The goal of this study is to learn more about omega-3 polyunsaturated fatty acids supplementation on blood lipid profile and platelets in patients with high cholesterol levels.
The purpose of this research is to gather information on the safety and effect of two different fish oils, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
Participants will:
Visit the clinic 5 times during study checkups, tests and blood collection. Randomized to either the EPA or the DHA supplementation group. Be given a 28-day food and activity log.

Start Date01 Feb 2025

Sponsor / Collaborator

The Miriam Hospital

[+2]

CTRI/2024/11/076144

/ Not yet recruitingPhase 3IIT

Trial on effectiveness of omega 3 fatty acid supplements compared to Topical Steroids in Oral Lichen Planus Management - Nil

Start Date10 Nov 2024

Sponsor / Collaborator-

ChiCTR2400091225

/ SuspendedNot ApplicableIIT

The Role and Mechanism of Omega-3 Unsaturated Fatty Acids in Left Heart Disease-Associated Pulmonary Hypertension

Start Date01 Nov 2024

Sponsor / Collaborator-

100 Clinical Results associated with Docosahexaenoic acid

100 Translational Medicine associated with Docosahexaenoic acid

100 Patents (Medical) associated with Docosahexaenoic acid

34,673

Literatures (Medical) associated with Docosahexaenoic acid

31 Dec 2025·Gut Microbes

Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project

Article

Author: Lecomte, Béryle ; Michalski, Marie-Caroline ; Thirion, Florence ; Morissette, Arianne ; Simon, Chantal ; Nazare, Julie-Anne ; Marette, André ; Vinoy, Sophie ; Lessard Lord, Jacob ; Cani, Patrice D. ; Penhoat, Armelle ; Desjardins, Yves ; Sanoner, Philippe ; Blond, Emilie ; Doré, Joël ; Laville, Martine ; Pilon, Geneviève ; Van-Den-Berghe, Laurie ; Panthu, Baptiste ; Hornero-Ramirez, Hugo ; Caussy, Cyrielle ; Feugier, Nathalie ; Marcotte, Bruno ; Meynier, Alexandra

The development of cardiometabolic (CM) diseases is associated with chronic low-grade inflammation, partly linked to alterations of the gut microbiota (GM) and reduced intestinal integrity. The SINFONI project investigates a multifunctional (MF) nutritional strategy's impact combining different bioactive compounds on inflammation, GM modulation and CM profile. In this randomized crossover-controlled study, 30 subjects at CM-risk consumed MF cereal-products, enriched with polyphenols, fibers, slowly-digestible starch, omega-3 fatty acids or Control cereal-products (without bioactive compounds) for 2 months. Metabolic endotoxemia (lipopolysaccharide (LPS), lipopolysaccharide-binding protein over soluble cluster of differentiation-14 (LBP/sCD14), systemic inflammation and cardiovascular risk markers, intestinal inflammation, CM profile and response to a one-week fructose supplementation, were assessed at fasting and post mixed-meal. GM composition and metabolomic analysis were conducted. Mixed linear models were employed, integrating time (pre/post), treatment (MF/control), and sequence/period. Compared to control, MF intervention reduced intestinal inflammation (fecal calprotectin, p = 0.007) and endotoxemia (fasting LPS, p < 0.05), without alteration of systemic inflammation. MF decreased serum branched-chain amino acids compared to control (p < 0.05) and increased B.ovatus, B.uniformis, A.butyriciproducens and unclassified Christensenellaceae.CAG-74 (p < 0.05). CM markers were unchanged. A 2-month dietary intervention combining multiple bioactive compounds improved intestinal inflammation and induced GM modulation. Such strategy appears as an effective strategy to target low-grade inflammation through multi-target approach.

