Delving into the Latest Updates on Scopolamine Butylbromide with Synapse

For outpatient hysteroscopy (OH), it is recommended to take a standard dose of NSAIDs or more hyoscine-n butyl bromide (HBB) an hour prior to the procedure to minimize pain during the first postoperative hour. As there is currently no clear consensus in the literature regarding the best approach to pain management associated with office hysteroscopy procedures. This Phase 4 study is being conducted to evaluate the effectiveness of oral ibuprofen alone and in combination with HBB to determine the most appropriate strategy for improving pain perception in outpatients.

Start Date01 Oct 2024

Sponsor / Collaborator

ASST Fatebenefratelli Sacco

NCT06056869

/ RecruitingNot ApplicableIIT

Effect of Hyoscine- Bromide on Duration of the First Stage of Labor

Spasmolytic drugs are frequently used in delivery rooms to overcome cervical spasms and thus reduce the duration of labor. The aim of this randomized double blind placebo controlled trial is to study the efficacy of hyoscine butylbromide (HBB) for shortening of the first stage of labor in primigravid women.

Start Date27 Sep 2023

Sponsor / Collaborator

Ain Shams University

NCT06207539

/ CompletedEarly Phase 1IIT

Use Of Hyoscine as An Adjuvant Treatment on Shortening the Time of Abortion Induction in Second Trimester: Randomized Controlled Clinical Trial

To compare between the effects of misoprostol with hyoscine N-butyl bromide and misoprostol alone on shortening the time of abortion induction in the second trimester.

Start Date01 Dec 2022

Sponsor / Collaborator

Ain Shams Maternity Hospital

100 Clinical Results associated with Scopolamine Butylbromide

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100 Translational Medicine associated with Scopolamine Butylbromide

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100 Patents (Medical) associated with Scopolamine Butylbromide

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1,746

Literatures (Medical) associated with Scopolamine Butylbromide

01 Feb 2025·JOURNAL OF ETHNOPHARMACOLOGY

Dihuang Yinzi improves scopolamine-induced learning and memory impairment by regulating plasma exosome-derived BDNF

Article

Author: Zhang, Junlong ; He, Wenbin ; Du, Yuzhong ; Li, Qinqing ; Wang, Wenting ; Su, Wenna

ETHNOPHARMACOLOGICAL RELEVANCE:

Dihuang Drink (DHD), formulated by Liu Hejian during the Yuan Dynasty, is listed as one of the first ancient classical prescriptions by the National Medical Products Administration of China. It is commonly used for the prevention and treatment of Alzheimer's disease (AD). This study further investigates the therapeutic effects and potential mechanisms of DHD in AD.

AIM OF THE STUDY:

This study aimed to evaluate the cognitive improvement effects of DHD on scopolamine (SCOP)-induced memory impairment in mice and to explore its anti-AD mechanisms mediated by exosomes.

MATERIALS AND METHODS:

A cognitive impairment model was established in C57BL/6J mice via intraperitoneal injection of SCOP (1 mg/kg) for 21 consecutive days, followed by DHD intervention to assess its effects on learning, memory, hippocampal synaptic density, and the cholinergic system. SD rats were gavaged with DHD (22.00 g/kg) for 7 days, and plasma exosomes were extracted. These exosomes were injected into SCOP-treated mice (2 mg/kg, every other day for 14 days, 7 injections) to verify the role of exosomes in improving cognitive function. Behavioral performance and brain ChAT and BDNF levels were measured.

RESULTS:

DHD improved learning and memory in SCOP model mice, attenuated neuronal loss and decreases in dendritic spines induced by scopolamine, and modulated the expression of BDNF, SYN-1, PSD95, and M1 mAChR. DHD-derived plasma exosomes further enhanced learning and memory function and significantly increased brain ChAT activity and BDNF levels.

CONCLUSIONS:

DHD may alleviate cognitive impairment in SCOP model mice, potentially through exosome-mediated neuroprotection.

01 Jan 2025·AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Early exposure to a cholinergic receptor blocking agent mitigates adult obesity and protects pancreatic islet function in male rats

Article

Author: de Freitas Mathias, Paulo Cezar ; Pavanello, Audrei ; Martins, Isabela Peixoto ; Moreira, Veridiana Mota ; Tófolo, Laize Peron ; de Lima, Lucas da Silva ; Ribeiro, Tatiane Aparecida ; Matiusso, Camila Cristina Ianoni ; Malta, Ananda ; Almeida, Douglas Lopes

High insulin levels during early life may lead to the late development of obesity and diabetes. We investigated whether attenuation of insulin levels by using an antimuscarinic agent could prevent diet-induced obesity and diabetes. Rats’ early exposure to an antimuscarinic agent reduced insulin levels during the lactation period and promoted protection against obesity and metabolic dysfunctions. Independent of the programming mechanisms, insulin levels during early life may be a defining factor of health or diseases later in life.

