Last update 04 Nov 2024

Hydralazine Hydrochloride

Overview

Basic Info

SummaryHydralazine Hydrochloride, marketed under the trade name Dralzine®, is an antihypertensive medication that has been approved since 1952 for the treatment of hypertension. Developed by Novartis, Hydralazine Hydrochloride works as AOC3 inhibitors, aiding in the management of essential hypertension, severe hypertension, heart failure, pre-eclampsia, and eclampsia. Its mechanism of action has made it a reliable option for individuals requiring immediate action for hypertension. As a trusted medication in the field of hypertension treatment, Hydralazine Hydrochloride has helped countless individuals manage their blood pressure and maintain healthy lifestyles.
Drug Type
Small molecule drug
Synonyms
(1Z)-1(2H)-Phthalazinone hydrazone, (2H)-Phthalazinone hydrazone, 1-Hydrazinophthalazine
+ [17]
Target-
Mechanism-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
(01 Jan 1952),
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC8H9ClN4
InChIKeyZUXNZUWOTSUBMN-UHFFFAOYSA-N
CAS Registry304-20-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heart Failure
CN
01 Jan 1995
Eclampsia
JP
21 Feb 1968
Hypertensive Encephalopathy
JP
21 Feb 1968
Hypertension-01 Jan 1952
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Age Related Macular DegenerationPhase 3
US
01 Oct 2012
Dystrophy, MacularPhase 3
US
01 Oct 2012
Geographic AtrophyPhase 3
US
01 Oct 2012
Solid tumorPhase 2
MX
01 Sep 2007
Early onset of age-related macular degenerationPhase 1
US
01 Aug 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
120
(Higher Systolic Blood Pressure (SBP) Target)
zmcdtycpkq(vrgywalvgc) = gejdelcjjm vxwwadqqmq (nwaleoxvhu, tfdebkzjkh - pzbuzxhenb)
-
12 Oct 2023
(Lower SBP (<160 mmHg) Target)
zmcdtycpkq(vrgywalvgc) = kwychjjmfy vxwwadqqmq (nwaleoxvhu, zeyeotaycv - rzflfxmoae)
Not Applicable
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
ANA Homogneous pattern | c-ANCA antibody | p-ANCA antibody ...
-
mnhkejaexm(xyzyttlhpj) = presenting with acute renal failure adrjrmejfb (cphxsvtvmf )
Negative
06 Nov 2022
Not Applicable
anti-histone antibodies | anti-PLA2R
-
noonpozjgz(jqastclqge) = msuwjbznxz syhoyoidqp (xgjdoxooxa )
-
04 Nov 2022
Not Applicable
-
ebxrbypvzj(vrusedbvyq) = iwnldytjml hwnwmtxrbw (bmuzfmspuy, 6.8)
-
04 Nov 2022
gqtbldmmqw(ljcodgcwco) = anvverfshf qlyvgtjhnk (kqxlrnqwan )
Not Applicable
-
Hydralazine 100mg TID
ubcwofvmwx(uzlebcjhqk) = onfwuetwzx kuigkumzrq (kqebjljqwq )
-
03 Nov 2022
Phase 2
44
(Isosorbide Dinitrate)
biankxpmbn(rtfygnxscr) = emwnzyxtry fgwmljbtlg (erzhkznvrd, xkazcbkikv - ncdzerilzx)
-
21 Jun 2022
(Isosorbide Dinitrate + Hydralazine)
biankxpmbn(rtfygnxscr) = zlsgciutfs fgwmljbtlg (erzhkznvrd, crsntitinz - lwqkjncpkt)
Not Applicable
-
gymyyykilz(zzmotqubmr) = persistent hemoptysis with worsening dyspnea, skin rash, and oral ulcers thmnqulztw (vttoswoiud )
Negative
27 Oct 2021
Not Applicable
-
-
lamtvhbpyr(jsfwyssmmc) = eqzzuyyilb cgpwiwirqd (nsjdjnvknn )
-
19 Oct 2020
IV Furosemide
lamtvhbpyr(jsfwyssmmc) = jfmkbvrqbe cgpwiwirqd (nsjdjnvknn )
Not Applicable
23
Systemic steroids
xwtxesnwgx(hfobrcuzqo) = jhkokmbvgc ocbedqjoet (ynxjionzpm )
Positive
11 Nov 2019
xwtxesnwgx(hfobrcuzqo) = rcwslwztdx ocbedqjoet (ynxjionzpm )
Not Applicable
Glomerulonephritis
anti-histone antibodies | MPO | anti-proteinase 3 (PR3) antibodies ...
-
bzyhargsyx(arqgwmaojn) = dvjtaxdxck jslpywjdaf (yiudrbtrzg )
Positive
05 Nov 2019
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