The appropriate form and dosing of vitamin K to benefit relevant outcomes in knee osteoarthritis (OA) are not known. In intervention studies for conditions other than knee OA (e.g., prevention of cardiovascular disease), the most commonly used forms and doses include phylloquinone (vitamin K1; 1000µg or 500µg daily) or menaquinone-7 (MK-7 or vitamin K2; 300µg daily). However, whether these doses are adequate to increase vitamin K to levels that ameliorate risk of adverse OA outcomes is not known. Furthermore, although some studies suggest enhanced bioavailability of MK-7 over vitamin K1, as well as extra-hepatic effects, whether this is relevant for an older population with knee OA is not known,
The overall goal of this pilot randomized clinical trial (RCT) is to test different subtypes and doses of vitamin K supplementation in older adults with knee OA and to measure changes in relevant biochemical measures.

Start Date01 May 2025

Sponsor / Collaborator

Boston University

CTR20250946

/ CompletedNot Applicable

评估受试制剂四烯甲萘醌软胶囊（规格：15 mg）与参比制剂固力康®（规格：15 mg）在中国健康成年参与者空腹状态下的单中心、开放、随机、单剂量、四周期、两序列、完全重复交叉生物等效性试验

[Translation] A single-center, open-label, randomized, single-dose, four-period, two-sequence, fully repeated crossover bioequivalence study to evaluate the test preparation menatetrenone soft capsules (15 mg) and the reference preparation Gulikang® (15 mg) in healthy adult participants in the fasting state in China

研究空腹状态下单次口服受试制剂四烯甲萘醌软胶囊（规格：15 mg，持证商：昆明邦宇制药有限公司）与参比制剂四烯甲萘醌软胶囊（固力康®，规格：15 mg，持证商：Eisai Co.,Ltd.）在健康参与者体内的药代动力学特征，评价空腹状态口服两种制剂的生物等效性。次要研究目的：评估受试制剂四烯甲萘醌软胶囊（规格：15 mg）和参比制剂四烯甲萘醌软胶囊（固力康®，规格：15 mg）在健康参与者中的安全性。

[Translation]

To study the pharmacokinetic characteristics of the test preparation tetrafenone soft capsule (specification: 15 mg, licensee: Kunming Bangyu Pharmaceutical Co., Ltd.) and the reference preparation tetrafenone soft capsule (Gulikang®, specification: 15 mg, licensee: Eisai Co., Ltd.) in healthy participants after a single oral administration under fasting state, and to evaluate the bioequivalence of the two preparations when taken orally under fasting state. Secondary study objectives: To evaluate the safety of the test preparation tetrafenone soft capsule (specification: 15 mg) and the reference preparation tetrafenone soft capsule (Gulikang®, specification: 15 mg) in healthy participants.

Start Date20 Mar 2025

Sponsor / Collaborator

Kunming Bangyu Pharmaceutical Co., Ltd.

NCT06707909

/ RecruitingPhase 4IIT

The Local Effect of Vitamin K2 on Bone Remodeling in Socket Preservation of Mandibular Single Rooted Teeth Randomized Clinical Trail

This study is a randomized controlled trial comparing the effects of socket grafting with crushed vitamin K2 (menaquinone)capsules versus no grafting on bone density and socket dimensions following tooth extraction. Patients are randomly assigned to one of two groups:
Study Group (Group I): Patients receive socket grafting with crushed vitamin K2 (menaquinone) capsules. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed to stabilize the graft material and achieve soft tissue stability.
Control Group (Group II): Patients undergo socket healing without grafting. The socket is covered with an absorbent sponge, and non-resorbable sutures are placed over it.
Outcome measures include bone socket dimensions evaluated immediately after extraction with graft material, as well as assessment after 4 months using cone beam computed tomography (CBCT) radiographs. Additionally, core biopsies are taken at the time of implant placement.

