This study is a randomized controlled trial comparing the effects of socket grafting with crushed vitamin K2 (menaquinone)capsules versus no grafting on bone density and socket dimensions following tooth extraction. Patients are randomly assigned to one of two groups:
Study Group (Group I): Patients receive socket grafting with crushed vitamin K2 (menaquinone) capsules. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed to stabilize the graft material and achieve soft tissue stability.
Control Group (Group II): Patients undergo socket healing without grafting. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed over it.
Outcome measures include bone socket dimensions evaluated immediately after extraction with graft material, as well as assessment after 4 months using cone beam computed tomography (CBCT) radiographs. Additionally, core biopsies are taken at the time of implant placement.

Start Date23 Nov 2024

Sponsor / Collaborator

Cairo University

DRKS00034742 / RecruitingNot ApplicableIIT

Vitamin supplementation in cystic fibrosis in the era of modulators: the impact of vitamin K2 on cardio-metabolic health – a randomised double-blind placebo-controlled trial

Start Date29 Oct 2024

Sponsor / Collaborator-

ChiCTR2400081931 / SuspendedNot ApplicableIIT

The effect of vitamin K2 fortified nutritional intervention on muscle condition and clinical outcomes in elderly patients with muscle wasting syndrome

Start Date19 Mar 2024

Sponsor / Collaborator-

100 Clinical Results associated with Menatetrenone

100 Translational Medicine associated with Menatetrenone

100 Patents (Medical) associated with Menatetrenone

1,361

Literatures (Medical) associated with Menatetrenone

01 Feb 2025·COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Short communication: Can Vitamin D be supplied from the large intestine?

Article

Author: Fraser, David R. ; Fraser, David R

The discovery that vitamin D₂ is being generated by anaerobic microbial metabolism in the alimentary tract, raises the question whether such a source of vitamin D could contribute to vitamin D supply for the animal hosting this microbial production system. In ruminants, this microbial generation in the forestomach allows vitamin D₂ to be readily absorbed when it reaches the small intestine, contributing to vitamin D₂ and 25-hydroxyvitamin D₂ [25(OH)D₂] found in their tissues. In monogastric animals like humans, the microbial generation of vitamin D₂ is occurring in the large intestine. There is evidence that vitamin D hydroxy metabolites, delivered to the lumen of the colon can be absorbed. However, the parent vitamin D is more lipophilic than its metabolites, and like lipophilic vitamin K₂ being produced by bacteria in the hindgut, may be poorly absorbed by the colon mucosa. It is now apparent that colon mucosal cells have the proteins megalin and cubilin in their basal membrane. These glycoproteins perform endocytosis of circulating proteins including vitamin D binding protein [DBP]. Inside the cell, DBP binds to cytoplasmic actin and thus provides an array of high affinity binding sites for vitamin D and its functional metabolites. Any traces of vitamin D₂ that may diffuse into the colon mucosal cells from the lumen would thus be retained and accumulate on the DBP-actin. It would then be a substrate for functional hydroxylase metabolism for local endocrine action in these cells, and subsequent delivery of 25(OH)D₂ by diffusion to apo-DBP in the circulation.

01 Feb 2025·FOOD CHEMISTRY

Vitamin K - content in food and dietary intake among the Danes

Article

Author: Jakobsen, Jette ; Christensen, Tue ; Langwagen, Marija ; Poulsen, Anders ; Jensen, Marie Bagge

Insufficient information on the content of vitamin K2 in our foods hinder estimation of the dietary intake. We aimed to establish content of eight vitamin K vitamers, vitamin K1 (phylloquinone; PK) and vitamin K2 (menaquinones; MK-4 to MK-10) in 88 composite food samples representing dairy, eggs, meat, fish, cereals, and plant-based alternatives to dairy. Combined with PK data for other foods, the dietary intake among Danes was estimated. The unit'PKeq' is used to compensate for the difference in molecular weight for MK-4 at 445 g/mol up to MK-10 at 853 g/mol. The highest content was found in chicken thigh with skin at 53 μg PKeq/100 g followed by 49 μg PKeq/100 g in Danablue (blue cheese). The daily intake of vitamin K is 139 μg to 160 μg PKeq for adults. The highest percentage comes from PK (64 %), 27 % from MK-4, 4.6 % from MK-9, and 2.4 % from MK-8.

