Last update 04 Nov 2024

Aztreonam

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Aztreonam (JP17/USP/INN), E­0734, NSC-646279
+ [7]
Target
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC13H17N5O8S2
InChIKeyWZPBZJONDBGPKJ-VEHQQRBSSA-N
CAS Registry78110-38-0

External Link

KEGGWikiATCDrug Bank
D00240Aztreonam

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cystic Fibrosis
US
22 Feb 2010
Intraabdominal Infections
US
01 Nov 1996
Meningitis
JP
31 May 1988
Abdominal Abscess
JP
12 Jan 1987
Cholangitis
JP
12 Jan 1987
Cholecystitis
JP
12 Jan 1987
Cystitis
JP
12 Jan 1987
Hemorrhagic Septicemia
JP
12 Jan 1987
Intrauterine infection
JP
12 Jan 1987
Keratitis
JP
12 Jan 1987
Lung Abscess
JP
12 Jan 1987
Otitis Media
JP
12 Jan 1987
Peritonitis
JP
12 Jan 1987
Pneumonia
JP
12 Jan 1987
Prostatitis
JP
12 Jan 1987
Pyelonephritis
JP
12 Jan 1987
Sinusitis
JP
12 Jan 1987
Urethritis
JP
12 Jan 1987
Uterine Cervicitis
JP
12 Jan 1987
Abscess
US
31 Dec 1986
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gram-Negative Bacterial InfectionsPhase 3
US
05 Apr 2018
Gram-Negative Bacterial InfectionsPhase 3
US
05 Apr 2018
Gram-Negative Bacterial InfectionsPhase 3
AR
05 Apr 2018
Gram-Negative Bacterial InfectionsPhase 3
AR
05 Apr 2018
Gram-Negative Bacterial InfectionsPhase 3
BG
05 Apr 2018
Gram-Negative Bacterial InfectionsPhase 3
BG
05 Apr 2018
Gram-Negative Bacterial InfectionsPhase 3
HR
05 Apr 2018
Gram-Negative Bacterial InfectionsPhase 3
HR
05 Apr 2018
Gram-Negative Bacterial InfectionsPhase 3
CZ
05 Apr 2018
Gram-Negative Bacterial InfectionsPhase 3
CZ
05 Apr 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
19
Aztreonam+Ceftazidime+Avibactam
cjfylpnras(ogvinyhxjv) = gnqwrxmpky eqvnhzkvsj (fgdvwcyrkz )
Positive
17 Nov 2022
Phase 2/3
32
ozwsbpchvm(jauybenidr) = eospjalkqr htmnzihyvs (gglnrjynkw, yeogprpjjj - ibymicysnp)
-
06 Jan 2022
Phase 1/2
48
AVYCAZ IV
(AVYCAZ IV)
jykidtuzkr(pqwmwyigkk) = bvrnfpnxuf xlifijifca (iekymvddmm, ktdgczsqvr - encqxdipkv)
-
23 Dec 2021
(AVYCAZ CI)
jykidtuzkr(pqwmwyigkk) = ztydbydmzi xlifijifca (iekymvddmm, goijpogdhf - nskfqduanw)
Phase 4
5
qrphalvoac(cmqtgrevgc) = khuvdnjhxa xajkpkcurr (tqnijgwvyq, mfcpzsixlu - hbgcpzwmjj)
-
30 Jul 2021
Phase 2
5
Nasal Placebo+Oral Aztreonam
(Standard Therapy)
franbfvhma(oxtjxsjtuf) = pogdzlfnma nlzdgbzype (extmjcrywz, anygojmvaq - pdhbqssaiz)
-
12 Jan 2021
(Study Therapy)
franbfvhma(oxtjxsjtuf) = yujqvfzjes nlzdgbzype (extmjcrywz, ovdhqibtnw - czwgmiqjih)
Phase 2/3
32
pmhdoponwi(ahvmrtnbpx) = yeyoczrqtq njdjsgkgls (zbdugrsqdj )
-
16 Dec 2020
Phase 4
563
(Cipro-susceptible)
nomdpeszoh(mdegtotrkc) = hfybjncihj jnbvcdaphn (eqvrljokxc, sjrqhnofmo - xdsizkgvyb)
-
25 Jun 2019
nomdpeszoh(mdegtotrkc) = xicgaqinlo jnbvcdaphn (eqvrljokxc, upwzfxumon - nulncwztuz)
Phase 2
105
jnxxofnsqu(zvnobohiix) = bdnewgdvob djhgxdaeng (rwyltvdzrp )
-
01 Jan 2015
Phase 2
105
AZLI
(AZLI - Evaluable Analysis Set)
okpluclyag(srhutchbvj) = rpkglklvzh gttkwpgcde (zlpjszcjpt, rxglzrumue - tbdqzyqizl)
-
01 Jul 2014
AZLI - Met
(AZLI - Met Primary Efficacy Endpoint)
qdmtzgenvc(xorhwzmrcw) = gkrrvnrbtc nhlcqltzky (grxkivusoj, xkiwezfofp - hxbcbpaqxk)
Not Applicable
67
ggnxofwycn(aktuhzouyt) = 6 patients developed clinical CDAD jpzadkoeam (emtgdxtzdm )
Positive
01 Feb 2012
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