A Phase Ib/II, Open-Label, Multicenter, Randomized Umbrella Study Evaluating The Efficacy And Safety Of Multiple Treatment Combinations In Patients With Metastatic Breast Cancer (Morpheus-panBC)

This is an umbrella study evaluating the efficacy and safety of multiple treatment combinations in participants with metastatic or inoperable locally advanced breast cancer.
The study will be performed in two stages. During Stage 1, four cohorts will be enrolled in parallel in this study:
Cohort 1 will consist of Programmed death-ligand 1 (PD-L1)-positive participants who have received no prior systemic therapy for metastatic or inoperable locally advanced triple-negative breast cancer (TNBC) (first-line [1L] PD-L1+ cohort).
Cohort 2 will consist of participants who had disease progression during or following 1L treatment with chemotherapy for metastatic or inoperable locally-advanced TNBC and have not received cancer immunotherapy (CIT) (second-line [2L] CIT-naive cohort).
Cohort 3 will consist of participants with locally-advanced or metastatic HR+, HER2-negative disease with PIK3CA mutation who may or may not have had disease progression during or following previous lines of treatment for metastatic disease (HR+cohort).
Cohort 4 will consist of participants with locally-advanced or metastatic HER2+ /HER2-low disease with PIK3CA mutation who had disease progression on standard-of-care therapies (HER2+ /HER2-low cohort).
In each cohort, eligible participants will initially be assigned to one of several treatment arms (Stage 1). In addition, participants in the 2L CIT-naïve cohort who experience disease progression, loss of clinical benefit, or unacceptable toxicity during Stage 1 may be eligible to continue treatment with a different treatment combination (Stage 2), provided Stage 2 is open for enrollment.

Start Date02 Apr 2018

Sponsor / Collaborator

Hoffmann-La Roche, Inc.

[+1]

NCT03239145 / Active, not recruitingPhase 1IIT

Phase Ib Study to Test the Safety and Potential Synergy of Pembrolizumab (Anti-PD-1) and AMG386 (Angiopoietin-2 (Ang-2) in Patients With Advanced Solid Tumor

This research study is studying an investigational combination of drugs as a possible treatment for advanced solid tumors: melanoma, ovarian, renal, or colorectal cancer.
The drugs involved in this study are:
Pembrolizumab
AMG386

Start Date31 Aug 2017

Sponsor / Collaborator

Dana-Farber Cancer Institute, Inc.

[+2]

NCT01907308 / WithdrawnPhase 2IIT

A Phase II Single-arm Study of AMG 386 in Combination With Docetaxel for Advanced Urothelial Carcinoma After Failure of a Platinum-containing Regimen

This study plans to learn more about the combination of AMG 386 and docetaxel for the treatment of advanced urothelial cancer. Subjects are being asked to be in this research study because they have advanced urothelial cancer which has progressed after treatment with a platinum-based therapy.
The hypothesis is that AMG 386 will increase the historical response rate of docetaxel as a single agent.

Start Date01 Feb 2014

Sponsor / Collaborator

University of Colorado Denver

[+1]

100 Clinical Results associated with Trebananib

100 Translational Medicine associated with Trebananib

100 Patents (Medical) associated with Trebananib

Literatures (Medical) associated with Trebananib

01 Sep 2024·Expert Review of Anticancer Therapy

Evaluating the efficacy and safety of trebananib in treating ovarian cancer and non-ovarian cancer patients: a meta-analysis and systematic review

Review

Author: Su, Jingyang ; Zhou, Yeyue ; Zhang, Jialin ; Lu, Jinhua

OBJECTIVES:

Due to its anti-angiogenic properties, trebananib is frequently employed in the treatment of cancer patients, particularly those with ovarian cancer. We conducted a meta-analysis to assess the efficacy and safety profile of trebananib in combination with other drugs for treating both ovarian and non-ovarian cancer patients.

METHODS:

Our search encompassed PubMed, Medline, Cochrane, and Embase databases, with a focus on evaluating study quality. Data extraction was conducted from randomized controlled trials (RCTs), and RevMan 5.3 facilitated result analysis.

