Delving into the Latest Updates on Hydroxyzine Hydrochloride with Synapse

Overview

Basic Info

SummaryHydroxyzine is a first-generation antihistamine that is commonly used for the treatment of various allergic conditions such as hives and itching. It works by blocking the action of histamine, a chemical released in response to an allergic reaction. Histamine causes symptoms such as itching, swelling, and rash. Hydroxyzine is available in oral and injectable formulations. It is generally well tolerated by patients. However, side effects can include drowsiness, dizziness and dry mouth. It is important to note that there is ongoing research regarding the potential use of hydroxyzine to treat anxiety disorders, as it has shown some anxiolytic activity in preclinical studies.

Drug Type

Small molecule drug

Synonyms

Hychotine, Hydroxine, Hydroxizine

+ [11]

Target

H1 receptor

Mechanism

H1 receptor antagonists(Histamine H1 receptor antagonists)

Therapeutic Areas

Immune System DiseasesSkin and Musculoskeletal DiseasesOther Diseases

Active Indication

UrticariaAnxiety DisordersDepressive Disorder+ [2]

Inactive Indication

Pruritus

Originator Organization

Pfizer Inc.

Active Organization

Shanghai Sine Pharmaceutical Co. Ltd.

Pfizer Inc.

Inactive Organization

Roerig SA

Drug Highest PhaseApproved

First Approval Date

US (12 Apr 1956),

Anxiety DisordersPruritusUrticaria

Regulation-

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Structure

Molecular FormulaC21H29Cl3N2O2

InChIKeyANOMHKZSQFYSBR-UHFFFAOYSA-N

CAS Registry2192-20-3

The aim of this study is to evaluate the efficacy of hydroxyzine compared to treatment as usual (TAU) for patients with panic disorder. By conducting a pilot study, we hope to provide initial data on the feasibility and potential impact of hydroxyzine for this population. This will inform the design and power calculations of a larger, more comprehensive study in the future.
Objectives:
To assess the feasibility of conducting a randomized controlled trial (RCT) of hydroxyzine for panic disorder.
To evaluate the effectiveness of hydroxyzine compared to TAU in reducing panic symptoms in patients with panic disorder.
To explore the potential side effects and tolerability of hydroxyzine in this population.
Methods:
This will be a single-center, open-label, randomized pilot study. A total of 30 patients with a primary diagnosis of panic disorder will be recruited from a psychiatric outpatient clinic. Participants will be randomly assigned to receive either hydroxyzine or TAU for 8 weeks. The primary outcome measure will be the change in panic symptoms as assessed by the Panic Disorder Severity Scale (PDSS). Secondary outcome measures will include the Hamilton Anxiety Rating Scale (HAM-A) and the Clinical Global Impression-Severity (CGI-S) scale. Participants will be assessed at baseline, 4 weeks, and 8 weeks. Adverse events will be monitored throughout the study.
Expected Results:
This pilot study is expected to provide preliminary data on the feasibility and potential efficacy of hydroxyzine for panic disorder. The results will inform the design of a larger RCT to further evaluate the efficacy of hydroxyzine for this population.
Significance:
There is a need for effective and well-tolerated treatments for panic disorder. If found to be effective, hydroxyzine could provide a new option for patients with this condition, potentially improving their quality of life and functioning. The results of this pilot study will inform the design of future studies and contribute to the development of evidence-based treatments for panic disorder.

Start Date30 Dec 2023

Sponsor / Collaborator

University of Sultan Qaboos

NCT05680584 / RecruitingPhase 1IIT

Comparison Between the Effect of Oral Melatonin and Hydroxyzine for Preventing Preoperative Anxiety in Pediatric Patients Undergoing Adenotonsillectomy

Comparison between the effect of oral Melatonin and Hydroxyzine for Preventing Preoperative Anxiety in pediatric Patients Undergoing Adenotonsillectomy

Start Date01 Feb 2023

Sponsor / Collaborator-

100 Clinical Results associated with Hydroxyzine Hydrochloride

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100 Translational Medicine associated with Hydroxyzine Hydrochloride

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100 Patents (Medical) associated with Hydroxyzine Hydrochloride

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1,378

Literatures (Medical) associated with Hydroxyzine Hydrochloride

31 Dec 2024·ANNALS OF MEDICINE

Psychotherapeutic and pharmacological agents for post-traumatic stress disorder with sleep disorder: network meta-analysis

Review

Author: Luo, Jie ; Zhang, Zhi-Xin ; Huang, Cheng-Yang ; Liu, Jia-Ling ; Yue, Li ; Zhang, Chao ; Zhao, Yi-Fan ; Liu, Run-Ben ; Li, Xiao-Zheng

OBJECTIVE:

The current guidelines and canonical norms of diagnosis or treatment for Post-traumatic stress disorder (PTSD) with sleep disorder are still conflicting and have not yet reached a consensus. This study aimed to unravel the most effective countermeasures between two categories (psychotherapy and pharmacotherapy) put forward by the National Institute for Health and Clinical Excellence (NICE) and World Federation of Societies of Biological Psychiatry (WFSBP) respectively to treat PTSD individuals co-exist with sleep disorders.

