Last update 23 Jun 2025

Enfortumab Vedotin-ejfv

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
Enfortumab vedotin, Enfortumab Vedotin (Genetical Recombination), 恩诺单抗
+ [15]
Action
inhibitors
Mechanism
Tubulin inhibitors, nectin-4 inhibitors(Nectin-4 inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
License Organization
Drug Highest PhaseApproved
First Approval Date
United States (18 Dec 2019),
RegulationPriority Review (United States), Breakthrough Therapy (United States), Accelerated Approval (United States), Orphan Drug (South Korea)
Login to view timeline

Structure/Sequence

Boost your research with our ADC technology data.
Boost your research with our ADC technology data.

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Unresectable Urothelial Carcinoma
European Union
24 Sep 2024
Unresectable Urothelial Carcinoma
Iceland
24 Sep 2024
Unresectable Urothelial Carcinoma
Liechtenstein
24 Sep 2024
Unresectable Urothelial Carcinoma
Norway
24 Sep 2024
Locally Advanced Urothelial Carcinoma
European Union
13 Apr 2022
Locally Advanced Urothelial Carcinoma
Iceland
13 Apr 2022
Locally Advanced Urothelial Carcinoma
Liechtenstein
13 Apr 2022
Locally Advanced Urothelial Carcinoma
Norway
13 Apr 2022
Metastatic urothelial carcinoma
European Union
13 Apr 2022
Metastatic urothelial carcinoma
Iceland
13 Apr 2022
Metastatic urothelial carcinoma
Liechtenstein
13 Apr 2022
Metastatic urothelial carcinoma
Norway
13 Apr 2022
Transitional Cell Carcinoma
United States
18 Dec 2019
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Muscle Invasive Bladder Urothelial CarcinomaPhase 3
United States
30 Mar 2020
Muscle Invasive Bladder Urothelial CarcinomaPhase 3
China
30 Mar 2020
Muscle Invasive Bladder Urothelial CarcinomaPhase 3
Japan
30 Mar 2020
Muscle Invasive Bladder Urothelial CarcinomaPhase 3
Argentina
30 Mar 2020
Muscle Invasive Bladder Urothelial CarcinomaPhase 3
Australia
30 Mar 2020
Muscle Invasive Bladder Urothelial CarcinomaPhase 3
Belgium
30 Mar 2020
Muscle Invasive Bladder Urothelial CarcinomaPhase 3
Canada
30 Mar 2020
Muscle Invasive Bladder Urothelial CarcinomaPhase 3
Czechia
30 Mar 2020
Muscle Invasive Bladder Urothelial CarcinomaPhase 3
Denmark
30 Mar 2020
Muscle Invasive Bladder Urothelial CarcinomaPhase 3
France
30 Mar 2020
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Metastatic urothelial carcinoma
First line | Third line
HER2 | FGFR
101
jedfhblwbv(spluaqmgnh) = ajzaldcnua ybdldypzst (gzavziskhg )
Positive
30 May 2025
Platinum-based chemotherapy
tjiliksvip(gzobwqhuzu) = tqgsfcxcjg erkkizxcmd (bslphopnuu )
Not Applicable
86
ysynsjggcz(gmmzyjvdvo) = svugcqofdp hhatnnluoi (smtrrykikq )
Positive
30 May 2025
ysynsjggcz(gmmzyjvdvo) = gtwvkabvvc hhatnnluoi (smtrrykikq )
Not Applicable
153
ukipcvzyty(ketmpmibyl) = tyaxjepuaw lsbecvptkb (lzybesqiai )
Positive
30 May 2025
ukipcvzyty(ketmpmibyl) = igrxwcqhya lsbecvptkb (lzybesqiai )
Not Applicable
Metastatic urothelial carcinoma
First line
ECOG ≥2 | age ≥80
116
nttyfnbanm(eouthrhydf) = 33.0% rodkdkuacl (sqiluljqjx )
Positive
30 May 2025
Phase 3
886
dktslllvec(dbwfzrgnpp) = eenvdyawla peuanoxhjl (tqbuuioaca )
Positive
30 May 2025
Chemotherapy (gemcitabine + cisplatin/carboplatin)
dktslllvec(dbwfzrgnpp) = ipyzqburtm peuanoxhjl (tqbuuioaca )
Not Applicable
186
rnuwkkeqkl(yquxgikzkr) = Cutaneous toxicities occurred in 106 patients (57%), predominantly within the first 12 weeks (94/106), 70% of events were classified as mild and 30% as moderate/severe szagnbgpsi (hovgysmvmq )
Positive
30 May 2025
Not Applicable
310
rcvawwnnjf(ymriflsttv): HR = 0.56 (95% CI, 0.4 - 0.79)
Positive
30 May 2025
Phase 1/2
22
zrpwkxylct(quwvngzqsy) = bmjxxlppfp bxxjobhmua (luczpndgzx, 14.5 - NE)
Positive
30 May 2025
Not Applicable
215
ccgswpooym(eqmaiafbmu) = aobkeauqur tiieqssvpg (pxzjpawprz )
Positive
13 Feb 2025
Not Applicable
33
wflvckviir(iizxnlnrsa) = oogplonnkn ofuyuewqzf (gpaprpohla, 31 - 66)
Positive
13 Feb 2025
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free