01 Aug 2025·Neural Regeneration Research

Interaction of major facilitator superfamily domain containing 2A with the blood–brain barrier

Article

Author: Miao, Feng ; Yang, Juanjuan ; Dong, Taiwei ; Luan, Fei ; Wei, Peifeng ; Ma, Yilun

The functional and structural integrity of the blood–brain barrier is crucial in maintaining homeostasis in the brain microenvironment; however, the molecular mechanisms underlying the formation and function of the blood–brain barrier remain poorly understood. The major facilitator superfamily domain containing 2A has been identified as a key regulator of blood–brain barrier function. It plays a critical role in promoting and maintaining the formation and functional stability of the blood–brain barrier, in addition to the transport of lipids, such as docosahexaenoic acid, across the blood–brain barrier. Furthermore, an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood–brain barrier dysfunction in a variety of neurological diseases; however, little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood–brain barrier. This paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood–brain barrier, including their basic structures and functions, cross-linking between major facilitator superfamily domain containing 2A and the blood–brain barrier, and the in-depth studies on lipid transport and the regulation of blood–brain barrier permeability. This comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood–brain barrier and the research progress to date. This will not only help to elucidate the pathogenesis of neurological diseases, improve the accuracy of laboratory diagnosis, and optimize clinical treatment strategies, but it may also play an important role in prognostic monitoring. In addition, the effects of major facilitator superfamily domain containing 2A on blood–brain barrier leakage in various diseases and the research progress on cross-blood–brain barrier drug delivery are summarized. This review may contribute to the development of new approaches for the treatment of neurological diseases.

01 Jun 2025·Journal of Stomatology, Oral and Maxillofacial Surgery

The implications of atorvastatin administration and the potential protective role of omega-3 on the submandibular salivary gland of albino rats (Histological, Histochemical, Ultrastructure, and Biochemical Study)

Article

Author: Gamal, Sherif ; Abd-Elmonsif, Nehad M ; Abd-elmonsif, Nehad M.

BACKGROUNDHyperlipidemia is a risky condition that can lead to atherosclerosis and other cardiovascular problems. Statins are used to treat hyperlipidemia. The most recommended medicine to treat hyperlipidemia is atorvastatin. On the contrary, clinical trials validated statins' negative effects. Omega-3 fatty acids have antioxidant properties and have been shown to improve a variety of disease processes in the general population, including inflammatory and immunological pathways, various cardiovascular diseases, and lipid regulation. The present research aimed to determine how atorvastatin affected the submandibular salivary gland (SMG) and whether omega-3 may have a protective impact.METHODSThirty adult male albino rats were divided into three equal groups and received drugs orally as a single daily dose for one week. Control group (I): received normal saline. Atorvastatin group (II): received a dose of 80 mg Kg^-1 of Atorvastatin. Group III: received Omega-3 before Atorvastatin. All rats were sacrificed 2 h following the last dose, and blood samples were gathered for the biochemical study of fasting blood glucose level (FBGL). Specimens were obtained and processed for histological and histochemical studies.RESULTSAtorvastatin-treated rats showed degeneration of SMG acini. The acinar cells showed cytoplasmic vacuoles with dilated RER. Histochemical results revealed a marked decrease in total proteins. The biochemical study revealed an elevation in FBGL. The administration of Omega-3 with Atorvastatin minimizes these changes.CONCLUSIONAtorvastatin has been proven to induce histological changes in SMG, and these changes can be attenuated by Omega-3. However, Omega-3 has no effect on FBGL.

News (Medical) associated with Docosahexaenoic acid

16 Aug 2024

·www.businesswire.com

Lobe Sciences Announces Creation of Wholly Owned Subsidiary, Alera Pharma, Inc.