METHODS:

Four databases, including PubMed, EMBASE, Cochrane Library, and APA PsyNet, were searched from inception to February 02, 2023.

RESULTS:

Twenty articles with 24 Randomized controlled trials (RCTs) and a total number of 1,647 participants were included. As demonstrated in the network meta-analysis comparison results, CBT-I (standardized mean differences (SMD) = -1.51,95% confidence interval (CI):-2.55 to -0.47), CBT-I plus IRT (SMD = -1.71, 95%CI:-3.39, -0.03), prazosin (SMD = -0.87,95%CI:-1.59 to -0.16) and hydroxyzine (SMD = -1.06, 95%CI: -1.94 to -0.19) significantly reduced PTSD symptoms compared with placebo. In contrast to placebo, CBT-I (SMD = -5.61,95%CI:-8.82 to -2.40) significantly improved sleep quality. For nightmare severity, IRT (SMD =-0.65, 95%CI:-1.00 to -0.31), prazosin (SMD = -1.20,95%CI:-1.72 to -0.67) and hydroxyzine (SMD = -0.98,95%CI:-1.58 to -0.37) significantly reduced nightmare severity in comparison with placebo.

CONCLUSIONS:

This study suggested that under most circumstances, psychotherapy namely CBT-I had a favorable profile, but pharmacotherapy with prazosin was effective in managing nightmare severity. The sole avail of CBT-I was recommended to improving sleep quality while CBT-I and CBT-I plus IRT showed excellent management of PTSD symptom severity. Exposure to CBT-I isrecommended for depression. The relevant clinical guidelines for the management of individuals with PTSD and sleep disorders may regard this as a reference.

PROSPERO:

CRD42023415240.

01 Dec 2024·RADIOTHERAPY AND ONCOLOGY

Effects of dopamine receptor antagonists and radiation on mouse neural stem/progenitor cells

Article

Author: Pajonk, Frank ; Ioannidis, Angeliki ; He, Ling ; Bhat, Kruttika

BACKGROUND:

Dopamine receptor antagonists have recently been identified as potential anti-cancer agents in combination with radiation, and a first drug of this class is in clinical trials against pediatric glioma. Radiotherapy causes cognitive impairment primarily by eliminating neural stem/progenitor cells and subsequent loss of neurogenesis, along with inducing inflammation, vascular damage, and synaptic alterations. Here, we tested the combined effects of dopamine receptor antagonists and radiation on neural stem/progenitor cells.

METHODS:

Using transgenic mice that report the presence of neural stem/progenitor cells through Nestin promoter-driven expression of EGFP, the effects of dopamine receptor antagonists alone or in combination with radiation on neural stem/progenitor cells were assessed in sphere-formation assays, extreme limiting dilution assays, flow cytometry and real-time PCR in vitro and in vivo in both sexes.

RESULTS:

We report that hydroxyzine and trifluoperazine exhibited sex-dependent effects on murine newborn neural stem/progenitor cells in vitro. In contrast, amisulpride, nemonapride, and quetiapine, when combined with radiation, significantly increased the number of neural stem/progenitor cells in both sexes. In vivo, trifluoperazine showed sex-dependent effects on adult neural stem/progenitor cells, while amisulpride demonstrated significant effects in both sexes. Further, amisulpride increased sphere forming capacity and stem cell frequency in both sexes when compared to controls.

CONCLUSION:

We conclude that a therapeutic window for dopamine receptor antagonists in combination with radiation potentially exists, making it a novel combination therapy against glioblastoma. Normal tissue toxicity following this treatment scheme likely differs depending on age and sex and should be taken into consideration when designing clinical trials.