RESULTS:

Combining trebananib with other drugs extended progression-free survival (PFS) [HR 0.81, (95%CI: 0.65, 0.99), p = 0.04] and overall survival (OS) [HR 0.88, (95%CI: 0.79, 1.00), p = 0.04] in ovarian cancer patients. Ovarian cancer patients exhibited a higher objective response rate (ORR) with trebananib compared to non-ovarian cancer cohorts. Moreover, the incorporation of trebananib into the standard treatment regimen for malignant tumors did not significantly elevate drug-related adverse events [RR 1.05, (95% CI: 1.00, 1.11), p = 0.05].

CONCLUSION:

Trebananib plus other drugs can improve the PFS, OS and ORR in patients with cancer, especially ovarian cancer. Our recommendation is to use trebananib plus other drugs to treat advanced cancer, and to continuously monitor and manage drug-related adverse events.

REGISTRATION:

PROSPERO (No. CRD42023466988).

16 Feb 2024·Clinical cancer research : an official journal of the American Association for Cancer Research

Neoadjuvant Trebananib plus Paclitaxel-based Chemotherapy for Stage II/III Breast Cancer in the Adaptively Randomized I-SPY2 Trial—Efficacy and Biomarker Discovery

Article

Author: Berry, Donald A ; Wilson, Amy ; Haddad, Tufia ; Blair, Sarah ; Esserman, Laura J ; Stringer-Reasor, Erica ; Euhus, David ; Symmans, W Fraser ; Lu, Janice ; Petricoin, Emanuel F ; Tripathy, Debu ; Boughey, Judy C ; Yau, Christina ; Wallace, Anne M ; Rugo, Hope S ; Forero-Torres, Andres ; Buxton, Meredith ; Pusztai, Lajos ; Gallagher, Rosa I ; Perlmutter, Jane ; Melisko, Michelle ; Hirst, Gillian L ; Wulfkuhle, Julia D ; DeMichele, Angela M ; Chen, Yunn Yi ; Wolf, Denise M ; Yee, Douglas ; Lang, Julie E ; Asare, Adam L ; Brown-Swigart, Lamorna ; Chien, A Jo ; Hylton, Nola M ; Elias, Anthony D ; Krings, Gregor ; Asare, Smita M ; Nanda, Rita ; Van't Veer, Laura J ; Potter, David A ; Albain, Kathy S ; Berry, Scott ; Yung, Rachel L ; Matthews, Jeffrey B ; Godellas, Constantine ; Singhrao, Ruby ; Sanil, Ashish ; Clennell, Julia L ; Kaplan, Henry ; Isaacs, Claudine ; Clark, Amy S

Abstract:

Purpose::

The neutralizing peptibody trebananib prevents angiopoietin-1 and angiopoietin-2 from binding with Tie2 receptors, inhibiting angiogenesis and proliferation. Trebananib was combined with paclitaxel±trastuzumab in the I-SPY2 breast cancer trial.

Patients and Methods::

I-SPY2, a phase II neoadjuvant trial, adaptively randomizes patients with high-risk, early-stage breast cancer to one of several experimental therapies or control based on receptor subtypes as defined by hormone receptor (HR) and HER2 status and MammaPrint risk (MP1, MP2). The primary endpoint is pathologic complete response (pCR). A therapy “graduates” if/when it achieves 85% Bayesian probability of success in a phase III trial within a given subtype. Patients received weekly paclitaxel (plus trastuzumab if HER2-positive) without (control) or with weekly intravenous trebananib, followed by doxorubicin/cyclophosphamide and surgery. Pathway-specific biomarkers were assessed for response prediction.

Results::

There were 134 participants randomized to trebananib and 133 to control. Although trebananib did not graduate in any signature [phase III probabilities: Hazard ratio (HR)-negative (78%), HR-negative/HER2-positive (74%), HR-negative/HER2-negative (77%), and MP2 (79%)], it demonstrated high probability of superior pCR rates over control (92%–99%) among these subtypes. Trebananib improved 3-year event-free survival (HR 0.67), with no significant increase in adverse events. Activation levels of the Tie2 receptor and downstream signaling partners predicted trebananib response in HER2-positive disease; high expression of a CD8 T-cell gene signature predicted response in HR-negative/HER2-negative disease.