01 Jan 2025·CLINICAL NEPHROLOGY

Hyperbaric oxygen treatment in addition to conventional multidisciplinary care in patients with calciphylaxis

Article

Author: Nordheim, Espen ; Brekke, Fredrik Barth ; Braaten, Martin ; Gudmundsdottir, Helga ; Røed, Ine ; Lippe, Nanna von der

BACKGROUND:

Calciphylaxis is a rare and serious complication in patients with kidney disease. It has few treatment options and poor prognosis. Hyperbaric oxygen therapy (HBOT) may improve wound healing and was added to our conventional care in 2012.

MATERIALS AND METHODS:

Data from all calciphylaxis patients treated from 2012 to 2022 were retrieved from hospital records. HBOT was added to our multidisciplinary care of calciphylaxis, which included sodium-thiosulphate, dialysis if indicated, medical optimization of calcium-phosphate homeostasis, substitution of vitamin K2, withdrawal of warfarin, iron and vitamin D, and minimization of systemic steroids. In addition, weight- and nutritional status was optimized, and wound care was thoroughly performed.

RESULTS:

25 patients received a total number of 1,493 HBOT treatments in addition to conventional care in the study period. Median HBOT per patient was 45 (range 1 - 267). One year after diagnosis, 18 out of 25 patients were alive. 15 out of the 18 patients alive 1 year after diagnosis had completely resolved wound lesions. Seven patients died within the first year after diagnosis due to cardiovascular disease (n = 3), infection (n = 3), and cancer (n = 1).

CONCLUSION:

Our results suggest that HBOT is well-tolerated and may be associated with beneficial effects on survival and wound-healing when combined with multidisciplinary care.