Start Date15 Feb 2025

Sponsor / Collaborator

Cairo University

100 Clinical Results associated with Menatetrenone

100 Translational Medicine associated with Menatetrenone

100 Patents (Medical) associated with Menatetrenone

1,889

Literatures (Medical) associated with Menatetrenone

01 Jun 2025·JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Low phylloquinone intake deteriorates endothelial function in normolipidemic and dyslipidaemic mice

Article

Author: Kus, Kamil ; Sternak, Magdalena ; Zeber-Lubecka, Natalia ; Przyborowski, Kamil ; Zakrzewska, Agnieszka ; Franczyk-Zarow, Magdalena ; Princen, Hans M G ; Proniewski, Bartosz ; Kulecka, Maria ; Mohaissen, Tasnim ; Strus, Magdalena ; Kwiatkowski, Grzegorz ; Kij, Agnieszka ; Bar, Anna ; Czyzynska-Cichon, Izabela ; Buczek, Elzbieta ; Kostogrys, Renata B ; Kozien, Lucja ; Chlopicki, Stefan ; Kieronska-Rudek, Anna ; Pieterman, Elsbeth J ; Wiecek, Grazyna

While the plasma phylloquinone (PK) concentration is inversely correlated with cardiovascular risk, the involvement of PK in regulating endothelial function has not been directly investigated. Therefore, in this study we assessed the effects of short-term treatment with PK-deficient diets (5-10 weeks) on endothelial function in normolipidemic 14-week-old male C57BL/6JCmd mice and age-matched dyslipidaemic male E3L.CETP mice. Our results show that in normolipidemic mice dietary PK deficiency was associated with a marked reduction of PK levels in the plasma and liver (liquid chromatography-mass spectrometry measurements) and with impaired endothelium-dependent vasodilation assessed in vivo by magnetic resonance imaging (MRI). Dietary PK deficiency-induced endothelial dysfunction was fully reversed by PK supplementation. In dyslipidaemic E3L.CETP mice, dietary PK deficiency exacerbated preexisting endothelial dysfunction. Furthermore, dietary PK deficiency decreased menaquinone-4 (MK-4) levels in the aorta but did not affect blood coagulation (calibrated automated thrombography), microbiota composition (culturing and next-generation sequencing), and gut menaquinone production. In conclusion, our study demonstrated for the first time that sufficient dietary PK intake supports endothelial function in normolipidemic and dyslipidaemic mice indicating nutritional significance of dietary PK in the maintenance of endothelial function in humans.

01 Jun 2025·BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vitamin K2 mitigates cognitive, and motor impairments induced by multiple surgery with anesthesia and analgesia in neonatal stage

Article

Author: Wang, Runjia ; Hou, Qi ; Li, Zhichao ; Zheng, Hui ; Li, Shuai ; Hou, Yu ; Shen, Yuan ; Xu, Xiyuan ; Liu, Qidong ; Ma, Linhui

Anesthesia and analgesia are essential components for surgical procedures. While the neurotoxic effects of multiple anesthesia exposures during brain development are well established, the combined impact of multiple surgery with anesthesia and analgesia exposures on neurodevelopmental remains unknown. In this study, neonatal mice underwent multiple surgery with fentanyl and sevoflurane (MSFS) exposures on postnatal days 6, 8, and 10, resulting in attention deficit hyperactivity disorder (ADHD)-like hyperactivity, impulsive behavior, cognitive impairment, and fine motor dysfunction in adulthood. Additionally, MSFS exposures inhibited neurogenesis in the nucleus accumbens (NAc) by reducing neural stem cells (NSCs) proliferation and differentiation into neurons and astrocytes. Pre-administration of Vitamin K2 (VK2) 30 min before each MSFS procedure significantly mitigated the behavioral impairments and restored neurogenesis. RNA-sequencing revealed that MSFS treatment induced 75 up-regulated and 140 down-regulated differentially expressed genes (DEGs) in the NAc, while VK2 pre-administration resulted in 149 up-regulated and 56 down-regulated DEGs. Among these, 32 DEGs were down-regulated by MSFS but restored by VK2 and 12 DEGs were up-regulated by MSFS but down-regulated by VK2. To identify key regulatory genes modulated by VK2, we performed protein-protein interaction analysis using CytoHubba, which revealed 10 hub genes-DLGAP5, TPX2, KIF20B, PLK1, SGO1, GTSE1, ASPM, CDCA2, BUB1B, and NUSAP1-with critical roles in cell cycle, cell division and NSCs pathways. The expression of hub genes was validated by RT-qPCR and immunofluorescence staining. These findings suggest that MSFS-induces ADHD-like behaviors, cognitive impairment, fine motor dysfunction, impaired neurogenesis and altering genes expression involved in cell cycle, cell division and NSCs pathways, which are rescued by VK2. This study presents the clinically MSFS model for investigating neurodevelopmental toxicity and highlights VK2's potential as a neuroprotective agent in pediatric involving multiple surgery with anesthesia and analgesia.

