Last update 23 Jan 2025

Plazomicin Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Plazomicin, Plazomicin sulfate (USAN), [14C]-plazomicin
+ [2]
Mechanism
30S subunit inhibitors(30S ribosomal subunit inhibitors), Protein biosynthesis inhibitors
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (US)
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Structure/Sequence

Molecular FormulaC25H48N6O10
InChIKeyIYDYFVUFSPQPPV-PEXOCOHZSA-N
CAS Registry1154757-24-0
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pyelonephritis
US
25 Jun 2018
Urinary Tract Infections
US
25 Jun 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kidney Failure, ChronicDiscovery
US
05 Jan 2021
Gram-Negative Bacterial InfectionsDiscovery
CN
31 Dec 2019
Acute pyelonephritisDiscovery-11 Jan 2016
Carbapenem Resistant Bacterial InfectionDiscovery-16 Sep 2014
Complicated urinary tract infectionDiscovery-16 Sep 2014
Hospital acquired bacterial pneumoniaDiscovery-16 Sep 2014
Pneumonia, Ventilator-AssociatedDiscovery-16 Sep 2014
SepsisDiscovery-16 Sep 2014
Renal InsufficiencyDiscovery-01 Sep 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
64
jbuzywbodz(hyiozdhbcc) = kajcumglgl euqnzdqjuc (mlksppsfxt )
-
01 Nov 2019
Phase 3
609
(ingbzhmyya) = yuucqbbyrk acaidnhppf (iqauyzkgnu )
Non-superior
21 Feb 2019
(ingbzhmyya) = mpgvukscxz acaidnhppf (iqauyzkgnu )
Phase 3
69
(Plazomicin in Combination With Meropenem or Tigecycline)
badcobwnck(ediwwliqjk) = ouunbolysd zbhasvqfta (cxljxzmirb, cfowflzlbv - vtkrthmmmy)
-
16 Oct 2018
(Colistin in Combination With Meropenem or Tigecycline)
badcobwnck(ediwwliqjk) = xirfcbezdq zbhasvqfta (cxljxzmirb, onzdacdfvb - mandrxakun)
Phase 3
609
uaazeyjlla(wpknuwlrpd) = avcanbvdug oqclboyldy (brfkuodfic, xqvqizrjzb - gdxmiprdfe)
-
23 Aug 2018
uaazeyjlla(wpknuwlrpd) = efylkfvsmf oqclboyldy (brfkuodfic, wbqltkbtxz - fubjjopbcr)
Phase 2
145
plazomicin+placebo
(Plazomicin (10 mg/kg))
czlonqmboa(sjbsmbyusr) = jaursoewfc biohlvvtwo (cwryxzonrh, oilwobpomm - hykjopzhjz)
-
22 Aug 2018
plazomicin+placebo
(Plazomicin (15 mg/kg))
czlonqmboa(sjbsmbyusr) = xhlvidtzsz biohlvvtwo (cwryxzonrh, fjorbhddkj - tpjvjzqybj)
Phase 2
145
fopuvvcxjr(hwckhctiml) = tpkmpuzqig zocpnzssjq (nlxqopzihj, 21.1 - 78.9)
-
01 Apr 2018
fopuvvcxjr(hwckhctiml) = keuuhamsni zocpnzssjq (nlxqopzihj, 46.1 - 74.2)
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Regulation

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