News (Medical) associated with Menatetrenone

04 Jan 2024

·www.globenewswire.com

Healthy Extracts Launches First Anti-Aging Formulation, LONGEVITY

LAS VEGAS, Jan. 04, 2024 (GLOBE NEWSWIRE) -- Healthy Extracts Inc. (OTCQB: HYEX), a platform for acquiring, developing, patenting, marketing, and distributing plant-based nutraceuticals that target select high-growth categories within the multibillion-dollar nutraceuticals market, has launched LONGEVITY Anti-Aging™, a new proprietary formulation designed to support skin vitality, arterial flexibility, and cellular and joint health. LONGEVITY Anti-Aging is available to order today on BergametNA.com. In celebration of the launch, for a limited time you can buy two and get one free. You can also subscribe and save 15% on every order. The formulation is a special blend of the most powerful anti-aging warriors that include trans-resveratrol, quercetin, vitamin D, and vitamin K2. These substances are known to boost blood flow and circulation, reduce the deleterious effects of misplaced calcium in the body, and slow the effects of aging with powerful antioxidants. “LONGEVITY Anti-Aging complements our growing heart health product portfolio which supports a holistic approach to anti-aging like healthy skin,” noted Healthy Extracts president, Duke Pitts. “We anticipate this new product, along with the others we’re planning to launch early this year, will continue drive our growth and market expansion, as they leverage our multiple sales and distribution channels and existing customer base.” LONGEVITY Anti-Aging represents a holistic approach to aging, with a proprietary blend focused on providing the nutrition the body needs for optimal health. It is formulated to help sustain vitality, support heart health, ensure robust bone strength, and contribute to a healthier aging process. The formulation is vegan friendly, non-GMO, gluten-free, and produced and tested by certified U.S. facilities. Key substances and benefits: Trans-resveratrol and quercetin are powerful antioxidants that shield cells from aging and oxidative stress for more youthful function.Vitamin D and K2 are vital for proper calcium absorption and distribution, bolstering bone health and reducing osteoporosis risk.For heart health, ingredients like vitamin K2 and trans-resveratrol are key in maintaining cardiovascular wellness, helping to lower the risk of heart ailments.Vitamin D and quercetin also strengthens immune defense, enhancing protection against infection and disease. LONGEVITY Anti-Aging is your ally for overall longevity, blending ingredients renowned for their anti-aging benefits that support a longer, healthier life. LONGEVITY Anti-Aging introduction follows the recent official launch of BERGAMET SLEEP BREATHING SUPPORT™ , a natural supplement designed to support respiratory function for deeper, more restorative sleep. Given the better than anticipated initial sales of this new product, it is on track to become one of the company’s best sellers in 2024. Healthy Extracts’ full line of natural heart health formulations address the fast-growing, multi-billion dollar heart-health supplement market which is projected to grow at 5.9% CAGR to reach $24.8 billion by 2027, according to ResearchAndMarkets. To learn more about Healthy Extracts’ full line of clinically-backed, natural brain and hearth health products, go to bergametna.com or tryubn.com. About Healthy Extracts “Live Life Young Again” Healthy Extracts Inc. is a platform for acquiring, developing, researching, patenting, marketing, and distributing plant-based nutraceuticals. The company’s subsidiaries, BergametNA™ and Ultimate Brain Nutrients™ (UBN), offer nutraceutical natural heart and brain health supplements. This includes the only heart health supplement distributed in North America containing Citrus Bergamot SuperFruit™. This superfruit has the highest known concentration of polyphenols and flavonoids. UBN’s KETONOMICS® proprietary formulations, which have been designed to enhance brain activity, focus, headache and cognitive behavior, provide many sales and intellectual property licensing opportunities. For more information visit: healthyextractsinc.com, bergametna.com or tryubn.com. Forward-Looking Statements and Safe Harbor Notice All statements other than statements of historical facts included in this press release are "forward-looking statements" (as defined in the Private Securities Litigation Reform Act of 1995). Such forward-looking statements include our expectations and those statements that use forward-looking words such as "projected," "expect," "possibility" and "anticipate." The achievement or success of the matters covered by such forward-looking statements involve significant risks, uncertainties and assumptions. Actual results could differ materially from current projections or implied results. Investors should read the risk factors set forth in the Company's Annual Report on Form 10-K filed with the SEC on March 31, 2023, and future periodic reports filed with the SEC. All of the Company's forward-looking statements are expressly qualified by all such risk factors and other cautionary statements. The Company cautions that statements and assumptions made in this news release constitute forward-looking statements and make no guarantee of future performance. Forward-looking statements are based on estimates and opinions of management at the time statements are made. The information set forth herein speaks only as of the date hereof. The Company and its management undertake no obligation to revise these statements following the date of this news release. Food & Drug Administration Disclosure The product and formulation featured in this release is not for use by or sale to persons under the age of 12. This product should be used only as directed on the label. Consult with a physician before use if you have a serious medical condition or use prescription medications. A doctor’s advice should be sought before using this and any supplemental dietary product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. BergametNA™, Ultimate Brain Nutrients™, UBN™, Citrus Bergamot SuperFruit™ and F4T® are registered trademarks of Healthy Extracts Inc.™ Company ContactDuke Pitts, PresidentHealthy Extracts Inc.Tel (720) 463-1004Email contact Investor ContactRonald Both CMA Investor RelationsTel (949) 432-7566Email contactMedia Contact:Tim RandallCMA Media RelationsTel (949) 432-7572Email Contact A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/200b922a-c04a-45ab-b819-dba1b9750c42