01 May 2025·Acta Physiologica

Vitamin K preserves gamma‐glutamyl carboxylase activity against carbamylations in uremia: Implications for vascular calcification and adjunct therapies

Article

Author: Grommes, Jochen ; Ziegler, Susanne ; Gombert, Alexander ; Roma, Leticia Prates ; Kuppe, Christoph ; Frisch, Janina ; Kaushik, Suresh ; Floege, Jürgen ; Jankowski, Vera ; de la Puente‐Secades, Sofia ; Kaesler, Nadine ; Kramann, Rafael ; Jankowski, Joachim

Abstract:

Aim:

Vascular calcification contributes to morbidity and mortality in aging and is accelerated in diabetes and in chronic kidney disease. Matrix Gla Protein is a potent inhibitor of vascular calcification, which is activated by the vitamin K‐dependent gamma‐glutamyl carboxylase (GGCX). However, through a currently unidentified mechanism, the activity of GGCX is reduced in experimental uremia, thereby contributing to the promotion of vascular calcifications. In this study, we aim to identify the cause of these functional alterations and to stimulate the enzyme activity by potential GGCX binding compounds as a new avenue of therapy.

Methods:

Two rodent models of experimental uremia and human carotid plaques were assessed for GGCX activity and modifications, as well as calcification. In silico compound screening via BindScope identified potential binding partners of GGCX which were further validated in functional assays for enzymatic activity changes and for in vitro calcification. Mass spectrometry was applied to monitor molecular mass changes of the GGCX.

Results:

Mass spectrometry analysis revealed post‐translational modifications of the GGCX in uremic rats and mice, as well as in calcified human carotid plaques. Functional assays showed that the post‐translational carbamylation of GGCX reduced the enzyme activity, which was prevented by vitamin K2. Chrysin, identified by compound screening, stimulated GGCX activity, reduced calcium deposition in VSMCs, and oxidized GGCX at lysine 517.

Conclusion:

In conclusion, this study clearly demonstrates that the vitamin K‐dependent enzyme GGCX plays a significant role in uremic calcification and may be modulated to help prevent pathological changes.

News (Medical) associated with Menatetrenone

05 May 2025

·www.prnewswire.com

Everwell Health Completes Third Strategic Transaction Within Three Months -- Acquires U.S.-Based American River Nutrition

