Delving into the Latest Updates on Acetaminophen/Aspirin/Codeine Phosphate Hydrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

COXs x Opioid receptors

Action

inhibitors, agonists

Mechanism

COX inhibitors(Cyclooxygenases inhibitors), Opioid receptors agonists(Opioid receptors agonists)

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

Mikart LLC

Active Organization

Mikart LLC

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

United States (26 Oct 1990)

Regulation-

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Structure/Sequence

Molecular FormulaC9H8O4

InChIKeyBSYNRYMUTXBXSQ-UHFFFAOYSA-N

CAS Registry50-78-2

View All Structures (3)

The purpose of this study is to evaluate the bioequivalence of a new paracetamol 1000 mg/codeine 30 mg formulation vs. the marketed reference Co-efferalgan® 500 mg/30 mg in terms of rate and extent of absorption, when administered as single oral dose (one tablet of the new A.C.R.A.F. formulation vs. two tablets of the reference formulation Co-efferalgan®) to healthy male and female volunteers, under fasting conditions, in two consecutive study periods.

Start Date01 Apr 2016

Sponsor / Collaborator

Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - SpA

[+1]

NCT02647788

/ CompletedPhase 4IIT

Pilot Study, Blinded Randomized Control Trial, Single Center Study to Compare Acetaminophen & Codeine Versus Ibuprofen/Acetaminophen for Pain Control and Patient Satisfaction After Ambulatory Hand Surgery

The purpose of this research study is to find out if taking Acetaminophen with Ibuprofen (e.g. Tylenol + Advil), a non-opioid regimen, provides the same type of pain relief after hand surgery compared to Acetaminophen and codeine (e.g. Tylenol 3), an opioid regimen.

Start Date01 Dec 2015

Sponsor / Collaborator

University of Pennsylvania

NCT02455518

/ CompletedPhase 4IIT

Comparative Efficacy of 4 Oral Analgesics for the Initial Management of Acute Musculoskeletal Extremity Pain

The purpose of this study is to perform a randomized, double blind 4-arm clinical trial of the comparative efficacy of 4 oral analgesics in the initial management of acute musculoskeletal extremity pain presenting to the ED.

Start Date01 Jul 2015

Sponsor / Collaborator

Montefiore Medical Center

100 Clinical Results associated with Acetaminophen/Aspirin/Codeine Phosphate Hydrate

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100 Translational Medicine associated with Acetaminophen/Aspirin/Codeine Phosphate Hydrate

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100 Patents (Medical) associated with Acetaminophen/Aspirin/Codeine Phosphate Hydrate

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100 Deals associated with Acetaminophen/Aspirin/Codeine Phosphate Hydrate

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R&D Status

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02647788 (CTgov)	Phase 4	Pain, Postoperative	144	Acetaminophen/Ibuprofen (Acetaminophen/Ibuprofen)	kolzmsfddv(zlapunmgpu) = huvikniuhp edrganlpsb (meksmqxsgd, 2.22) View more	-	18 Feb 2019
				Acetaminophen/Codeine (Acetaminophen/Codeine)	kolzmsfddv(zlapunmgpu) = qlsnhfnefg edrganlpsb (meksmqxsgd, 2.69) View more
NCT02455518 (CTgov)	Phase 4	Musculoskeletal Pain	416	Oxycodone/acetaminophen (Oxycodone/Acetaminophen)	pfthtsgomx = hrosgimmwm erwcbivyhu (tretlecmcf, orqbvcqnjj - qybhqvcrsm) View more	-	13 Feb 2018
				Hydrocodone/acetaminophen (Hydrocodone/Acetaminophen)	pfthtsgomx = pdfsjlmram erwcbivyhu (tretlecmcf, cgbxnssjwn - vlljeqyquq) View more