VANCOUVER, British Columbia--( BUSINESS WIRE )-- Lobe Sciences, Ltd ("Lobe Sciences" or the "Company") (CSE: LOBE), (OTCQB: LOBEF) , a biopharmaceutical company focused on developing products to treat diseases with unmet medical needs, today announced that is has formed a wholly owned U.S. subsidiary named Alera Pharma, Inc. (Alera). Alera will be assigned the intellectual property rights focused on the Company’s neurological assets and its new chemical entity Psilocin Mucate. Mr. Rick Goulburn has been appointed as the Chief Executive Officer of Alera. Dr. Fred D. Sancilio will be Chairman of its Board of Directors and be joined on the board by Dr. Harry Jacobson, Mr. Wesley Ramjeet and Mr. Goulburn. Alera will be the operating company within the Lobe Sciences group focused on neurology and will join Altemia, LLC as the second operating subsidiary of Lobe Sciences. It is expected that the Company’s Australian subsidiary, Lobe Sciences Australia Pty Ltd., will become a subsidiary of Alera. Mr. Ilan Hayman will become a member of the executive management team of Alera. Dr. Sancilio, Chairman and CEO of Lobe Sciences said, “At present, Lobe Sciences has a complex corporate structure. By establishing Alera Pharma, we are simplifying the operations of the Company into just three entities. Lobe Sciences, Ltd will provide common services to the two operating subsidiaries - Alera and Altemia, LLC. The creation of two separate operating companies will allow each entity to create value within their respective therapeutic areas; neurology and hematology.” The Company also announces the receipt from the US PTO of a Notice of Allowance for its U.S. Patent Application Serial No. 18/411,576. About Lobe Sciences Ltd. Lobe Sciences is a biopharmaceutical company focused on developing medicines to treat diseases with unmet medical needs. The Company, through collaboration with industry-leading partners, is engaged in novel research and development focused on treating chronic cluster headache (an orphan disease), refractive anxiety, and sickle cell disease. The Company is engaged in Phase 1 and Phase 2 activities in its drug portfolio, and intends to initiate the launch of Altemia ® , a medical food designed to meet the needs of sickle cell patients globally. Cautionary Statement Regarding "Forward-Looking" Information This news release includes certain statements and information that may constitute forward-looking information within the meaning of applicable Canadian securities laws. All statements in this news release, other than statements of historical facts, including statements regarding future estimates, plans, objectives, timing, assumptions or expectations of future performance, including, without limitation: the composition of the management team of Alera and the ownership of Lobe Sciences Australia Pty Ltd., are forward-looking statements and contain forward-looking information. Generally, forward-looking statements and information can be identified by the use of forward-looking terminology such as “intends” or “anticipates”, or variations of such words and phrases or statements that certain actions, events or results “may”, “could”, “should” or “would” or occur. Forward-looking statements are based on certain material assumptions and analysis made by the Company and the opinions and estimates of management as of the date of this press release, including, among other things, that: the management team of Alera will be appointed as currently expected and that Lobe Sciences Australia Pty Ltd. will become a subsidiary of Alera as currently anticipated. These forward-looking statements are subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of the Company to be materially different from those expressed or implied by such forward-looking statements or forward-looking information. Important risks that may cause actual results to vary, include, without limitation, the risk that: the management team of Alera will be appointed differently as currently expected and that Lobe Sciences Australia Pty Ltd. will not become a subsidiary of Alera as currently anticipated. Although management of the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking statements or forward-looking information, there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no assurance that such statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements and forward-looking information. Readers are cautioned that reliance on such information may not be appropriate for other purposes. The Company does not undertake to update any forward-looking statement, forward-looking information or financial out-look that are incorporated by reference herein, except in accordance with applicable securities laws.

Executive ChangePhase 1Phase 2

19 Jul 2024

·www.drugs.com

Micronutrient Supplementation Slows Geographic Atrophy Progression

FRIDAY, July 19, 2024 -- Oral micronutrient supplementation slows geographic atrophy (GA) progression in age-related macular degeneration (AMD), according to a study published online July 16 in Ophthalmology . Tiarnan D.L. Keenan, B.M., B.Ch., Ph.D., from the National Institutes of Health in Bethesda, Maryland, and colleagues examined whether oral supplements slow GA progression in AMD in a post-hoc analysis of the Age-Related Eye Diseases Study (AREDS) and AREDS2 multicenter, randomized trials. A total of 392 eyes from 318 participants with GA were included in AREDS, and 1,210 eyes from 891 participants with GA were included in AREDS2. AREDS participants were randomly allocated to oral antioxidants; zinc (80 mg); combination; or placebo. AREDS2 participants were randomly assigned to lutein/zeaxanthin; docosahexaenoic acid/eicosapentaenoic acid; combination; or placebo. AREDS2 participants were also randomly assigned to alternative AREDS formulations: original, no β-carotene, zinc (25 mg), or both. The researchers found that proximity-based progression toward the central macula was significantly slower in AREDS eyes with noncentral GA with randomization to antioxidants versus none (50.7 versus 72.9 µm/year). In AREDS2 eyes with noncentral GA, proximity-based progression was significantly slower with randomization to lutein/zeaxanthin versus none among those assigned to AREDS antioxidants without β-carotene (80.1 versus 114.4 µm/year). Area-based progression was not significantly different with randomization to antioxidants versus none in AREDS2 eyes with any GA. "We've known for a long time that AREDS2 supplements help slow the progression from intermediate to late AMD. Our analysis shows that taking AREDS2 supplements can also slow disease progression in people with late dry AMD," Keenan said in a statement. "These findings support the continued use of AREDS2 supplements by people with late dry AMD." Several authors disclosed ties to the pharmaceutical industry.

