Delving into the Latest Updates on Docosahexaenoic acid with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

(4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid, 22:6-4, 7,10,13,16,19, 4,7,10,13,16,19-docosahexaenoic acid

+ [17]

Target

AHSG

Action

modulators

Mechanism

AHSG modulators(alpha 2-HS glycoprotein modulators)

Therapeutic Areas

NeoplasmsNervous System DiseasesCardiovascular Diseases+ [6]

Active Indication

Chronic Kidney DiseasesVision DisordersNon-Small Cell Lung Cancer+ [5]

Inactive Indication

Acute Chest SyndromeAttention Deficit DisorderHemoglobin SC Disease+ [1]

Originator Organization

DSM Biomedical, Inc.

Active Organization

Chungnam National University

Case Western Reserve University

Seoul National University

+ [4]

Inactive Organization

Sancilio & Co., Inc.

Micelle BioPharma, Inc.

DSM Nutritional Products LLC

License Organization

Pentec Health, Inc.

Drug Highest PhasePreclinical

First Approval Date-

RegulationOrphan Drug (United States)

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Structure/Sequence

Molecular FormulaC22H32O2

InChIKeyMBMBGCFOFBJSGT-KUBAVDMBSA-N

CAS Registry6217-54-5

The goal of this clinical trial is to learn if Omega-3 works to treat Polycystic ovary syndrome in women. It will also learn about the safety of drug Omega-3. The main questions it aims to answer are:
Does Omega-3 lower the number of times participant to treat metabolic syndrome What medical problems do participants have when taking drug Omega-3.Researchers will compare drug Omega-3 to a placebo (a look-alike substance that contains no drug) to see if drug Omega-3 used to treat PCOS.
Participants will:
Take Omega-3 or a placebo every day for 3 months Visit the clinic once every 6 weeks for checkups and tests Keep a diary of their symptoms and menstrual history.

Start Date22 Apr 2025

Sponsor / Collaborator

Bangabandhu Sheikh Mujib Medical University

ChiCTR2500096807

/ SuspendedPhase 4IIT

A study of the efficacy and safety of parenteral nutrition preparations supplemented with omega-3 triglycerides in patients after colorectal surgery

Start Date20 Feb 2025

Sponsor / Collaborator-

NCT06494488

/ Not yet recruitingEarly Phase 1IIT

Differential Thrombogenesis Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) Mediated by High-Density Lipoprotein (HDL)

The goal of this study is to learn more about omega-3 polyunsaturated fatty acids supplementation on blood lipid profile and platelets in patients with high cholesterol levels.
The purpose of this research is to gather information on the safety and effect of two different fish oils, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
Participants will:
Visit the clinic 5 times during study checkups, tests and blood collection. Randomized to either the EPA or the DHA supplementation group. Be given a 28-day food and activity log.

Start Date01 Feb 2025

Sponsor / Collaborator

The Miriam Hospital

[+2]

100 Clinical Results associated with Docosahexaenoic acid

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100 Translational Medicine associated with Docosahexaenoic acid

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100 Patents (Medical) associated with Docosahexaenoic acid

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48,598

Literatures (Medical) associated with Docosahexaenoic acid

31 Dec 2025·Journal of Maternal-Fetal & Neonatal Medicine

Effects of omega-3 fatty acids supplementation on lipids and pregnancy outcomes in pregnant women

Article

Author: Wei, Xue ; Jiang, Lu ; Wang, Fang ; Wang, Mei ; Liu, Cai ; Wang, Weijing

OBJECTIVES:

To assess the impact of Omega-3 fatty acid supplementation on maternal blood lipid profiles and pregnancy outcomes.

METHODS:

This study retrospectively analyzed data from pregnant women with previous pregnancy loss and infertility, divided participants into an intervention group (n = 60) and a control group (n = 218) based on the use of Omega-3 fatty acid supplements during pregnancy, compared blood lipids between the two groups, and analyzed the effect of Omega-3 fatty acids on pregnancy outcomes.

