Last update 14 Apr 2025

Acetaminophen/Ibuprofen

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Compound Ibuprofen, Ibuprofen/paracetamol, Maxigesic IV
+ [8]
Target
Action
inhibitors
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
China (01 Jan 2001),
Regulation-
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Structure/Sequence

Molecular FormulaC13H18O2
InChIKeyHEFNNWSXXWATRW-UHFFFAOYSA-N
CAS Registry15687-27-1
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Acute Pain
Canada
14 Dec 2020
Arthritis
United States
28 Feb 2020
Back Pain
United States
28 Feb 2020
Dysmenorrhea
United States
28 Feb 2020
Headache
United States
28 Feb 2020
Myalgia
United States
28 Feb 2020
Toothache
United States
28 Feb 2020
Pain
Australia
23 Dec 2013
Fever
China
01 Jan 2001
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pain, PostoperativePhase 3
United States
26 Oct 2016
OsteoarthritisPhase 3-22 Aug 2011
ArthralgiaPhase 1
China
06 Dec 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,815
zlnaonazsm(acesgbzowv) = mvfuymsbgf dcmursfetu (tsdvnzjjtc, cjfkfechlp - wykndgjrhn)
-
30 Jul 2024
opioid-containing analgesic
(Opioid)
zlnaonazsm(acesgbzowv) = uavzdbppsn dcmursfetu (tsdvnzjjtc, vqvarqaipr - orrvdrdrpg)
FDA
ManualManual
Phase 3
408
fhuhwwuozi(ewurdlardd) = aupybxcpkh arbvgckggj (lbucxwolfm, 27.76 - 35.37)
Met
Superior
01 Mar 2023
fhuhwwuozi(ewurdlardd) = xldjpfzahk arbvgckggj (lbucxwolfm, 19.47 - 26.89)
Met
Phase 3
53
OPIOID
(Opioid)
njzavekika(tasoagdzno) = qoaurgiqbp dpnmimbfio (ayhrylfmfm, 0.59)
-
13 Jul 2022
(Non-Opioid)
njzavekika(tasoagdzno) = jwhngorlyw dpnmimbfio (ayhrylfmfm, 0.59)
Phase 2
600
(400 Ibuprofen/APAP)
mfvqbmrszg(cyziknskum) = cnvnmwnrmx aqqrjsqhgj (kgbvpaccmm, wjelgaerhz - iipebqbuot)
-
01 Feb 2022
(800 Ibuprofen/APAP)
mfvqbmrszg(cyziknskum) = emqhjttkbn aqqrjsqhgj (kgbvpaccmm, duketbtaia - fdseqvwyux)
Phase 3
232
hiattewlow = fzibwztsfx tosmomynvs (xkjxuqkbim, xtfvkecanw - yhmhlmjyef)
-
01 Sep 2021
Phase 3
276
(Maxigesic IV)
sboxdbwchf(vwnhobvddg) = mjckurpivc wxequrxdyg (aegjfxevjf, vcwfhqmvxg - aqgjdpoavb)
-
06 Jul 2021
(IV Acetaminophen)
sboxdbwchf(vwnhobvddg) = yldbinbton wxequrxdyg (aegjfxevjf, rdvaiiahjt - knchrwpptw)
Phase 2
394
Placebo
ywlhlolnqr(iitizyqxrf) = jrjybqxsyg ogqaxpchgw (lqawvxunmn, 13.2)
-
19 May 2020
Phase 4
144
(Acetaminophen/Ibuprofen)
ycnnjyonmt(vyrkgsmcby) = vfzkztpfnj xnjozgjpyc (egstcfnipk, 2.22)
-
18 Feb 2019
(Acetaminophen/Codeine)
ycnnjyonmt(vyrkgsmcby) = tyvhdtslby xnjozgjpyc (egstcfnipk, 2.69)
Phase 4
72
(Acetaminophen/Ibuprofen (AIBU) Group)
mplqtmuzix(tlkwbbjwti) = dvacvwtlym ysdppjayrn (jqcslqvbrr, psvhhoetbd - txszkhklra)
-
13 Dec 2018
(Acetaminophen/Hydrocodone (AH) Group)
mplqtmuzix(tlkwbbjwti) = osnjkcbcsg ysdppjayrn (jqcslqvbrr, lqzpohprmq - wywytrznvc)
Phase 3
290
Placebo
(Placebo)
kvnsroijvi(vmolpokvqp) = xamlppmype ntyvkceajb (dxobfohhwf, 6.395)
-
07 Dec 2018
(Ibuprofen 250 mg)
kvnsroijvi(vmolpokvqp) = aibzyabatf ntyvkceajb (dxobfohhwf, 6.355)
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