01 Jan 2025·GUT

Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study

Article

Author: Atkinson, David ; Zdanaviciene, Ausra ; Hoad, Caroline Louise ; Marciani, Luca ; Gowland, Penny ; Coupland, Carol ; Dinning, Philip ; Scott, Mark ; Wilkinson-Smith, Victoria ; Sansone, Stefano ; Knowles, Charles H ; Taylor, Stuart A ; Menys, Alex ; Spiller, Robin C ; Wiklendt, Lukasz ; Corsetti, Maura

Background:

Colonic motility in constipation can be assessed non-invasively using MRI.

Objective:

To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response.

Design:

Part 1: 44 healthy volunteers (HVs), 43 patients with irritable bowel syndrome with constipation (IBS-C) and 37 with functional constipation (FC) completed stool diaries and questionnaires and underwent oral macrogol (500–1000 mL) challenge. Whole gut transit time (WGTT), segmental colonic volumes (CV), MRI-derived Motility Index and chyme movement by ‘tagging’ were assessed using MRI and time to defecation after macrogol recorded. Left colonic HRCM was recorded before and after a 700 kcal meal. Patients then proceeded to Part 2: a randomised cross-over study of 10-days bisacodyl 10 mg daily versus hyoscine 20 mg three times per day, assessing daily pain and constipation.

Results:

Part 1: Total CVs median (range) were significantly greater in IBS-C (776 (595–1033)) and FC (802 (633–951)) vs HV (645 (467–780)), p<0.001. Patients also had longer WGTT and delayed evacuation after macrogol. IBS-C patients showed significantly reduced tagging index and less propagated pressure wave (PPW) activity during HRCM versus HV. Compared with FC, IBS-C patients were more anxious and reported more pain. Abnormally large colons predicted significantly delayed evacuation after macrogol challenge (p<0.02), impaired manometric meal response and reduced pain with bisacodyl (p<0.05).Part 2: Bisacodyl compared with hyoscine increased bowel movements but caused more pain in both groups (p<0.03).

Conclusion:

An abnormally large colon is an important feature in constipation which predicts impaired manometric response to feeding and treatment responses. HRCM shows that IBS-C patients have reduced PPW activity.

Trial registration number:

The study was preregistered on ClinicalTrials.gov, Reference:NCT03226145.

4

News (Medical) associated with Scopolamine Butylbromide

22 Oct 2024

·www.echemi.com

Sanofi's Negotiations to Sell Opella Stake Exposed, €16 Billion Deal Triggers Threat of Strikes from French Unions!

Sanofi is currently in "exclusive talks" with U.S. private equity firm Clayton, Dubilier & Rice (CD&R) to sell a 50% controlling stake in its consumer healthcare business Opella. The French government has confirmed a commitment from CD&R, based in New York, to ensure that Opella's production facilities in France will remain intact and that there will be no disruption to the supply of drugs to the country, removing a potential obstacle to the deal. Sanofi said the proposed deal valued Opella at 16 billion euros and stressed that CD&R's offer for a 50 percent stake was "binding and fully funded." In addition, French public sector investment bank Bpifrance plans to buy a 2% stake in Opella and take a seat on its board. The deal, expected to close "at the earliest" in the second quarter of next year, will see Sanofi step up its investment in innovative drugs and vaccines and mark the French drugmaker's formal joining the ranks of biopharmaceutical giants Johnson & Johnson, Pfizer and GlaxoSmithKline. "With this transaction, Sanofi will be able to focus even more on providing innovative treatments for patients suffering from debilitating or fatal diseases and viruses, such as RSV, COPD or multiple sclerosis," Sanofi CEO Paul Hudson said in a press release. Analysts at ODDO BHF supported the decision, arguing that a divestiture or partial divestiture of the consumer business would allow Sanofi to reallocate capital to research and business development, and recommended that Sanofi use some of the capital to offset the financial impact of the divestiture through share buybacks. Hudson first floated the idea of spinning off the consumer health division last October. Since then, CD&R and PAI Partners, another private equity giant, have made separate bids for Opella. Earlier this month, Reuters reported that CD&R had made a formal offer to buy 50 percent of Opella's consumer healthcare business. Last week, Sanofi said it was surprised by PAI's move to raise its 200 million euro offer after the deadline. Sanofi's commitment that Opella would continue to operate in France followed a call by French unions for workers to strike on Thursday in protest at the deal. Opella is a leader in over-the-counter medicines, vitamins, minerals and supplements. Its product line includes the well-known antihistamine Allegra, non-opioid painkiller Doliprane, stomach cramping relief Buscopan, Selsun Blue shampoo, and pain treatments Icy Hot and Gold Bond, among others. Opella employs 11,000 people in 100 countries and generated sales of 5.2 billion euros ($5.6 billion) in 2023, accounting for 11% of Sanofi's total revenue. In addition, the company operates 13 production sites and four research and development innovation centers.

