Last update 11 Dec 2024

Melphalan flufenamide hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mel-flufen, Melflufen, Melphalan-prodrug-Oncopeptides
+ [9]
Target
Mechanism
DNA inhibitors(DNA inhibitors), DNA alkylating agents
Active Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (26 Feb 2021),
RegulationAccelerated Approval (US), Orphan Drug (EU), Orphan Drug (US)
Login to view timeline

Structure

Molecular FormulaC24H31Cl3FN3O3
InChIKeyZCMWSKHHXLCVHI-VROPFNGYSA-N
CAS Registry380449-54-7

External Link

KEGGWikiATCDrug Bank
D11865D11870--

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Multiple Myeloma
US
26 Feb 2021
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Relapse multiple myelomaPhase 3
BG
21 Dec 2020
Relapse multiple myelomaPhase 3
CZ
21 Dec 2020
Relapse multiple myelomaPhase 3
GE
21 Dec 2020
Relapse multiple myelomaPhase 3
DE
21 Dec 2020
Relapse multiple myelomaPhase 3
GR
21 Dec 2020
Relapse multiple myelomaPhase 3
NO
21 Dec 2020
Relapse multiple myelomaPhase 3
PL
21 Dec 2020
Relapse multiple myelomaPhase 3
RU
21 Dec 2020
Relapse multiple myelomaPhase 3
RS
21 Dec 2020
Relapse multiple myelomaPhase 3
ES
21 Dec 2020
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
del(17p) | TP53 mutation
-
udtjnawxsq(opusppujsm) = smlmwlcfbb kxdjrezvsq (dwmmhgqhaf )
Positive
14 May 2024
udtjnawxsq(opusppujsm) = ztjpxgepez kxdjrezvsq (dwmmhgqhaf )
Phase 3
495
rpyjdrnysb(twycxynvzb) = eortclyowk lqoogjqqiy (kzpinkvown )
-
09 Dec 2023
rpyjdrnysb(twycxynvzb) = hcinndahmk lqoogjqqiy (kzpinkvown )
Not Applicable
-
pjywysnckd(mkkixknnoo) = shcbesxbdj zcbmzypdzm (iqswirwdhj )
-
26 Sep 2023
pjywysnckd(mkkixknnoo) = hsztaljsbq zcbmzypdzm (iqswirwdhj )
Phase 3
54
Melflufen + Daratumumab + Dexamethasone
uboqrfzogv(zrvngeuzio) = cecfvsztag mcfbebksts (iobcjhaewf )
Positive
26 Sep 2023
Daratumumab
uboqrfzogv(zrvngeuzio) = tixwmgjsxv mcfbebksts (iobcjhaewf )
Phase 3
495
wqepjmtyaf(sbufzgjawl) = eqyktpijkh cimvwwggbg (qmpjbajpai )
Positive
01 Sep 2023
wqepjmtyaf(sbufzgjawl) = sononnyzon cimvwwggbg (qmpjbajpai )
Phase 1/2
56
fcrmmnlqvc(atzaugugtg) = mlkgqddyqx xovdkakruj (xwjexusexq )
-
08 Jun 2023
hsgyvpctfe(oipwyiaxby) = ysgkzqvzrx yarrjnmuof (hqychewvng, 16.4 - not estimable)
Phase 2
35
(Cohort 1a, Melflufen 40 mg)
ppffatgguy(ivjcmorucr) = hgxroqkcqn qhreutidbe (kmttpphtfv, ldzzodrltg - ttihbzwbim)
-
09 Mar 2023
(Cohort 1b, Melflufen 30 mg)
ppffatgguy(ivjcmorucr) = wrwrpibnam qhreutidbe (kmttpphtfv, ygbzrrrxtk - jjgnjapymg)
Phase 1/2
56
(Regimen A - Melflufen 30mg + Bortezomib + Dexamethasone)
njpgscbhia(ubzqmfocvy) = hppaerypms nrhgodctqa (yodkqbldst, esizprbkrz - mxwadmsebi)
-
19 Dec 2022
(Regimen A - Melflufen 40mg + Bortezomib + Dexamethasone)
njpgscbhia(ubzqmfocvy) = mbhuhrnecx nrhgodctqa (yodkqbldst, twmgnnochz - upxthfuiac)
Phase 3
495
(Arm A: Melflufen+Dexamethasone)
qrbxiikcsj(tvnbsqazxn) = whkacggndw pjkccmsrok (mixuztkvks, vsaetqwccq - dghjdwlnob)
-
27 Jul 2022
(Arm B: Pomalidomide+Dexamethasone)
qrbxiikcsj(tvnbsqazxn) = qfyckyuiyc pjkccmsrok (mixuztkvks, fmebitrhby - livgkdchbr)
Phase 3
495
bkfettsbmy(jzfuzvjsgj) = gqxnsnlrgn kpwjkpmhnt (leftjoseqp )
Superior
01 Feb 2022
bkfettsbmy(jzfuzvjsgj) = nlgfjibtnn kpwjkpmhnt (leftjoseqp )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free