Conclusions::

The angiopoietin (Ang)/Tie2 axis inhibitor trebananib combined with standard neoadjuvant therapy increased estimated pCR rates across HR-negative and MP2 subtypes, with probabilities of superiority >90%. Further study of Ang/Tie2 receptor axis inhibitors in validated, biomarker-predicted sensitive subtypes is warranted.

01 Mar 2023·The Journal of pharmacology and experimental therapeutics

Pharmacodynamic and Antitumor Activity of BI 836880, a Dual Vascular Endothelial Growth Factor and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition

Article

Author: Depla, Erik ; Baum, Anke ; Gschwind, Andreas ; Hilberg, Frank ; Hofmann, Irmgard ; Künkele, Klaus-Peter ; Kraut, Norbert ; Budano, Nicole ; Trapani, Francesca ; Ebner, Florian ; Hofmann, Marco H ; Boucneau, Joachim ; Sykora, Martina ; Aichinger, Martin ; Reichel-Voda, Claudia ; Schweifer, Norbert ; Ehrensperger, Diane

Vascular endothelial growth factor (VEGF) and angiopoietin (ANG)-2 have complementary roles in angiogenesis and promote an immunosuppressive tumor microenvironment. It is anticipated that the combination of VEGF and ANG2 blockade could provide superior activity to the blockade of either pathway alone and that the addition of VEGF/ANG2 inhibition to an anti-programmed cell death protein-1 (PD-1) antibody could change the tumor microenvironment to support T-cell-mediated tumor cytotoxicity. Here, we describe the pharmacologic and antitumor activity of BI 836880, a humanized bispecific nanobody comprising two single-variable domains blocking VEGF and ANG2, and an additional module for half-life extension in vivo. BI 836880 demonstrated high affinity and selectivity for human VEGF-A and ANG2, resulting in inhibition of the downstream signaling of VEGF/ANG2 and a decrease in endothelial cell proliferation and survival. In vivo, BI 836880 exhibited significant antitumor activity in all patient-derived xenograft models tested, showing significantly greater tumor growth inhibition (TGI) than bevacizumab (VEGF inhibition) and AMG386 (ANG1/2 inhibition) in a range of models. In a Lewis lung carcinoma syngeneic tumor model, the combination of PD-1 inhibition with VEGF inhibition showed superior efficacy versus the blockade of either pathway alone. TGI was further increased with the addition of ANG2 inhibition to VEGF/PD-1 blockade. VEGF/ANG2 inhibition had a strong antiangiogenic effect. Our data suggest that the blockade of VEGF and ANG2 with BI 836880 may offer improved antitumor activity versus the blockade of either pathway alone and that combining VEGF/ANG2 inhibition with PD-1 blockade can further enhance antitumor effects. SIGNIFICANCE STATEMENT: Vascular endothelial growth factor (VEGF) and angiopoietin (ANG)-2 play key roles in angiogenesis and have an immunosuppressive effect in the tumor microenvironment. This study shows that BI 836880, a bispecific nanobody targeting VEGF and ANG2, demonstrates substantial antitumor activity in preclinical models. Combining VEGF/ANG2 inhibition with the blockade of the PD-1 pathway can further improve antitumor activity.

News (Medical) associated with Trebananib

13 Jun 2022

·www.prnewswire.com

Fallopian Tube Cancer Therapeutics Market Size to Grow by USD 628.28 million | 39% of Market Growth to Originate from North America | Technavio

