Delving into the Latest Updates on Scopolamine Butylbromide with Synapse

For outpatient hysteroscopy (OH), it is recommended to take a standard dose of NSAIDs or more hyoscine-n butyl bromide (HBB) an hour prior to the procedure to minimize pain during the first postoperative hour. As there is currently no clear consensus in the literature regarding the best approach to pain management associated with office hysteroscopy procedures. This Phase 4 study is being conducted to evaluate the effectiveness of oral ibuprofen alone and in combination with HBB to determine the most appropriate strategy for improving pain perception in outpatients.

Start Date01 Oct 2024

Sponsor / Collaborator

ASST Fatebenefratelli Sacco

NCT06056869 / RecruitingNot ApplicableIIT

Effect of Hyoscine- Bromide on Duration of the First Stage of Labor

Spasmolytic drugs are frequently used in delivery rooms to overcome cervical spasms and thus reduce the duration of labor. The aim of this randomized double blind placebo controlled trial is to study the efficacy of hyoscine butylbromide (HBB) for shortening of the first stage of labor in primigravid women.

Start Date27 Sep 2023

Sponsor / Collaborator

Ain Shams University

NCT06207539 / CompletedEarly Phase 1IIT

Use Of Hyoscine as An Adjuvant Treatment on Shortening the Time of Abortion Induction in Second Trimester: Randomized Controlled Clinical Trial

To compare between the effects of misoprostol with hyoscine N-butyl bromide and misoprostol alone on shortening the time of abortion induction in the second trimester.

Start Date01 Dec 2022

Sponsor / Collaborator

Ain Shams Maternity Hospital

100 Clinical Results associated with Scopolamine Butylbromide

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100 Translational Medicine associated with Scopolamine Butylbromide

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100 Patents (Medical) associated with Scopolamine Butylbromide

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1,644

Literatures (Medical) associated with Scopolamine Butylbromide

01 Jan 2025·JOURNAL OF ETHNOPHARMACOLOGY

Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway

Article

Author: Ni, Mingyue ; He, Yingxi ; Hu, Yanli ; Qi, Yanqiang ; Li, Le ; Wang, Yanyou

ETHNOPHARMACOLOGICAL RELEVANCE:

Carthamus tinctorius L. (Safflower) was believed to have multiple benefits, including antioxidant effects, enhanced learning and memory, and improving neuronal injury. Safflower Yellow(SY) are the main active ingredients of Safflower, displays strong pharmacological potential treatment of Alzheimer's disease(AD). However, its effect on memory impairments remains insufficiently investigated.

AIM OF THE STUDY:

The study aims to investigate the effects of SY on cognitive functions in memory impairments model and to explore the mechanism of its action.

MATERIALS AND METHODS:

We utilized the Morris Water Maze, Step-Through Test, Step-Down Test to assess the potential of SY in ameliorating learning and memory dysfunction caused by SCOP, NaNO₂ and ethanol in mice. Bioinformatic analysis and molecular biological approaches were used to study the related mechanisms of SY on anti-memory impairments.

RESULTS:

The results of the Morris Water Test suggested that SY could shorten the escape latency and the time of the first crossing platform in the mice with memory acquisition and memory consolidation impairments, and increase the platform crossing times. The results of the Step-Though test and Step-Down test showed that the escape latency in the mice was prolonged and the number of errors was reduced after SY treatment. ELISA experiments indicated that SY decreased the AChE activities, increased the ChAT activities, and modulated oxidative stress markers (SOD, MDA, and GSH-PX) in scopolamine-induced mice. Western Blot and Nissl staining showed that SY could activated BDNF/TrkB/CREB signaling pathway and reduced neuronal damage.

CONCLUSION:

The findings present that SY can restore the function of the cholinergic system, inhibit oxidative stress, regulate the expression of upstream and downstream proteins in the CREB/BDNF/TrkB pathway, and alleviate brain tissue damage to improve memory impairment in mice.

