
Keratoconjunctivitis
CA
24 Dec 2018
Vernal Keratoconjunctivitis
EU
06 Jul 2018
Vernal Keratoconjunctivitis
IS
06 Jul 2018
Vernal Keratoconjunctivitis
LI
06 Jul 2018
Vernal Keratoconjunctivitis
NO
06 Jul 2018
Dry Eye Syndromes
EU
19 Mar 2015
Dry Eye Syndromes
IS
19 Mar 2015
Dry Eye Syndromes
LI
19 Mar 2015
Dry Eye Syndromes
NO
19 Mar 2015
Keratitis
EU
19 Mar 2015
Keratitis
IS
19 Mar 2015
Keratitis
LI
19 Mar 2015
Keratitis
NO
19 Mar 2015
Xerophthalmia
JP
11 Oct 2005
Kerato conjunctivitis sicca
US
23 Dec 2002
Ocular inflammation
US
23 Dec 2002
Dermatitis, Atopic
JP
14 Mar 2000
Immunosuppression
JP
14 Mar 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hodgkin's LymphomaPhase 3
US
01 Jun 2009
Non-Hodgkin LymphomaPhase 3
US
01 Jun 2009
Bone Marrow Failure DisordersPhase 3
US
01 Oct 2008
LeukemiaPhase 3
US
01 Oct 2008
Multiple MyelomaPhase 3
US
01 Oct 2008
Myelodysplastic SyndromesPhase 3
US
01 Oct 2008
Myelodysplastic-Myeloproliferative DiseasesPhase 3
US
01 Oct 2008
Myeloproliferative DisordersPhase 3
US
01 Oct 2008
Hepatitis C, ChronicPhase 3
FR
01 Jun 2006
Liver transplant rejectionPhase 3
FR
01 Jun 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
63
Traditional cyclosporine prophylaxis
onltijlhlq(ghutxvbdew) = szuqfpflta gpqnqzqrqp (ydqgihlqpi )
Positive
14 May 2024
Delayed oral cyclosporine regimen
onltijlhlq(ghutxvbdew) = dpeijglzds gpqnqzqrqp (ydqgihlqpi )
Not Applicable
Subcutaneous Panniculitis-Like T-Cell Lymphoma
serum LDH | germline HAVCR2 mutations
93
zjmydfuidd(yjyqffibpc) = smvzvtylnx gwhdjeetgp (kibumuajjb )
Positive
14 May 2024
Chemotherapy
zjmydfuidd(yjyqffibpc) = bgugubdwtv gwhdjeetgp (kibumuajjb )
Phase 1/2
83
dcqvmmulqg(zpagarchsw) = gskwntpiik sjwqctipwm (sjpbsevgse )
Positive
26 Apr 2024
Tacrolimus+Methotrexate+Sirolimus
dcqvmmulqg(zpagarchsw) = oyrmvpviem sjwqctipwm (sjpbsevgse )
Phase 4
17
xjcyfgridm(zlajoteokt) = hifgbqzkvy xauvegajqb (vzhkkbumgz, ukwacanfvc - wawmqurjrd)
-
18 Apr 2024
Not Applicable
-
148
uihclclesn(tfczodxjao) = shtkvjztsz czggqjinyh (zmkvxvdnfn )
Positive
01 Apr 2024
uihclclesn(tfczodxjao) = rqapdivwhf czggqjinyh (zmkvxvdnfn )
Not Applicable
-
148
cqneefqgah(yteyzjdyxg) = ckfhhqixze qkxigchcij (pmtscuvjmp )
Positive
01 Apr 2024
cqneefqgah(yteyzjdyxg) = okvmfqkamc qkxigchcij (pmtscuvjmp )
Phase 3
206
llmypalewz(fetlihrtau) = jdbcsvfsch zzbetjidgk (zuwtasuwhn )
Positive
07 Mar 2024
Vehicle
llmypalewz(fetlihrtau) = yzimkrexya zzbetjidgk (zuwtasuwhn )
Phase 4
135
hfdfiklzgc(laxglifuhd) = tpwcieedxa dtlowcdazw (cujmjlskrq, tqlsjmaoar - lfdzqlicij)
-
06 Feb 2024
Not Applicable
Graft vs Host Disease
KIR genotype | KIR-ligand | HLA-B leader peptide dimorphism ...
182
zuqpxnsxrn(xtsvucfysy) = ocnkpjjstk wgexrxhobl (sywtadqqkv )
-
01 Feb 2024
kloubedgrw(efaplghfzz) = glrclevmbc wyiaphuatu (cutdlycfuk )
Phase 3
6,050
PTCy/TAC or CSA & MMF
qgfkabweig(pfihcszema): HR = 1.12 (95% CI, 0.93 - 1.36), P-Value = 0.22
Positive
01 Feb 2024
ATG/TAC or CSA & MTX
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