NEW YORK, June 13, 2022 /PRNewswire/ -- Fallopian tube cancer, also known as tubal cancer, is a type of cancer that is caused by an abnormal cell division in the fallopian tubes that connect to the ovaries and the uterus. It is a less common type of gynecologic cancer. The fallopian tube cancer therapeutics market size is expected to grow by USD 628.28 mn from 2021 to 2026. Moreover, the growth momentum of the market will accelerate at a CAGR of 9.06% during the forecast period. Technavio has announced its latest market research report titled Fallopian Tube Cancer Therapeutics Market by Product and Geography - Forecast and Analysis 2022-2026 Download an Exclusive Sample Report to learn more about market growth Top Key players in Fallopian Tube Cancer Therapeutics Market Amgen Inc. - The company offers fallopian tube cancer therapeutics, namely Trebananib. Baxter International Inc. - The company offers fallopian tube cancer therapeutics, namely Doxil. Bristol Myers Squibb Co. - The company offers fallopian tube cancer therapeutics, namely Opdivo. Clovis Oncology Inc. - The company offers fallopian tube cancer therapeutics, namely Rucaparib. Eli Lilly and Co. - The company offers fallopian tube cancer therapeutics, namely Gemzar. View an Exclusive Sample Report for a list of other key vendors operating in the market Market Trend and Challenge The growing research on regenerative therapies is driving the market growth. Various institutes and vendors are conducting research on developing novel regenerative therapies, including gene therapy, for the treatment of fallopian tube cancer. This, in turn, will fuel the fallopian tube cancer therapeutics market growth during the forecast period. Difficulty in diagnosis is challenging the fallopian tube cancer therapeutics market growth. The use of therapeutics may be carried out for long durations, which is a disadvantage for patients with late-stage fallopian tube cancer. This delay in diagnosis is resulting in an increased preference for alternative treatment options, such as surgeries. Market Segmentation Fallopian Tube Cancer Therapeutics Market Split by Product Targeted therapy: This segment will have the highest market share growth during the forecast period. The benefits of targeted therapy will drive the growth of the segment during the forecast period. Chemotherapy Fallopian Tube Cancer Therapeutics Market Split by Geography North America: The region will have the highest market share growth during the forecast period. This growth will be driven by factors such as the increasing adoption of therapeutics for the treatment of the indication. Moreover, market growth in this region will be faster than the growth of the market in other regions. Europe Asia Rest of World (ROW) Imperative Insights on the following aspects: What was the size of the global fallopian tube cancer therapeutics industry by value in 2020? What will be the size of the global fallopian tube cancer therapeutics industry in 2026? What factors are affecting the strength of competition in the global fallopian tube cancer therapeutics industry? How has the industry performed over the last five years? What are the main segments that make up the global fallopian tube cancer therapeutics market? Get lifetime access to our Technavio Insights! Subscribe to our "Basic Plan" billed annually at USD 5000 Why buy? Identify growth Strategies across markets Analyze your competitor market Know the financial performance of competitors with better insight Related Reports Payment Gateways Market by End-user and Geographic Landscape - Forecast and Analysis 2021-2025 Payment Gateways Market by End-user and Geographic Landscape - Forecast and Analysis 2021-2025 Table of Content: 1 Executive Summary 1.1 Market overview Exhibit 01: Executive Summary – Chart on Market Overview Exhibit 02: Executive Summary – Data Table on Market Overview Exhibit 03: Executive Summary – Chart on Global Market Characteristics Exhibit 04: Executive Summary – Chart on Market by Geography Exhibit 05: Executive Summary – Chart on Market Segmentation by Product Exhibit 06: Executive Summary – Chart on Incremental Growth Exhibit 07: Executive Summary – Data Table on Incremental Growth Exhibit 08: Executive Summary – Chart on Vendor Market Positioning 2 Market Landscape 2.1 Market ecosystem Exhibit 09: Parent market Exhibit 10: Market Characteristics 3 Market Sizing 3.1 Market definition Exhibit 11: Offerings of vendors included in the market definition 3.2 Market segment analysis Exhibit 12: Market segments 3.3 Market size 2021 3.4 Market outlook: Forecast for 2021-2026 Exhibit 13: Chart on Global - Market size and forecast 2021-2026 ($ million) Exhibit 14: Data Table on Global - Market size and forecast 2021-2026 ($ million) Exhibit 15: Chart on Global Market: Year-over-year growth 2021-2026 (%) Exhibit 16: Data Table on Global Market: Year-over-year growth 2021-2026 (%) 4 Five Forces Analysis 4.1 Five forces summary Exhibit 17: Five forces analysis - Comparison between 2021 and 2026 4.2 Bargaining power of buyers Exhibit 18: Chart on Bargaining power of buyers – Impact of key factors 2021 and 2026 4.3 Bargaining power of suppliers Exhibit 19: Bargaining power of suppliers – Impact of key factors in 2021 and 2026 4.4 Threat of new entrants Exhibit 20: Threat of new entrants – Impact of key factors in 2021 and 2026 4.5 Threat of substitutes Exhibit 21: Threat of substitutes – Impact of key factors in 2021 and 2026 4.6 Threat of rivalry Exhibit 22: Threat of rivalry – Impact of key factors in 2021 and 2026 4.7 Market condition Exhibit 23: Chart on Market condition - Five forces 2021 and 2026 5 Market Segmentation by Product 5.1 Market segments Exhibit 24: Chart on Product - Market share 2021-2026 (%) Exhibit 25: Data Table on Product - Market share 2021-2026 (%) 5.2 Comparison by Product Exhibit 26: Chart on Comparison by Product Exhibit 27: Data Table on Comparison by Product 5.3 Targeted therapy - Market size and forecast 2021-2026 Exhibit 28: Chart on Targeted therapy - Market size and forecast 2021-2026 ($ million) Exhibit 29: Data Table on Targeted therapy - Market size and forecast 2021-2026 ($ million) Exhibit 30: Chart on Targeted therapy - Year-over-year growth 2021-2026 (%) Exhibit 31: Data Table on Targeted therapy - Year-over-year growth 2021-2026 (%) 5.4 Chemotherapy - Market size and forecast 2021-2026 Exhibit 32: Chart on Chemotherapy - Market size and forecast 2021-2026 ($ million) Exhibit 33: Data Table on Chemotherapy - Market size and forecast 2021-2026 ($ million) Exhibit 34: Chart on Chemotherapy - Year-over-year growth 2021-2026 (%) Exhibit 35: Data Table on Chemotherapy - Year-over-year growth 2021-2026 (%) 5.5 Market opportunity by Product Exhibit 36: Market opportunity by Product ($ million) 6 Customer Landscape 6.1 Customer landscape overview Exhibit 37: Analysis of price sensitivity, lifecycle, customer purchase basket, adoption rates, and purchase criteria 7 Geographic Landscape 7.1 Geographic segmentation Exhibit 38: Chart on Market share by geography 2021-2026 (%) Exhibit 39: Data Table on Market share by geography 2021-2026 (%) 7.2 Geographic comparison