01 Jan 2025·GUT

Combined MRI, high-resolution manometry and a randomised trial of bisacodyl versus hyoscine show the significance of an enlarged colon in constipation: the RECLAIM study

Article

Author: Atkinson, David ; Zdanaviciene, Ausra ; Hoad, Caroline Louise ; Marciani, Luca ; Gowland, Penny ; Coupland, Carol ; Dinning, Philip ; Scott, Mark ; Wilkinson-Smith, Victoria ; Sansone, Stefano ; Knowles, Charles H ; Taylor, Stuart A ; Menys, Alex ; Spiller, Robin C ; Wiklendt, Lukasz ; Corsetti, Maura

Background:

Colonic motility in constipation can be assessed non-invasively using MRI.

Objective:

To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response.

Design:

Part 1: 44 healthy volunteers (HVs), 43 patients with irritable bowel syndrome with constipation (IBS-C) and 37 with functional constipation (FC) completed stool diaries and questionnaires and underwent oral macrogol (500–1000 mL) challenge. Whole gut transit time (WGTT), segmental colonic volumes (CV), MRI-derived Motility Index and chyme movement by ‘tagging’ were assessed using MRI and time to defecation after macrogol recorded. Left colonic HRCM was recorded before and after a 700 kcal meal. Patients then proceeded to Part 2: a randomised cross-over study of 10-days bisacodyl 10 mg daily versus hyoscine 20 mg three times per day, assessing daily pain and constipation.

Results:

Part 1: Total CVs median (range) were significantly greater in IBS-C (776 (595–1033)) and FC (802 (633–951)) vs HV (645 (467–780)), p<0.001. Patients also had longer WGTT and delayed evacuation after macrogol. IBS-C patients showed significantly reduced tagging index and less propagated pressure wave (PPW) activity during HRCM versus HV. Compared with FC, IBS-C patients were more anxious and reported more pain. Abnormally large colons predicted significantly delayed evacuation after macrogol challenge (p<0.02), impaired manometric meal response and reduced pain with bisacodyl (p<0.05).Part 2: Bisacodyl compared with hyoscine increased bowel movements but caused more pain in both groups (p<0.03).

Conclusion:

An abnormally large colon is an important feature in constipation which predicts impaired manometric response to feeding and treatment responses. HRCM shows that IBS-C patients have reduced PPW activity.

Trial registration number:

The study was preregistered on ClinicalTrials.gov, Reference:NCT03226145.

01 Dec 2024·JOURNAL OF ETHNOPHARMACOLOGY

A refined formula derived from Jiawei-Xiaoyao pill exerts rapid antidepressant-like effects in LPS-induced depression by reducing neuroinflammation and restoring neuroplasticity signaling

Article

Author: Chen, Gang ; Wu, Lei ; Li, Xianhui ; Sun, Yan ; Yin, Ying ; Wu, Zhangjie ; Liu, Yan ; Adzic, Miroslav ; Liu, Ruiyi ; Zhang, Hailou ; Yau, Suk-Yu

ETHNOPHARMACOLOGICAL RELEVANCE:

Jiawei-Xiaoyao Pill (JWX), a classic formula in traditional Chinese medicine, is derived from Xiaoyao Pill by adding significant amounts of Gardeniae Fructus (GF) and Moutan Cortex (MC). It is frequently used for the treatment of depression. JWX has been demonstrated to uniquely elicit rapid antidepressant-like effects within the prescribed dosage range. To date, GF has been shown to have rapid antidepressant-like effects, but a much higher dose is required than its proportion in JWX. It is assumed that the synergism of GF with a minimum number of other herbs in JWX serves as a refined formula that exerts these rapid antidepressant-like effects. Identification of a refined formula is important for prioritizing the herbs and ingredients to optimize the quality control of JWX. However, such a refined formula for JWX has not been identified yet.

AIM OF THE STUDY:

Here we aimed to identify a refined formula derived from JWX for optimized rapid antidepressant-like effects. Since the neuroinflammation mechanism involving in depression treatment has not been previously investigated for JWX, we tested the mechanism for both JWX and the refined formula.