Clinical Result

10 Jul 2024

·www.drugs.com

Adherence to Mediterranean Diet, Omega-3 Fatty Acids Beneficial in Acne

WEDNESDAY, July 10, 2024 -- Adherence to a Mediterranean diet incorporating eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduces skin lesions and improves quality of life in patients with acne, according to a study published online July 10 in the Journal of Cosmetic Dermatology . Anne Guertler, M.D., from Ludwig Maximilian University in Munich, and colleagues examined the clinical effects associated with increasing EPA/DHA levels in patients with acne. Sixty participants without prescription medication (23 with acne comedonica [AC] and 37 with acne papulopustulosa [AP]) adhered to a Mediterranean diet, incorporating omega-3 fatty acid supplementation. Blood EPA/DHA levels were tracked at four visits (V1 to V4) using the HS-omega 3 index (EPA/DHA [percent] of total identified fatty acids in erythrocytes: target, 8 to 11 percent; deficit, <8 percent; severe deficit, <4 percent). The researchers found that 98.3 percent of patients had an EPA/DHA deficit at baseline, with the mean HS-omega 3 index increasing from 4.9 to 8.3 percent at V1 to V4. At V4, significantly higher indices were seen for AC than AP. In both inflammatory and noninflammatory lesions, there were objective improvements observed. Four patients self-reported worsened appearance, but overall quality of life improved, especially in AP. Compared with beneficial foods, dietary triggers were more clearly defined. Cow's milk and dairy product intake was reduced. A high rate of compliance was observed, and there were no reports of adverse events. "Lifestyle interventions, including dietary recommendations, should not be considered in opposition to prescription medications, but rather as a valuable adjunct to any modern acne treatment plan," Guertler said in a statement. Omegametrix® GmbH performed the analysis of the HS-omega-3 Index® free of charge. Queisser Pharma GmbH & Co. KG offered omega-3 supplements free of charge.

Clinical Result

100 Deals associated with Docosahexaenoic acid

External Link

KEGG	Wiki	ATC	Drug Bank
-	Docosahexaenoic acid	V06D	DB03756

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Anemia, Sickle Cell	Phase 3	-	Micelle BioPharma, Inc.Startup	01 Mar 2019
Hypertriglyceridemia	Phase 3	-	Sancilio & Co., Inc.	28 Nov 2013
Non-Small Cell Lung Cancer	Preclinical	KR	Chungnam National University	15 Jul 2016
Attention Deficit Disorder	Preclinical	US	DSM Nutritional Products LLC	01 Sep 2013
Coronary Disease	Preclinical	US	Veterans Administration Medical Center	30 Oct 2012
Colorectal Cancer	Preclinical	US	Texas A&M University	15 Apr 2010
Breast Cancer	Preclinical	US	University of Nevada	01 May 2009
Adenocarcinoma of Lung	Preclinical	US	University of Nevada	01 May 2008
Colonic Cancer	Preclinical	US	University of Nevada	01 May 2008

