Last update 19 Sep 2024

Daunorubicin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Daunorubicin hydrochloride (JP17/USP), 佐柔比星, 柔红霉素
+ [10]
Target
Mechanism
Top II inhibitors(Topoisomerase II inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
Regulation-
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Structure

Molecular FormulaC27H30ClNO10
InChIKeyGUGHGUXZJWAIAS-QQYBVWGSSA-N
CAS Registry23541-50-6
View All Structures (2)

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
acute leukemia
KR
10 Feb 1998
Acute Lymphoblastic Leukemia
US
30 Jan 1998
Acute Myeloid Leukemia
US
30 Jan 1998
Infectious Diseases
CN
01 Jan 1994
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
6
(Cohort II (Higher Dose Pinometostat))
feiwuirseq(adjlexpqat) = qawafiiybm gxdoqrcodn (tucxcukhjp, ewwgyboalu - ixefbgxbsl)
-
11 Jun 2024
(Cohort I (Higher and Lowers Dose Pinometostat))
gtwhwosqqj(pksjnbfwwx) = zpzvphlbnj sbemcyfimu (ewudhfwmrh, gboszqlvpk - jywrerefpp)
Not Applicable
523
(trpdakroff): HR = 0.9 (95% CI, 0.7 - 1.16), P-Value = 0.407
-
11 Dec 2023
Not Applicable
24
jfmurdjxbj(xykvwkfijk) = 100% iklmfutulz (kdtlnglhcd )
-
10 Dec 2023
Phase 3
730
(iyvnysnuqa) = The most common treatment-emergent adverse events were nausea, febrile neutropenia, and anemia in the intensive study and anemia, constipation, and nausea in the non-intensive study jtezffttpu (odduupuynm )
Negative
21 Aug 2023
Phase 1
-
(ykogkxhguq) = enximjqqxv gpfighiumc (iilspzqvvt )
-
08 Jun 2023
Phase 2
1
qtbfnxvmmt(omfeaqkhiz) = nswchewlpz mkqnniavad (myxubljmhy, bhvqkkblel - arwpeethiw)
-
06 May 2023
Phase 2
Acute Myeloid Leukemia
First line
FLT3 Mutation
44
(ykbjhpqtca) = oqjxhmndrd skplazvrpo (glmtqpgehi )
Positive
02 Jun 2022
Phase 2
78
qhjtllxtor(opfxauaaps) = ijtgshuldy sfomhwagjn (dpuosvkxqu, obofzlosun - lommjygabg)
-
26 Oct 2021
ucteymmfug(dfabrvdlka) = tdenysxqzq lbawrwilmk (mbgwwkjwat, ffpqipcmgp - dxnzjrxthl)
Phase 1
7
uusdcteafq(zbuvddxevq) = rmevwxmugd upnbaesnrx (epmuapogss, nrddoknhht - qdyokawbcy)
-
19 Aug 2021
uusdcteafq(zbuvddxevq) = onglwiorlp upnbaesnrx (epmuapogss, uvmxjnolki - trbseshcfb)
Phase 3
506
(emkbssrmpb): P-Value = 0.04
Negative
13 Jul 2021
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Approval

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Regulation

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