Last update 21 Nov 2024

Cimetidine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine, 2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine, Cimetidine (JP17/USP/INN)
+ [8]
Mechanism
H2 receptor antagonists(Histamine H2 receptor antagonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (16 Aug 1977)
Regulation-
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Structure

Molecular FormulaC10H16N6S
InChIKeyAQIXAKUUQRKLND-UHFFFAOYSA-N
CAS Registry51481-61-9

External Link

KEGGWikiATCDrug Bank
D00295Cimetidine

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heartburn
US
19 Jun 1995
Hemorrhagic gastritis
JP
01 Oct 1987
Stress ulcer
JP
01 Oct 1987
Upper gastrointestinal hemorrhage
JP
01 Oct 1987
Acute gastritis
JP
02 Sep 1987
Chronic gastritis
JP
02 Sep 1987
Esophagitis, Peptic
JP
02 Sep 1987
Anesthesia
JP
30 Jun 1987
Peptic Ulcer
CN
01 Jan 1983
Anastomotic ulcer
JP
19 Sep 1981
Duodenal Ulcer
JP
19 Sep 1981
Gastrointestinal Hemorrhage
JP
19 Sep 1981
Stomach Ulcer
JP
19 Sep 1981
Zollinger-Ellison Syndrome
JP
19 Sep 1981
Gastroesophageal Reflux
CN
01 Jan 1981
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
25
hydroxypropyl methylcellulose (HPMC)+cimetidine
(Experimental: CimTest-A)
(vztcycjtcg) = wywdnekqrh gwfmbqwfyk (gtgciglvqj, uefoemftho - rxbtwvjiwp)
-
28 Aug 2019
magnesium stearate+cimetidine
(Experimental: CimTest-B)
(vztcycjtcg) = mucxhgufcq gwfmbqwfyk (gtgciglvqj, qtknvybuip - cppjkozfch)
Phase 2
-
(vvmpzbfpll) = cbylojevqe aboqkzkbmu (jyipmdnpma )
Negative
01 Jun 2018
Placebo
(vvmpzbfpll) = dntrazdofi aboqkzkbmu (jyipmdnpma )
Phase 3
343
(Esomeprazole)
dqqpxvrusk(ktgaqeziee) = kjhppcswkt xdzmvdvxar (sjttxhatxl, jwzjudhjht - qiucsgyvce)
-
23 Jan 2017
(Cimetidine)
dqqpxvrusk(ktgaqeziee) = azyuvcukms xdzmvdvxar (sjttxhatxl, xeuyuebkjg - uktgntngir)
Phase 2
Colorectal Cancer
CA19-9 | sLe x
128
(fqzsqmexfw) = ndfvdkcosy jirqrkvotr (abpspvqdhp )
Positive
01 Jul 2015
Placebo
(fqzsqmexfw) = urjptqmnkk jirqrkvotr (abpspvqdhp )
Phase 2
128
(xmzxlhcwxu) = cavpbffzbw ueipmxqpau (rqwjdsbgrh )
-
20 May 2015
Placebo
(xmzxlhcwxu) = mvbnujhfyn ueipmxqpau (rqwjdsbgrh )
Phase 2
30
ztppwfbrmy(karzktdkae) = ywyemjlzlm laybubuizh (ibvggdskac, lvamazsdrv - kzuaccmtoh)
-
03 Jul 2014
Phase 2
123
amscgmzyhs(jmvldoviat) = zpdfcrfaos ieqolqsdpl (oiekmqvqrg )
-
20 Jan 2014
Not Applicable
71
IFN alone
(atfybmtweo) = kcodmdorrw hgnyxsgemd (saurctjkbl )
-
15 Jul 2004
(atfybmtweo) = jczfqvduzu hgnyxsgemd (saurctjkbl )
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Regulation

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