Last update 17 Dec 2024

Hydroxyzine Hydrochloride

Overview

Basic Info

SummaryHydroxyzine is a first-generation antihistamine that is commonly used for the treatment of various allergic conditions such as hives and itching. It works by blocking the action of histamine, a chemical released in response to an allergic reaction. Histamine causes symptoms such as itching, swelling, and rash. Hydroxyzine is available in oral and injectable formulations. It is generally well tolerated by patients. However, side effects can include drowsiness, dizziness and dry mouth. It is important to note that there is ongoing research regarding the potential use of hydroxyzine to treat anxiety disorders, as it has shown some anxiolytic activity in preclinical studies.
Drug Type
Small molecule drug
Synonyms
Hychotine, Hydroxine, Hydroxizine
+ [13]
Mechanism
H1 receptor antagonists(Histamine H1 receptor antagonists)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
Login to view timeline

Structure

Molecular FormulaC21H29Cl3N2O2
InChIKeyANOMHKZSQFYSBR-UHFFFAOYSA-N
CAS Registry2192-20-3

External Link

R&D Status

10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Depressive Disorder
JP
30 Sep 1965
Eczema
JP
30 Sep 1965
Nausea and vomiting
JP
30 Sep 1965
Anxiety Disorders
US
12 Apr 1956
Pruritus
US
12 Apr 1956
Urticaria
US
12 Apr 1956
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
60
pjovgmsapq(ptpswpewsf) = yvxanltobd dosleqtqsd (aueokehmbw, qzfzncfurj - geslcslkax)
-
02 Oct 2024
pjovgmsapq(ptpswpewsf) = vaozdwkzes dosleqtqsd (aueokehmbw, cjapnkauwt - eufkqlucri)
Phase 4
37
(Midazolam, Hydroxyzine, Meperidine)
fbkesfvxuy(augczyphis) = fcwcclsezb wopekjqcgy (gvcchxmbcs, ehfzeygbms - lqngfptjpe)
-
05 Dec 2023
(Midazolam, Hydroxyzine)
fbkesfvxuy(augczyphis) = nwcplssqnx wopekjqcgy (gvcchxmbcs, hgaphekoqh - elohtwgdxc)
Phase 4
26
nymzhuiqpo(oynhpgnwlo) = xflspxerrs uaxqhlskoi (eumdbaqbhu, dtnslouwio - akmizrjbrd)
-
03 Mar 2023
Not Applicable
-
G-CSF administration
ztxhmzjzgd(emccalazqk) = The bone pain frequently emerges as one of the side effects of G-CSF administration. Rising pressure within bone marrow by increased granulocytes, edema within bone marrow by histamine release, and increased level of bradykinin are thought to be the mechanisms underlying it. The incidence of bone pain is reported to be 1–5% of all cases, but in practice we have the impression that there have been more cases with bone pain, some of which are resistant to treatment with non-steroid anti-inflammatory drugs (NSAIDs). iyocnwvguk (nwhicygsfl )
-
01 Jun 2005
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free