Science-backed healthy aging ingredients further diversify the Everwell Health portfolio, while adding specialized U.S.-based manufacturing capabilities to produce highly potent bioactives SADDLE BROOK, N.J., May 5, 2025 /PRNewswire/ -- Everwell Health announced it has acquired American River Nutrition (ARN), from Designs for Health. The proprietary and scientifically studied annatto-based extract ingredients and manufacturing technologies from ARN will be integrated into Everwell Health's functional ingredient platform of one-of-a-kind ingredient solutions empowering individuals to look, feel, and perform their best. The acquisition includes patented, branded ingredients, DeltaGold® and GG-Gold®, along with additional functional ingredients and intellectual property in ARN's pipeline. Operations at the Hadley, Massachusetts manufacturing site will continue and Everwell Health plans further investments in the facility to serve as the company's primary Innovation Center. The ingredient DuoQuinol is not part of the transaction, and its ownership will remain with Designs for Health. Nutrition21 (PRNewsfoto/Nutrition21) American River Nutrition, an Everwell Health Company This acquisition of science-backed healthy aging ingredients further diversifies the Everwell Health portfolio. Post this ARN, based in Hadley, MA, was founded in 1998 by Dr. Barrie Tan with a mission focused on the scientific advancement of the health benefits of Bixa orellana, a tropically grown plant commonly known as annatto. The ingredient portfolio includes DeltaGold®, the only tocopherol-free source of tocotrienols offering a range of powerful antioxidant benefits, and GG-Gold® Geranylgeraniol, an important endogenous nutrient that declines as we age, essential for protein synthesis, and the production of key compounds such as testosterone, progesterone, CoQ10, and MK4 (meaquinone-4, a form of vitamin K2). Providing the purest form of annatto-derived ingredients, ARN uses proprietary processes and technologies at a state-of-the-art manufacturing site in Hadley. The ingredients are produced using a specialized distillation process to isolate and concentrate key bioactive compounds without the use of solvents or harsh chemicals. The facility also features an in-house lab for analytical analysis, quality control, and research and development. Steve Rosenman, CEO of Everwell Health stated, "Our acquisition of American River Nutrition reinforces our commitment to providing scientifically substantiated ingredients which support consumers in living life to their fullest potential. These unique and powerful plant-based ingredients further build upon our vision to deliver ingredients that empower all to look, feel, and perform their best. Our customers will benefit from new opportunities that our expanded ingredient portfolio delivers to innovate new products in key health areas including metabolic, cardiovascular, mitochondrial, men's health, muscle, and bone health. Beyond the ingredient portfolio, the vertical integration of ARN's highly specialized manufacturing facility adds value and strengthens our capabilities as we will continue investing in nature-based bioactive ingredients." Amardeep Kahlon, CEO of Designs for Health shared, "Everwell Health shares our commitment to science, quality, and innovation, and we know ARN will thrive under Everwell's leadership. This move positions Designs for Health to further deliver on our core mission of advancing clinical nutrition and integrative health solutions through healthcare practitioners with our core Designs for Health products." All commercial and manufacturing operations will continue without interruption, with ARN operating as 'American River Nutrition, an Everwell Health Company' for the remainder of 2025, before integrating into Everwell Health's portfolio of brands. Throughout this process, ARN's customers and supply chain partners will gain access to the capabilities and expertise of Everwell Health, an organization solely committed to developing exclusive science-backed functional ingredients with exceptional value. ABOUT EVERWELL HEALTH HOLDINGS, LLC Everwell Health aims to help people look, feel, and perform their best by advancing the science of safe, convenient, and attainable functional ingredients. The company adds meaningful value to dietary supplement, food, and beverage brands by offering scientifically substantiated functional ingredient solutions. The company is actively focused on business development partnerships across the functional ingredients market. For more information on Everwell Health, visit: . ABOUT NUTRITION21 Nutrition21, an Everwell Health company, is an industry-leading developer and marketer of one-of-a-kind, science-backed ingredients for use in dietary supplements, functional foods, and beverages that empower individuals to look, feel, and perform their best. Grounded in decades of scientific research, Nutrition21 places efficacy and safety at the forefront of their efforts to create unique, patented products that are both safe and clinically effective. More than 50 scientific publications have been fielded in their portfolio—all working to build consumer trust and prove the efficacy and safety of their ingredients. Ingredients from Nutrition21 empower consumers in the pursuit of proactive health and optimal performance in every body through any stage of life. By understanding consumer needs and interests, such as sports nutrition, weight management, cognitive health, beauty from within, and more, Nutrition21 ingredients are optimized to support health outcomes and help individuals live their best life. For more information on Nutrition21, visit: Nutrition21.com. ABOUT DESIGNS FOR HEALTH, INC. Family-owned Designs for Health, Inc. offers high-quality nutritional supplements and functional foods to health care professionals and their patients. Guided by its founding philosophy of "Science-First™," the company holds an unwavering commitment to creating research-driven formulations with meaningful quantities of functional ingredients that maximize the potential for successful health outcomes. For over 35 years, Designs for Health has been many healthcare professionals' trusted source for not only product innovation but also leadership in clinical education and practice development solutions. For more information on Designs for Health, visit: . Media Contact: Carrie Livingston, VP Media Relations, ColinKurtis Advertising, [email protected], 815-519-8302 SOURCE Everwell Health WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Acquisition