Exhibit 40: Chart on Geographic comparison Exhibit 41: Data Table on Geographic comparison 7.3 North America - Market size and forecast 2021-2026 Exhibit 42: Chart on North America - Market size and forecast 2021-2026 ($ million) Exhibit 43: Data Table on North America - Market size and forecast 2021-2026 ($ million) Exhibit 44: Chart on North America - Year-over-year growth 2021-2026 (%) Exhibit 45: Data Table on North America - Year-over-year growth 2021-2026 (%) 7.4 Europe - Market size and forecast 2021-2026 Exhibit 46: Chart on Europe - Market size and forecast 2021-2026 ($ million) Exhibit 47: Data Table on Europe - Market size and forecast 2021-2026 ($ million) Exhibit 48: Chart on Europe - Year-over-year growth 2021-2026 (%) Exhibit 49: Data Table on Europe - Year-over-year growth 2021-2026 (%) 7.5 Asia - Market size and forecast 2021-2026 Exhibit 50: Chart on Asia - Market size and forecast 2021-2026 ($ million) Exhibit 51: Data Table on Asia - Market size and forecast 2021-2026 ($ million) Exhibit 52: Chart on Asia - Year-over-year growth 2021-2026 (%) Exhibit 53: Data Table on Asia - Year-over-year growth 2021-2026 (%) 7.6 Rest of World (ROW) - Market size and forecast 2021-2026 Exhibit 54: Chart on Rest of World (ROW) - Market size and forecast 2021-2026 ($ million) Exhibit 55: Data Table on Rest of World (ROW) - Market size and forecast 2021-2026 ($ million) Exhibit 56: Chart on Rest of World (ROW) - Year-over-year growth 2021-2026 (%) Exhibit 57: Data Table on Rest of World (ROW) - Year-over-year growth 2021-2026 (%) 7.7 US - Market size and forecast 2021-2026 Exhibit 58: Chart on US - Market size and forecast 2021-2026 ($ million) Exhibit 59: Data Table on US - Market size and forecast 2021-2026 ($ million) Exhibit 60: Chart on US - Year-over-year growth 2021-2026 (%) Exhibit 61: Data Table on US - Year-over-year growth 2021-2026 (%) 7.8 Austria - Market size and forecast 2021-2026 Exhibit 62: Chart on Austria - Market size and forecast 2021-2026 ($ million) Exhibit 63: Data Table on Austria - Market size and forecast 2021-2026 ($ million) Exhibit 64: Chart on Austria - Year-over-year growth 2021-2026 (%) Exhibit 65: Data Table on Austria - Year-over-year growth 2021-2026 (%) 7.9 China - Market size and forecast 2021-2026 Exhibit 66: Chart on China - Market size and forecast 2021-2026 ($ million) Exhibit 67: Data Table on China - Market size and forecast 2021-2026 ($ million) Exhibit 68: Chart on China - Year-over-year growth 2021-2026 (%) Exhibit 69: Data Table on China - Year-over-year growth 2021-2026 (%) 7.10 Switzerland - Market size and forecast 2021-2026 Exhibit 70: Chart on Switzerland - Market size and forecast 2021-2026 ($ million) Exhibit 71: Data Table on Switzerland - Market size and forecast 2021-2026 ($ million) Exhibit 72: Chart on Switzerland - Year-over-year growth 2021-2026 (%) Exhibit 73: Data Table on Switzerland - Year-over-year growth 2021-2026 (%) 7.11 India - Market size and forecast 2021-2026 Exhibit 74: Chart on India - Market size and forecast 2021-2026 ($ million) Exhibit 75: Data Table on India - Market size and forecast 2021-2026 ($ million) Exhibit 76: Chart on India - Year-over-year growth 2021-2026 (%) Exhibit 77: Data Table on India - Year-over-year growth 2021-2026 (%) 7.12 Market opportunity by geography Exhibit 78: Market opportunity by geography ($ million) 8 Drivers, Challenges, and Trends 8.1 Market drivers 8.2 Market challenges 8.3 Impact of drivers and challenges Exhibit 79: Impact of drivers and challenges in 2021 and 2026 8.4 Market trends 9 Vendor Landscape 9.1 Overview 9.2 Vendor landscape Exhibit 80: Overview on Criticality of inputs and Factors of differentiation 9.3 Landscape disruption Exhibit 81: Overview on factors of disruption 9.4 Industry risks Exhibit 82: Impact of key risks on business 10 Vendor Analysis 10.1 Vendors covered Exhibit 83: Vendors covered 10.2 Market positioning of vendors Exhibit 84: Matrix on vendor position and classification 10.3 Amgen Inc. Exhibit 85: Amgen Inc. - Overview Exhibit 86: Amgen Inc. - Product / Service Exhibit 87: Amgen Inc. - Key offerings 10.4 Baxter International Inc. Exhibit 88: Baxter International Inc. - Overview Exhibit 89: Baxter International Inc. - Business segments Exhibit 90: Baxter International Inc. - Key news Exhibit 91: Baxter International Inc. - Key offerings Exhibit 92: Baxter International Inc. - Segment focus 10.5 Bristol Myers Squibb Co. Exhibit 93: Bristol Myers Squibb Co. - Overview Exhibit 94: Bristol Myers Squibb Co. - Product / Service Exhibit 95: Bristol Myers Squibb Co. - Key offerings 10.6 Clovis Oncology Inc. Exhibit 96: Clovis Oncology Inc. - Overview Exhibit 97: Clovis Oncology Inc. - Business segments Exhibit 98: Clovis Oncology Inc. - Key offerings Exhibit 99: Clovis Oncology Inc. - Segment focus 10.7 Eli Lilly and Co. Exhibit 100: Eli Lilly and Co. - Overview Exhibit 101: Eli Lilly and Co. - Product / Service Exhibit 102: Eli Lilly and Co. - Key offerings 10.8 F. Hoffmann La Roche Ltd. Exhibit 103: F. Hoffmann La Roche Ltd. - Overview Exhibit 104: F. Hoffmann La Roche Ltd. - Business segments Exhibit 105: F. Hoffmann La Roche Ltd. - Key news Exhibit 106: F. Hoffmann La Roche Ltd. - Key offerings Exhibit 107: F. Hoffmann La Roche Ltd. - Segment focus 10.9 GlaxoSmithKline Plc Exhibit 108: GlaxoSmithKline Plc - Overview Exhibit 109: GlaxoSmithKline Plc - Business segments Exhibit 110: GlaxoSmithKline Plc - Key news Exhibit 111: GlaxoSmithKline Plc - Key offerings Exhibit 112: GlaxoSmithKline Plc - Segment focus 10.10 ImmunoGen Inc. Exhibit 113: ImmunoGen Inc. - Overview Exhibit 114: ImmunoGen Inc. - Product / Service Exhibit 115: ImmunoGen Inc. - Key offerings 10.11 Johnson and Johnson Exhibit 116: Johnson and Johnson - Overview Exhibit 117: Johnson and Johnson - Business segments Exhibit 118: Johnson and Johnson - Key news Exhibit 119: Johnson and Johnson - Key offerings Exhibit 120: Johnson and Johnson - Segment focus 10.12 Merck and Co. Inc. Exhibit 121: Merck and Co. Inc. - Overview Exhibit 122: Merck and Co. Inc. - Business segments Exhibit 123: Merck and Co. Inc. - Key news Exhibit 124: Merck and Co. Inc. - Key offerings Exhibit 125: Merck and Co. Inc. - Segment focus 11 Appendix 11.1 Scope of the report 11.2 Inclusions and exclusions checklist Exhibit 126: Inclusions checklist Exhibit 127: Exclusions checklist 11.3 Currency conversion rates for US$ Exhibit 128: Currency conversion rates for US$ 11.4 Research methodology Exhibit 129: Research methodology Exhibit 130: Validation techniques employed for market sizing Exhibit 131: Information sources 11.5 List of abbreviations Exhibit 132: List of abbreviations About Us Technavio is a leading global technology research and advisory company. Their research and analysis focus on emerging market trends and provide actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavio's report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio's comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios. Contact Us: Technavio Research Jesse Maida Media & Marketing Executive US: +1 844 364 1100 UK: +44 203 893 3200 Email: [email protected] Website: SOURCE Technavio

