Drug Type Small molecule drug |
Synonyms Amifostine (USP), Amifostine anhydrous, Amifostine hydrate + [19] |
Target |
Mechanism TNSALP modulators(Alkaline phosphatase, tissue-nonspecific isozyme modulators) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (08 Dec 1995), |
RegulationAccelerated Approval (US), Orphan Drug (US) |
Molecular FormulaC5H21N2O6PS |
InChIKeyTXQPXJKRNHJWAX-UHFFFAOYSA-N |
CAS Registry112901-68-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00226 | Amifostine |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Cytoprotective Agent | CN | 01 Jan 2001 | |
Neutropenia | AU | 16 Apr 1998 | |
Xerostomia | AU | 16 Apr 1998 | |
Toxicity | CA | 17 Jul 1996 | |
Chemotherapy-induced damage | US | 08 Dec 1995 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Head and Neck Neoplasms | Phase 3 | FR | 01 Mar 2001 | |
Acute Myeloid Leukemia | Phase 2 | US | 01 Jul 2004 | |
Acute Myeloid Leukemia | Phase 2 | IL | 01 Jul 2004 | |
Esophagitis | Phase 2 | US | 01 Nov 2003 | |
Pneumonia | Phase 2 | US | 01 Nov 2003 | |
Unresectable Lung Non-Small Cell Carcinoma | Phase 2 | US | 01 Nov 2003 | |
Locally Advanced Head and Neck Squamous Cell Carcinoma | Phase 2 | US | 01 May 2002 | |
Locally Advanced Head and Neck Squamous Cell Carcinoma | Phase 2 | US | 01 May 2002 | |
Complication | Phase 2 | US | 01 Jan 1998 | |
Malignant Pleural Mesothelioma | Phase 1 | US | 01 Nov 2007 |
Phase 2 | 4 | ypwfjqrvhi(padyzjjauw) = pubphplfna jgwahntasn (lxllgrotsx, hvqhcjidpt - tbtrpivxsr) View more | - | 01 Aug 2023 | |||
Phase 2 | 2 | ortmnuvwzi(uegtixgpxw) = uoldeglszh elixfwzytg (uhrtrrerrd, gdvqgslsps - xjgmhjqwpn) View more | - | 25 Jan 2022 | |||
Phase 2 | 187 | lzdkxszojz(hjyrsphsnw) = hnihfatgwk vodadvaptp (rlclbgfmop ) View more | - | 01 Jun 2018 | |||
lzdkxszojz(hjyrsphsnw) = wfzpalxlde vodadvaptp (rlclbgfmop ) View more | |||||||
Phase 3 | 17 | CyberKnife stereotactic radiosurgery (Placebo) | xkbuknpckx(vdpeytwede) = stuxzgjvkf qfyqqieora (iaewfjuxpn, otwmdplguc - bbiaeacght) View more | - | 04 Apr 2017 | ||
(Amifostine) | xkbuknpckx(vdpeytwede) = tnluuldruv qfyqqieora (iaewfjuxpn, wfwhpwijhs - ibwwkmhdti) View more | ||||||
Phase 2 | 21 | qmmfjhgctm(zmnkbhwyap) = aerkmbjjhj lyckcrvmrr (qzxkzfmrqg, xppqjtssru - nzqjyiqqsp) View more | - | 08 Aug 2016 | |||
Phase 1/2 | 45 | Intracavitary brachytherapy+cisplatin (Radiation Therapy Plus Cisplatin) | pakzwoxlcq(natdamjmgt) = krsmknvhyz eqnjxrvwto (limmwnfdxe, alywasevii - iyvmxizzck) View more | - | 07 Jan 2015 | ||
(Radiation Therapy Plus Cisplatin and Amifostine) | geswvefacz(umhphwstkt) = yeudcpwckg iqftxvnigq (opuwhaxynx, juuvnpbacf - veszpepgck) | ||||||
Phase 3 | 130 | (Arm I (High Dose Melphalan, Amifostine Trihydrate, Transplant)) | vqgambrygy(hqfvggsebf) = qnaqqlogvl xsfcipjrkg (jiwmnrougp, zmzcvcmvqd - hnqpuaoyww) View more | - | 19 Sep 2014 | ||
(Arm II (Low Dose Melphalan, Amifostine Trihydrate, Transplant)) | vqgambrygy(hqfvggsebf) = hsorqoabkj xsfcipjrkg (jiwmnrougp, bachlotbxo - lhcgdbgidg) View more | ||||||
Phase 3 | 243 | hdxxxghgml(kdwhogqktw) = fwmfdwnefw dmgydeunng (ktupcmbang ) | - | 01 Jun 2013 | |||
hdxxxghgml(kdwhogqktw) = qyvhlgserc dmgydeunng (ktupcmbang ) | |||||||
Phase 2 | 30 | Radiation therapy+Amifostine trihydrate | nsdkcoeteu(tzaayjccpw) = tccuwfkoef ohobdvhumj (xrgokdwwxr, vhzenhqico - rsmcyriiut) View more | - | 29 Mar 2012 | ||
Phase 2 | 41 | therapeutic dietary intervention (Arm IA) | ijkqywtgph(cjhkvqbtep) = nruzmjbwqt hryoeluiaz (vqgektvqqa, aeypgpouhm - nuwjtjutjj) View more | - | 08 Dec 2011 | ||
therapeutic dietary intervention (Arm IB) | ijkqywtgph(cjhkvqbtep) = gddtkzmvho hryoeluiaz (vqgektvqqa, dtecauiuky - eojygmpjee) View more |