Drug Approval

07 Mar 2023

·www.prnewswire.com

NUTRISHOP® Launches Comprehensive Heart Formula To Support Cardiovascular Health

Heart Formula by Nu-Tek Nutrition® is now available exclusively at Nutrishop HENDERSON, Nev., March 7, 2023 /PRNewswire/ -- Nutrishop, a leading national retail nutrition franchise specializing in dietary and nutritional supplements, vitamins and wellness, is proud to announce the launch of Heart Formula by Nu-Tek Nutrition®. This product's comprehensive approach to cardiovascular health contains some of the most sought-after, heart-healthy ingredients on the market. And, it is now available exclusively through Nutrishop. Continue Reading "We all have only one heart, and it is never too early to start caring for it." Tweet this Let’s face it, wellness is the new fitness. Introducing Heart Formula by Nu-Tek Nutrition. It’s loaded with heart-healthy ingredients like Olive Leaf Extract, Garlic, Organic Beet Root, Turmeric, CoEnzymeQ10, and more. Let’s be as healthy on the inside as we look on the outside. "We all know the importance of a healthy heart, yet some of us may overlook it in pursuit of a fit physique. However, the importance of a healthy heart cannot be overstated," said Nutrishop Founder and CEO Bryon McLendon. "If the interior of our bodies is not functioning properly, nothing on the exterior matters. Nu-Tek Nutrition's Heart Formula is the perfect solution to support our body's most important muscle." Loaded with heart-healthy ingredients such as Olive Leaf Extract, Garlic Extract, Turmeric Root, Hawthorn Berry, Organic Beet Root, CoEnzymeQ10, Grape Seed Extract, and Vitamin K2, Heart Formula is easy to incorporate into any wellness routine. In addition to maintaining a healthy body weight, regularly engaging in cardio exercise (brisk walking counts!), reducing stress and consuming good-for-your-heart foods, such as salmon, vegetables, whole grains, nuts and seeds, simply take three capsules daily or as directed by your healthcare professional. "We all have only one heart, and it is never too early to start caring for it," McLendon said. "With Heart Formula by Nu-Tek Nutrition combined with a healthy lifestyle, you're definitely stepping in the right direction." To learn more or purchase Heart Formula, visit NutrishopUSA.com or stop by any Nutrishop location nationwide. About Nu-Tek Nutrition ®: For nearly 20 years, Nu-Tek Nutrition has dedicated itself to building the foundation of health and wellness with innovative, complex powders like Supergreens, Superfruits, and Daily Detox and supplements like Gut Formula and Super Multi+. The brand's products are backed by over 25 years of formulating experience to offer the best wellness supplementation and help people live their best lives. About NUTRISHOP ® Since 2003, NUTRISHOP® has helped countless individuals live a fit, healthy, happy lifestyle. Nutrishop stores offer customers a low-price guarantee on a wide array of cutting-edge dietary supplements along with exceptional, individualized customer service, easy-to-follow meal plans, body composition assessment tools, and sound nutritional guidance. The Nutrishop business model focuses primarily on franchisee-owned and operated stores that provide consumers with the tools required to achieve their health and fitness goals. For more information, visit NutrishopUSA.com and follow on Instagram @NutrishopUSA. To learn more about becoming a Nutrishop franchisee, visit NutrishopFranchise.com. SOURCE Nutrishop

21 Jul 2022

·www.prnewswire.com

Ortek to Launch Oral Care Prebiotic Soft Chew with Added Nutrients for Enamel, Bone, Immune and Cardiovascular Support