RESULTS:

After a 5-week intervention with Omega-3 fatty acids, significant reductions in triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c) levels were observed. Significant decreases in hemoglobin count and platelet count were identified after pharmacological intervention, and no significant changes in liver and kidney function or coagulation function were found in the participants. There were no statistically significant differences in the incidence of live births, pregnancy loss, preterm birth, hypertensive disorders of pregnancy, oligohydramnios, macrosomia, gestational weeks of delivery, and birth weight of newborns between the two groups.

CONCLUSIONS:

Omega-3 fatty acid supplementation during pregnancy significantly reduced TG and had no significant negative effect on pregnancy outcomes.

31 Dec 2025·Italian Journal of Animal Science

Effects of dietary hemp co-product inclusion on laying hens performances and on egg nutritional and functional profile

Author: Skřivan, M. ; Englmaierová, M. ; Petrosillo, E. ; Lanzoni, D. ; Baldi, A. ; Skřivanová, V. ; Giromini, C. ; Marchetti, L. ; Bontempo, V. ; Rebucci, R.

Farm to Fork strategy aims to guide the agri-sector to sustainable food system.Hemp co-products are featured by an interesting nutritional and functional profile.The 9% inclusion of the hemp co-product improved the performance of laying hens and the nutritional and functional profile of eggs.

31 Dec 2025·Italian Journal of Animal Science

Nile tilapia juveniles reared at cold suboptimal water temperatures do not benefit from dietary supplementation with cholesterol

Author: Nobrega, Renata Oselame ; Carvalho, Katharinne Ingrid Moraes de ; Banze, Jorge Filipe ; Fracalossi, Débora Machado ; Marques, Maria Risoleta Freire ; Mattioni, Bruna ; Mattos, Jacó Joaquim ; Pettigrew, James Eugene ; Richter, Bianca Leticia

Cholesterol is important to restructure the phospholipid classes ensuring adequate membrane function at different temperaturesThis study aimed to assess the dietary cholesterol supplementation effect on growth, nutrient digestibility, and lipid metabolism of Nile tilapia under suboptimal water temperature (22°C).Two feeding trials were conducted: a dose-response trial and a subsequent digestibility trial lasting 91 and 30 d, resp.In the dose-response trial, increasing levels of dietary cholesterol (0, 0.25, 0.5, 0.75, and 1.0%) were fed to juveniles (initial weight 29.24 ± 0.02 g) in six replicates.In the digestibility trial, we tested 0.00 and 0.25% levels in triplicate (initial weight 230.47 ± 1.51 g).Increasing dietary cholesterol supplementation did not affect growth but affected lipid metabolism resulting in increased body and hepatic cholesterol deposition.Addnl., in plasma, we registered an increase in cholesterol and non-HDL lipoproteins but a decrease in the triacylglycerols.Supplementation with 0.5% was enough to reduce the transcription levels of HMGCr - a gene related to cholesterol synthesis in the liver - and to promote morphol. changes.For instance, congestion and dilation of the sinusoids, intensified macrosteatosis, and loss of hepatocyte nuclei.Dietary cholesterol at 0.25% was sufficient to compromise the digestibility of protein and fatty acids.Despite not affecting Nile tilapia growth, supplementation with cholesterol reduced nutrient digestibility and affected lipid metabolism, resulting in significant changes in the morphol. and composition of the liver.Thus, Nile tilapia juveniles do not benefit from dietary supplementation with cholesterol when reared at cold suboptimal water temperatures

70

News (Medical) associated with Docosahexaenoic acid

16 Aug 2024

·www.businesswire.com

Lobe Sciences Announces Creation of Wholly Owned Subsidiary, Alera Pharma, Inc.