04 Jan 2024

·www.globenewswire.com

Healthy Extracts Launches First Anti-Aging Formulation, LONGEVITY

LAS VEGAS, Jan. 04, 2024 (GLOBE NEWSWIRE) -- Healthy Extracts Inc. (OTCQB: HYEX), a platform for acquiring, developing, patenting, marketing, and distributing plant-based nutraceuticals that target select high-growth categories within the multibillion-dollar nutraceuticals market, has launched LONGEVITY Anti-Aging™, a new proprietary formulation designed to support skin vitality, arterial flexibility, and cellular and joint health. LONGEVITY Anti-Aging is available to order today on BergametNA.com. In celebration of the launch, for a limited time you can buy two and get one free. You can also subscribe and save 15% on every order. The formulation is a special blend of the most powerful anti-aging warriors that include trans-resveratrol, quercetin, vitamin D, and vitamin K2. These substances are known to boost blood flow and circulation, reduce the deleterious effects of misplaced calcium in the body, and slow the effects of aging with powerful antioxidants. “LONGEVITY Anti-Aging complements our growing heart health product portfolio which supports a holistic approach to anti-aging like healthy skin,” noted Healthy Extracts president, Duke Pitts. “We anticipate this new product, along with the others we’re planning to launch early this year, will continue drive our growth and market expansion, as they leverage our multiple sales and distribution channels and existing customer base.” LONGEVITY Anti-Aging represents a holistic approach to aging, with a proprietary blend focused on providing the nutrition the body needs for optimal health. It is formulated to help sustain vitality, support heart health, ensure robust bone strength, and contribute to a healthier aging process. The formulation is vegan friendly, non-GMO, gluten-free, and produced and tested by certified U.S. facilities. Key substances and benefits: Trans-resveratrol and quercetin are powerful antioxidants that shield cells from aging and oxidative stress for more youthful function.Vitamin D and K2 are vital for proper calcium absorption and distribution, bolstering bone health and reducing osteoporosis risk.For heart health, ingredients like vitamin K2 and trans-resveratrol are key in maintaining cardiovascular wellness, helping to lower the risk of heart ailments.Vitamin D and quercetin also strengthens immune defense, enhancing protection against infection and disease. LONGEVITY Anti-Aging is your ally for overall longevity, blending ingredients renowned for their anti-aging benefits that support a longer, healthier life. LONGEVITY Anti-Aging introduction follows the recent official launch of BERGAMET SLEEP BREATHING SUPPORT™ , a natural supplement designed to support respiratory function for deeper, more restorative sleep. Given the better than anticipated initial sales of this new product, it is on track to become one of the company’s best sellers in 2024. Healthy Extracts’ full line of natural heart health formulations address the fast-growing, multi-billion dollar heart-health supplement market which is projected to grow at 5.9% CAGR to reach $24.8 billion by 2027, according to ResearchAndMarkets. To learn more about Healthy Extracts’ full line of clinically-backed, natural brain and hearth health products, go to bergametna.com or tryubn.com. About Healthy Extracts “Live Life Young Again” Healthy Extracts Inc. is a platform for acquiring, developing, researching, patenting, marketing, and distributing plant-based nutraceuticals. The company’s subsidiaries, BergametNA™ and Ultimate Brain Nutrients™ (UBN), offer nutraceutical natural heart and brain health supplements. This includes the only heart health supplement distributed in North America containing Citrus Bergamot SuperFruit™. This superfruit has the highest known concentration of polyphenols and flavonoids. UBN’s KETONOMICS® proprietary formulations, which have been designed to enhance brain activity, focus, headache and cognitive behavior, provide many sales and intellectual property licensing opportunities. For more information visit: healthyextractsinc.com, bergametna.com or tryubn.com. Forward-Looking Statements and Safe Harbor Notice All statements other than statements of historical facts included in this press release are "forward-looking statements" (as defined in the Private Securities Litigation Reform Act of 1995). Such forward-looking statements include our expectations and those statements that use forward-looking words such as "projected," "expect," "possibility" and "anticipate." The achievement or success of the matters covered by such forward-looking statements involve significant risks, uncertainties and assumptions. Actual results could differ materially from current projections or implied results. Investors should read the risk factors set forth in the Company's Annual Report on Form 10-K filed with the SEC on March 31, 2023, and future periodic reports filed with the SEC. All of the Company's forward-looking statements are expressly qualified by all such risk factors and other cautionary statements. The Company cautions that statements and assumptions made in this news release constitute forward-looking statements and make no guarantee of future performance. Forward-looking statements are based on estimates and opinions of management at the time statements are made. The information set forth herein speaks only as of the date hereof. The Company and its management undertake no obligation to revise these statements following the date of this news release. Food & Drug Administration Disclosure The product and formulation featured in this release is not for use by or sale to persons under the age of 12. This product should be used only as directed on the label. Consult with a physician before use if you have a serious medical condition or use prescription medications. A doctor’s advice should be sought before using this and any supplemental dietary product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. BergametNA™, Ultimate Brain Nutrients™, UBN™, Citrus Bergamot SuperFruit™ and F4T® are registered trademarks of Healthy Extracts Inc.™ Company ContactDuke Pitts, PresidentHealthy Extracts Inc.Tel (720) 463-1004Email contact Investor ContactRonald Both CMA Investor RelationsTel (949) 432-7566Email contactMedia Contact:Tim RandallCMA Media RelationsTel (949) 432-7572Email Contact A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/200b922a-c04a-45ab-b819-dba1b9750c42

