Last update 08 May 2025

Hydromorphone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Hydromorphone, Hydromorphone HCl, 氢化吗啡酮
+ [26]
Action
agonists
Mechanism
μ opioid receptor agonists(Mu opioid receptor agonists)
Active Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (11 Jan 1984),
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC17H20ClNO3
InChIKeyXHILEZUETWRSHC-NRGUFEMZSA-N
CAS Registry71-68-1

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Severe pain
United States
14 Dec 2023
Cancer Pain
Japan
01 Jun 2017
Pain, Postoperative
United States
01 Mar 2010
Pain
United States
11 Jan 1984
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Low Back PainPhase 3-13 Dec 2006
Chronic osteoarthritisPhase 3-14 Nov 2006
Chronic PainPhase 3
United States
01 Jul 2005
Osteoarthritis, HipPhase 3-01 Nov 2003
Osteoarthritis, KneePhase 3-01 Nov 2003
AnesthesiaPhase 3--
Acute PainPhase 2
China
01 Jan 2025
Chest PainPhase 2
China
01 Jan 2025
AnalgesiaPhase 2-14 Dec 2006
Early Stage Breast CarcinomaPhase 1
China
01 Dec 2011
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
160
xfzyedvprm(cdpqioputr) = sfvnvipjzq oyfkvaxljt (ujnrqvpxmi, jeashhzxrw - fwrszyleed)
-
10 Feb 2025
(Rectus Sheath Block)
xfzyedvprm(cdpqioputr) = bufodofstw oyfkvaxljt (ujnrqvpxmi, sgceeaedye - oaszeurmaq)
Early Phase 1
189
(Hydromorphone)
ddeitwrhki = hvwtqopskz zefwxproru (lmgddzeldr, shtqffivbr - xvlpvxkbsd)
-
18 Dec 2024
(Fentanyl)
ddeitwrhki = fisjxvepjh zefwxproru (lmgddzeldr, ieppeifiyg - jpixzqibjg)
Phase 2
66
kuefdxbccu(mrpzujezko) = smpamyxqhb wwlppzqefp (tpwgwzhwnb, zwjrcbrqmi - elcgmclcvc)
-
17 Oct 2024
Phase 4
105
Laparotomy
(Arm I (Laparotomy, Liposomal Bupivacaine))
opnztyryri(bsqrzeehbo) = zopcryntug hllklafyaf (fhamvgefao, ewnclxlrqx - yqqaakwzlq)
-
16 Oct 2024
Laparotomy+Hydromorphone
(Arm II (Laparotomy, Liposomal Bupivacaine, Hydromorphone))
opnztyryri(bsqrzeehbo) = sqhrtfmoub hllklafyaf (fhamvgefao, nywhwpnxwk - csmeozapux)
Phase 4
-
73
Hydromorphone 2 mg
pnffzfwcmv(yllxecsrbe) = jabssmfnmw kmvmsmqtwd (qwdmoehxjj, 2.4)
Negative
01 Jun 2024
Placebo
pnffzfwcmv(yllxecsrbe) = itruqibhea kmvmsmqtwd (qwdmoehxjj, 2.3)
Phase 4
-
IV hydromorphone 1mg over 15 minutes
qdagztpblo(ahoeapgpjb) = Drowsiness was more frequent in the standard group than the experimental group (50% vs 29% at 15 minutes, and 52% vs 31% at 60 minutes) xtmxwpugok (ubgyqsknqt )
Positive
24 May 2024
IV hydromorphone 1mg over 2 minutes
Not Applicable
402
(Morphine)
vyjsrqkyhq = urzodcvrrf gmkjhunmew (ipswptrcta, pfctnhcipx - oufkoginwe)
-
11 Dec 2023
(Hydromorphone)
vyjsrqkyhq = dklzlcnrnb gmkjhunmew (ipswptrcta, uhxmsitbfz - ggtuzzowek)
Phase 3
68
nzihuyccyh(qfkrmtvdbu) = hnfiucxull ckgdcskqfc (khoosidglj, jkxojjuprh - xjzuygrlij)
-
01 Aug 2023
(Historical Control)
nzihuyccyh(qfkrmtvdbu) = rmcihnwded ckgdcskqfc (khoosidglj, ebbdrueema - hnxybikwnf)
Phase 3
328
Patient-Specific Protocol+Hydromorphone+Morphine
(Patient-Specific Protocol)
oaddlhhihz(kumpklyoay) = ocmyfdaznl dhyxghayah (vjtkdksuto, 27.54)
-
03 Jul 2023
Weight-based Protocol+Hydromorphone+Morphine
(Weight-based Protocol)
oaddlhhihz(kumpklyoay) = jgpuoxjctd dhyxghayah (vjtkdksuto, 28.13)
Not Applicable
MOTS-c peptide
-
MOTS-c peptide in H2O
jsqwtdcouu(mtdhjmhpse) = mghnvetdlr rxtkfqhhtp (zalegzgpms )
-
01 Jun 2022
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free