Multi-Action BasicBites Synergy Plus™ Poised to Capitalize on the Multibillion Dollar Oral Care, Supplement and Prebiotic Markets ROSLYN HEIGHTS, N.Y., July 21, 2022 /PRNewswire/ -- Ortek Therapeutics, Inc., a leader in developing and commercializing novel oral care technologies, has announced its plans to extend its successful BasicBites® product line later this year with the introduction of BasicBites Synergy Plus™ soft chew. This revolutionary patent pending product combines Ortek's breakthrough microbiome oral care technology with vital nutrients to help support tooth enamel and maintain healthy bones and immune and cardiovascular systems. BasicBites Synergy Plus Soft Chews BasicBites Synergy Plus will further strengthen Ortek's ability to capitalize on opportunities in the global oral care, supplement, and prebiotic markets which last year were valued at approximately $200 billion. The company is also developing additional BasicBites line extensions that it plans to announce soon. "Our products have been well received by our loyal and growing customer base of thousands of consumers and dental professionals," said Mitchell Goldberg, President of Ortek Therapeutics, Inc. As this new product line extension shows, we continually find new ways to take advantage of our university developed microbiome oral care technology." What makes BasicBites Synergy Plus a one-of-a-kind prebiotic and nutritional supplement is its patent pending formula which includes all of the following ingredients: Arginine Bicarbonate and Calcium Carbonate which work together to create a healthy, balanced oral pH environment that protects teeth from harm caused by dry mouth–which effects 1 in 4 adults–and sugary foods and drinks. Arginine, an amino acid, nourishes the beneficial pH-raising bacteria discovered in dental plaque, resulting in immediate and sustained buffering on tooth surfaces that helps neutralize harmful plaque acids-a prebiotic process. The calcium carbonate also enriches tooth enamel and bones and plays an important role in supporting the health of cardiovascular, muscular and nervous systems. K2VITAL®, a novel K2 MK-7 formula superior to other Vitamin K2 supplements. Vitamin K2 facilitates the transport and integration of calcium into bones and teeth. It helps maintain a normal calcium balance in arteries, which may inhibit their calcification and prevent or slow the progression of arterial stiffness. This novel formulation from Kappa Bioscience maintains Vitamin K2's potency in higher pH products such as BasicBites Synergy Plus. Vitamin D3 which helps the body absorb calcium into the bloodstream and has a vital role in maintaining strong teeth and bones. It also helps support a strong immune system and respiratory and neuromuscular functions and could play a role in maintaining cardiovascular health and metabolizing blood glucose. About Ortek Ortek Therapeutics, Inc. is a global leader in developing and commercializing cutting-edge oral care technologies. For more information on the company, visit ortekinc.com. SOURCE Ortek Therapeutics, Inc.

100 Deals associated with Menatetrenone

External Link

KEGG	Wiki	ATC	Drug Bank
D00100	Menatetrenone	B02BA	DB12148

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Osteoporosis, Postmenopausal	CN	Eisai Co., Ltd.	21 Jul 2013
Vitamin K Deficiency Bleeding	JP	Sannova KK	25 May 2012
Vitamin K Deficiency Bleeding	JP	Alfresa Pharma Corp.	25 May 2012
Pain	CN	Eisai Co., Ltd.	29 Jun 2010
Osteoporosis	JP	Eisai Co., Ltd.	30 Jun 1995
Hemorrhage	JP	Eisai Co., Ltd.	29 Jun 1972
Hypoprothrombinemias	JP	Eisai Co., Ltd.	29 Jun 1972

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Hepatocellular Carcinoma	Phase 3	JP	Eisai Co., Ltd.	01 Mar 2004
Cerebral Hemorrhage	Preclinical	JP	Kumamoto University	10 May 2024
Leukemia	Preclinical	JP	Tokyo Medical University	16 Nov 2007

