Last update 25 Mar 2025

Alitretinoin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid, (7E,9Z,11E,13E)-retinoic acid, 9(Z)-Retinoic acid
+ [15]
Action
agonists
Mechanism
RARα agonists(Retinoic acid receptor alpha agonists), RARβ2 agonists(Retinoic acid receptor beta agonists), RARγ agonists(Retinoic acid receptor gamma agonists)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
United States (02 Feb 1999),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC20H28O2
InChIKeySHGAZHPCJJPHSC-ZVCIMWCZSA-N
CAS Registry5300-03-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
AIDS-related Kaposi Sarcoma
United States
02 Feb 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Promyelocytic LeukemiaPhase 3
United States
30 Jun 1999
Bronchial DiseasesPhase 2
United States
01 Jan 2001
Myelodysplastic SyndromesPhase 2
United States
26 Mar 1998
Breast CancerPhase 2
United States
23 May 1997
Prostatic CancerPhase 2
United States
23 May 1997
Head and Neck NeoplasmsPhase 2
United States
27 Aug 1996
Ovarian CancerPhase 2
United States
27 Aug 1996
Squamous Cell CarcinomaPhase 2
United States
27 Aug 1996
Kidney NeoplasmsPhase 2
Canada
23 May 1995
Non-Hodgkin LymphomaPhase 2
United States
23 May 1995
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
599
Placebo
jiccybvpcp = unmaqgrmeb mcfxysodkz (awvbcqkrag, hrvadmcjki - mfbtaokuso)
-
09 Nov 2017
Phase 2
33
placebo
(Matching Placebo)
kvnplpeioo(psspncosgf) = iwnokwwxsx hyluxlfblr (foixcjldti, 45.9)
-
04 Apr 2017
(Alitretinoin 30 mg)
kvnplpeioo(psspncosgf) = koybqragbo hyluxlfblr (foixcjldti, 32.8)
Phase 3
596
tiqpgjricv(bdmpxpeshm) = muldpzctlp xjkwxlxcam (nfzigvypfw )
Positive
01 Oct 2014
Placebo
uwzncokdqv(hxunitebko) = nodejzspol dwfxomlhtt (tydxitjwkl )
Phase 1/2
1
sisihxvbwi = lpcpiiyuhx zdvrvjthwg (jetsehqari, tealjylrml - kxpeatxqpa)
-
02 Mar 2012
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Regulation

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