MATERIALS AND METHODS:

Individual herbs (MC; ASR, Angelica Sinensis Radix; Bupleuri Radix; Paeonia Radix Alba) that show antidepressant-like responses were mixed with GF at the proportional dosage in JWX to identify the refined formula. Rapid antidepressant-like effects were assessed by using NSF (Novelty Suppressed Feeding Test) and other behavioral tests following a single administration. The identified formula was further tested in a lipopolysaccharide (LPS)-induced depressive model, and the molecular signaling mechanisms were investigated using Western blot analysis, immunofluorescence, and pharmacological inhibition of mTOR signaling. Scopolamine (Scop) was used as a positive control for induction of rapid antidepressant effects.

RESULTS:

A combination of GF, MC and ASR (GMA) at their dosages proportional to JWX induced behavioral signs of rapid antidepressant-like responses in both normal and LPS-treated mice, with the antidepressant-like effects sustained for 5 d. Similar to JWX or Scop, GMA rapidly reduced the neuroinflammation signaling of Iba-1-NF-кB, enhanced neuroplasticity signaling of CaMKII-mTOR-BDNF, and attenuated the upregulated expressions of the NMDAR sub-units GluN1 and GluN2B in the hippocampus of LPS-treated mice. GMA, JWX and Scop rapidly restored the number of BDNF-positive cells reduced by LPS treatment in the CA3 region of the hippocampus. Furthermore, rapamycin, a selective inhibitor of mTOR, blunted the rapid antidepressant-like effects and hippocampal BDNF signaling upregulation by GMA.

CONCLUSION:

GMA may serve as a refined formula from JWX, capable of inducing rapid antidepressant-like effects. In the LPS-induced depression model, the effects of GMA were mediated via rapidly alleviating neuroinflammation and enhancing neuroplasticity.

4

News (Medical) associated with Scopolamine Butylbromide

22 Oct 2024

·www.echemi.com

Sanofi's Negotiations to Sell Opella Stake Exposed, €16 Billion Deal Triggers Threat of Strikes from French Unions!

Sanofi is currently in "exclusive talks" with U.S. private equity firm Clayton, Dubilier & Rice (CD&R) to sell a 50% controlling stake in its consumer healthcare business Opella. The French government has confirmed a commitment from CD&R, based in New York, to ensure that Opella's production facilities in France will remain intact and that there will be no disruption to the supply of drugs to the country, removing a potential obstacle to the deal. Sanofi said the proposed deal valued Opella at 16 billion euros and stressed that CD&R's offer for a 50 percent stake was "binding and fully funded." In addition, French public sector investment bank Bpifrance plans to buy a 2% stake in Opella and take a seat on its board. The deal, expected to close "at the earliest" in the second quarter of next year, will see Sanofi step up its investment in innovative drugs and vaccines and mark the French drugmaker's formal joining the ranks of biopharmaceutical giants Johnson & Johnson, Pfizer and GlaxoSmithKline. "With this transaction, Sanofi will be able to focus even more on providing innovative treatments for patients suffering from debilitating or fatal diseases and viruses, such as RSV, COPD or multiple sclerosis," Sanofi CEO Paul Hudson said in a press release. Analysts at ODDO BHF supported the decision, arguing that a divestiture or partial divestiture of the consumer business would allow Sanofi to reallocate capital to research and business development, and recommended that Sanofi use some of the capital to offset the financial impact of the divestiture through share buybacks. Hudson first floated the idea of spinning off the consumer health division last October. Since then, CD&R and PAI Partners, another private equity giant, have made separate bids for Opella. Earlier this month, Reuters reported that CD&R had made a formal offer to buy 50 percent of Opella's consumer healthcare business. Last week, Sanofi said it was surprised by PAI's move to raise its 200 million euro offer after the deadline. Sanofi's commitment that Opella would continue to operate in France followed a call by French unions for workers to strike on Thursday in protest at the deal. Opella is a leader in over-the-counter medicines, vitamins, minerals and supplements. Its product line includes the well-known antihistamine Allegra, non-opioid painkiller Doliprane, stomach cramping relief Buscopan, Selsun Blue shampoo, and pain treatments Icy Hot and Gold Bond, among others. Opella employs 11,000 people in 100 countries and generated sales of 5.2 billion euros ($5.6 billion) in 2023, accounting for 11% of Sanofi's total revenue. In addition, the company operates 13 production sites and four research and development innovation centers.

