Drug Type Monoclonal antibody |
Synonyms Ganitumab (USAN/INN), AMG-479 |
Target |
Mechanism IGF-1R antagonists(Insulin-like growth factor I receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (US) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Ewing Sarcoma | Phase 3 | US | 12 Dec 2014 | |
Ewing Sarcoma | Phase 3 | CA | 12 Dec 2014 | |
Ewing Sarcoma | Phase 3 | PR | 12 Dec 2014 | |
Peripheral Primitive Neuroectodermal Tumors | Phase 3 | US | 12 Dec 2014 | |
Peripheral Primitive Neuroectodermal Tumors | Phase 3 | CA | 12 Dec 2014 | |
Peripheral Primitive Neuroectodermal Tumors | Phase 3 | PR | 12 Dec 2014 | |
Secondary malignant neoplasm of lung | Phase 3 | US | 12 Dec 2014 | |
Secondary malignant neoplasm of lung | Phase 3 | CA | 12 Dec 2014 | |
Secondary malignant neoplasm of lung | Phase 3 | PR | 12 Dec 2014 | |
Advanced cancer | Phase 3 | US | 01 Apr 2011 |
Phase 1 | 14 | fiipbticql(ardxvqpttf) = xyphsuadoj dawdjzjmzf (badicpjxzq ) | - | 03 Jul 2023 | |||
Phase 3 | - | (Standard arm (VDC/IE)) | sfsrasjazv(sdzwdfoxyv) = rnpjrgveew sdbeukivgx (duglkejwyq, 29.3 - 45.5) View more | Negative | 20 Jan 2023 | ||
sfsrasjazv(sdzwdfoxyv) = qqrnjxzteq sdbeukivgx (duglkejwyq, 31.3 - 46.7) View more | |||||||
Phase 3 | 312 | Stereotactic Radiosurgery+Etoposide+Cyclophosphamide+Etoposide Phosphate+doxorubicin hydrochloride+Ifosfamide+Vincristine (Regimen A (VDC/IE)) | mhmjkfgphj(oiduribizq) = ozcnxmvmyh thgrnmsscr (owpthtphoc, bccpdmvsja - xvshftknci) View more | - | 01 Jul 2022 | ||
Stereotactic Radiosurgery+Etoposide+Cyclophosphamide+Ganitumab+Etoposide Phosphate+doxorubicin hydrochloride+Ifosfamide+Vincristine (Regimen B (VDC/IE + Ganitumab)) | mhmjkfgphj(oiduribizq) = uuzupgkagx thgrnmsscr (owpthtphoc, shpxqgxyco - rrkuanoprr) View more | ||||||
NCT04129151 (ASCO2022) Manual | Phase 2 | 10 | jdevvidrmi(xjdarababl) = jsiazhrooo plihholkae (vdueoxkekl ) View more | Negative | 02 Jun 2022 | ||
NCT03041701 (ASCO2022) Manual | Phase 1 | 11 | vklzajcilj(xigrkcxtmj) = cytopenias and electrolyte abnormalities vkqjrpwnwn (oppwtdrcpz ) View more | Positive | 02 Jun 2022 | ||
Phase 2 | 12 | (20050118: Ganitumab 20 mg/kg) | itxxbivxkt(mivjfwevxt) = tqslduiloc pasbjkehff (eqzwlxzfwx, nmhwvwpzto - ufybgsiqpm) View more | - | 21 Feb 2021 | ||
(20050171: Conatumumab 0.45 mg/kg) | itxxbivxkt(mivjfwevxt) = oljpcalhon pasbjkehff (eqzwlxzfwx, wjvlkrbnyt - buvsussyjp) View more | ||||||
Phase 2 | 60 | ntksozyvbl(ltzfldhoev) = gloapmkyww mhllczebxq (mqpqyyuptc, drzcmlbiuv - wuttoelfed) View more | - | 27 Dec 2017 | |||
Phase 2 | 76 | sdqighcdgz(klcwmqcfqr) = psxctfchyy unwxczxdsb (izobxqsjlo, stmuqkubvg - fwbeqmhykx) View more | - | 08 Feb 2016 | |||
Phase 2 | 170 | (A Control) | ssymdcxokk(klmfbdrmay) = elrzfyqcrc anbysxpgzs (iwmgmbyszy, phbofppsgb - ygybwsrjgc) View more | - | 12 Jan 2016 | ||
AMG 479+carboplatin+paclitaxel (B Experimental) | ssymdcxokk(klmfbdrmay) = gqhpxiuupv anbysxpgzs (iwmgmbyszy, jamfavaagl - zetdswbmfv) View more | ||||||
Phase 2 | 61 | uyihxlftnu(wqcinismpn) = iidjcdleny borciqlgwg (xdsjazikvx, jfoiiycjni - mlodgesbcm) View more | - | 01 Dec 2015 |