VANCOUVER, British Columbia--( BUSINESS WIRE )-- Lobe Sciences, Ltd ("Lobe Sciences" or the "Company") (CSE: LOBE), (OTCQB: LOBEF) , a biopharmaceutical company focused on developing products to treat diseases with unmet medical needs, today announced that is has formed a wholly owned U.S. subsidiary named Alera Pharma, Inc. (Alera). Alera will be assigned the intellectual property rights focused on the Company’s neurological assets and its new chemical entity Psilocin Mucate. Mr. Rick Goulburn has been appointed as the Chief Executive Officer of Alera. Dr. Fred D. Sancilio will be Chairman of its Board of Directors and be joined on the board by Dr. Harry Jacobson, Mr. Wesley Ramjeet and Mr. Goulburn. Alera will be the operating company within the Lobe Sciences group focused on neurology and will join Altemia, LLC as the second operating subsidiary of Lobe Sciences. It is expected that the Company’s Australian subsidiary, Lobe Sciences Australia Pty Ltd., will become a subsidiary of Alera. Mr. Ilan Hayman will become a member of the executive management team of Alera. Dr. Sancilio, Chairman and CEO of Lobe Sciences said, “At present, Lobe Sciences has a complex corporate structure. By establishing Alera Pharma, we are simplifying the operations of the Company into just three entities. Lobe Sciences, Ltd will provide common services to the two operating subsidiaries - Alera and Altemia, LLC. The creation of two separate operating companies will allow each entity to create value within their respective therapeutic areas; neurology and hematology.” The Company also announces the receipt from the US PTO of a Notice of Allowance for its U.S. Patent Application Serial No. 18/411,576. About Lobe Sciences Ltd. Lobe Sciences is a biopharmaceutical company focused on developing medicines to treat diseases with unmet medical needs. The Company, through collaboration with industry-leading partners, is engaged in novel research and development focused on treating chronic cluster headache (an orphan disease), refractive anxiety, and sickle cell disease. The Company is engaged in Phase 1 and Phase 2 activities in its drug portfolio, and intends to initiate the launch of Altemia ® , a medical food designed to meet the needs of sickle cell patients globally. Cautionary Statement Regarding "Forward-Looking" Information This news release includes certain statements and information that may constitute forward-looking information within the meaning of applicable Canadian securities laws. All statements in this news release, other than statements of historical facts, including statements regarding future estimates, plans, objectives, timing, assumptions or expectations of future performance, including, without limitation: the composition of the management team of Alera and the ownership of Lobe Sciences Australia Pty Ltd., are forward-looking statements and contain forward-looking information. Generally, forward-looking statements and information can be identified by the use of forward-looking terminology such as “intends” or “anticipates”, or variations of such words and phrases or statements that certain actions, events or results “may”, “could”, “should” or “would” or occur. Forward-looking statements are based on certain material assumptions and analysis made by the Company and the opinions and estimates of management as of the date of this press release, including, among other things, that: the management team of Alera will be appointed as currently expected and that Lobe Sciences Australia Pty Ltd. will become a subsidiary of Alera as currently anticipated. These forward-looking statements are subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of the Company to be materially different from those expressed or implied by such forward-looking statements or forward-looking information. Important risks that may cause actual results to vary, include, without limitation, the risk that: the management team of Alera will be appointed differently as currently expected and that Lobe Sciences Australia Pty Ltd. will not become a subsidiary of Alera as currently anticipated. Although management of the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements or forward-looking information, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements and forward-looking information. Readers are cautioned that reliance on such information may not be appropriate for other purposes. The Company does not undertake to update any forward-looking statement, forward-looking information or financial out-look that are incorporated by reference herein, except in accordance with applicable securities laws.

Executive ChangePhase 1Phase 2

19 Jul 2024

·www.drugs.com

Micronutrient Supplementation Slows Geographic Atrophy Progression

FRIDAY, July 19, 2024 -- Oral micronutrient supplementation slows geographic atrophy (GA) progression in age-related macular degeneration (AMD), according to a study published online July 16 in Ophthalmology . Tiarnan D.L. Keenan, B.M., B.Ch., Ph.D., from the National Institutes of Health in Bethesda, Maryland, and colleagues examined whether oral supplements slow GA progression in AMD in a post-hoc analysis of the Age-Related Eye Diseases Study (AREDS) and AREDS2 multicenter, randomized trials. A total of 392 eyes from 318 participants with GA were included in AREDS, and 1,210 eyes from 891 participants with GA were included in AREDS2. AREDS participants were randomly allocated to oral antioxidants; zinc (80 mg); combination; or placebo. AREDS2 participants were randomly assigned to lutein/zeaxanthin; docosahexaenoic acid/eicosapentaenoic acid; combination; or placebo. AREDS2 participants were also randomly assigned to alternative AREDS formulations: original, no β-carotene, zinc (25 mg), or both. The researchers found that proximity-based progression toward the central macula was significantly slower in AREDS eyes with noncentral GA with randomization to antioxidants versus none (50.7 versus 72.9 µm/year). In AREDS2 eyes with noncentral GA, proximity-based progression was significantly slower with randomization to lutein/zeaxanthin versus none among those assigned to AREDS antioxidants without β-carotene (80.1 versus 114.4 µm/year). Area-based progression was not significantly different with randomization to antioxidants versus none in AREDS2 eyes with any GA. "We've known for a long time that AREDS2 supplements help slow the progression from intermediate to late AMD. Our analysis shows that taking AREDS2 supplements can also slow disease progression in people with late dry AMD," Keenan said in a statement. "These findings support the continued use of AREDS2 supplements by people with late dry AMD." Several authors disclosed ties to the pharmaceutical industry.

