Drug Type Small molecule drug |
Synonyms (+-)-Methadone, (+/-)-Methadone, (±)-methadone + [19] |
Action antagonists, agonists |
Mechanism NMDA receptor antagonists(Glutamate [NMDA] receptor antagonists), μ opioid receptor agonists(Mu opioid receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (13 Aug 1947), |
Regulation- |
Molecular FormulaC21H28ClNO |
InChIKeyFJQXCDYVZAHXNS-UHFFFAOYSA-N |
CAS Registry1095-90-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D02102 | Methadone Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Cancer Pain | Japan | 01 Mar 2013 | |
Opioid-Related Disorders | China | 01 Jan 1997 | |
Opioid abuse | United States | 14 Mar 1973 | |
psychological symptoms behavior compulsive behavior addiction | United States | 14 Mar 1973 | |
psychological symptoms behavior compulsive behavior addiction | United States | 14 Mar 1973 | |
Opium Dependence | United States | 13 Aug 1947 | |
Pain | United States | 13 Aug 1947 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Diabetic Neuropathies | Phase 2 | - | 01 Jan 2012 |
Phase 3 | 189 | tfoxnpdnzq(vafuhkvmpy) = jxadfknzsr uywlhrljlz (ahjiytpyyb, 6.3) View more | - | 13 Mar 2025 | |||
tfoxnpdnzq(vafuhkvmpy) = eqezzfxivc uywlhrljlz (ahjiytpyyb, 6.1) View more | |||||||
Phase 1/2 | 22 | wezgcdhtne(kkeivjwogw) = knhvcfofnp uscufcyakz (dayjwtrfml, 1.42) View more | - | 10 Feb 2025 | |||
Phase 2 | 66 | zemkwkzvkp(kkqqeuspti) = fgdlcssmez xrviqyisio (vizranbzqr, wibrzrqecs - cjqfktarss) View more | - | 17 Oct 2024 | |||
Not Applicable | - | 60 | wlawptgzbd(hplgwxkxag) = nwuleudbzo wpyzqmngmi (msqsraoogp, 0.1 - 1.4) | Positive | 01 Sep 2024 | ||
wlawptgzbd(hplgwxkxag) = iclxmblrry wpyzqmngmi (msqsraoogp, 0 - 1.4) | |||||||
Not Applicable | 303 | hcfmscswpt(hjismuydaa) = hqpesrtlaa femafwkood (gqjwrlzfyx ) View more | Positive | 01 Jul 2024 | |||
hcfmscswpt(hjismuydaa) = hrrmsogaqj femafwkood (gqjwrlzfyx ) View more | |||||||
Phase 4 | 272 | pjzzsdcavx(aacqfsgrnj) = efvsplczmf jkddqxxtij (xzuccrxrap ) View more | Positive | 01 Jul 2024 | |||
pjzzsdcavx(aacqfsgrnj) = ifuylljatd jkddqxxtij (xzuccrxrap ) View more | |||||||
Not Applicable | - | xhamzcbjkc(mquuxqqksx) = ctwzicyagz ujfrmncfeq (sqllnvewlr, 0.5 - 3.3) View more | - | 01 Jun 2024 | |||
Not Applicable | - | bcdimoudsg(aywvvkuyft) = Methadone induced hypoglycemia okhjjefidg (omflxgebcv ) | - | 01 Jun 2024 | |||
Phase 4 | 268 | - | Negative | 01 Mar 2024 | |||
Methadone Maintenance Therapy (MMT) | oksjyjedqk(tdcafcedub) = aanjksqfdv ymikiotsze (qyqhrxqxpr ) View more | ||||||
Phase 4 | 13 | xpjzuarutx(zqfvobmrpw) = tdqaixwzsq eigjzhbgjh (feekexwarj, 20) View more | - | 29 Feb 2024 | |||
xpjzuarutx(zqfvobmrpw) = axetqckgbk eigjzhbgjh (feekexwarj, 16) View more |