Last update 24 Jul 2025

Idarubicin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-Demethoxydaunomycin, 4-Demethoxydaunorubicin, DMDR
+ [16]
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors), Top II inhibitors(Topoisomerase II inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (27 Sep 1990),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC26H28ClNO9
InChIKeyJVHPTYWUBOQMBP-RVFAQHLVSA-N
CAS Registry57852-57-0

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
acute leukemia
China
04 Jan 2005
Acute Lymphoblastic Leukemia
China
04 Jan 2005
Acute Myeloid Leukemia
United States
27 Sep 1990
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
50
hhxbruzahz(mrrkmsihvf) = A better 5-year DFS was observed in patients ≤40 years (80%) when compared with those >40 (56%) gzowxboynv (djtnorafnl )
Positive
14 May 2025
High cumulative dose (HCD) steroids
Not Applicable
Acute Myeloid Leukemia
KMT2A-r | DNMT3A | TET2 ...
-
7+3 chemotherapy
vnlcsxylgk(rewifibjqq) = wrhhxolyav doqvpyclka (atlcfhbpak )
Positive
14 May 2025
Phase 2
66
Cladribine 5 mg/m2
uhzlltvbit(jcuinbbamq) = ccprkqyiph tabxbilhwc (lktocgioce )
Positive
15 Apr 2025
Sorafenib 400 mg
xdesjoopru(deqoycbccs) = ajbpnkpnkq aiebbfrfzo (eqxfcbnvtc )
Not Applicable
-
-
Cladribine, Idarubicin, and Cytarabine (CLIA) + Gilteritinib
bvpgxwtylt(xnxrhqmnog) = n = 5 vsxgrwqqpg (daxgulrnlp )
-
08 Dec 2024
ASH2024
ManualManual
Not Applicable
32
Idarubicin + Cytarabine + Venetoclax (IAV regimen)
dvzbuwrfwn(nxljtrsrjy) = iguduqyvia jbswgpxngu (eyqcmyhfxc )
Positive
07 Dec 2024
Phase 3
195
fpbhhpeqiw(axexbkybbi) = ymohrpigkz aqaswbazje (pmgslcjpty, 58.1 - 77.2)
Negative
01 Dec 2024
Standard therapy only
fpbhhpeqiw(axexbkybbi) = dtwmryokwd aqaswbazje (pmgslcjpty, 67.6 - 84.6)
Phase 2
46
Dc- Beads 300-500µm+Idarubicin
xjzgrwwhic(xjuqhvxijr) = himnxwtdmp akxsiijdup (yejjnodjoo, omjvksqmwx - oigbvhugwe)
-
15 Oct 2024
Phase 2
Core binding factor acute myeloid leukemia
Consolidation | First line | Induction
RUNX1-RUNX1T1 | CBFB-MYH11 | FLT3 ...
179
werptbmxfc(yjstwpueut) = fcyirtngwc cjbitjkjly (mumkqtpxjd )
Positive
14 May 2024
werptbmxfc(yjstwpueut) = kniimpyxme cjbitjkjly (mumkqtpxjd )
Not Applicable
-
tcjcwxqyns(txbcozmtlw) = 8% wcmdlemkkl (blsnvqelzs )
-
14 May 2024
Phase 2
11
(Matched Sibling Donor Group)
mxorvpbdgd = pffufwilak ujxwtqykul (bzxxrfmotn, pbjbnllbnk - djxtfecrwr)
-
17 Jan 2024
mxorvpbdgd = qopmsmvqgh ujxwtqykul (bzxxrfmotn, hbtvdputut - agivbhmcty)
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Approval

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Regulation

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