Acquisition

23 Oct 2023

·www.fiercepharma.com

EU authorities fine Boehringer, others for operating drug-ingredient 'cartel'

All six companies “admitted their involvement in the cartel and agreed to settle the case,” the European Commission said in a release. Five pharmaceutical companies, including the global player Boehringer Ingelheim, have landed in hot water for running a "cartel" to dominate the market for a specific drug ingredient in Europe. The European Commission (EC) is fining Alkaloids of Australia, Alkaloids Corporation, Boehringer, Linnea and Transo-Pharm a total of €13.4 million ($14.2 million) to settle claims that the companies agreed to fix prices and allocate business on the pharmaceutical component N-Butylbromide Scopolamine/ Hyoscine (SNBB), which is used to make the decades-old abdominal antispasmodic Buscopan and its generics. Boehringer received the largest fine by far, settling with the EC for €10.4 million. A spokesperson for Boehringer said the company "accepts the settlement decision and remains committed to fair competition, integrity, and compliance." "We have a zero-tolerance policy for any illegal or illicit business practices and are dedicated to always doing the right thing," the spokesperson added. Notably, C2 Pharma—which prides itself on tackling human rights, labor, the environment and corruption—has dodged all fines for blowing the whistle on the cartel to the EC. All six companies “admitted their involvement in the cartel and agreed to settle the case,” the European Commission said in a press release. The companies were accused of conspiring to fix the minimum sales price of SNBB, allocating quotas and exchanging “commercially sensitive” information, the EC said. The behavior ran from late 2005 to Sept. 17, 2019, according to authorities. Notably, Boehringer stopped its participation in the cartel at the end of 2014, with whistleblower C2 Pharma calling it quits in February of 2016. The EC said this is the first time it’s sanctioned a pharmaceutical cartel over an active pharmaceutical ingredient (API). The agency worked in tandem with Swiss and Australian competition authorities to level the charges. A seventh company, Alchem, is also being investigated but decided not to settle. Proceedings against that company will continue in tandem with Europe’s cartel procedure, the EC said.

Patent InfringementBiosimilar

20 Oct 2023

·endpts.com

A first for the European Commission: Five pharma companies fined $14M for API price fixing

The European Commission on Thursday announced a first for its regulation of the pharma industry: It’s fining five pharma companies — Alkaloids of Australia, Alkaloids Corporation, Boehringer Ingelheim, Linnea and Transo-Pharm — €13.4 million ($14.2 million) for colluding to fix the price of a pharmaceutical ingredient used in a drug to treat stomach cramps. The Commission said its investigation revealed that six companies — the sixth company C2 Pharma revealed the price fixing to the Commission and was not fined — coordinated and agreed to fix the minimum sales price of the ingredient, known as N-butylbromide scopolamine/hyoscine, which is commonly used in the antispasmodic drug Buscopan as well as in its generic versions. The ingredients were shipped to customers such as distributors and generic drugmakers, and the companies collaborated to allocate quotas.

100 Deals associated with Scopolamine Butylbromide

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External Link

KEGG	Wiki	ATC	Drug Bank
D00138	Scopolamine Butylbromide	S01FA02 N05CM05 A04AD01	DB09300

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Gastrointestinal spasm	AU	Sanofi /Consumer Healthcare Products/	26 Sep 1991
Renal Colic	AU	Sanofi /Consumer Healthcare Products/	26 Sep 1991
Spasm biliary	AU	Sanofi /Consumer Healthcare Products/	26 Sep 1991
Motion Sickness	US	Baxter Healthcare Corp.	31 Dec 1979
Postoperative Nausea and Vomiting	US	Baxter Healthcare Corp.	31 Dec 1979
Habit Spasms	JP	Sanofi KK	17 Mar 1955

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Intestinal Diseases	Phase 3	CN	Boehringer Ingelheim GmbH	01 Aug 2013
Abdominal Pain	Phase 3	-	Boehringer Ingelheim GmbH	01 Nov 2008
Gastralgia	Phase 3	-	Boehringer Ingelheim GmbH	01 Nov 2008
Myalgia	Phase 3	-	Boehringer Ingelheim GmbH	01 Nov 2008
Colic	Phase 2	-	Boehringer Ingelheim GmbH	01 Apr 2006
Muscle Cramp	Phase 2	-	Boehringer Ingelheim GmbH	01 Apr 2006

