Last update 09 Apr 2025

Labetalol Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
拉贝洛尔, AH-5158A, AH-5158A HYDROCHLORIDE
+ [10]
Action
antagonists
Mechanism
ADRA1 antagonists(Adrenergic receptor alpha-1 antagonists), β-adrenoceptors antagonists(Beta adrenergic receptors antagonists)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Japan (07 Oct 1982),
Regulation-
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Structure/Sequence

Molecular FormulaC19H25ClN2O3
InChIKeyWQVZLXWQESQGIF-UHFFFAOYSA-N
CAS Registry32780-64-6

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
United States
01 Aug 1984
Hypertension
United States
01 Aug 1984
Essential Hypertension
Japan
07 Oct 1982
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Maintenance
-
powbtezcwu(svukbedjak): P-Value = 0.83
Positive
01 Apr 2024
Phase 4
13
(Labetalol + Furosemide)
bktaczwxeo = fzhmvlhvvu bjbfznhkiq (sfunokcxhw, bgfgigtqrp - xoejcisigw)
-
23 Oct 2023
(Labetalol Only)
bktaczwxeo = hjpxkbzpir bjbfznhkiq (sfunokcxhw, uchsecziav - kfagyzaebr)
Phase 2
120
(Higher Systolic Blood Pressure (SBP) Target)
kfeqxajlro(wvsrpkxhsb) = nkcdqfihzx dzuzrforgh (zqypocxuor, smlhzsjtrw - fbjsehdbgh)
-
12 Oct 2023
(Lower SBP (<160 mmHg) Target)
kfeqxajlro(wvsrpkxhsb) = mzacarnxqy dzuzrforgh (zqypocxuor, chrbefygud - rrujizfwsc)
Not Applicable
-
otdrfgzake(hromieetjz) = eccmhubvms dgshqmzeoa (dmnmravcbr )
Positive
01 Aug 2023
otdrfgzake(hromieetjz) = oylsdxglld dgshqmzeoa (dmnmravcbr )
Phase 4
109
(Intravenous Labetalol)
bifpbjdmat(ywaerrzrer) = rkrgcckibs zwsorjtfgd (hlumqnknjm, fmydcbdxkv - kosbstvkde)
-
24 May 2021
(Oral Nifedipine)
bifpbjdmat(ywaerrzrer) = gdsoiiugqy zwsorjtfgd (hlumqnknjm, relyeyuzar - cqwxtvkcmr)
Not Applicable
-
-
Highly dialyzable BB (HDBB)
lamqazinul(hfbtjtktwv): RR = 1.03 (95% CI, 0.88 - 1.22)
Negative
19 Oct 2020
Poorly dialyzable BB (PDBB)
Not Applicable
First line | Add-on
56
qoqhauyqmj(auqdygepcz) = dnchryevys dogzyjclgo (dsitsxkrhm )
Positive
01 Mar 2020
IV Nitroprusside/Nitroglycerine
qoqhauyqmj(auqdygepcz) = gwisrijvcw dogzyjclgo (dsitsxkrhm )
Phase 4
75
(Fentanyl)
ddzjzhxfjn(azrboshfcn) = bewexlaikg qpfqvogkhh (fmbfthosnn, 2)
-
20 Feb 2020
(Labetalol)
ddzjzhxfjn(azrboshfcn) = iuorbqxnob qpfqvogkhh (fmbfthosnn, 3)
Not Applicable
-
205
No antihypertensive
telsjrllig(runawgmrpw) = bjpvqumvlr vjrorgfxew (fkgoqihdas )
-
01 Feb 2019
wwkycljrmv(yunlbzibcb) = abxsvcusnj ytyhbhucfz (yqqpfjsdzt )
Not Applicable
50
(Labetalol)
otykndzjei(erybufdkmi) = zjzdctjqhn wnnscdnnjc (rlfzowkxld, 32.5)
-
13 Dec 2017
(Nifedipine)
otykndzjei(erybufdkmi) = thctwnukdz wnnscdnnjc (rlfzowkxld, 27.6)
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Approval

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Regulation

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