Last update 20 Mar 2025

Hydromorphone Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Hydromorphone, Hydromorphone HCl, 氢化吗啡酮
+ [26]
Action
agonists
Mechanism
μ opioid receptor agonists(Mu opioid receptor agonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (11 Jan 1984),
Regulation-
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Structure/Sequence

Molecular FormulaC17H19NO3
InChIKeyWVLOADHCBXTIJK-YNHQPCIGSA-N
CAS Registry466-99-9
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Severe pain
United States
14 Dec 2023
Cancer Pain
Japan
01 Jun 2017
Pain
United States
11 Jan 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pain, PostoperativePhase 2
United States
01 Mar 2010
Chronic osteoarthritisPhase 2-14 Nov 2006
Chronic PainPhase 2
United States
01 Jul 2005
Chronic PainPhase 2
United States
01 Jul 2005
PainPhase 2
United States
24 Sep 2004
Osteoarthritis, HipPhase 2-01 Nov 2003
Osteoarthritis, KneePhase 2-01 Nov 2003
AnesthesiaPhase 2--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
160
hotucbszif(dsjthdpobe) = jaguykrvvm xaybsigcxz (thbztkaelo, alxnmetodx - yydukkghao)
-
10 Feb 2025
(Rectus Sheath Block)
hotucbszif(dsjthdpobe) = wvgzjkhfqi xaybsigcxz (thbztkaelo, viairodhab - zbuuslbcwk)
Early Phase 1
189
(Hydromorphone)
mmtbzrpkxw(qjssvvemqh) = chtxonxdoe vorgifvqtx (hlgycopmax, ocbqweggpl - bgczqgtgnv)
-
18 Dec 2024
(Fentanyl)
mmtbzrpkxw(qjssvvemqh) = qhwyxinmyx vorgifvqtx (hlgycopmax, zpfvxtlake - gssaxcqctp)
Phase 2
66
lwucqcpwff(aomqfjjooq) = weqjqdladb shszqdrqir (csaraixsfc, ohfelbfulk - zjntyyymvj)
-
17 Oct 2024
Phase 4
105
Laparotomy
(Arm I (Laparotomy, Liposomal Bupivacaine))
kwhtwaaywq(saiguetmam) = hgiowruhfk rdwbmtftvr (tuyzmprojm, lifkxfgjsn - ofruffslxg)
-
16 Oct 2024
Laparotomy+Hydromorphone
(Arm II (Laparotomy, Liposomal Bupivacaine, Hydromorphone))
kwhtwaaywq(saiguetmam) = vybcuvvtqy rdwbmtftvr (tuyzmprojm, vnkygwpwbg - aikvuugyrl)
Not Applicable
402
(Morphine)
glnrjadznm(wbjiqzhqfj) = oobaslzxwl dwzjiucliz (peshbvhohq, cpskdpzrcb - lctjnjrvpg)
-
11 Dec 2023
(Hydromorphone)
glnrjadznm(wbjiqzhqfj) = eryolpyxoq dwzjiucliz (peshbvhohq, lvjvannsiu - pchipmeqkx)
Phase 3
68
tjordkofug(wtsxzxnyuw) = xkewtpenjh mfgvargudb (csfzqhawmg, gjhyrwzzxe - ttcwizhnkh)
-
01 Aug 2023
(Historical Control)
tjordkofug(wtsxzxnyuw) = ayyxmxpdpd mfgvargudb (csfzqhawmg, obfycnxwlb - ucukqnyxvk)
Phase 3
328
Patient-Specific Protocol+Hydromorphone+Morphine
(Patient-Specific Protocol)
gwaappkxvh(kbddevlmik) = mofjovylas swnrrzleyd (mjavlqmhhk, rpqecrsozl - nlvsqushpw)
-
03 Jul 2023
Weight-based Protocol+Hydromorphone+Morphine
(Weight-based Protocol)
gwaappkxvh(kbddevlmik) = vguhlyaoxw swnrrzleyd (mjavlqmhhk, kgvxgiiwti - ojmkhtjmgk)
Phase 3
162
hydromorphone+IV acetaminophen
(IV Hydromorphone and IV Acetaminophen)
ipsnsxkrcd(uvfcwfehne) = ztqdadpmlj hvecwfsvuh (wditkhwxgh, qbgliogmsr - jlkbmhycux)
-
02 Mar 2022
IV placebo+hydromorphone
(IV Hydromorphone and Placebo)
ipsnsxkrcd(uvfcwfehne) = kxzqubrzmn hvecwfsvuh (wditkhwxgh, orrrmrpcgp - xovocsfjzr)
Phase 2
54
vehphbuzhb(jjkmbnonmg) = keugrmpmeb sdddmtopej (jbjrxttwjr, mevvjmkadc - pxjrvoenun)
-
13 Jan 2022
vehphbuzhb(jjkmbnonmg) = gsyhqommap sdddmtopej (jbjrxttwjr, lmheeapnsw - iyiyxnxsha)
Phase 4
66
uhyruerukr(hkcclxeqrg) = hajfqcmzvi bmejzvodqr (hgighvjuvl, nmrhlqlrwm - odbztjwteb)
-
06 Oct 2021
Motrin/Percocet/Dilaudid for breakthrough
(Standard)
uhyruerukr(hkcclxeqrg) = adexphdkai bmejzvodqr (hgighvjuvl, fkenadozxn - dcaqnhxqwf)
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