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


WCO_IOF_ESCEO2023	Not Applicable	MGP \| P \| ALP ... View more	40	Vitamin K2 (MK-7) 120 g/d	ytwxyabxpx(lgflwocbll) = xzvwwhewvf eexsnihlfs (pqxkxakzjm )	Positive	04 May 2023
AVADEC (ESC2022)	Not Applicable	Coronary Artery Disease	389	Vitamin K2 (720 μg/day) and Vitamin D (25 μg/day)	qqhprsfsdd(wkurfcfwtj) = mgbyjdytqk kdwagmpcxn (zrioeegcvx ) View more	-	28 Aug 2022
				vitamin k2	qqhprsfsdd(wkurfcfwtj) = lerhebckcb kdwagmpcxn (zrioeegcvx ) View more
MO789 (ERA2022)	Not Applicable	matrix Gla protein (MGP)	120	Vitamin K1	lbnkhqkkyp(qjjrdbrajx) = tzebggmstt rndblromlo (qpqcomcxgk )	Positive	03 May 2022
				Vitamin K2	lbnkhqkkyp(qjjrdbrajx) = qeviejkenu rndblromlo (qpqcomcxgk )
WCO_IOF_ESCEO2022	Not Applicable	Osteoporosis, Postmenopausal	46	Vitamin K2 (Women with Postmenopausal Osteoporosis)	eyzghssegp(vtxtyagxeo) = sebrhsuich ltbwjwqwcy (meyakcjuxm, 10.09) View more	-	24 Mar 2022
				Vitamin K2 (Postmenopausal Women without Osteoporosis)	eyzghssegp(vtxtyagxeo) = imjscsqqyo ltbwjwqwcy (meyakcjuxm, 6.94) View more
CHANGE IN HEMODYNAMIC PARAMETERS AND CAROTID STIFFNESS INDICES AFTER VITAMIN K2 SUPPLEMENTATION (ESH2021)	Not Applicable	Diabetes Mellitus, Type 2	18	Vitamin K2 (Menaquinone-7) 75 μg	dzeqrjmmjq(unidtmmtmd) = jdfrrwqymn tlxxaunpph (eccgimfhsj ) View more	Negative	01 Apr 2021
FP608 (ERA2019)	Not Applicable	Vascular Calcification uncarboxylated-MGP	102	Vitamin K2 supplementation (200μg/day)	nltpwqmfrf(jnfyhavxze) = tfrzibtxcw ojmynchxho (lzoqrhnlvy ) View more	Negative	13 Jun 2019
				Vitamin K2 (Control (no treatment))	nltpwqmfrf(jnfyhavxze) = irenrkraxw ojmynchxho (lzoqrhnlvy ) View more
NCT02876354 (Pubmed)	Phase 4	Hemodialysis complication	50	Vitamin K2 (menaquinone-7)	npmmbjavti(mstooqfctl) = kavgeoglhj tsrwixdkkg (teilftaiay )	-	07 Jun 2017
NCT02876354 (MO021, ERA2017)	Phase 4	Hemodialysis complication dp-ucMGP \| MGP \| vitamin K2	50	Vitamin K2 (menaquinone-7)	mcodolgxzz(nlyunajbur) = cuvmloydom rlqbxbdpnt (iwxiewtplr )	Positive	26 May 2017
NCT01101698 \| NCT04247087 (Pubmed \| Pol Arch Intern Med)	Phase 4	Chronic Kidney Diseases	42	Vitamin K2 + cholecalciferol (K+D)	nkjvuffytj(dspqsxejnv) = jjongijpbg xzlpekjewd (cmrvxwgncz )	-	01 Jan 2015
				Cholecalciferol (D)	nkjvuffytj(dspqsxejnv) = qvlnknxgkj xzlpekjewd (cmrvxwgncz )
SP230 (ERA2014)	Not Applicable	Chronic Kidney Diseases dp-ucMGP positive \| MGP positive \| osteocalcin	42	Vitamin K2 (menaquinone-7, MK-7) + cholecalciferol	ftddubmdkf(cdhaiymptf) = dgptqecigm xjqqdzooju (fcykikgvfz, 1077.1±507.7) View more	Positive	01 May 2014
				Vitamin D	ftddubmdkf(cdhaiymptf) = ryjljxyqmj xjqqdzooju (fcykikgvfz, 793.9±400.3) View more

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