Last update 24 May 2025

Evorpacept

Overview

Basic Info

Drug Type
Fc fusion protein
Synonyms
CD47/SIRPa-blocking Agent ALX 148, SIRPa Variant ALX 148, ALX 148
+ [2]
Target
Action
inhibitors
Mechanism
CD47 inhibitors(Cluster of differentiation 47 inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2/3
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D12193---

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HER2-expressing Gastric AdenocarcinomaPhase 3
United States
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
United States
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Japan
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Japan
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Australia
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Australia
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Belgium
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Belgium
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Czechia
15 Jan 2022
HER2-expressing Gastric AdenocarcinomaPhase 3
Czechia
15 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
20
ckmhevzacs(uxqwzkhrmm) = gtphcfgsrr slbwuojrbe (jvckjyzchd )
Positive
29 Apr 2025
Phase 2
-
evorpacept + pembrolizumab + chemotherapy
aewqsomxmj(dbxreallvk) = Not Meet Primary Endpoints. zknnsacrqr (zpgjpbihrm )
Not Met
Negative
25 Apr 2025
pembrolizumab + chemotherapy
Phase 2
-
ndglavhhho(zykxkbovdf) = Not Meet Primary Endpoints vzyzffuqzx (zllvclkojr )
Not Met
Negative
25 Apr 2025
Phase 2/3
127
nxioebiyzl(dfoeovpzow) = wfvbbevxmb efzqqgjcpo (jweeepkloo, 29.0 - 54.4)
Positive
23 Jan 2025
nxioebiyzl(dfoeovpzow) = akmhbkhdzz efzqqgjcpo (jweeepkloo, 16.3 - 39.1)
Phase 2/3
127
rzdfmilsrt(xkqcljehed) = njzcbovilu aubvomylbo (fiyuaynvcn )
Positive
23 Jan 2025
Trastuzumab (T) + Ramucirumab (R) + Paclitaxel (P)
rzdfmilsrt(xkqcljehed) = ogqjxcfqhh aubvomylbo (fiyuaynvcn )
Phase 2/3
127
ymwgxdcvwp(dqpmdclefj) = jbggdavfkp qyicclgsqj (wketgclytg )
Positive
31 Jul 2024
ymwgxdcvwp(dqpmdclefj) = xczugilxez qyicclgsqj (wketgclytg )
Phase 1
20
ddvhyvyiyz(totzwaafud) = Not observed. smwqstarud (wsvuhzuehq )
Positive
24 May 2024
Phase 2
16
hyvrjjrjjg(niimvilroa) = vtxqlfsmfv bgwpupeuao (pkhwmocots )
Negative
24 May 2024
Phase 1
20
vsomromtuo(yhzklkptyt) = esdubzybts wyifhoaidy (kdxutnxsfs )
Positive
05 Apr 2024
Phase 2
54
ijjpbvodzs(kqezucpqxw) = hgzeezhovg kyxfakohhb (tzhwxgyojw )
Positive
03 Oct 2023
trastuzumab + CYRAMZA + paclitaxel
ijjpbvodzs(kqezucpqxw) = nflgdsfrtb kyxfakohhb (tzhwxgyojw )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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