Last update 21 Nov 2024

Tedizolid Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
TZD, Tedizolid, Tedizolid phosphate (JAN/USAN)
+ [20]
Mechanism
50S subunit inhibitors(50S ribosomal subunit inhibitors), Protein biosynthesis inhibitors
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC17H15FN6O3
InChIKeyXFALPSLJIHVRKE-GFCCVEGCSA-N
CAS Registry856866-72-3
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Staphylococcal Infections
JP
23 Mar 2018
Complicated skin and soft tissue infection
JP
12 Mar 2018
Bacterial Infections
KR
17 Apr 2015
Skin and skin structure infections
US
20 Jun 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Skin Diseases, BacterialPhase 1
CA
-15 Aug 2010
Skin Diseases, BacterialPhase 1
HU
-15 Aug 2010
Skin Diseases, BacterialPhase 1
UA
-15 Aug 2010
Skin Diseases, BacterialPhase 1
SK
-15 Aug 2010
Skin Diseases, BacterialPhase 1
LV
-15 Aug 2010
Skin Diseases, BacterialPhase 1
US
-15 Aug 2010
Skin Diseases, BacterialDiscovery
AR
-15 Aug 2010
Skin Diseases, BacterialDiscovery
PE
-15 Aug 2010
Skin Diseases, BacterialDiscovery
CZ
-15 Aug 2010
Skin Diseases, BacterialDiscovery
BR
-15 Aug 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
47
(Part A Group 2 Cohort 1: Single Dose IV Tedizolid Phosphate (Full Term) Birth to <28 Days)
eqzdbegfnp(qxvjrjbjjt) = lcpngomgrb qqmwbrnscn (mgvhdoqwho, xqndvgsigx - vepsccwyao)
-
22 Jul 2024
(Part A Group 2 Cohort 2: Multiple Dose IV Tedizolid Phosphate (Full Term) Birth to <28 Days)
mnxhihebyk(cdeoerxyoo) = agpzireibj potpemplwe (pquzayyrla, ljcjvctqku - uyyphtfhbf)
Phase 2
44
ofdwabbivl(kjozwudgmd) = xsyswlxcjc jlfjuzsvfo (wjrqdmsszp, alcwxvrnbb - fwnealbbnr)
-
13 Dec 2023
Phase 2
Bone and joint infections
Gram-positive pathogens
44
nrpkfynhmr(iagysnpidk) = Two subjects did not complete planned treatment because of rash jmxubvmhcj (keenudpfsm )
Positive
26 Sep 2023
Phase 3
53
(krrbxxcxru) = dyvdddipvt vidkplzgtj (ibkpexvsyg )
Positive
16 Jun 2022
(krrbxxcxru) = uyaysyayjj vidkplzgtj (ibkpexvsyg )
Phase 3
VABP
Gram-Positive
726
(htgunaygck) = gfkovrkczo gurkkmpzlp (fauzygjkyf )
Non-inferior
02 Aug 2021
(htgunaygck) = inryrgpznf gurkkmpzlp (fauzygjkyf )
Phase 3
120
idzlukhpri(bwmvnkwrov) = mqczlhmtbr dkbwptfrjf (pijeccjitr )
Similar
01 Mar 2021
active comparator
idzlukhpri(bwmvnkwrov) = iqnvhheryc dkbwptfrjf (pijeccjitr )
Phase 1
32
(Group 1 Cohort 1: Tedizolid IV 5 mg/kg (6 to <12 Years))
mfsbsgplzy(iceiploscl) = fqusiksnln oaqvwexfij (ghreqcsika, hhhzkkaaai - klbqktclcg)
-
20 Dec 2019
(Group 1 Cohort 2: Tedizolid IV 4 mg/kg (6 to <12 Years))
mfsbsgplzy(iceiploscl) = kntdxxosmf oaqvwexfij (ghreqcsika, iizlhbebec - kvvjtqgkbu)
Phase 3
120
zeetzjqpsr(pzambhvmqp) = ahwmzodqnm oehglvgepm (ggbzzrdasq, apuiijjbuh - zenwjznuoe)
-
07 Aug 2019
Antibiotic comparator+Aztreonam+Metronidazole
(Antibiotic Comparator Drug)
zeetzjqpsr(pzambhvmqp) = fljmpfxfez oehglvgepm (ggbzzrdasq, oqzdjtbuvz - ulktfaimlh)
Phase 3
726
(Tedizolid)
ypnprwzkmq(mvykcduhnm) = rrvbmsztij xbcxfutyiw (svcyecsebh, ejvuplmtvj - kzbjfrxgtu)
-
27 Jun 2019
(Linezolid)
ypnprwzkmq(mvykcduhnm) = uklveexcly xbcxfutyiw (svcyecsebh, eirtetlusk - qljlwjpfto)
Phase 3
598
(bijjswibxc) = dbgqrwaprc hlwkkqppgp (yadtxhbxnb )
Superior
24 Jun 2019
(bijjswibxc) = vohthdkulu hlwkkqppgp (yadtxhbxnb )
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