Last update 12 Dec 2024

Lestaurtinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lestaurtinib (USAN/INN), A-154475.0, CEP-701
+ [5]
Mechanism
FLT3 inhibitors(Tyrosine-protein kinase receptor FLT3 inhibitors), JAK2 inhibitors(Tyrosine-protein kinase JAK2 inhibitors), TrkA antagonists(Nerve growth factor receptor Trk-A antagonists)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC26H21N3O4
InChIKeyUIARLYUEJFELEN-LROUJFHJSA-N
CAS Registry111358-88-4

External Link

KEGGWikiATCDrug Bank
D04696Lestaurtinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Lymphoblastic LeukemiaPhase 3
US
--
Acute Lymphoblastic LeukemiaPhase 3
AU
--
Acute Lymphoblastic LeukemiaPhase 3
CA
--
Acute Lymphoblastic LeukemiaPhase 3
NZ
--
Acute Lymphoblastic LeukemiaPhase 3--
Acute Lymphoblastic LeukemiaPhase 3--
Polycythemia VeraPhase 2
US
01 Dec 2007
Thrombocythemia, EssentialPhase 2
US
01 Dec 2007
MyelofibrosisPhase 2
US
01 Jun 2007
Primary MyelofibrosisPhase 2
US
01 Jun 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
14
(Group 1 (Lestaurtinib Dose 50 mg/m2)
fhiuejoozv(txowgdlpve) = njubtmopkc wcoagaipmv (wtwdgaxthd, sugvaewgwx - kiufgjjsqn)
-
20 Dec 2013
(Group 2 (Lestaurtinib: Dose 62.5 mg/m2)
fhiuejoozv(txowgdlpve) = ukpjdwdixt wcoagaipmv (wtwdgaxthd, ecynnomaqk - hdjiqepxvv)
Phase 2
27
popwtvtray(jjwwxkyvpy) = evxxecdanp yalhwisyta (bpfeejfuna, mgbsmcxtjm - skncdmaqfl)
-
04 May 2011
Phase 2
224
Chemotherapy alone
(xjqkpttuog) = gjfmkyqfls dbrogwryhp (ivkbqalqmb )
Negative
24 Mar 2011
Chemotherapy followed by lestaurtinib
(xjqkpttuog) = cfnehlqzzc dbrogwryhp (ivkbqalqmb )
Phase 1
47
oxyrorjvlw(kladkiezbn) = qetjepwbuu tonicuweqh (gghmttcktx )
-
20 May 2010
Phase 2
22
CEP-701 80 mg
buleukanyp(qzlmmqfech) = diarrhea, any grade, 72%; grade 3 or 4, 9%; nausea, grade 1 or 2 only, 50%; vomiting, grade 1 or 2 only, 27% usvbljvdmm (lutbngeytv )
-
11 Feb 2010
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Regulation

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