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00932737 (CTgov)	Phase 2	Abdominal Pain \| Muscle Cramp	197	Placebo	bcbwsjpmfr(hkmqggksbv) = huadrfumol dkqwillhvs (triyuphhwp, poubtmrkak - bflumdkznh) View more	-	03 May 2022
NCT03430362 (not provided, Pubmed \| Arch Gynecol Obstet)	Not Applicable	-	100	Hyoscine butyl bromide (HBB)	opmrfhnezk(xwywxrsigd) = fdzqohftze xxscokdpxv (cghnhavbex )	-	13 May 2021
				Normal saline	opmrfhnezk(xwywxrsigd) = xtavzivued xxscokdpxv (cghnhavbex )
NCT02582307 (Pubmed \| CMAJ)	Phase 3	Colic	236	Hyoscine butylbromide	bpsrexvaid(gtpsrupofl) = rihzizkxmh ycfyhrbpud (kszszwdzel ) View more	-	30 Nov 2020
				Acetaminophen	bpsrexvaid(gtpsrupofl) = kkujqlrtgn ycfyhrbpud (kszszwdzel ) View more
NCT01734902 (CTgov)	Phase 1	-	30	Hyoscine Butylbromide (Hyoscine Butylbromide Drops (T))	cdqudixzky(jlpdigouqo) = bnesjvvpms egwfqpozug (rqabldwntt, lkeyuqgeyu - ikfacndkxz) View more	-	23 Apr 2019
				Buscopan (Buscopan® Tablet (R))	cdqudixzky(jlpdigouqo) = bjruczugmh egwfqpozug (rqabldwntt, dnissjthtp - wwobfukvrx) View more
NCT03029650 (CTgov)	Phase 4	-	26	Intravenous scopolamine hydrobromide+Transderm Scop® (Transderm Scop®)	fieiiilmir(eljqvwocdb) = yrlgetjuav omhvnigftn (bbooijtbij, ndlxvvwsig - ycqzthldan) View more	-	21 Jun 2018
				Intravenous scopolamine hydrobromide+Transderm Scop® (Intravenous Scopolamine Hydrobromide)	fieiiilmir(eljqvwocdb) = phecuocglf omhvnigftn (bbooijtbij, oysdbixyxh - fyhvbtkvsx) View more
NCT02242305 (CTgov)	Phase 3	Abdominal Pain \| Myalgia \| Gastralgia	302	Placebo+Hyoscine Butylbromide - Tablet (Hyoscine Butylbromide - Tablet)	uahbbxmlac(yzrmgfetxn) = exogxlfaqp oyvvryhwvc (bhcopkrqmz, fymycouidw - fpgyglcgbg) View more	-	27 Jul 2017
				Placebo+Hyoscine Butylbromide - Capsule (Hyoscine Butylbromide - Capsule)	uahbbxmlac(yzrmgfetxn) = stftgjcjsl oyvvryhwvc (bhcopkrqmz, qcykcrwllb - xxebhjfcmy) View more
NCT02516098 (CTgov)	Phase 1	-	56	Buscopan (Buscopan® (REF))	eplprlgiuw(nubjjmhlbl) = jskstwjkdn yqdnyvudut (spynoagcxg, kijfewidza - hayovtxmvc) View more	-	13 Feb 2017
				Buscapina (Buscapina® (T))	eplprlgiuw(nubjjmhlbl) = kcoivlgmfy yqdnyvudut (spynoagcxg, sgfthloewy - cqmbdcfmwo) View more
NCT01929044 (CTgov)	Phase 3	Intestinal Diseases \| Gastralgia	299	Buscopan® (hyoscine butylbromide)	uzwgirtrcw(nayhxczkqp) = rryulbfgpi jneqgkuqzm (cyqsoovtds, rmqpowiept - dpbfroygub) View more	-	08 Mar 2016
NCT01281501 (CTgov)	Phase 4	Dyspepsia \| Acute Pain	87	Hyoscine butylbromide+Oral antacid+Normal Saline (Conventional)	msgopkpfok(sygdpgenxf) = hshtbjselk sntbuiedlo (ibannbtngn, vkotzrfqox - vlsnqibeim) View more	-	27 Jul 2012
				Hyoscine butylbromide+Oral antacid+Pantoprazole (Pantoprazole)	msgopkpfok(sygdpgenxf) = weqgalfkir sntbuiedlo (ibannbtngn, ubhjpwcnzm - omgreesrcb) View more
ISRCTN25405865 (Pubmed \| Gastrointest Endosc)	Not Applicable	-	674	Hyoscine N-butylbromide	fvalgcszet(jngkvasviw) = wwupxmabkw bkqnmmosqq (bdrfqxyvcb ) View more	Negative	01 Apr 2012
				Placebo	fvalgcszet(jngkvasviw) = cuwecoypmj bkqnmmosqq (bdrfqxyvcb ) View more