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ESC2024	Not Applicable	Cardiovascular Diseases	-	Eicosapentaenoic acid (EPA)	(stodonjqpz) = ylesnqtmun owcmljxuib (bngqgdotyd, 0.95 - 0.98)	-	02 Sep 2024
				Docosahexaenoic acid (DHA)	(stodonjqpz) = aytfmusybd owcmljxuib (bngqgdotyd, 0.86 - 0.89)
NCT03965988 (Pubmed \| Pediatr Neurol)	Phase 3	Syncope	-	Docosahexaenoic Acid (DHA) plus Piracetam	kffshthntc(rbvitjqdyh) = mtaeuoshsw snkjuvntav (aajqgkdazt )	Positive	01 Nov 2023
				Piracetam plus Placebo	kffshthntc(rbvitjqdyh) = jjmcwnpnbm snkjuvntav (aajqgkdazt )
ARVO2023	Not Applicable	Glaucoma	-	DHA and Citicoline	yigtngtarp(dbccstzsuw) = hgsielslgz nnvbfxpjnj (wwqudydfgo ) View more	Positive	23 Apr 2023
VITAL (EULAR2022)	Not Applicable	Autoimmune Diseases	-	Vitamin D 3 (2000 IU/d)	-	Positive	01 Jun 2022
				n-3 fatty acidsVITAMIN D (n-3 fatty acids (1000 mg/d))
NCT01883817 (CTgov)	Phase 3	Attention Deficit Disorder	30	Placebo (Placebo)	thxqhrrjmw(tdigmyhyzi) = zfyhcmzepm mzzouxpupo (feyvxkdfku, xfmqhkcjzs - ztaxhagfei) View more	-	16 Mar 2022
				DHA Omega-3 (DHA Omega-3)	thxqhrrjmw(tdigmyhyzi) = ipzvmiappb mzzouxpupo (feyvxkdfku, jduwlhawto - jugpljnsyy) View more
NCT01849250 (CTgov)	Phase 2	Triple Negative Breast Cancer \| Fibrocystic Breast Disease \| Invasive Mammary Carcinoma \| Breast Cancer 3 \| Mammary Paget's Disease \| Precancerous Conditions	65	Placebo (Placebo)	ophtllitcr(ijiuouvsan) = qzlnojstzr aaepltgaqx (ruouunhcrl, tzulvvwmfa - yruirxiotx) View more	-	28 Dec 2021
				Docosahexaenoic Acid (Docosahexaenoic Acid)	ophtllitcr(ijiuouvsan) = snmuqilzbn aaepltgaqx (ruouunhcrl, hrrstwzzpv - zqllrhijyg) View more
NCT03784963 (CTgov)	Phase 1/2	Gastrointestinal Hemorrhage \| Heart Failure	35	Omega 3 fatty acids (Primary Prevention Intervention)	ougpedmeir(hzhtaltuod) = sxuhyoelgn lmxwybcjvr (grzyjzbktb, gysvotgjxz - aipwzjnvgz) View more	-	13 Jul 2021
				Placebo (Primary Prevention Non-Intervention)	ougpedmeir(hzhtaltuod) = mxbvoixlby lmxwybcjvr (grzyjzbktb, guxojcfuzh - lwqmiaxccs) View more
NCT02626299 (Pubmed)	Phase 3	Pregnancy \| Obstetric Labor, Premature	1,100	1000 mg DHA	klmolmsdkf(vldhyfcqfe) = ccryboditf utkxjvwted (oowxmezkhn )	Positive	01 Jun 2021
				200 mg DHA	klmolmsdkf(vldhyfcqfe) = rvscglcdpl utkxjvwted (oowxmezkhn )
NCT01903525 (CTgov)	Phase 1	Athletic Injuries \| Brain Concussion	40	Placebo (Placebo)	elhngpxdsu(sciwqsbixh) = gtnehifkxf yeynykvnxq (dszbpdwwix, lnkteubakc - qsveqtoger) View more	-	11 Jan 2021
				Docosahexaenoic acid (DHA) (Docosahexaenoic Acid (DHA))	elhngpxdsu(sciwqsbixh) = ynqlgnikeb yeynykvnxq (dszbpdwwix, eldytcujgd - keiclpskif) View more
Pubmed \| Adv Nutr	Not Applicable	-	-	Docosahexaenoic Acid (DHA)	(mokphmhjbg) = vtcrflxldn sdvoupzszo (apgviesiai, -0.57 to 0.85) View more	-	01 Jan 2021

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