Drug Approval

07 Mar 2023

·www.prnewswire.com

NUTRISHOP® Launches Comprehensive Heart Formula To Support Cardiovascular Health

Heart Formula by Nu-Tek Nutrition® is now available exclusively at Nutrishop HENDERSON, Nev., March 7, 2023 /PRNewswire/ -- Nutrishop, a leading national retail nutrition franchise specializing in dietary and nutritional supplements, vitamins and wellness, is proud to announce the launch of Heart Formula by Nu-Tek Nutrition®. This product's comprehensive approach to cardiovascular health contains some of the most sought-after, heart-healthy ingredients on the market. And, it is now available exclusively through Nutrishop. Continue Reading "We all have only one heart, and it is never too early to start caring for it." Tweet this Let’s face it, wellness is the new fitness. Introducing Heart Formula by Nu-Tek Nutrition. It’s loaded with heart-healthy ingredients like Olive Leaf Extract, Garlic, Organic Beet Root, Turmeric, CoEnzymeQ10, and more. Let’s be as healthy on the inside as we look on the outside. "We all know the importance of a healthy heart, yet some of us may overlook it in pursuit of a fit physique. However, the importance of a healthy heart cannot be overstated," said Nutrishop Founder and CEO Bryon McLendon. "If the interior of our bodies is not functioning properly, nothing on the exterior matters. Nu-Tek Nutrition's Heart Formula is the perfect solution to support our body's most important muscle." Loaded with heart-healthy ingredients such as Olive Leaf Extract, Garlic Extract, Turmeric Root, Hawthorn Berry, Organic Beet Root, CoEnzymeQ10, Grape Seed Extract, and Vitamin K2, Heart Formula is easy to incorporate into any wellness routine. In addition to maintaining a healthy body weight, regularly engaging in cardio exercise (brisk walking counts!), reducing stress and consuming good-for-your-heart foods, such as salmon, vegetables, whole grains, nuts and seeds, simply take three capsules daily or as directed by your healthcare professional. "We all have only one heart, and it is never too early to start caring for it," McLendon said. "With Heart Formula by Nu-Tek Nutrition combined with a healthy lifestyle, you're definitely stepping in the right direction." To learn more or purchase Heart Formula, visit NutrishopUSA.com or stop by any Nutrishop location nationwide. About Nu-Tek Nutrition ®: For nearly 20 years, Nu-Tek Nutrition has dedicated itself to building the foundation of health and wellness with innovative, complex powders like Supergreens, Superfruits, and Daily Detox and supplements like Gut Formula and Super Multi+. The brand's products are backed by over 25 years of formulating experience to offer the best wellness supplementation and help people live their best lives. About NUTRISHOP ® Since 2003, NUTRISHOP® has helped countless individuals live a fit, healthy, happy lifestyle. Nutrishop stores offer customers a low-price guarantee on a wide array of cutting-edge dietary supplements along with exceptional, individualized customer service, easy-to-follow meal plans, body composition assessment tools, and sound nutritional guidance. The Nutrishop business model focuses primarily on franchisee-owned and operated stores that provide consumers with the tools required to achieve their health and fitness goals. For more information, visit NutrishopUSA.com and follow on Instagram @NutrishopUSA. To learn more about becoming a Nutrishop franchisee, visit NutrishopFranchise.com. SOURCE Nutrishop

100 Deals associated with Menatetrenone

External Link

KEGG	Wiki	ATC	Drug Bank
D00100	Menatetrenone	B02BA	DB12148

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Osteoporosis, Postmenopausal	China	Eisai Co., Ltd.	21 Jul 2013
Vitamin K Deficiency Bleeding	Japan	Sannova KK	25 May 2012
Vitamin K Deficiency Bleeding	Japan	Alfresa Pharma Corp.	25 May 2012
Pain	China	Eisai Co., Ltd.	29 Jun 2010
Osteoporosis	Japan	Eisai Co., Ltd.	30 Jun 1995
Hemorrhage	Japan	Eisai Co., Ltd.	29 Jun 1972
Hypoprothrombinemias	Japan	Eisai Co., Ltd.	29 Jun 1972

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Hepatocellular Carcinoma	Phase 3	Japan	Eisai Co., Ltd.	01 Mar 2004
Cerebral Hemorrhage	Preclinical	Japan	Kumamoto University	10 May 2024
Leukemia	Preclinical	Japan	Tokyo Medical University	16 Nov 2007