Clinical Result

10 Jul 2024

·www.drugs.com

Adherence to Mediterranean Diet, Omega-3 Fatty Acids Beneficial in Acne

WEDNESDAY, July 10, 2024 -- Adherence to a Mediterranean diet incorporating eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduces skin lesions and improves quality of life in patients with acne, according to a study published online July 10 in the Journal of Cosmetic Dermatology . Anne Guertler, M.D., from Ludwig Maximilian University in Munich, and colleagues examined the clinical effects associated with increasing EPA/DHA levels in patients with acne. Sixty participants without prescription medication (23 with acne comedonica [AC] and 37 with acne papulopustulosa [AP]) adhered to a Mediterranean diet, incorporating omega-3 fatty acid supplementation. Blood EPA/DHA levels were tracked at four visits (V1 to V4) using the HS-omega 3 index (EPA/DHA [percent] of total identified fatty acids in erythrocytes: target, 8 to 11 percent; deficit, <8 percent; severe deficit, <4 percent). The researchers found that 98.3 percent of patients had an EPA/DHA deficit at baseline, with the mean HS-omega 3 index increasing from 4.9 to 8.3 percent at V1 to V4. At V4, significantly higher indices were seen for AC than AP. In both inflammatory and noninflammatory lesions, there were objective improvements observed. Four patients self-reported worsened appearance, but overall quality of life improved, especially in AP. Compared with beneficial foods, dietary triggers were more clearly defined. Cow's milk and dairy product intake was reduced. A high rate of compliance was observed, and there were no reports of adverse events. "Lifestyle interventions, including dietary recommendations, should not be considered in opposition to prescription medications, but rather as a valuable adjunct to any modern acne treatment plan," Guertler said in a statement. Omegametrix® GmbH performed the analysis of the HS-omega-3 Index® free of charge. Queisser Pharma GmbH & Co. KG offered omega-3 supplements free of charge.

Clinical Result

100 Deals associated with Docosahexaenoic acid

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Docosahexaenoic acid	V06D	DB03756

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Hemoglobin SC Disease	Phase 3	-	Micelle BioPharma, Inc.	01 Mar 2019
Hypertriglyceridemia	Phase 3	-	Sancilio & Co., Inc.	28 Nov 2013
Attention Deficit Disorder	Phase 3	United States	DSM Nutritional Products LLC	01 Sep 2013
Acute Chest Syndrome	Phase 2	United States	Micelle BioPharma, Inc.	02 Mar 2017
Chronic Kidney Diseases	Preclinical	Japan	Hiroshima University	13 Jun 2019
Vision Disorders	Preclinical	United States	Case Western Reserve University	07 May 2017
Non-Small Cell Lung Cancer	Preclinical	South Korea	Chungnam National University	15 Jul 2016
Coronary Disease	Preclinical	United States	Veterans Administration Medical Center	30 Oct 2012
Colorectal Cancer	Preclinical	United States	Texas A&M University	15 Apr 2010
Breast Cancer	Preclinical	United States	University of Nevada	01 May 2009

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Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03757585 (CTgov)	Phase 4	Learning Disabilities \| Autism Spectrum Disorder \| Autistic Disorder	54	Open-label Treatment with N-acetylcysteine (N-Acetylcysteine)	ilkprfzvcq(qswkcqwmcw) = ikyxpoiphj svzpsgayzi (iblggztvcb, 8.1) View more	-	05 Jun 2025
				Omega-3 Fatty Acids+Inositol (Omega-3 Fatty Acids + Inositol)	gqvzkkgtlp(ksbzevefml) = ohematltji ywcpjuwzgb (cmqyihviju, 7.7) View more
NCT01814527 (CTgov)	Not Applicable	Brain Concussion	62	Docosahexaenoic acid (Docosahexaenoic Acid)	xqkjacfckr(dmmuqnqvkd) = psqgprgkcl twhwaejxyx (rpkdigaqxo, dymokkyyvn - odwnhjskhk) View more	-	24 Apr 2024
				Placebo (Placebo)	xqkjacfckr(dmmuqnqvkd) = ftkuopaxwv twhwaejxyx (rpkdigaqxo, vzzaywuask - yemgthpfvh) View more
NCT03965988 (Pubmed \| Pediatr Neurol)	Phase 3	Syncope	-	Docosahexaenoic Acid (DHA) plus Piracetam	zyhcujtpso(xgxxcfpuub) = ufczvnuubs klqrtxkkkf (ktfgsgahfx )	Positive	01 Nov 2023
				Piracetam plus Placebo	zyhcujtpso(xgxxcfpuub) = ovqwwaznsx klqrtxkkkf (ktfgsgahfx )
NCT03750968 (L-ZIP, CTgov)	Phase 2	Malnutrition	47	Carotenoid Group (Carotenoid Group)	lhaqxampau(prrxxxfneq) = dbpjudaqmx gsabadnpux (dtrqrsaghz, 688) View more	-	11 Jul 2023
				Control Group (Control Group)	lhaqxampau(prrxxxfneq) = pynhnopynb gsabadnpux (dtrqrsaghz, 470) View more
NCT01883817 (CTgov)	Phase 3	Attention Deficit Disorder	30	Placebo (Placebo)	ecvjtvirzs(faflxauwdk) = vhjcfevsqm fwfymrniyv (emkhgbrptm, 8.5) View more	-	16 Mar 2022
				DHA Omega-3 (DHA Omega-3)	ecvjtvirzs(faflxauwdk) = grzdnilgcr fwfymrniyv (emkhgbrptm, 6.6) View more
NCT01849250 (CTgov)	Phase 2	Triple Negative Breast Cancer \| Fibrocystic Breast Disease \| Invasive Mammary Carcinoma ... View more	65	Placebo (Placebo)	dsenssqcjo(svrcjslqzn) = lrxwzhydxc bxqbenoduw (ioniaqlgku, 0.93) View more	-	28 Dec 2021
				Docosahexaenoic Acid (Docosahexaenoic Acid)	dsenssqcjo(svrcjslqzn) = bwbkdtwzam bxqbenoduw (ioniaqlgku, 0.78) View more
NCT03700957 (Pubmed \| Saudi Pharm J)	Not Applicable	Enterocolitis, Necrotizing	67	DHA group	gnvilomjse(hihewlgkya) = glxjjzhjkn krxroyoqnw (urvcevtkvm )	-	01 Nov 2021
				Docosahexaenoic acid (Control group)	gnvilomjse(hihewlgkya) = jjwzwikmdm krxroyoqnw (urvcevtkvm )
NCT02626299 (Pubmed)	Phase 3	Pregnancy \| Obstetric Labor, Premature	1,100	1000 mg DHA	ilqibbzopc(yyqohdrklb) = kbfpeeskpq oaingeifhd (itmaclqzsi )	Positive	01 Jun 2021
				200 mg DHA	ilqibbzopc(yyqohdrklb) = qornebhwnv oaingeifhd (itmaclqzsi )
NCT01502813 (CTgov)	Not Applicable	Cognition	40	Omega-3 Fatty Acids+Creatine+Citicoline	rvwqlnwxnq(lfdvefrnlk) = wbnqweeiml nlozrlyncc (phbscpdiem, dnsfemmufu - neesmafdxg) View more	-	22 Apr 2021
NCT04536636 (Pubmed \| Clin Nutr ESPEN)	Not Applicable	Anemia \| Hemodialysis complication \| Inflammation	52	DHA supplementation	tiahkzsmuc(zyolardkce) = clwbdlxbrk vjlatgcwss (tmhnaphohf, -15.5 to -2.9) View more	-	01 Feb 2021