Acquisition

23 Oct 2023

·www.fiercepharma.com

EU authorities fine Boehringer, others for operating drug-ingredient 'cartel'

All six companies “admitted their involvement in the cartel and agreed to settle the case,” the European Commission said in a release. Five pharmaceutical companies, including the global player Boehringer Ingelheim, have landed in hot water for running a "cartel" to dominate the market for a specific drug ingredient in Europe. The European Commission (EC) is fining Alkaloids of Australia, Alkaloids Corporation, Boehringer, Linnea and Transo-Pharm a total of €13.4 million ($14.2 million) to settle claims that the companies agreed to fix prices and allocate business on the pharmaceutical component N-Butylbromide Scopolamine/ Hyoscine (SNBB), which is used to make the decades-old abdominal antispasmodic Buscopan and its generics. Boehringer received the largest fine by far, settling with the EC for €10.4 million. A spokesperson for Boehringer said the company "accepts the settlement decision and remains committed to fair competition, integrity, and compliance." "We have a zero-tolerance policy for any illegal or illicit business practices and are dedicated to always doing the right thing," the spokesperson added. Notably, C2 Pharma—which prides itself on tackling human rights, labor, the environment and corruption—has dodged all fines for blowing the whistle on the cartel to the EC. All six companies “admitted their involvement in the cartel and agreed to settle the case,” the European Commission said in a press release. The companies were accused of conspiring to fix the minimum sales price of SNBB, allocating quotas and exchanging “commercially sensitive” information, the EC said. The behavior ran from late 2005 to Sept. 17, 2019, according to authorities. Notably, Boehringer stopped its participation in the cartel at the end of 2014, with whistleblower C2 Pharma calling it quits in February of 2016. The EC said this is the first time it’s sanctioned a pharmaceutical cartel over an active pharmaceutical ingredient (API). The agency worked in tandem with Swiss and Australian competition authorities to level the charges. A seventh company, Alchem, is also being investigated but decided not to settle. Proceedings against that company will continue in tandem with Europe’s cartel procedure, the EC said.

Patent InfringementBiosimilar

20 Oct 2023

·endpts.com

A first for the European Commission: Five pharma companies fined $14M for API price fixing

The European Commission on Thursday announced a first for its regulation of the pharma industry: It’s fining five pharma companies — Alkaloids of Australia, Alkaloids Corporation, Boehringer Ingelheim, Linnea and Transo-Pharm — €13.4 million ($14.2 million) for colluding to fix the price of a pharmaceutical ingredient used in a drug to treat stomach cramps. The Commission said its investigation revealed that six companies — the sixth company C2 Pharma revealed the price fixing to the Commission and was not fined — coordinated and agreed to fix the minimum sales price of the ingredient, known as N-butylbromide scopolamine/hyoscine, which is commonly used in the antispasmodic drug Buscopan as well as in its generic versions. The ingredients were shipped to customers such as distributors and generic drugmakers, and the companies collaborated to allocate quotas.

100 Deals associated with Scopolamine Butylbromide

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External Link

KEGG	Wiki	ATC	Drug Bank
D00138	Scopolamine Butylbromide	S01FA02 N05CM05 A04AD01	DB09300

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Gastrointestinal spasm	AU	Sanofi /Consumer Healthcare Products/	26 Sep 1991
Renal Colic	AU	Sanofi /Consumer Healthcare Products/	26 Sep 1991
Spasm biliary	AU	Sanofi /Consumer Healthcare Products/	26 Sep 1991
Motion Sickness	US	Baxter Healthcare Corp.	31 Dec 1979
Postoperative Nausea and Vomiting	US	Baxter Healthcare Corp.	31 Dec 1979
Habit Spasms	JP	Sanofi KK	17 Mar 1955

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Intestinal Diseases	Phase 3	CN	Boehringer Ingelheim GmbH	01 Aug 2013
Abdominal Pain	Phase 3	-	Boehringer Ingelheim GmbH	01 Nov 2008
Gastralgia	Phase 3	-	Boehringer Ingelheim GmbH	01 Nov 2008
Myalgia	Phase 3	-	Boehringer Ingelheim GmbH	01 Nov 2008
Colic	Phase 2	-	Boehringer Ingelheim GmbH	01 Apr 2006
Muscle Cramp	Phase 2	-	Boehringer Ingelheim GmbH	01 Apr 2006