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


WCO_IOF_ESCEO2023	Not Applicable	Tendinopathy MGP \| P \| ALP ... View more	40	Vitamin K2 (MK-7) 120 g/d	hzleybglkj(qrynrtdenj) = gszddjwing wswvsftscd (ozawfixjze )	Positive	04 May 2023
AVADEC (ESC2022)	Not Applicable	Coronary Artery Disease	389	Vitamin K2 (720 μg/day) and Vitamin D (25 μg/day)	qigqiguiuz(lfosbukhwc) = bdzfwapemu impofjlxur (bduemlkixv ) View more	-	28 Aug 2022
				vitamin k2	qigqiguiuz(lfosbukhwc) = ikbhxsvqvz impofjlxur (bduemlkixv ) View more
MO789 (ERA2022)	Not Applicable	matrix Gla protein (MGP)	120	Vitamin K1	fobxamgbre(dklvjfvazb) = gyenoliqlg bcticakljj (kyotvdiodp )	Positive	03 May 2022
				Vitamin K2	fobxamgbre(dklvjfvazb) = ahibsfqdfl bcticakljj (kyotvdiodp )
WCO_IOF_ESCEO2022	Not Applicable	Osteoporosis, Postmenopausal	46	Vitamin K2 (Women with Postmenopausal Osteoporosis)	vrumpjittz(vooxfdzmyu) = zdrbhhivxu vypmsmlnwf (luslytveux, 10.09) View more	-	24 Mar 2022
				Vitamin K2 (Postmenopausal Women without Osteoporosis)	vrumpjittz(vooxfdzmyu) = evnbxcsxwo vypmsmlnwf (luslytveux, 6.94) View more
CHANGE IN HEMODYNAMIC PARAMETERS AND CAROTID STIFFNESS INDICES AFTER VITAMIN K2 SUPPLEMENTATION (ESH2021)	Not Applicable	Diabetes Mellitus, Type 2	18	Vitamin K2 (Menaquinone-7) 75 μg	bikpaoscvo(eicvxkrshl) = xdnbgnzgcw agngdjzgaw (kgtprfligq ) View more	Negative	01 Apr 2021
FP608 (ERA2019)	Not Applicable	Vascular Calcification uncarboxylated-MGP	102	Vitamin K2 supplementation (200μg/day)	rkiinxrmsi(sumkqrbyjk) = yuagpsojdq tkmoldthix (szsrlaeqnx ) View more	Negative	13 Jun 2019
				Vitamin K2 (Control (no treatment))	rkiinxrmsi(sumkqrbyjk) = rmecupolok tkmoldthix (szsrlaeqnx ) View more
NCT02876354 (Pubmed)	Phase 4	Hemodialysis complication	50	Vitamin K2 (menaquinone-7)	pqpcjdqxuh(agxtdpvahv) = wyotgloiiy grndevkvbf (plucgskskl )	-	07 Jun 2017
NCT02876354 (MO021, ERA2017)	Phase 4	Hemodialysis complication dp-ucMGP \| MGP \| vitamin K2	50	Vitamin K2 (menaquinone-7)	hgqdhoiswr(egpehpryqm) = kszbbhpqzd azyiaivnrw (krxjlhxgmb )	Positive	26 May 2017
NCT04247087 \| NCT01101698 (Pubmed \| Pol Arch Intern Med)	Phase 4	Chronic Kidney Diseases	42	Vitamin K2 + cholecalciferol (K+D)	qbirzgkhcs(ibizdoqtlw) = pokmmpsqbg whhamockgm (dbqkatnafx )	-	01 Jan 2015
				Cholecalciferol (D)	qbirzgkhcs(ibizdoqtlw) = gjajupfjxg whhamockgm (dbqkatnafx )
SP230 (ERA2014)	Not Applicable	Chronic Kidney Diseases dp-ucMGP positive \| MGP positive \| osteocalcin	42	Vitamin K2 (menaquinone-7, MK-7) + cholecalciferol	lqssvynrau(icdaxpuomq) = bwpsbnemto dfwlfgnslq (poamyrnilr, 1077.1±507.7) View more	Positive	01 May 2014
				Vitamin D	lqssvynrau(icdaxpuomq) = dmbvmkdkzt dfwlfgnslq (poamyrnilr, 793.9±400.3) View more

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Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis