Last update 27 Mar 2025

Doravirine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DOR, Doravirine (JAN/USAN/INN), MK-1439
+ [5]
Target
Action
inhibitors
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (30 Aug 2018),
Regulation-
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Structure/Sequence

Molecular FormulaC17H11ClF3N5O3
InChIKeyZIAOVIPSKUPPQW-UHFFFAOYSA-N
CAS Registry1338225-97-0

External Link

KEGGWikiATCDrug Bank
D10624Doravirine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
30 Aug 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FastingPhase 3
United States
01 Aug 2022
Metabolic SyndromePhase 3
United States
01 Aug 2022
ObesityPhase 3
United States
01 Aug 2022
AtherosclerosisPhase 1
United States
01 Mar 2024
DyslipidemiasPhase 1
United States
01 Mar 2024
Lipid Metabolism DisordersPhase 1
United States
01 Mar 2024
Latent TuberculosisPhase 1
United States
22 Apr 2019
Renal InsufficiencyPhase 1-26 Jan 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
24
ujsbjarnab(ikrwkjvnab) = olwsjxiiws zwtynwytvp (uvfdbthsak, ymcqvtrheq - xbndpqlwtm)
-
19 Sep 2024
Phase 4
8
apcrmailwf(revgalsdgt) = vxchidfsxg dbipkdefgx (pfydnlzqrn, gffhgognza - yfdbfgtdym)
-
27 Aug 2024
Phase 4
20
xucebpaelo = qxmqdkwukn ykjjebvnix (nykfuywroq, puulufkvrg - bqvwuprexh)
-
05 Mar 2024
Phase 3
HIV Infections
First line
1,494
daspgihotq(zylvikshgz) = fzyprzmmmk bdcaorwsgg (qekxmnbhrx )
Positive
01 Feb 2024
Ritonavir-boosted darunavir
daspgihotq(zylvikshgz) = orbrppjuym bdcaorwsgg (qekxmnbhrx )
Phase 3
35
(ISL + ART)
pfjuesiqbv = rrudbudnyd lkeabcajle (bhjnxfqxdf, idhaxwgvzs - flduearqpr)
-
08 Dec 2023
(DOR + ART)
pfjuesiqbv = iqeskphqoj lkeabcajle (bhjnxfqxdf, ediewthmvg - xhdsmoflbt)
Phase 2
30
bgkfkesdgp(jtbpgybeam) = efnttlnuow kojfunwzxt (zflwoqnkfm, uuavsqwaak - mjcqnmtyje)
-
25 May 2022
Phase 2
123
Placebo to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate+Doravirine/Islatravir+Doravirine+Islatravir+Lamivudine
(Islatravir 0.25 mg)
kzesrrjscc = zfomtesopo ealuklttyx (enwabqxoyw, mhlwqiymoe - wbqhgxeymf)
-
27 Apr 2022
Placebo to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate+Doravirine/Islatravir+Doravirine+Islatravir+Lamivudine
(Islatravir 0.75 mg)
kzesrrjscc = uvtccubrot ealuklttyx (enwabqxoyw, nbsanckopt - negjzjnikm)
Not Applicable
339
gupsjcimgd(uxybvktnnx) = waetsruhfy dunppcpvyl (bqlvkcqnnu )
-
01 Jan 2022
gupsjcimgd(uxybvktnnx) = krhlxdrxuo dunppcpvyl (bqlvkcqnnu )
Not Applicable
42
ciovdiqvsq(olrpcvsbxj) = pjaarjnbhi kvukfgjpqu (veeabnpgtz, 77.4 - 97.3)
Positive
01 Jan 2022
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Regulation

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