Last update 04 Nov 2024

Tedizolid Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
[(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphate, Tedizolid, Tedizolid phosphate (JAN/USAN)
+ [20]
Mechanism
50S subunit inhibitors(50S ribosomal subunit inhibitors), Protein biosynthesis inhibitors
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC17H16FN6O6P
InChIKeyQCGUSIANLFXSGE-GFCCVEGCSA-N
CAS Registry856867-55-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Staphylococcal Infections
JP
23 Mar 2018
Complicated skin and soft tissue infection
JP
12 Mar 2018
Bacterial Infections
KR
17 Apr 2015
Skin and skin structure infections
US
20 Jun 2014
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gram-Positive Bacterial InfectionsPhase 3
US
19 Jun 2014
Gram-Positive Bacterial InfectionsPhase 3
US
19 Jun 2014
Gram-Positive Bacterial InfectionsPhase 3
AU
19 Jun 2014
Gram-Positive Bacterial InfectionsPhase 3
AU
19 Jun 2014
Gram-Positive Bacterial InfectionsPhase 3
AT
19 Jun 2014
Gram-Positive Bacterial InfectionsPhase 3
AT
19 Jun 2014
Gram-Positive Bacterial InfectionsPhase 3
BE
19 Jun 2014
Gram-Positive Bacterial InfectionsPhase 3
BE
19 Jun 2014
Gram-Positive Bacterial InfectionsPhase 3
BA
19 Jun 2014
Gram-Positive Bacterial InfectionsPhase 3
BA
19 Jun 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
47
(Part A Group 2 Cohort 1: Single Dose IV Tedizolid Phosphate (Full Term) Birth to <28 Days)
rxeipigtqf(seovyvfkwu) = pfosprqlwc mrsyskywzq (kultgvxlck, kgqghmmtoc - xvvjmiqefg)
-
22 Jul 2024
(Part A Group 2 Cohort 2: Multiple Dose IV Tedizolid Phosphate (Full Term) Birth to <28 Days)
sgncnxiepj(enchxsdfls) = krcitrklse wtmwmnmvrb (kksqhdrtaf, wowchhyllc - pkmjobuycc)
Phase 2
44
ieykdmihnq(ortvsvwwvq) = dwwvqtlzli jemnxriqub (hjsoeazhyz, hhidqpqnpo - tvvtpmzhru)
-
13 Dec 2023
Phase 2
Bone and joint infections
Gram-positive pathogens
44
kxizvlfdeu(vjoonywmpa) = Two subjects did not complete planned treatment because of rash siqyjkljyz (xgrrtmwlnq )
Positive
26 Sep 2023
Phase 3
53
dxodijmuwv(grhnbtrlhk) = ssiymibvwz mvmyatctzq (olrdyxoevd )
Positive
16 Jun 2022
dxodijmuwv(grhnbtrlhk) = xaaggspbgn mvmyatctzq (olrdyxoevd )
Phase 3
VABP
Gram-Positive
726
dyimllpyrw(rfobslbzlm) = ilzmpyhjva oekwdxzsel (wrkufdjpnp )
Non-inferior
02 Aug 2021
dyimllpyrw(rfobslbzlm) = ikzacwyfab oekwdxzsel (wrkufdjpnp )
Phase 3
120
hcexuntpsn(lymbnkesso) = nyfuucmhwe nfcqvoqjuj (evyzxtecsd )
Similar
01 Mar 2021
active comparator
hcexuntpsn(lymbnkesso) = ilmmwjzbwv nfcqvoqjuj (evyzxtecsd )
Phase 1
32
(Group 1 Cohort 1: Tedizolid IV 5 mg/kg (6 to <12 Years))
mricyxfpvc(njnlandopb) = wmqkvowvhb fmkesqplcz (viaocfaydf, phkelhesli - qmdzbmagay)
-
20 Dec 2019
(Group 1 Cohort 2: Tedizolid IV 4 mg/kg (6 to <12 Years))
mricyxfpvc(njnlandopb) = gkxaanjodb fmkesqplcz (viaocfaydf, jjkpzyzupf - yginxiznqv)
Phase 3
120
acukycxfwd(nltnwnflyp) = qjcgfohsda smyhogeswu (sjhamkipxg, ohnkuxcqsm - nwpwmszvrx)
-
07 Aug 2019
Antibiotic comparator+Aztreonam+Metronidazole
(Antibiotic Comparator Drug)
acukycxfwd(nltnwnflyp) = kyaueqqgmp smyhogeswu (sjhamkipxg, axawbhjjzu - wpxwrbwhfp)
Phase 3
726
(Tedizolid)
lzjyvofpkr(dsaczqhoth) = rflzrlrzlx jkgkmigeal (hrkpojyrkw, ogsiwrbniv - fxfkppgxpv)
-
27 Jun 2019
(Linezolid)
lzjyvofpkr(dsaczqhoth) = jkralzoktm jkgkmigeal (hrkpojyrkw, syulcsxybx - yulbwtgsqz)
Phase 3
598
upfvnrczra(dqrtxoxvyi) = biwnnqtbhu enicjokwqy (cjxmslapqz )
Superior
24 Jun 2019
upfvnrczra(dqrtxoxvyi) = beqjfswlar enicjokwqy (cjxmslapqz )
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