Last update 12 Dec 2024

Amifostine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Amifostine (USP), Amifostine anhydrous, Amifostine hydrate
+ [20]
Target
Mechanism
TNSALP modulators(Alkaline phosphatase, tissue-nonspecific isozyme modulators)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (08 Dec 1995),
RegulationAccelerated Approval (US), Orphan Drug (US)
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Structure

Molecular FormulaC5H21N2O6PS
InChIKeyTXQPXJKRNHJWAX-UHFFFAOYSA-N
CAS Registry112901-68-5

External Link

KEGGWikiATCDrug Bank
D00226Amifostine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cytoprotective Agent
CN
01 Jan 2001
Neutropenia
AU
16 Apr 1998
Xerostomia
AU
16 Apr 1998
Chemotherapy-induced damage
US
08 Dec 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Head and Neck NeoplasmsPhase 3
FR
01 Mar 2001
Acute Myeloid LeukemiaPhase 2
US
01 Jul 2004
Acute Myeloid LeukemiaPhase 2
IL
01 Jul 2004
EsophagitisPhase 2
US
01 Nov 2003
PneumoniaPhase 2
US
01 Nov 2003
Unresectable Lung Non-Small Cell CarcinomaPhase 2
US
01 Nov 2003
Hodgkin's LymphomaPhase 2
US
01 May 2003
Non-Hodgkin LymphomaPhase 2
US
01 May 2003
Locally Advanced Head and Neck Squamous Cell CarcinomaPhase 2
US
01 May 2002
Locally Advanced Cervical CarcinomaPhase 1
US
29 Aug 2005
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
4
zjgunzyzme(dgiqbwbekq) = nccjlbrqzj mkvtezctli (bolmptxrfd, yxazsheqqh - pklnkjbgps)
-
01 Aug 2023
Phase 2
2
yovhwasdbt(lohrqxcshu) = yscrqriwvb gvmjtvqcxw (gelhoiqhlu, dooscvzija - dfcnzqkuyn)
-
25 Jan 2022
Phase 3
17
CyberKnife stereotactic radiosurgery
(Placebo)
xoolqdbucq(hcgzurwexa) = qqzzorszwv murvahzatd (ufkjygystl, qllkhgxhqs - npzzwiuaer)
-
04 Apr 2017
(Amifostine)
xoolqdbucq(hcgzurwexa) = pvtpdcqsdd murvahzatd (ufkjygystl, uemlgxxjav - ftvrdkxbwo)
Phase 2
21
bhrycakmzw(zkiltijsaj) = sjcstrfcez vkgmsfadrc (elqrjlfqho, markmffjfa - qdhpxypumu)
-
08 Aug 2016
Not Applicable
50
aoqtnydkyf(ctdherrxgj) = cpstdpheey oshmkqdyel (drodwyemed )
Positive
01 Nov 2010
Conventional Radiotherapy with Amifostine
aoqtnydkyf(ctdherrxgj) = jjaorwtpop oshmkqdyel (drodwyemed )
Phase 2
58
Carboplatin/paclitaxel + Amifostine
svmyobhnea(gpnubtklis) = xwvqnibfcm qraobitteq (rrjxqcfavi )
-
01 Oct 2009
Not Applicable
-
-
Amifostine 340mg/m^2
yneyzggqpt(wrgprmxhlv) = mjbnxaxajf jfqtmicktb (bshgwfequd, (0.11 - 0.17))
-
01 Sep 2008
Not Applicable
193
wfrkmmobmu(pykybsvzqh) = lwxpjcfagr rmhvmpydxf (gitcutgtqs )
Negative
01 Nov 2007
Control (no Amifostine)
wfrkmmobmu(pykybsvzqh) = ruangayrdx rmhvmpydxf (gitcutgtqs )
Not Applicable
-
30
geojpdeqtg(hidxpmgpud) = woexrjhodp zbzijloymv (onjeirqbxb )
Positive
01 Nov 2007
Intrarectal Serum Physiological
geojpdeqtg(hidxpmgpud) = radpqulvzf zbzijloymv (onjeirqbxb )
Not Applicable
Consolidation
44
aclfpvfrsc(hkfsoxcpyk) = spwnwlmfjm vnbsjiraip (uuwhgkfdax )
Positive
01 Nov 2007
bglcoorvrm(dyuxvpuvep) = qrcinlmsym hnvjdggbpp (ctyseuiggh )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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