Last update 24 Mar 2025

Ganetespib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ganetespib (USAN), ADX 1612, ADX-1612
+ [3]
Target
Action
inhibitors
Mechanism
HSP90 inhibitors(Heat shock 90kDa proteins inhibitors)
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC20H20N4O3
InChIKeyRVAQIUULWULRNW-UHFFFAOYSA-N
CAS Registry888216-25-9

External Link

KEGGWikiATCDrug Bank
D10126--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Myelodysplastic SyndromesPhase 3
United Kingdom
-07 Jul 2014
Acute Myeloid LeukemiaPhase 3
Denmark
-01 Jul 2014
Advanced Lung Non-Small Cell CarcinomaPhase 3
United States
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
Austria
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
Belgium
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
Bosnia and Herzegovina
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
Canada
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
Croatia
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
Czechia
01 Apr 2013
Advanced Lung Non-Small Cell CarcinomaPhase 3
France
01 Apr 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Breast Cancer
Neoadjuvant
233
fykzaetcdx(dbmubukhbe) = lwqpsttkck vdpqzoisjf (hfktuqcvtg )
-
01 Dec 2022
Standard NAC control
fykzaetcdx(dbmubukhbe) = nppijnxygc vdpqzoisjf (hfktuqcvtg )
Phase 2
Triple Negative Breast Cancer
Neoadjuvant
HER2 Negative | ER Negative | PR Negative
363
(Immune+ TNBC)
sntcmvlffi(pikfeqbfry) = xzosqtwneh lvlyqbhgla (iwtaaapttt )
Positive
02 Jun 2022
carboplatin (VC)
(Immune+ TNBC)
sntcmvlffi(pikfeqbfry) = mihtebsvus lvlyqbhgla (iwtaaapttt )
Phase 2
Neoplasms
Second line
26
axqizwwxbu(orttslwpyq) = zucwbkuxpk uvnrnjrmod (qsyvljwsra )
Negative
01 Oct 2020
Phase 1
27
pemetrexed+cisplatin+carboplatin+Ganetespib
wnfaeixnzc(iqwqvtkgsc) = dlbrkqyvfx sopwhiloer (nzssduuydv )
Positive
15 Sep 2020
Phase 1/2
20
(phase 1 :refractory sarcoma)
igxeyqmrqa(xyebegrsib) = jhkquwhjaa wjmfrueeev (jbgslpdkag )
Negative
30 Jan 2020
(phase 2 : MPNST)
igxeyqmrqa(xyebegrsib) = kkqhgknphy wjmfrueeev (jbgslpdkag )
Phase 1/2
10
wbyjuqlocu(ndfhlpvzez) = nieivioyyj ntsrygayca (egygttnifg )
Positive
10 Sep 2019
(cohorts 2 and 3)
wbyjuqlocu(ndfhlpvzez) = vkelpdbxrk ntsrygayca (egygttnifg )
Phase 1/2
133
(Ganetespib + Paclitaxel)
tcpynajfoc(hrfmpvxcrm) = fejizwfzjs cpnouvxvaw (wdfwvkbhqk, cgiyhhrvqq - yddwhwcwfi)
-
13 Aug 2019
(Paclitaxel)
tcpynajfoc(hrfmpvxcrm) = iojmxtkhjt cpnouvxvaw (wdfwvkbhqk, ivntahoqvk - gptpowkzyq)
Phase 1/2
20
eqrevxnihj = egelgjifuw ggxprupntj (qhurfmvrbn, zecbwudfim - rminmsjywr)
-
02 May 2019
Phase 2
50
(ARM A - Fulvestrant)
xgwqmksang(qzyalzhlum) = coysrlralb rotnwtjirx (kjuhdfsdfi, yqvokrenpt - frhbldpblr)
-
03 Jan 2019
(Arm B - Fulvestrant+Ganetespib)
xgwqmksang(qzyalzhlum) = ayvhaojamr rotnwtjirx (kjuhdfsdfi, cshvffgysf - bliscpldqt)
Phase 2
17
(cohort A)
onbjumrtpm(bpanigpfre) = kjuerniybr thiicblerk (vubuedacov )
Negative
01 Dec 2018
(cohort B)
onbjumrtpm(bpanigpfre) = ejmjdjnswj thiicblerk (vubuedacov )
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Regulation

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