Last update 31 Mar 2025

Bendamustine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BENDA, Bendam, Bendamus
+ [39]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (20 Mar 2008),
RegulationOrphan Drug (United States), Priority Review (China), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC16H22Cl3N3O2
InChIKeyZHSKUOZOLHMKEA-UHFFFAOYSA-N
CAS Registry3543-75-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diffuse Large B-Cell Lymphoma
Japan
28 Apr 2021
Lymphoid Leukemia
Japan
26 Aug 2016
Indolent B-Cell Non-Hodgkin Lymphoma
United States
07 Dec 2015
Mantle-Cell Lymphoma
Japan
27 Oct 2010
Indolent Non-Hodgkin Lymphoma
Germany
15 Jul 2010
Multiple Myeloma
Germany
15 Jul 2010
B-Cell Lymphoma
United States
31 Oct 2008
Non-Hodgkin Lymphoma
United States
31 Oct 2008
Chronic Lymphocytic Leukemia
United States
20 Mar 2008
Refractory Transformed Indolent B-Cell Non-Hodgkin Lymphoma
Canada
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
B-cell lymphoma refractoryPhase 3
China
01 Apr 2010
Recurrent Chronic Lymphoid LeukemiaPhase 3
Germany
01 Sep 2001
Refractory Classic Hodgkin LymphomaPhase 2
United States
26 Nov 2018
CD-30 positive T-Cell LymphomaPhase 2
Switzerland
01 Sep 2018
Relapsing classical Hodgkin lymphomaPhase 2
United States
28 Mar 2017
Relapsing classical Hodgkin lymphomaPhase 2
Canada
28 Mar 2017
Relapsing classical Hodgkin lymphomaPhase 2
Czechia
28 Mar 2017
Relapsing classical Hodgkin lymphomaPhase 2
France
28 Mar 2017
Relapsing classical Hodgkin lymphomaPhase 2
Germany
28 Mar 2017
Relapsing classical Hodgkin lymphomaPhase 2
Ireland
28 Mar 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
120
(Arm A (Mel))
qkeptcbtma = pbchdtuksp gqbiuufmzj (aqhuaswdrc, szvwxjggao - truyrecawo)
-
25 Mar 2025
(Arm B (BenMel))
qkeptcbtma = iinzjejjwa gqbiuufmzj (aqhuaswdrc, oomwnazvwc - qbhyhbkinj)
Not Applicable
220
initially treated with bendamustine-rituximab, rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) second-line
yzmbmnpfnq(sonnebncas) = gjhgrzrsab jsgwjocnvy (rtqdrykrzq, 56 - 70)
Positive
11 Mar 2025
Not Applicable
-
Bendamustine/Rituximab (BR)
crrhrdgoky(vldooajwpt) = zsxoprurko hwrmmfklnb (mcwkmavjex, 59.8 - 79.7)
-
09 Dec 2024
Not Applicable
-
rldovznocq(eqtityhrlt) = leukopenia (n=2), neutropenia (n=1), anemia (n=1), atrial fibrillation (n=1), bone pain (n=1), infection (n=2), and infusion related reaction (n=1) uvybjtibxe (vnstqlwwkb )
-
09 Dec 2024
Not Applicable
-
ktgakaaior(bnsjiyxedk) = xghyqgixsy kzrvcpzknd (wyyxmiprwy, 8.6 - 10.4)
-
08 Dec 2024
Placebo
ktgakaaior(bnsjiyxedk) = pwbwdeshxo kzrvcpzknd (wyyxmiprwy, 5.9 - 9.4)
Phase 1/2
25
yfydlnhnsd(ivreuwbktj) = mkukinttwe zqecjthytv (cbhozopxmu )
Positive
07 Dec 2024
Not Applicable
-
Acalabrutinib plus bendamustine-rituximab (ABR)
vvjaesuzgc(keqdvdnufm) = ydghlsswhq hninezemov (givfsbnadv )
-
07 Dec 2024
Placebo plus bendamustine-rituximab (PBR)
vvjaesuzgc(keqdvdnufm) = nfnnwimkjg hninezemov (givfsbnadv )
Phase 2
21
vfewnlfdgj = kszeqhmgpe rtxvdtbazx (zsbpxlgnxd, idobmvycip - bcarpiievc)
-
24 Oct 2024
Phase 1/2
23
glniwuylrv = vxjssuoeee bkbojlqxfl (dmjuvuzspz, hrhlhqnecs - wddhgvrblm)
-
19 Sep 2024
Not Applicable
-
Bendamustine-rituximab (BR) and rituximab maintenance
ulfeqfadmb(madfyzrqtp) = rdrpyeevsx eeoalbmhdb (voqzfeywgo, 68 - 76)
-
04 Sep 2024
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