01 Dec 2024·ARCHIVES OF TOXICOLOGY

Development of two ultra-sensitive UHPLC–QqQ-MS/MS methods for the simultaneous determination of hydroxyzine and its active metabolite (cetirizine) in human blood: applications to real cases of forensic toxicology

Article

Author: Kukula-Koch, Wirginia ; Chłopaś-Konowałek, Agnieszka ; Zawadzki, Marcin ; Szpot, Paweł ; Dudzińska, Ewa

Abstract:

Both postmortem toxicological and medical-forensic examinations are very important in the case of analyzing various types of chemical substances. Hydroxyzine (HZ) is a first-generation antihistamine drug with a sedative effect that disrupts cognitive function and affects the ability to drive motor vehicles. Enzymatic oxidation of the hydroxy-methyl group to the carboxyl group leads to the formation of its main metabolite—cetirizine (CZ). CZ is the active substance of antiallergic drugs. Because it does not cross the BBB (blood–brain barrier) easily, it is less likely to cause drowsiness or affect memory and impair cognitive function. Therefore, in criminal studies, it is often important what medication had been taken by a person involved, e.g., in a car accident, HZ or CZ. The analysis of both antihistamine drugs is challenging, as usually very low concentrations of the compound of interest need to be determined. Thus, an ultra-sensitive UHPLC–QqQ-MS/MS method was developed for simultaneous determination of HZ and CZ in biological fluid samples. The lower limit of quantification (LOQ) for HZ and CZ was calculated as 0.345 and 0.3696 ng/mL, respectively. Together with a reduced sample volume to 200 μL, it makes the developed method suitable for a sensitive multidrug forensic toxicological analysis. Samples were extracted with simple and fast liquid–liquid extraction (ethyl acetate, pH 9). The present method for the determination of HZ and CZ in human blood proved to be simple, fast, selective, and sensitive. The quantification by LC–MS/MS was successfully applied to the samples coming from 28 authentic biological fluids (blood, urine, vitreous humor, bile and stomach content), both antemortem and postmortem. The performed studies confirm that the developed method is characterized by a high extraction efficiency. Its accuracy, reproducibility, simplicity, and selectivity suggest its application in clinical, toxicological, and forensic laboratories.

100 Deals associated with Hydroxyzine Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D00672	Hydroxyzine Hydrochloride	N05BB01	DB00557

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Depressive Disorder	JP	Pfizer Inc.	30 Sep 1965
Eczema	JP	Pfizer Inc.	30 Sep 1965
Nausea and vomiting	JP	Pfizer Inc.	30 Sep 1965
Anxiety Disorders	US	Pfizer Inc.	12 Apr 1956
Pruritus	US	Pfizer Inc.	12 Apr 1956
Urticaria	US	Pfizer Inc.	12 Apr 1956

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05126459 (CTgov)	Phase 3	Dental Caries	60	Meperidine+Hydroxyzine +Midazolam (Regimen 1)	axjjnzeybw(coemkovkpo) = qvofdgdtbv ukhpnhavtw (tcygtowunq, bpviqdfzwd - ldcuxwdscm) View more	-	02 Oct 2024
NCT05126459 (CTgov)	Phase 3	Dental Caries	60	Meperidine+Hydroxyzine (Regimen 2)	axjjnzeybw(coemkovkpo) = lettprxhvv ukhpnhavtw (tcygtowunq, yzcwwowjyv - gbvsesvglz) View more	-	02 Oct 2024
NCT04068948 (CTgov)	Phase 4	Sedation \| Dental Caries	37	Meperidine+Hydroxyzine+Midazolam (Midazolam, Hydroxyzine, Meperidine)	fgjoxifvnp(opxoxqtuqd) = xrhthaukwm ytisqtyrgl (jxbryaahms, lfdjiioind - ievwtvjpiz) View more	-	05 Dec 2023
NCT04068948 (CTgov)	Phase 4	Sedation \| Dental Caries	37	Hydroxyzine+Midazolam (Midazolam, Hydroxyzine)	fgjoxifvnp(opxoxqtuqd) = culqavmwja ytisqtyrgl (jxbryaahms, yilefdwfml - utgjxehfvj) View more	-	05 Dec 2023
NCT04188106 (HAVE, CTgov)	Phase 4	Nausea \| Dyssomnias \| Smoking Cessation	26	Varenicline Pill+Hydroxyzine Pill	jwhrcpgmvf(zafvdrdpbh) = zecifutpfz ntyvjmvzzs (uxfozcsthw, nhwwpaielw - tbztnecunj) View more	-	03 Mar 2023
ASCO2005	Not Applicable	Ostealgia	-	G-CSF administration	cznxggalan(yuksckwlmi) = The bone pain frequently emerges as one of the side effects of G-CSF administration. Rising pressure within bone marrow by increased granulocytes, edema within bone marrow by histamine release, and increased level of bradykinin are thought to be the mechanisms underlying it. The incidence of bone pain is reported to be 1–5% of all cases, but in practice we have the impression that there have been more cases with bone pain, some of which are resistant to treatment with non-steroid anti-inflammatory drugs (NSAIDs). yvwsfpsitk (iuslyyluiz )	-	01 Jun 2005