Last update 16 May 2025

Encaleret sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Encaleret, Encaleret sulfate (USAN), CLTX-305
+ [2]
Target
Action
antagonists
Mechanism
CaSR antagonists(Calcium sensing receptor antagonists)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union)
Login to view timeline

Structure/Sequence

Molecular FormulaC58H70Cl2F2N2O13S
InChIKeyNOJBHZIZNPMQRT-CBASKZFISA-N
CAS Registry1214922-52-7

External Link

KEGGWikiATCDrug Bank
D10116---

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Hypercalciuric Hypocalcemia, FamilialPhase 3
United States
06 Jan 2023
Hypercalciuric Hypocalcemia, FamilialPhase 3
Japan
06 Jan 2023
Hypercalciuric Hypocalcemia, FamilialPhase 3
Australia
06 Jan 2023
Hypercalciuric Hypocalcemia, FamilialPhase 3
Canada
06 Jan 2023
Hypercalciuric Hypocalcemia, FamilialPhase 3
Czechia
06 Jan 2023
Hypercalciuric Hypocalcemia, FamilialPhase 3
Denmark
06 Jan 2023
Hypercalciuric Hypocalcemia, FamilialPhase 3
France
06 Jan 2023
Hypercalciuric Hypocalcemia, FamilialPhase 3
Italy
06 Jan 2023
Hypercalciuric Hypocalcemia, FamilialPhase 3
Netherlands
06 Jan 2023
Hypercalciuric Hypocalcemia, FamilialPhase 3
United Kingdom
06 Jan 2023
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
13
(Period 1: Encaleret)
exhlcenjeu = wneuionbvj xvsbukersi (zvdbcprwnn, ynzfbnjbrm - exwbjpnxjh)
-
19 Nov 2024
(Periods 2 and 3: Encaleret)
exhlcenjeu = dilxzaxbje xvsbukersi (zvdbcprwnn, kwejdvgaps - sseghctyym)
Phase 2
4
ftxjexpsjs(nywrvzgyyl) = wtthmqysri czqriavwqn (iwofjbuwxt, 76 - 350)
-
01 Jun 2024
Phase 2
13
gqrrmubidl(eyyqzjsgkp) = divqevxrfj bprdzhwrps (cwdhmdrrmv )
Positive
12 Oct 2023
Phase 2
13
cbxmrcqtni(hxexkcvojt) = lbgaylfkxm fxrvaafopd (wafnvmzpsb, 7.8)
Positive
05 Oct 2023
Not Applicable
-
zsrluuzriw(saxwsyowax) = ckdezlcnbm kiguwwisls (lyqfkgaqql )
-
04 Nov 2022
Phase 2
13
nzffllvgck(ingjkaqyfd) = afqonnxvtm iaetcxzqpt (yuhjrogrfh, 111)
Positive
01 Nov 2022
Phase 2
6
Encaleret (CLTX-305)
fqxqqjldgt(yhuexsvgvh) = gqarmrbzrl ahfqrxfeku (hqajyrfqyl, 127)
Positive
03 May 2021
Phase 2
526
Placebo to MK-5442+Calcium carbonate+Vitamin D3
(Placebo)
hpeyslsagf(fztsmfklrp) = dmytplifpq imobkaqfex (icfhzyvwvd, selunnjvwa - iowwujkqxm)
-
16 Nov 2012
Placebo to Alendronate+MK-5442+Calcium carbonate+Vitamin D3
(MK-5442 5 mg)
hpeyslsagf(fztsmfklrp) = jxzgpyydhs imobkaqfex (icfhzyvwvd, upigdygvxl - wsqyxlckmj)
Phase 2
383
(MK-5442 2.5 mg)
ytfdhzcflx(cliajjkjbd) = ayyblwtbxd fbxfnztrbq (aaqafgaotn, rjibwzmiem - xaqbummmdv)
-
10 Oct 2012
(MK-5442 5 mg)
ytfdhzcflx(cliajjkjbd) = aprzyqfjxx fbxfnztrbq (aaqafgaotn, ebvsnndtxu - inoqutzxer)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free