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00932737 (CTgov)	Phase 2	Abdominal Pain \| Muscle Cramp	197	Placebo	qpamxdtcqf(jnkznixbaf) = slrotvdvmt hzxjybtcew (rncolcbghf, exvzfremdr - wlulatnjol) View more	-	03 May 2022
NCT01734902 (CTgov)	Phase 1	-	30	Hyoscine Butylbromide (Hyoscine Butylbromide Drops (T))	totcupsdnf(lnnjwyillf) = mwagqnsasj zavzraebqi (qzptaxebfn, owjxnboupa - cofcafsaab) View more	-	23 Apr 2019
				Buscopan (Buscopan® Tablet (R))	totcupsdnf(lnnjwyillf) = ehdzzzctim zavzraebqi (qzptaxebfn, srtcalzxmr - qhalpgnype) View more
Pubmed \| J Minim Invasive Gynecol	Not Applicable	Infertility \| occlusions	-	Hyoscine-N-butylbromide 20mg	oztfsrheiu(bxriwbpscl) = qettgspeuz ezvtlbeqod (qfbpgpwlgs )	Positive	01 Jan 2019
				Placebo	oztfsrheiu(bxriwbpscl) = avixraxctp ezvtlbeqod (qfbpgpwlgs )
NCT03029650 (CTgov)	Phase 4	-	26	Intravenous scopolamine hydrobromide+Transderm Scop® (Transderm Scop®)	ewckypvclb(coproxsecv) = gxpsywcppv nlckixzuet (otpizbpzgg, atgetofwoz - vsjwkkihlk) View more	-	21 Jun 2018
				Intravenous scopolamine hydrobromide+Transderm Scop® (Intravenous Scopolamine Hydrobromide)	ewckypvclb(coproxsecv) = kmdyyhmrrb nlckixzuet (otpizbpzgg, kkhkeujynv - izbhzpskoz) View more
NCT02242305 (CTgov)	Phase 3	Abdominal Pain \| Myalgia \| Gastralgia	302	Placebo+Hyoscine Butylbromide - Tablet (Hyoscine Butylbromide - Tablet)	xeymtwaanx(kzyzpvhhzf) = ubsfbvqszs zizeoyqvck (cgdormeoyr, ntyqqofsab - dalzztmqrw) View more	-	27 Jul 2017
				Placebo+Hyoscine Butylbromide - Capsule (Hyoscine Butylbromide - Capsule)	xeymtwaanx(kzyzpvhhzf) = uxxshlsdjx zizeoyqvck (cgdormeoyr, dgsamvftfx - tezjjemksp) View more
NCT02516098 (CTgov)	Phase 1	-	56	Buscopan (Buscopan® (REF))	gcefbqfaqq(rcakaibqcw) = aougraqwdt mdxudciddz (nibcucoasn, poajzmqzmv - kvulljhjzn) View more	-	13 Feb 2017
				Buscapina (Buscapina® (T))	gcefbqfaqq(rcakaibqcw) = nknhrcdljg mdxudciddz (nibcucoasn, udbndmmhrf - nwwtzkxibg) View more
NCT01929044 (CTgov)	Phase 3	Intestinal Diseases \| Gastralgia	299	Buscopan® (hyoscine butylbromide)	bvxxbwgjct(sidnlwwmfa) = dvamubasxx bmwkjxxion (sjmzosaunx, hiummptlug - urpudrtcyg) View more	-	08 Mar 2016
NCT01281501 (CTgov)	Phase 4	Dyspepsia \| Acute Pain	87	Hyoscine butylbromide+Oral antacid+Normal Saline (Conventional)	ulakvelgky(nzqsplmyiq) = hrgbbdzhvu lcmjueihve (zdteimzbem, ajlxjqcfua - qgqukhjozp) View more	-	27 Jul 2012
				Hyoscine butylbromide+Oral antacid+Pantoprazole (Pantoprazole)	ulakvelgky(nzqsplmyiq) = ywvmcyfvet lcmjueihve (zdteimzbem, pwvjbwlibi - qkgvpayoyu) View more