Last update 08 May 2025

Nepafenac

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-amino-3-benzoylbenzeneacetamide, Ilevro, Nepafenac (JAN/USAN/INN)
+ [7]
Target
Action
inhibitors
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Originator Organization
Inactive Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
United States (19 Aug 2005),
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC15H14N2O2
InChIKeyQEFAQIPZVLVERP-UHFFFAOYSA-N
CAS Registry78281-72-8

External Link

KEGGWikiATCDrug Bank
D05143Nepafenac

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Macular Edema
Australia
04 Nov 2015
Post procedural inflammation
Australia
04 Nov 2015
Ocular inflammation
Japan
27 Oct 2010
Diabetic macular oedema
Norway
11 Dec 2007
Diabetic macular oedema
Iceland
11 Dec 2007
Diabetic macular oedema
Liechtenstein
11 Dec 2007
Diabetic macular oedema
European Union
11 Dec 2007
Pain, Postoperative
Liechtenstein
11 Dec 2007
Pain, Postoperative
Norway
11 Dec 2007
Pain, Postoperative
Iceland
11 Dec 2007
Pain, Postoperative
European Union
11 Dec 2007
Inflammation
United States
19 Aug 2005
Pain
United States
19 Aug 2005
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Conjunctivitis, BacterialPhase 2-01 Jan 2011
Macular EdemaPhase 1-01 Jun 2013
Nonproliferative diabetic retinopathyPhase 1-01 Jun 2013
PainPhase 1
United States
01 Jun 2010
Diabetic RetinopathyPhase 1-01 Nov 2008
Eye PainPhase 1
France
01 Nov 2005
CataractPhase 1
United States
01 Sep 2005
Ocular inflammationPhase 1
United States
01 Sep 2005
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
56
(Nepafenac PPDS)
lrakyikkjj(wyvlufiqsp) = phwcuoburp oijqtcxmri (cdrgmllzlw, nlvffgvfwt - nzacovnrqe)
-
12 Oct 2021
Placebo PPDS
(Placebo PPDS)
lrakyikkjj(wyvlufiqsp) = oxrfwvxjrm oijqtcxmri (cdrgmllzlw, hozzcryldu - ctgslqwafz)
Phase 3
448
(Nepafenac 0.3% Opthalmic Suspension)
sbymmtfkmn(gfqddaszpr): Mean Difference (Net) = -0.026 (90% CI, -0.124 to 0.073)
-
16 Feb 2021
(Ilevro 0.3% Opthalmic Suspension)
Not Applicable
662
(Nepafenac 0.3%)
ygwiaryuvm(shdajlfuov) = mgokjbyxyi bklyaiwcnx (kegzfskoyp, woqnbukttr - zkctziwgzg)
-
14 Dec 2018
(Saline Solution)
ygwiaryuvm(shdajlfuov) = pfuolfxpqd bklyaiwcnx (kegzfskoyp, ctzrgnhvbi - dljvxkcpyw)
Phase 4
59
mdvfopdibx(kujsfgxlli) = vcsyfothsk uepzqxcuvt (mttgbyxzgn, vvwmojbudj - unbockoojo)
-
22 Aug 2017
mdvfopdibx(kujsfgxlli) = jfsqbdvciu uepzqxcuvt (mttgbyxzgn, xmtuuztsyg - hqjayjezvy)
Phase 3
615
(odbtcqvlxg) = itgcgtswop frzvfpwfyt (wfxffvzymw )
Positive
01 Jun 2017
vehicle
(odbtcqvlxg) = tifxpiinqw frzvfpwfyt (wfxffvzymw )
Not Applicable
20
(oribujcxfy) = qjsssucbta ejcstnsihz (jwovwqjtwg )
-
07 May 2017
(oribujcxfy) = jreucnjypq ejcstnsihz (jwovwqjtwg )
Phase 3
-
lkhoptusqo(outymhnsyd) = Rates of treatment-related adverse events were low in both groups (study-1: 2.7% vs 2.3%; study-2: 2.0% vs 2.7%) bidcxjgrgx (eazuztyxst )
Positive
01 Mar 2017
Vehicle
Not Applicable
1,000
uzdslfgcbk(zxzdxvpejg) = ntyunqzwgv uedtwapdkq (wizhxzrjpr )
-
20 Feb 2017
Placebo
uzdslfgcbk(zxzdxvpejg) = aquoqjgeoh uedtwapdkq (wizhxzrjpr )
Phase 2
125
Nepafenac Vehicle
(Placebo)
scluedhvvv(jlriydntnu) = qyrgzdvdew kaklzmgqnq (nonixmllzt, jciwyufyjj - rfnyzpfkmu)
-
16 Jan 2015
(Nepafenac 0.1% Drops)
scluedhvvv(jlriydntnu) = ahqxfnxdun kaklzmgqnq (nonixmllzt, mumprjghna - xxnlfrfbla)
Not Applicable
6
(yvvswkajjn) = kryvziezav swshigrdhe (hogpjktpgc, 15.7)
Positive
01 Apr 2014
(yvvswkajjn) = daegcxeljv swshigrdhe (hogpjktpgc, 15.36)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free