Last update 22 Jul 2025

Methadone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+-)-Methadone, (+/-)-Methadone, (±)-methadone
+ [19]
Action
antagonists, agonists
Mechanism
NMDA receptor antagonists(Glutamate [NMDA] receptor antagonists), μ opioid receptor agonists(Mu opioid receptor agonists)
Inactive Indication
Originator Organization
Inactive Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
United States (13 Aug 1947),
Regulation-
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Structure/Sequence

Molecular FormulaC21H28ClNO
InChIKeyFJQXCDYVZAHXNS-UHFFFAOYSA-N
CAS Registry1095-90-5

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Cancer Pain
Japan
01 Mar 2013
Opioid-Related Disorders
China
01 Jan 1997
Opioid abuse
United States
14 Mar 1973
psychological symptoms behavior compulsive behavior addiction
United States
14 Mar 1973
psychological symptoms behavior compulsive behavior addiction
United States
14 Mar 1973
Opium Dependence
United States
13 Aug 1947
Pain
United States
13 Aug 1947
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic NeuropathiesPhase 2-01 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
189
(Rapid Wean)
tfoxnpdnzq(vafuhkvmpy) = jxadfknzsr uywlhrljlz (ahjiytpyyb, 6.3)
-
13 Mar 2025
(Slow Wean)
tfoxnpdnzq(vafuhkvmpy) = eqezzfxivc uywlhrljlz (ahjiytpyyb, 6.1)
Phase 1/2
22
wezgcdhtne(kkeivjwogw) = knhvcfofnp uscufcyakz (dayjwtrfml, 1.42)
-
10 Feb 2025
Phase 2
66
zemkwkzvkp(kkqqeuspti) = fgdlcssmez xrviqyisio (vizranbzqr, wibrzrqecs - cjqfktarss)
-
17 Oct 2024
Not Applicable
-
60
wlawptgzbd(hplgwxkxag) = nwuleudbzo wpyzqmngmi (msqsraoogp, 0.1 - 1.4)
Positive
01 Sep 2024
wlawptgzbd(hplgwxkxag) = iclxmblrry wpyzqmngmi (msqsraoogp, 0 - 1.4)
Not Applicable
303
hcfmscswpt(hjismuydaa) = hqpesrtlaa femafwkood (gqjwrlzfyx )
Positive
01 Jul 2024
hcfmscswpt(hjismuydaa) = hrrmsogaqj femafwkood (gqjwrlzfyx )
Phase 4
272
pjzzsdcavx(aacqfsgrnj) = efvsplczmf jkddqxxtij (xzuccrxrap )
Positive
01 Jul 2024
pjzzsdcavx(aacqfsgrnj) = ifuylljatd jkddqxxtij (xzuccrxrap )
Not Applicable
-
xhamzcbjkc(mquuxqqksx) = ctwzicyagz ujfrmncfeq (sqllnvewlr, 0.5 - 3.3)
-
01 Jun 2024
Not Applicable
-
bcdimoudsg(aywvvkuyft) = Methadone induced hypoglycemia okhjjefidg (omflxgebcv )
-
01 Jun 2024
Phase 4
268
-
Negative
01 Mar 2024
Methadone Maintenance Therapy (MMT)
oksjyjedqk(tdcafcedub) = aanjksqfdv ymikiotsze (qyqhrxqxpr )
Phase 4
13
xpjzuarutx(zqfvobmrpw) = tdqaixwzsq eigjzhbgjh (feekexwarj, 20)
-
29 Feb 2024
(Methadone)
xpjzuarutx(zqfvobmrpw) = axetqckgbk eigjzhbgjh (feekexwarj, 16)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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