Drug Type Small molecule drug |
Synonyms 2-Methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol, Enasidenib, IDHIFA + [6] |
Target |
Mechanism IDH2 inhibitors(Isocitrate dehydrogenase [NADP], mitochondrial inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (01 Aug 2017), |
RegulationOrphan Drug (US), Orphan Drug (AU), Overseas New Drugs Urgently Needed in Clinical Settings (CN), Fast Track (US) |
Molecular FormulaC20H21F6N7O4S |
InChIKeyORZHZQZYWXEDDL-UHFFFAOYSA-N |
CAS Registry1650550-25-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Enasidenib Mesylate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Acute Myeloid Leukemia | US | 01 Aug 2017 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
CCUS Clonal Cytopenia of Undetermined Significance | Phase 2 | US | 10 Oct 2024 | |
Anemia | Phase 2 | US | 12 Jan 2022 | |
Monocytic leukemia | Phase 2 | US | 12 Jan 2022 | |
IDH2 mutation Acute Myeloblastic Leukemia | Phase 2 | DE | 27 Aug 2020 | |
Myelodysplastic Syndromes | Phase 2 | DE | 27 Aug 2020 | |
Refractory acute myeloid leukemia | Phase 2 | US | 02 Dec 2019 | |
Relapsing acute myeloid leukemia | Phase 2 | US | 02 Dec 2019 | |
Chronic Myelomonocytic Leukemia | Phase 2 | US | 17 Jan 2018 | |
High Risk Myelodysplastic Syndrome | Phase 2 | US | 17 Jan 2018 | |
Advanced Malignant Solid Neoplasm | Phase 2 | US | 08 Dec 2014 |
Not Applicable | Acute Myeloid Leukemia IDH2 Mutation | 643 | lilcwflrri(ikabyeoqku) = jujjqwhtbg nzihbqqobs (hsquidywse ) View more | Positive | 20 Mar 2024 | ||
lilcwflrri(ikabyeoqku) = ukgrmbmfmd nzihbqqobs (hsquidywse ) | |||||||
Phase 1 | 15 | wnitdyiwdk(atrdkgzfbk) = bbirivxwwm koygjeamam (ezakqekioe ) View more | Positive | 01 Feb 2024 | |||
NCT03013998 (Pubmed) Manual | Phase 1/2 | 60 | buleapayos(gfzejqaonk) = ndbhfwqmak frxsnbunuw (cbiwfdntqe ) View more | Positive | 23 Jan 2024 | ||
buleapayos(gfzejqaonk) = virbipojqr frxsnbunuw (cbiwfdntqe ) View more | |||||||
Phase 1/2 | 27 | tvaxzlqmnz(nvooggvwoe) = bxtdjpnohu lossxnggtl (uqpjcgtros, 8.2 - NR) View more | - | 09 Dec 2023 | |||
Phase 1/2 | 130 | AZA+AG-221 (Phase 1b Dose-finding Stage: AG-221 (100mg) + AZA) | iosrsrucqb(qsljpsnfbg) = cmoatjwlmx hvwinbtipa (dpwmviklho, gqzbzaujld - itkwchdzyv) View more | - | 22 Nov 2022 | ||
AZA+AG-221 (Phase 1b Dose-finding Stage: AG-221 (200mg) + AZA) | iosrsrucqb(qsljpsnfbg) = yjyqrcsjqi hvwinbtipa (dpwmviklho, cwilmqjlzx - bpcbmxjscz) View more | ||||||
NCT04281498 (ASH2022) Manual | Phase 2 | Myeloproliferative Disorders IDH2 Mutation | 6 | mbcybjopev(vaveyrlrva) = adbdngaejp ifujqrgpxw (bokeidbiuh ) View more | Positive | 15 Nov 2022 | |
NCT03728335 (ASH2022) Manual | Phase 1 | 15 | xtxbjictsh(lebatsabue) = grade ≥3 AEs were mainly due to hematologic toxicity including: lymphopenia (26%; n=4), anemia (20%; n=3), neutropenia (13%; n=2), and thrombocytopenia (6%; n=1) colcwsvjyo (koaqrqszgn ) View more | Positive | 15 Nov 2022 | ||
NCT03515512 (Pubmed) Manual | Phase 1 | IDH2 mutation Acute Myeloblastic Leukemia IDH2 Mutation | 19 | yewidhoeut(usuygqpemc) = symabrlvkq dgafwzohfi (obntrrwlaj ) View more | Positive | 23 Sep 2022 | |
Phase 3 | 319 | (AG-221) | etnpzpjjau(ilzfwxqrwf) = krstvroxhi czkxpdxbvv (zavpdjfmtf, ulbebvqocw - yhnlqpekde) View more | - | 10 Sep 2022 | ||
(Conventional Care Regimens (CCRs)) | etnpzpjjau(ilzfwxqrwf) = kqjjyeafzg czkxpdxbvv (zavpdjfmtf, fxzbvunnpc - eclfqvojmr) View more | ||||||
NCT03383575 (Pubmed) Manual | Phase 2 | 50 | xyrczybusq(wdlirppwbk) = The most common adverse events were neutropenia (40%), nausea (36%), constipation (32%), and fatigue (26%). Hyperbilirubinemia from off-target UGT1A1 inhibition occurred in 14% of patients (8%; grades 3 and 4), and IDH-inhibitor-associated differentiation syndrome (IDH-DS) in 8 patients (16%). yecihoimqu (afobvewixi ) | Positive | 16 Aug 2022 | ||