Gene Therapy

100 Deals associated with Trebananib

External Link

KEGG	Wiki	ATC	Drug Bank
D10177	-	-	DB12056

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Fallopian Tube Carcinoma	Phase 3	NL	Amgen, Inc.	01 Jan 2012
Peritoneal Neoplasms	Phase 3	NL	Amgen, Inc.	01 Jan 2012
Ovarian Cancer	Phase 3	AT	Amgen, Inc.	18 Apr 2011
Ovarian Cancer	Phase 3	DK	Amgen, Inc.	18 Apr 2011
Ovarian Cancer	Phase 3	DE	Amgen, Inc.	18 Apr 2011
Ovarian Cancer	Phase 3	HU	Amgen, Inc.	18 Apr 2011
Ovarian Cancer	Phase 3	NZ	Amgen, Inc.	18 Apr 2011
Ovarian Cancer	Phase 3	SG	Amgen, Inc.	18 Apr 2011
Ovarian Cancer	Phase 3	SK	Amgen, Inc.	18 Apr 2011
Ovarian Cancer	Phase 3	TW	Amgen, Inc.	18 Apr 2011

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00853372 (CTgov)	Phase 2	Metastatic Renal Cell Carcinoma \| Advanced Renal Cell Carcinoma	85	Trebananib+sunitinib (Trebananib 10 mg/kg + Sunitinib)	minmybviwf(wkcvzkulfc) = mwsjggyrbb mqwghoergl (ltojblciuy, nlvearzxmu - dhmeloneya) View more	-	01 Jul 2020
				Trebananib+sunitinib (Trebananib 15 mg/kg + Sunitinib)	minmybviwf(wkcvzkulfc) = rqvvyqbyte mqwghoergl (ltojblciuy, ufthrwcvjz - gbwabazxfr) View more
NCT01493505 (TRINOVA-3, Pubmed \| Lancet Oncol) Manual	Phase 3	Ovarian Cancer First line	1,015	carboplatin+paclitaxel+Trebananib	gcgitmrnwl(aqpelxhxva) = jihfgqtyoq cdpuufiqfb (jgaojgoqdl ) View more	Negative	01 Jun 2019
				carboplatin+paclitaxel+Placebo	gcgitmrnwl(aqpelxhxva) = lkrpvlulfl cdpuufiqfb (jgaojgoqdl ) View more
NCT03239145 (ASCO 12019 \| ASCO 22019) Manual	Phase 1	Colorectal Cancer	18	trebananib+pembrolizumab	ekikowwqvx(iwtwnikpja) = None oejybvewlo (gdbpzblguv ) View more	Positive	31 May 2019
NCT01553188 (CTgov)	Phase 2	Metastatic castration-resistant prostate cancer \| Advanced Prostate Carcinoma	36	Prednisone+Abiraterone+AMG 386 (Abiraterone, Prednisone and AMG)	nhtgipupys(xjnevjsdhg) = haybqnwmnm jtrtfyukqm (wnkrsslapi, dqtrmzeayk - lrlqparerh) View more	-	16 Oct 2018
				Prednisone+Abiraterone (Abiraterone and Prednisone Only)	nhtgipupys(xjnevjsdhg) = nfbyqyubss jtrtfyukqm (wnkrsslapi, tatebgnwlg - gefqeoxbcp) View more
NCT01290263 (CTgov)	Phase 1/2	Glioblastoma Multiforme \| Recurrent Glioblastoma	48	Bevacizumab+AMG 386 (All Cohort B Participants: AMG 386 + Bevacizumab)	yurbnefjiv(dpkgholsvs) = caioilgmpe urktbqgymj (uxvgopbilu, nlrqzjhbdn - aeaqkcnxyz) View more	-	25 May 2017
				AMG 386 (Cohort A: AMG 386 30 mg/kg)	yurbnefjiv(dpkgholsvs) = vvilgwjeck urktbqgymj (uxvgopbilu, odkokhbjkq - ujzldrmeuj) View more
NCT01281254 (ENGOT-ov-6 \| TRINOVA-2, Pubmed \| Eur J Cancer Care (Engl) \| Eur J Cancer) Manual	Phase 3	Ovarian Cancer	223	pegylated liposomal doxorubicin+trebananib	wqttsepzvs(ocgybyxxea) = egnmdkqulq tspiwuwijs (eqrxillmsq, 7.2 - 9.0) View more	Negative	01 Jan 2017
				pegylated liposomal doxorubicin+Placebo	wqttsepzvs(ocgybyxxea) = njsorxeztn tspiwuwijs (eqrxillmsq, 4.8 - 8.2) View more
NCT01204749 (TRINOVA-1, Pubmed \| Obstet Gynecol Surv) Manual	Phase 3	Recurrent ovarian cancer	919	paclitaxel+trebananib	furaxndfcm(dlppukksyl) = jduupshpix txvvrjqghu (fusfecwlid ) View more	Negative	01 Oct 2016
				paclitaxel+Placebo	furaxndfcm(dlppukksyl) = fhvofueckj txvvrjqghu (fusfecwlid ) View more
NCT00853372 (Pubmed \| J Urol \| J Clin Oncol) Manual	Phase 2	Metastatic Renal Cell Carcinoma	85	Trebananib+Sunitinib (sunitinib 50 mg and trebananib 10 mg/kg)	xsgtreqkyd(ropvrcpnrt) = gncuqmsyic yfuzfgbtyz (fafcydxcpq ) View more	Positive	20 Oct 2015
				Trebananib+Sunitinib (sunitinib 50 mg and trebananib 15 mg/kg)	xsgtreqkyd(ropvrcpnrt) = azxjjrpyxd yfuzfgbtyz (fafcydxcpq ) View more
NCT01623869 (Alliance A091103, CTgov)	Phase 2	Hemangiosarcoma	16	Laboratory Biomarker Analysis+Trebananib	ocbywdsszc(pyiugoadek) = gqvlaslvpq sanhhvxxtg (gfxkfomscm, dmeylivpwr - ualrtwjhyx) View more	-	02 Jul 2015
NCT01204749 (TRINOVA-1, ASCO2015)	Phase 3	Recurrent ovarian cancer	919	Trebananib 15 mg/kg + Paclitaxel	vwgaffwstp(ypluutawpp) = oxasosdrmc zgwgqkagoz (ygkrujbweq ) View more	Positive	20 May 2015
				Paclitaxel	vwgaffwstp(ypluutawpp) = ybilxzyxcp zgwgqkagoz (ygkrujbweq ) View more

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Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

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Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis