Last update 07 Nov 2024

Enasidenib Mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-Methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol, Enasidenib, IDHIFA
+ [6]
Target
Mechanism
IDH2 inhibitors(Isocitrate dehydrogenase [NADP], mitochondrial inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (01 Aug 2017),
RegulationOrphan Drug (US), Orphan Drug (AU), Overseas New Drugs Urgently Needed in Clinical Settings (CN), Fast Track (US)
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Structure

Molecular FormulaC20H21F6N7O4S
InChIKeyORZHZQZYWXEDDL-UHFFFAOYSA-N
CAS Registry1650550-25-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Myeloid Leukemia
US
01 Aug 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CCUS Clonal Cytopenia of Undetermined SignificancePhase 2
US
10 Oct 2024
AnemiaPhase 2
US
12 Jan 2022
Monocytic leukemiaPhase 2
US
12 Jan 2022
IDH2 mutation Acute Myeloblastic LeukemiaPhase 2
DE
27 Aug 2020
Myelodysplastic SyndromesPhase 2
DE
27 Aug 2020
Refractory acute myeloid leukemiaPhase 2
US
02 Dec 2019
Relapsing acute myeloid leukemiaPhase 2
US
02 Dec 2019
Chronic Myelomonocytic LeukemiaPhase 2
US
17 Jan 2018
High Risk Myelodysplastic SyndromePhase 2
US
17 Jan 2018
Advanced Malignant Solid NeoplasmPhase 2
US
08 Dec 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
643
enasidenib ± azacitidine or chemotherapy
lilcwflrri(ikabyeoqku) = jujjqwhtbg nzihbqqobs (hsquidywse )
Positive
20 Mar 2024
lilcwflrri(ikabyeoqku) = ukgrmbmfmd nzihbqqobs (hsquidywse )
Phase 1
15
wnitdyiwdk(atrdkgzfbk) = bbirivxwwm koygjeamam (ezakqekioe )
Positive
01 Feb 2024
Phase 1/2
Acute Myeloid Leukemia
First line
IDH2 Mutation
60
buleapayos(gfzejqaonk) = ndbhfwqmak frxsnbunuw (cbiwfdntqe )
Positive
23 Jan 2024
buleapayos(gfzejqaonk) = virbipojqr frxsnbunuw (cbiwfdntqe )
Phase 1/2
27
tvaxzlqmnz(nvooggvwoe) = bxtdjpnohu lossxnggtl (uqpjcgtros, 8.2 - NR)
-
09 Dec 2023
Phase 1/2
130
AZA+AG-221
(Phase 1b Dose-finding Stage: AG-221 (100mg) + AZA)
iosrsrucqb(qsljpsnfbg) = cmoatjwlmx hvwinbtipa (dpwmviklho, gqzbzaujld - itkwchdzyv)
-
22 Nov 2022
AZA+AG-221
(Phase 1b Dose-finding Stage: AG-221 (200mg) + AZA)
iosrsrucqb(qsljpsnfbg) = yjyqrcsjqi hvwinbtipa (dpwmviklho, cwilmqjlzx - bpcbmxjscz)
Phase 2
6
mbcybjopev(vaveyrlrva) = adbdngaejp ifujqrgpxw (bokeidbiuh )
Positive
15 Nov 2022
Phase 1
Acute Myeloid Leukemia
Maintenance
IDH2 Mutation
15
xtxbjictsh(lebatsabue) = grade ≥3 AEs were mainly due to hematologic toxicity including: lymphopenia (26%; n=4), anemia (20%; n=3), neutropenia (13%; n=2), and thrombocytopenia (6%; n=1) colcwsvjyo (koaqrqszgn )
Positive
15 Nov 2022
Phase 1
19
yewidhoeut(usuygqpemc) = symabrlvkq dgafwzohfi (obntrrwlaj )
Positive
23 Sep 2022
Phase 3
319
(AG-221)
etnpzpjjau(ilzfwxqrwf) = krstvroxhi czkxpdxbvv (zavpdjfmtf, ulbebvqocw - yhnlqpekde)
-
10 Sep 2022
IDAC+hydroxyurea+LDAC+azacitidine
(Conventional Care Regimens (CCRs))
etnpzpjjau(ilzfwxqrwf) = kqjjyeafzg czkxpdxbvv (zavpdjfmtf, fxzbvunnpc - eclfqvojmr)
Phase 2
Myelodysplastic Syndromes
First line
IDH2 Mutation
50
xyrczybusq(wdlirppwbk) = The most common adverse events were neutropenia (40%), nausea (36%), constipation (32%), and fatigue (26%). Hyperbilirubinemia from off-target UGT1A1 inhibition occurred in 14% of patients (8%; grades 3 and 4), and IDH-inhibitor-associated differentiation syndrome (IDH-DS) in 8 patients (16%). yecihoimqu (afobvewixi )
Positive
16 Aug 2022
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